Differential changes in MAP kinases, histone modifications, and liver injury in rats acutely treated with ethanol

Alcoholism: Clinical and Experimental Research

Volumn 34, Issue 9, 2010, Pages 1543-1551

  Aroor, Annayya R ^a   James, Taryn T ^a   Jackson, Daniel E ^a   Shukla, Shivendra D ^a  

^a University of Missouri   (United States)

Author keywords

Alcoholic Liver Disease; Binge Drinking; Epigenetics; MAPK Signaling; Steatosis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; CASPASE 3; HISTONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; LIVER CELL; LIVER INJURY; MALE; METHYLATION; MICROSCOPY; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; STEATOSIS; WESTERN BLOTTING;

ACETYLATION; ALANINE TRANSAMINASE; ANIMALS; CASPASE 3; ETHANOL; HISTONES; LIVER; MALE; METHYLATION; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 77956044644     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2010.01239.x     Document Type: Article

References (39)

1. Ait-Si-Ali S, Carlisi D, Ramirez S, Upegui-Gonzalez LC, Duquet A, Robin PR, Rudkin B, Harel-Bellan A, Trouche D (1999) Phosphorylation by p44 MAP kinase/ERK1 stimulates CBP histone acetyl transferase activity in vitro. Biochem Biophys Res Commun 262 : 157 162.
2. Aroor AR, Lee YJ, Shukla SD (2009) Activation of MEK 1/2 and p42/44 MAPK by angiotensin II in hepatocyte nucleus and their potentiation by ethanol. Alcohol 43 : 315 322.
3. Aroor AR, Shukla SD (2004) MAP kinase signaling in diverse effects of ethanol. Life Sci 74 : 2339 2364.
4. Bardag-Gorce F, Oliva J, Dedes J, Li J, French BA, French SW (2009) Chronic ethanol feeding alters hepatocyte memory which is not altered by acute feeding. Alcohol Clin Exp Res 33 : 684 692.
5. Bártová E, Krejcí J, Harnicarová A, Galiová G, Kozubek S (2008) Histone modifications and nuclear architecture: a review. J Histochem Cytochem 56 : 711 721.
6. Beier JI, Guo L, von Montfort C, Kaiser JP, Joshi-Barve S, Arteel GE (2008) New role of resistin in lipopolysaccharide-induced liver damage in mice. J Pharmacol Exp Ther 325 : 801 808.
7. Boutros T, Chevet E, Metrakos P (2008) Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev 60 : 261 310.
8. Brown MD, Sacks DB (2008) Compartmentalized MAPK pathways. Handb Exp Pharmacol 186 : 205 235.
9. Cheung P, Tanner KG, Cheung WL, Sassone-Corsi P, Denu JM, Allis CD (2000) Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol Cell 5 : 905 915.
10. Clayton AL, Mahadevan LC (2003) MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation. FEBS Lett 546 : 51 58.
11. Deitrich RA, Harris RA (1996) How much alcohol should I use in my experiments? Alcohol Clin Exp Res 20 : 1 2.
12. Delcuve GP, Rastegar M, Davie JR (2009) Epigenetic regulation. J Cell Physiol 219 : 243 250.
13. Emanuele NV, Emanuele MA, Morgan MO, Sulo D, Yong S, Kovacs EJ, Himes RD, Callaci JJ (2009) Ethanol potentiates the acute fatty infiltration of liver caused by burn injury: prevention by insulin treatment. J Burn Care Res 30 : 482 488.
14. French SW (2004) The role of hypoxia in the pathogenesis of alcoholic liver disease. Hepatol Res 29 : 69 74.
15. Kaizu T, Ikeda A, Nakao A, Tsung A, Toyokawa H, Ueki S, Geller DA, Murase N (2008) Protection of transplant induced hepatic ischemia/reperfusion injury with carbon monoxide via MEK/ERK1/2 pathway down regulation. Am J Physiol Gastrointest Liver Physiol 294 : G236 G244.
16. Kawasaki H, Schiltz L, Chiu R, Itakura K, Taira K, Yokoyama KK (2000) ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation. Nature 405 : 195 200.
17. Lee YJ, Aroor AR, Shukla SD (2002) Temporal activation of p42/44 mitogen-activated protein kinase and c-Jun N-terminal kinase by acetaldehyde in rat hepatocytes and its loss after chronic ethanol exposure. J Pharmacol Exp Ther 301 : 908 914.
18. Lee YJ, Shukla SD (2005) Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes. Eur J Pharmacol 508 : 31 45.
19. Lee YJ, Shukla YJ (2007) Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde. Eur J Pharmacol 573 : 29 38.
20. Li J, Gorospe M, Hutter D, Barnes J, Keyse SM, Liu Y (2001) Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation. Mol Cell Biol 21 : 8213 8224.
21. Li QJ, Yang SH, Maeda Y, Sladek FM, Sharrocks AD, Martins-Green M (2003) MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300. EMBO J 22 : 281 291.
22. Lucey MR, Mathurin P, Morgan TR (2009) Alcoholic hepatitis. N Engl J Med 360 : 2758 2769.
23. Mathurin P, Deltenre P (2009) Effect of binge drinking on the liver: an alarming public health issue? Gut 58 : 613 617.
24. Merienne K, Pannetier S, Harel-Bellan A, Sassone-Corsi P (2001) Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities. Mol Cell Biol 21 : 7089 7096.
25. Pal-Bhadra M, Bhadra U, Jackson DE, Mamatha L, Park PH, Shukla SD (2007) Distinct methylation patterns in histone H3 at Lys-4 and Lys-9 correlate with up- & down-regulation of genes by ethanol in hepatocytes. Life Sci 81 : 979 987.
26. Park PH, Lim RW, Shukla SD (2005) Involvement of histone acetyltransferase (HAT) in ethanol-induced acetylation of histone H3 in hepatocytes: potential mechanism for gene expression. Am J Physiol Gastrointest Liver Physiol 289 : G1124 G1136.
27. Purohit V, Gao B, Song BJ (2009) Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res 33 : 191 205.
28. Rivara PF, Jurkovich GJ, Gurney JG, Seguin D, Fligner CL, Ries R, Raisys VA, Copass M (1993) The magnitude of acute and chronic alcohol abuse in trauma patients. Arch Surg 128 : 907 913.
29. Roux PP, Blenis J (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68 : 320 344.
30. Sabbatini M, Santillo M, Pisani A, Paternò R, Uccello F, Serù R, Matrone G, Spagnuolo G, Andreucci M, Serio V, Esposito P, Cianciaruso B, Fuiano G, Avvedimento EV (2006) Inhibition of Ras/ERK1/2 signaling protects against postischemic renal injury. Am J Physiol Renal Physiol. 290 : F1408 F1415.
31. Sassone-Corsi P, Mizzen CA, Cheung P, Crosio C, Monaco L, Jacquot S, Hanauer A, Allis CD (1999) Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science 285 : 886 891.
32. Schattenberg JM, Wang Y, Rigoli RM, Koop DR, Czaza MJ (2004) CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling. Hepatology 39 : 444 455.
33. Shukla SD, Velazquez J, French SW, Lu SC, Ticku MK, Zakhari S (2008) Emerging role of epigenetics in the actions of alcohol. Alcohol Clin Exp Res 32 : 1525 1534.
34. Tikoo K, Lau SS, Monks TJ (2001) Histone H3 phosphorylation is coupled to poly-(ADP-ribosylation) during reactive oxygen species-induced cell death in renal proximal tubular epithelial cells. Mol Pharmacol 60 : 399 402.
35. Waring P, Khan T, Sjaarda A (1997) Apoptosis induced by gliotoxin is preceded by phosphorylation of histone H3 and enhanced sensitivity of chromatin to nuclease digestion. J Biol Chem 272 : 17929 17936.
36. Weng Yu-I, Shukla SD (2000) Ethanol alters angiotensin II stimulated mitogen activated protein kinase in hepatocytes: agonist selectivity and ethanol metabolic independence. Eur J Pharmacol 398 : 323 331.
37. You M, Cao Q, Liang X, Ajmo JM, Ness GC (2008) Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice. J Nutr 138 : 497 501.
38. Zhang Y, Venugopal SK, He S, Liu P, Wu J, Zern MA (2007) Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms. Cell Signal 19 : 2339 2350.
39. Zhong S, Zhang Y, Jansen C, Goto H, Inagaki M, Dong Z (2001) MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28. J Biol Chem 276 : 12932 12937.