Activation of ASK-1 and downstream MAP kinases in cytochrome P4502E1 potentiated tumor necrosis factor α liver injury

Free Radical Biology and Medicine

Volumn 49, Issue 3, 2010, Pages 348-360

  Wu, Defeng ^a   Cederbaum, Arthur ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

ASK 1; CYP2E1; Free radicals; Liver injury; MAP kinases; Oxidative stress; ROS; TNF

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE 3; CASPASE 8; CYTOCHROME P450 2E1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; PROTEIN BCL 2; PYRAZOLE; STRESS ACTIVATED PROTEIN KINASE; THIOREDOXIN; TUMOR NECROSIS FACTOR ALPHA; MAP2K3 PROTEIN, MOUSE; MAP2K6 PROTEIN, MOUSE; MAP2K7 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PYRAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; KNOCKOUT MOUSE; LIVER INJURY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; WILD TYPE; ANIMAL; DRUG EFFECTS; DRUG POTENTIATION; DRUG-INDUCED LIVER INJURY; METABOLISM; PHYSIOLOGY; TOXICITY;

ANIMALS; CYTOCHROME P-450 CYP2E1; DRUG SYNERGISM; DRUG-INDUCED LIVER INJURY; ENZYME ACTIVATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE KINASE 3; MAP KINASE KINASE 6; MAP KINASE KINASE 7; MAP KINASE KINASE KINASE 5; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRAZOLES; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 77954142707     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.04.021     Document Type: Article

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