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Volumn 1833, Issue 6, 2013, Pages 1454-1462

Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells

Author keywords

Prolyl hydroxylase domain containing protein; Renal fibrosis; Smad signaling pathway

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALVASCULIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; P CADHERIN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE DOMAIN CONTAINING PROTEIN 1; PROLYL HYDROXYLASE DOMAIN CONTAINING PROTEIN 2; PROLYL HYDROXYLASE DOMAIN CONTAINING PROTEIN 3; PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 84875790987     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2013.02.029     Document Type: Article
Times cited : (74)

References (65)
  • 1
    • 82355190219 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of renal fibrosis
    • Liu Y. Cellular and molecular mechanisms of renal fibrosis. Nat. Rev. Nephrol. 2011, 7:684-696.
    • (2011) Nat. Rev. Nephrol. , vol.7 , pp. 684-696
    • Liu, Y.1
  • 2
    • 80052317444 scopus 로고    scopus 로고
    • The role of TGF-beta and epithelial-to mesenchymal transition in diabetic nephropathy
    • Hills C.E., Squires P.E. The role of TGF-beta and epithelial-to mesenchymal transition in diabetic nephropathy. Cytokine Growth Factor Rev. 2011, 22:131-139.
    • (2011) Cytokine Growth Factor Rev. , vol.22 , pp. 131-139
    • Hills, C.E.1    Squires, P.E.2
  • 3
    • 70350545853 scopus 로고    scopus 로고
    • TGF-beta1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy
    • Hills C.E., Squires P.E. TGF-beta1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy. Am. J. Nephrol. 2010, 31:68-74.
    • (2010) Am. J. Nephrol. , vol.31 , pp. 68-74
    • Hills, C.E.1    Squires, P.E.2
  • 6
    • 0029076281 scopus 로고
    • Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator
    • Sharma K., Ziyadeh F.N. Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator. Diabetes 1995, 44:1139-1146.
    • (1995) Diabetes , vol.44 , pp. 1139-1146
    • Sharma, K.1    Ziyadeh, F.N.2
  • 8
    • 33748031093 scopus 로고    scopus 로고
    • Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease
    • Burns W.C., Twigg S.M., Forbes J.M., Pete J., Tikellis C., Thallas-Bonke V., Thomas M.C., Cooper M.E., Kantharidis P. Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease. J. Am. Soc. Nephrol. 2006, 17:2484-2494.
    • (2006) J. Am. Soc. Nephrol. , vol.17 , pp. 2484-2494
    • Burns, W.C.1    Twigg, S.M.2    Forbes, J.M.3    Pete, J.4    Tikellis, C.5    Thallas-Bonke, V.6    Thomas, M.C.7    Cooper, M.E.8    Kantharidis, P.9
  • 9
    • 77957334362 scopus 로고    scopus 로고
    • Transforming growth factor-{beta}1 induces Smad3-dependent {beta}1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis
    • Yeh Y.C., Wei W.C., Wang Y.K., Lin S.C., Sung J.M., Tang M.J. Transforming growth factor-{beta}1 induces Smad3-dependent {beta}1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis. Am. J. Pathol. 2010, 177:1743-1754.
    • (2010) Am. J. Pathol. , vol.177 , pp. 1743-1754
    • Yeh, Y.C.1    Wei, W.C.2    Wang, Y.K.3    Lin, S.C.4    Sung, J.M.5    Tang, M.J.6
  • 11
    • 39049119220 scopus 로고    scopus 로고
    • Activation of the renin-angiotensin system and chronic hypoxia of the kidney
    • Nangaku M., Fujita T. Activation of the renin-angiotensin system and chronic hypoxia of the kidney. Hypertens. Res. 2008, 31:175-184.
    • (2008) Hypertens. Res. , vol.31 , pp. 175-184
    • Nangaku, M.1    Fujita, T.2
  • 12
    • 33645452371 scopus 로고    scopus 로고
    • Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure
    • Nangaku M. Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J. Am. Soc. Nephrol. 2006, 17:17-25.
    • (2006) J. Am. Soc. Nephrol. , vol.17 , pp. 17-25
    • Nangaku, M.1
  • 14
    • 77954372059 scopus 로고    scopus 로고
    • Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms
    • Copple B.L. Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms. Liver Int. 2010, 30:669-682.
    • (2010) Liver Int. , vol.30 , pp. 669-682
    • Copple, B.L.1
  • 17
    • 84863283168 scopus 로고    scopus 로고
    • 2-induced cell death in colon cancer cells via the Smad2/ERK1/2/HIF-1alpha pathway
    • 2-induced cell death in colon cancer cells via the Smad2/ERK1/2/HIF-1alpha pathway. Int. J. Mol. Med. 2012, 29:906-912.
    • (2012) Int. J. Mol. Med. , vol.29 , pp. 906-912
    • Huang, Y.1    Fang, W.2    Wang, Y.3    Yang, W.4    Xiong, B.5
  • 20
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick R.K., McKnight S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001, 294:1337-1340.
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 23
    • 33747691662 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression
    • McMahon S., Charbonneau M., Grandmont S., Richard D.E., Dubois C.M. Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression. J. Biol. Chem. 2006, 281:24171-24181.
    • (2006) J. Biol. Chem. , vol.281 , pp. 24171-24181
    • McMahon, S.1    Charbonneau, M.2    Grandmont, S.3    Richard, D.E.4    Dubois, C.M.5
  • 24
    • 65649126007 scopus 로고    scopus 로고
    • Non-hypoxic activation of the negative regulatory feedback loop of prolyl-hydroxylase oxygen sensors
    • Tug S., Delos Reyes B., Fandrey J., Berchner-Pfannschmidt U. Non-hypoxic activation of the negative regulatory feedback loop of prolyl-hydroxylase oxygen sensors. Biochem. Biophys. Res. Commun. 2009, 384:519-523.
    • (2009) Biochem. Biophys. Res. Commun. , vol.384 , pp. 519-523
    • Tug, S.1    Delos Reyes, B.2    Fandrey, J.3    Berchner-Pfannschmidt, U.4
  • 25
    • 34547905406 scopus 로고    scopus 로고
    • Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system
    • Takeda K., Cowan A., Fong G.-H. Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation 2007, 116:774-781.
    • (2007) Circulation , vol.116 , pp. 774-781
    • Takeda, K.1    Cowan, A.2    Fong, G.-H.3
  • 29
    • 66049134863 scopus 로고    scopus 로고
    • C-peptide reverses TGF-beta1-induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy
    • Hills C.E., Al-Rasheed N., Al-Rasheed N., Willars G.B., Brunskill N.J. C-peptide reverses TGF-beta1-induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy. Am. J. Physiol. Renal. Physiol. 2009, 296:F614-F621.
    • (2009) Am. J. Physiol. Renal. Physiol. , vol.296
    • Hills, C.E.1    Al-Rasheed, N.2    Al-Rasheed, N.3    Willars, G.B.4    Brunskill, N.J.5
  • 30
    • 78651395628 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells
    • Wang Z., Tang L., Zhu Q., Yi F., Zhang F., Li P.L., Li N. Hypoxia-inducible factor-1alpha contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells. Kidney Int. 2011, 79:300-310.
    • (2011) Kidney Int. , vol.79 , pp. 300-310
    • Wang, Z.1    Tang, L.2    Zhu, Q.3    Yi, F.4    Zhang, F.5    Li, P.L.6    Li, N.7
  • 31
    • 0037131159 scopus 로고    scopus 로고
    • Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3
    • Huang J., Zhao Q., Mooney S.M., Lee F.S. Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3. J. Biol. Chem. 2002, 277:39792-39800.
    • (2002) J. Biol. Chem. , vol.277 , pp. 39792-39800
    • Huang, J.1    Zhao, Q.2    Mooney, S.M.3    Lee, F.S.4
  • 33
    • 84868115582 scopus 로고    scopus 로고
    • Overexpression of HIF prolyl-hydoxylase-2 transgene in the renal medulla induced a salt-sensitive hypertension
    • Zhu Q., Liu M., Han W., Li P.L., Wang Z., Li N. Overexpression of HIF prolyl-hydoxylase-2 transgene in the renal medulla induced a salt-sensitive hypertension. J. Cell Mol. Med. 2012.
    • (2012) J. Cell Mol. Med.
    • Zhu, Q.1    Liu, M.2    Han, W.3    Li, P.L.4    Wang, Z.5    Li, N.6
  • 34
    • 80053564265 scopus 로고    scopus 로고
    • Silencing of hypoxia-inducible factor-1alpha gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats
    • Zhu Q., Wang Z., Xia M., Li P.L., Van Tassell B.W., Abbate A., Dhaduk R., Li N. Silencing of hypoxia-inducible factor-1alpha gene attenuated angiotensin II-induced renal injury in Sprague-Dawley rats. Hypertension 2011, 58:657-664.
    • (2011) Hypertension , vol.58 , pp. 657-664
    • Zhu, Q.1    Wang, Z.2    Xia, M.3    Li, P.L.4    Van Tassell, B.W.5    Abbate, A.6    Dhaduk, R.7    Li, N.8
  • 35
    • 77951463662 scopus 로고    scopus 로고
    • Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla
    • Wang Z., Zhu Q., Xia M., Li P.L., Hinton S.J., Li N. Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla. Hypertension 2010, 55:1129-1136.
    • (2010) Hypertension , vol.55 , pp. 1129-1136
    • Wang, Z.1    Zhu, Q.2    Xia, M.3    Li, P.L.4    Hinton, S.J.5    Li, N.6
  • 36
    • 51049103235 scopus 로고    scopus 로고
    • Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals
    • Tacchini L., Gammella E., De Ponti C., Recalcati S., Cairo G. Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals. J. Biol. Chem. 2008, 283:20674-20686.
    • (2008) J. Biol. Chem. , vol.283 , pp. 20674-20686
    • Tacchini, L.1    Gammella, E.2    De Ponti, C.3    Recalcati, S.4    Cairo, G.5
  • 37
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    • Peinado H., Olmeda D., Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?. Nat. Rev. Cancer 2007, 7:415-428.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 40
    • 79959427105 scopus 로고    scopus 로고
    • Reversal by growth hormone of homocysteine-induced epithelial-to-mesenchymal transition through membrane raft-redox signaling in podocytes
    • Li C.X., Xia M., Han W.Q., Li X.X., Zhang C., Boini K.M., Liu X.C., Li P.L. Reversal by growth hormone of homocysteine-induced epithelial-to-mesenchymal transition through membrane raft-redox signaling in podocytes. Cell. Physiol. Biochem. 2011, 27:691-702.
    • (2011) Cell. Physiol. Biochem. , vol.27 , pp. 691-702
    • Li, C.X.1    Xia, M.2    Han, W.Q.3    Li, X.X.4    Zhang, C.5    Boini, K.M.6    Liu, X.C.7    Li, P.L.8
  • 41
    • 27844461512 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways
    • Larue L., Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene 2005, 24:7443-7454.
    • (2005) Oncogene , vol.24 , pp. 7443-7454
    • Larue, L.1    Bellacosa, A.2
  • 42
    • 77952495532 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and proliferation of retinal pigment epithelial cells initiated upon loss of cell-cell contact
    • Tamiya S., Liu L., Kaplan H.J. Epithelial-mesenchymal transition and proliferation of retinal pigment epithelial cells initiated upon loss of cell-cell contact. Invest. Ophthalmol. Vis. Sci. 2010, 51:2755-2763.
    • (2010) Invest. Ophthalmol. Vis. Sci. , vol.51 , pp. 2755-2763
    • Tamiya, S.1    Liu, L.2    Kaplan, H.J.3
  • 44
    • 77955595272 scopus 로고    scopus 로고
    • TGF-beta signaling and the renal tubular epithelial cell: too much, too little, and just right
    • Kopp J.B. TGF-beta signaling and the renal tubular epithelial cell: too much, too little, and just right. J. Am. Soc. Nephrol. 2010, 21:1241-1243.
    • (2010) J. Am. Soc. Nephrol. , vol.21 , pp. 1241-1243
    • Kopp, J.B.1
  • 45
    • 0034791260 scopus 로고    scopus 로고
    • Role of AP-1 and HIF-1 transcription factors in TGF-beta activation of VEGF expression
    • Shih S.C., Claffey K.P. Role of AP-1 and HIF-1 transcription factors in TGF-beta activation of VEGF expression. Growth Factors 2001, 19:19-34.
    • (2001) Growth Factors , vol.19 , pp. 19-34
    • Shih, S.C.1    Claffey, K.P.2
  • 47
    • 34547905406 scopus 로고    scopus 로고
    • Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system
    • Takeda K., Cowan A., Fong G.H. Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation 2007, 116:774-781.
    • (2007) Circulation , vol.116 , pp. 774-781
    • Takeda, K.1    Cowan, A.2    Fong, G.H.3
  • 54
    • 77955602944 scopus 로고    scopus 로고
    • Resolved: EMT produces fibroblasts in the kidney
    • Zeisberg M., Duffield J.S. Resolved: EMT produces fibroblasts in the kidney. J. Am. Soc. Nephrol. 2010, 21:1247-1253.
    • (2010) J. Am. Soc. Nephrol. , vol.21 , pp. 1247-1253
    • Zeisberg, M.1    Duffield, J.S.2
  • 56
    • 77954863900 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-alpha
    • Camara J., Jarai G. Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-alpha. Fibrogenesis Tissue Repair 2010, 3:2.
    • (2010) Fibrogenesis Tissue Repair , vol.3 , pp. 2
    • Camara, J.1    Jarai, G.2
  • 57
    • 16344378397 scopus 로고    scopus 로고
    • TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
    • Valcourt U., Kowanetz M., Niimi H., Heldin C.H., Moustakas A. TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol. Biol. Cell 2005, 16:1987-2002.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 1987-2002
    • Valcourt, U.1    Kowanetz, M.2    Niimi, H.3    Heldin, C.H.4    Moustakas, A.5
  • 58
    • 84867186245 scopus 로고    scopus 로고
    • Activation of Smad-mediated TGF-beta signaling triggers epithelial-mesenchymal transitions in murine cloned corneal progenitor cells
    • Kawakita T., Espana E.M., Higa K., Kato N., Li W., Tseng S.C. Activation of Smad-mediated TGF-beta signaling triggers epithelial-mesenchymal transitions in murine cloned corneal progenitor cells. J. Cell. Physiol. 2012, 228:225-234.
    • (2012) J. Cell. Physiol. , vol.228 , pp. 225-234
    • Kawakita, T.1    Espana, E.M.2    Higa, K.3    Kato, N.4    Li, W.5    Tseng, S.C.6
  • 59
    • 78649755556 scopus 로고    scopus 로고
    • IKK(alpha) controls canonical TGF(ss)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells
    • Brandl M., Seidler B., Haller F., Adamski J., Schmid R.M., Saur D., Schneider G. IKK(alpha) controls canonical TGF(ss)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells. J. Cell Sci. 2010, 123:4231-4239.
    • (2010) J. Cell Sci. , vol.123 , pp. 4231-4239
    • Brandl, M.1    Seidler, B.2    Haller, F.3    Adamski, J.4    Schmid, R.M.5    Saur, D.6    Schneider, G.7
  • 60
    • 0346727324 scopus 로고    scopus 로고
    • Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    • Sato M., Muragaki Y., Saika S., Roberts A.B., Ooshima A. Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J. Clin. Invest. 2003, 112:1486-1494.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1486-1494
    • Sato, M.1    Muragaki, Y.2    Saika, S.3    Roberts, A.B.4    Ooshima, A.5
  • 61
    • 59449090107 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial to mesenchymal transition
    • Xu J., Lamouille S., Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 2009, 19:156-172.
    • (2009) Cell Res. , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 62
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R., Weinberg R.A. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 2009, 119:1420-1428.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 63
    • 79551521517 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?
    • Kriz W., Kaissling B., Le Hir M. Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?. J. Clin. Invest. 2011, 121:468-474.
    • (2011) J. Clin. Invest. , vol.121 , pp. 468-474
    • Kriz, W.1    Kaissling, B.2    Le Hir, M.3
  • 64
    • 79955955054 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in renal fibrosis - evidence for and against
    • Fragiadaki M., Mason R.M. Epithelial-mesenchymal transition in renal fibrosis - evidence for and against. Int. J. Exp. Pathol. 2011, 92:143-150.
    • (2011) Int. J. Exp. Pathol. , vol.92 , pp. 143-150
    • Fragiadaki, M.1    Mason, R.M.2
  • 65
    • 78149298226 scopus 로고    scopus 로고
    • Mechanisms of tubulointerstitial fibrosis
    • Zeisberg M., Neilson E.G. Mechanisms of tubulointerstitial fibrosis. J. Am. Soc. Nephrol. 2010, 21:1819-1834.
    • (2010) J. Am. Soc. Nephrol. , vol.21 , pp. 1819-1834
    • Zeisberg, M.1    Neilson, E.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.