Synergistic toxic Interactions Between CYP2E1, LPS/TNFα, and JNK/p38 MAP kinase and their implications in alcohol-induced liver injury

Advances in Experimental Medicine and Biology

Volumn 815, Issue , 2015, Pages 145-172

  Cederbaum, Arthur I ^a   Lu, Yongke ^a   Wang, Xiaodong ^a   Wu, Defeng ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol liver injury; CYP2E1 dependent toxicity; CYP2E1 tumor necrosis factor alpha toxicity; JNK and p38 mitogen activated kinases; Lipopolysaccharide CYP2E1 interactions; Mitochondrial dysfunction; Oxidative stress and liver injury

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; APOPTOSIS SIGNAL REGULATING KINASE 1; ASPARTATE AMINOTRANSFERASE; CYCLOSPORIN A; CYTOCHROME P450 2E1; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; PYRAZOLE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; PYRAZOLE DERIVATIVE;

ALCOHOL LIVER CIRRHOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; KUPFFER CELL; LIVER CARCINOGENESIS; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; RISK FACTOR; ANIMAL; HUMAN; LIVER DISEASES, ALCOHOLIC; PHYSIOLOGY; TOXICITY;

MUS;

ANIMALS; CYTOCHROME P-450 CYP2E1; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; LIVER DISEASES, ALCOHOLIC; MAP KINASE KINASE KINASE 5; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRAZOLES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84925310792     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-09614-8_9     Document Type: Article

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