c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis

Molecular and Cellular Biology

Volumn 24, Issue 24, 2004, Pages 10844-10856

  Liu, Jing ^a   Minemoto, Yuzuru ^a   Lin, Anning ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM;

ANIMALS; APOPTOSIS; CASPASES; CELL EXTRACTS; CELL LINE, TRANSFORMED; ENZYME ACTIVATION; FIBROBLASTS; GLUTATHIONE TRANSFERASE; IMMUNOBLOTTING; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; MODELS, BIOLOGICAL; PHOSPHORYLATION; PRECIPITIN TESTS; PROTO-ONCOGENE PROTEINS C-JUN; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 10044247350     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.24.10844-10856.2004     Document Type: Article

References (31)

1. Chang, L., and M. Karin. 2001. Mammalian MAP kinase signaling cascades. Nature 410:37-40.
2. + T cell activation. J. Exp. Med. 195:811-823.
3. Davis, R. J. 2000. Signal transduction by the JNK group of MAP kinases. Cell 103:239-252.
4. Deng, Y., X. Ren, L. Yang, Y. Lin, and X. Wu. 2003. A JNK-dependent pathway is required for TNFα-induced apoptosis. Cell 115:61-70.
5. Derijard, B., J. Raingeaud, T. Barrett, I. H. Wu, J. Han, R. J. Ulevitch, and R. J. Davis. 1995. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682-685.
6. Dietrich, N., J. Thastrup, C. Holmberg, M. Gyrd-Hansen, N. Fehrenbacher, U. Lademann, M. Lerdrup, T. Herdegen, M. Jaattela, and T. Kallunki. 2004. JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways. Cell Death Differ. 11:301-313.
7. Eferl, R., R. Ricci, L. Kenner, R. Zenz, J. P. David, M. Rath, and E. F. Wagner. 2003. Liver tumor development: c-Jun antagonizes the proapoptotic activity of p53. Cell 112:181-192.
8. Hibi, M., A. Lin, T. Smeal, A. Minden, and M. Karin. 1993. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7:2135-2148.
9. Hirosumi, J., G. Tuncman, L. Chang, C. Z. Gorgun, K. T. Uysal, K. Maeda, M. Karin, and G. S. Hotamisligil. 2002. A central role for JNK in obesity and insulin resistance. Nature 420:333-336.
10. Hochedlinger, K., E. F. Wagner, and K. Sabapathy. 2002. Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis. Oncogene 21:2441-2445.
11. Kallunki, T., B. Su, I. Tsigelny, H. K. Sluss, B. Derijard, G. Moore, R. Davis, and M. Karin. 1994. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 8:2996-3007.
12. Karin, M. 1995. The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem. 270:16483-16486.
13. Karin, M., and A. Lin. 2002. NF-κB at the crossroads of life and death. Nat. Immunol. 3:221-227.
14. Kuan, C. Y., D. D. Yang, D. R. Samanta Roy, R. J. Davis, P. Rakic, and R. A. Flavell. 1999. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22:667-676.
15. Lamb, J. A., J. J. Ventura, P. Hess, R. A. Flavell, and R. J. Davis. 2003. JunD mediates survival signaling by the JNK signal transduction pathway. Mol. Cell 11:1479-1489.
16. Lin, A. 2003. Activation of the JNK signaling pathway: breaking the brake on apoptosis. Bioessays 25:1-8.
17. Lin, A., A. Minden, H. Martinetto, F. X. Claret, C. Lange-Carter, F. Mercurio, G. L. Johnson, and M. Karin. 1995. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268:286-290.
18. 2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. J. Biol. Chem. 272:24751-24754.
19. Maeda, S., L. Chang, Z.-W. Li, J.-L. Luo, H. Leffert, and M. Karin. 2003. IKKβ is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFα. Immunity 19:725-737.
20. Sabapathy, K., W. Jochum, K. Hochedlinger, L. Chang, M. Karin, and E. F. Wagner. 1999. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech. Dev. 89:115-124.
21. Sanchez, I., R. T. Hughes, B. J. Mayer, K. Yee, J. R. Woodgett, J. Avruch, J. M. Kyriakis, and L. I. Zon. 1994. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 372:794-798.
22. Shaulian, E., and M. Karin. 2002. AP-1 as a regulator of cell life and death. Nat. Cell Biol. 4:E131-E136.
23. 2-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 62:1343-1348.
24. Tang, F., G. Tang, J. Xiang, Q. Dai, M. R. Rosner, and A. Lin. 2002. Absence of NF-κB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol. Cell. Biol. 24:8571-8579.
25. Tang, G., Y. Minemoto, B. Dibling, N. H. Purcell, Z. Li, M. Karin, and A. Lin. 2001. Inhibition of JNK activation through NF-κB target genes. Nature 414:313-317.
26. Tang, G., J. Yang, Y. Minemoto, and A. Lin. 2001. Blocking caspase 3-mediated proteolysis of IKKβ suppresses TNF-α-induced apoptosis. Mol. Cell 8:1005-1016.
27. Tournier, C., P. Hess, D. D. Yang, J. Xu, T. K. Turner, A. Nimnual, D. Bar-Sagi, S. N. Jones, R. A. Flavell, and R. J. Davis. 2000. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288:870-874.
28. 2/M cell-cycle progression and cellular senescence. Nat. Cell Biol. 6:215-226.
29. Wisdom, R., R. S. Johnson, and C. Moore. 1999. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J. 18:188-197.
30. Yu, C., Y. Minemoto, J. Zhang, J. Liu, F. Tang, T. N. Bui, J. Xiang, and A. Lin. 2004. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol. Cell 13:329-340.
31. Zheng, C., J. Xiang, T. Hunter, and A. Lin. 1999. The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity. J. Biol. Chem. 274:28966-28971.