Nrf2 and antioxidant defense against CYP2E1 toxicity

Expert Opinion on Drug Metabolism and Toxicology

Volumn 5, Issue 10, 2009, Pages 1223-1244

  Cederbaum, Arthur ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidants; CYP2E1; Ethanol hepatotoxicity; HepG2 cells; Nrf2; Oxidative stress

Indexed keywords

1 [2 CYANO 3 12 DIOXOOLEANA 1,9(11) DIEN 28 OYL]IMIDAZOLE; ACETYLCYSTEINE; ALCOHOL; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CATALASE; CYTOCHROME P450 2E1; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; IRON; MESSENGER RNA; OLTIPRAZ; POLYUNSATURATED FATTY ACID; PYRAZOLE; REACTIVE OXYGEN METABOLITE; S ADENOSYLMETHIONINE; SMALL INTERFERING RNA; SULFORAPHANE; THIOUREA; TRANSCRIPTION FACTOR NRF2; TRITERPENOID; TROLOX C; UNCLASSIFIED DRUG;

ALCOHOL INTOXICATION; ALCOHOL METABOLISM; ALCOHOL OXIDATION; CELL DAMAGE; CELL STRAIN HEPG2; CELL SURVIVAL; CELL VIABILITY; CYTOSOL; CYTOTOXICITY; DRUG ACTIVITY; HUMAN; KNOCKOUT MOUSE; LIPID PEROXIDATION; LIVER; LIVER CARCINOGENESIS; LIVER CELL; LIVER INJURY; LIVER TOXICITY; MICROSOME; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; REVIEW; UPREGULATION; WILD TYPE;

ANIMALS; ANTIOXIDANTS; CELL LINE, TUMOR; CYTOCHROME P-450 CYP2E1; ETHANOL; HUMANS; LIVER; MICE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; RATS; SIGNAL TRANSDUCTION;

MUS; RATTUS;

EID: 70349389635     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425250903143769     Document Type: Review

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