Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2 -/- but not in c-Jun N-terminal kinase 1 -/- mice

Hepatology

Volumn 54, Issue 5, 2011, Pages 1753-1766

  Wang, Xiaodong ^a   Wu, Defeng ^a   Yang, Lili ^a   Cederbaum, Arthur I ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; ANTIOXIDANT; CATALASE; CYTOCHROME C; CYTOCHROME P450 2E1; GLUTATHIONE; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE 9; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; PYRAZOLE; PYRAZOLE PLUS TUMOR NECROSIS FACTOR ALPHA; STRESS ACTIVATED PROTEIN KINASE 1; SUPEROXIDE; THIOREDOXIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; LIPID PEROXIDATION; LIVER TOXICITY; MALE; MITOCHONDRION; MONOTHERAPY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ALANINE TRANSAMINASE; ANIMALS; CASPASE 3; CASPASE 8; CATALASE; DRUG-INDUCED LIVER INJURY; ENZYME INHIBITORS; FEMALE; LIPID PEROXIDATION; LIVER DISEASES, ALCOHOLIC; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PYRAZOLES; RISK FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80055040928     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24540     Document Type: Article

References (33)

1. Albano E. Alcohol, oxidative stress, and free radical damage. Proc Nutr Soc 2006; 65: 278-290.
2. Bondy SC. Ethanol toxicity and oxidative stress. Toxicol Lett 1992; 63: 231-242.
3. Nordman R, Riviere C, Rouach H. Implication of free radical mechanisms in ethanol-induced cellular injury. Free Rad Biol Med 1992; 12: 219-240.
4. Bailey SM. A review of the role of reactive oxygen and nitrogen species in alcohol-induced mitochondrial dysfunction. Free Radic Res 2003; 37: 585-596.
5. Iimuro Y, Gallucci RM, Luster MI, Kono H, Thurman RG. Antibodies to tumor necrosis factor alpha attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. HEPATOLOGY 1997; 26: 1530-1537.
6. Lieber CS. Cytochrome P4502E1: its physiological and pathological role. Physiol Rev 1997; 77: 517-544.
7. Thurman RG. Mechanisms of hepatic toxicity. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol 1998; 275: G605-G611.
8. Yin M, Wheeler MD, Kono H, Bradford BU, Galluci RM, Luster MI, et al. Essential role of TNFα in alcohol-induced liver injury in mice. Gastroenterology 1999; 117: 942-952.
9. Tsukamoto H. How is the liver primed or sensitized for alcoholic liver disease? Alcohol Clin Exp Res 2001; 25: 171S-181S.
10. Pastorino JG, Hoek JB. Ethanol potentiates tumor necrosis factor-alpha cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition. HEPATOLOGY 2000; 31: 1141-1152
11. Liu H, Jones BE, Bradham C, Czaja MJ. Increased cytochrome P-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-alpha. Am J Physiol Gastrointest Liver Physiol 2002b; 282: G257-G266.
12. Lu Y, Cederbaum AI. Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5. HEPATOLOGY 2006; 44: 263-274.
13. Lu Y, Wang X, Cederbaum AI. Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole. Am J Physiol Gastrointest Liver Physiol 2005; 289: G308-G319.
14. Wu D, Cederbaum AI. Cytochrome P4502E1 sensitizes to tumor necrosis factor alpha-induced liver injury through activation of mitogen-activeted protein kineses in mice. HEPATOLOGY 2008; 47: 1005-1017.
15. Liu H, Lo CR, Czaja MJ. NF-kappaB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun. HEPATOLOGY 2002a; 35: 772-778.
16. Czaja MJ. The future of GI and liver research: editorial perspectives. III. JNK/AP-1 regulation of hepatocyte death. Am J Physiol Gastrointest Liver Physiol 2003; 284: G875-G879.
17. Schattenberg JM, Singh R, Wang Y, Lefkowitch JH, Rigoli RM, Scherer PE, et al. JNK1 but not JNK2 promotes the development of steatohepatitis in mice. HEPATOLOGY 2006; 43: 163-172.
18. Gunawan BK, Liu ZX, Han D, Hanawa N, Gaarde WA, Kaplowitz N. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology 2006; 131: 165-178.
19. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000; 103: 239-252.
20. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ, Brenner DA. Differential requirement for c-Jun NH2-terminal kinase in TNFα- and Fas-mediated apoptosis in hepatocytes. FASEB J 2004; 18: 720-722.
21. Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, et al. Bile acid regulation of C/EBPβ, CREB, and c-Jun function via the extracellular signal-regulated kinase and c-Jun NH2 terminal kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol 2003; 23: 3052-3066.
22. Lee YJ, Shukla SD. Pro- and anti-apoptotic roles of c-Jun N terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes. Eur J Pharmacol 2005; 508: 31-45.
23. Minamiyama Y, Takemura S, Toyokuni S, Imaoka S, Funae Y, Hirohashi K, et al. CYP3A induction aggravates endotoxemic liver injury via reactive oxygen species in male rats. Free Rad Biol Med 2004; 37: 703-712.
24. Wu D, Cederbaum AI. Activation of ASK-1 and downstream MAP kinases in cytochrome P4502e1 potetiated TNFα liver injury. Free Rad Biol Med 2010; 49: 348-360.
25. Lindstrom TD, Aust SD. Studies on cytochrome P450-dependent lipid hydroperoxide reduction. Arch Biochem Biophys 1984; 233: 80-87.
26. Shen HM, Pervaiz S. TNF receptor superfamily-induced cell death: redox-dependent execution. FASEB J 2006; 20: 1589-1598.
27. Schwabe RF, Brenner DA. Mechanisms of liver injury. TNFα-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol 2006; 290: G583-G589.
28. Liu J, Minemoto Y, Lin A. C-Jun N-terminal kinase1 (JNK1) but not JNK2 is essential for TNFα-induced c-Jun kinase activation and apoptosis. Mol Cell Biol 2004; 24: 10844-10856.
29. Wang Y, Singh R, Lefkowitch JH, Rigoli RM, Scherer PE, Czaja MJ. Tumor necrosis factor induced liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway. J Biol Chem 2006; 281: 15258-15267.
30. Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA, Czaja M.J. Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. HEPATOLOGY 2009; 49: 87-96.
31. Eminel S, Klettner K, Roemer L, Herdegan T, Waetzig V. JNK2 translocates to the mitochondria and mediates cytochrome relaease in PC12 cells in response to 6-hydroxydopamine. J Biol Chem 2004; 279: 55385-55392.
32. Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell 2004; 15: 713-725.
33. Antosiewicz J, Ziolkowski W, Kaczor JJ, Herman-Antosiewicz A. TNFα-induced reactive oxygen species formation is mediated by JNK1-dependent ferritin degradation and elevation of labile iron pool. Free Rad Biol Med 2007; 43: 265-270.