Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway

Journal of Biological Chemistry

Volumn 281, Issue 22, 2006, Pages 15258-15267

  Wang, Yongjun ^a   Singh, Rajat ^a   Lefkowitch, Jay H ^b   Rigoli, Raina M ^a   Czaja, Mark J ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b New York Presbyterian Morgan Stanley Children's Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ENZYME KINETICS; ENZYMES; TOXIC MATERIALS; TUMORS;

ACTIVATION; HEPATOCYTES; KINASE; NECROSIS FACTOR;

CYTOLOGY;

CASPASE 3; CASPASE 7; CASPASE 8; CYTOCHROME C; GALACTOSAMINE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; LIVER INJURY; LIVER MITOCHONDRION; MALE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; CASPASE 8; CASPASES; ENZYME ACTIVATION; FEMALE; GALACTOSAMINE; LIPOPOLYSACCHARIDES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33744956373     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M512953200     Document Type: Article

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