Overexpression of hypoxia-inducible-factor 1α(HIF-1α) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage

British Journal of Cancer

Volumn 89, Issue 6, 2003, Pages 1042-1047

  Kurokawa, T ^a   Miyamoto, M ^a   Kato, K ^a   Cho, Y ^a   Kawarada, Y ^a   Hida, Y ^a   Shinohara, T ^b   Itoh, T ^c   Okushiba, S ^a   Kondo, S ^a   Katoh, H ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TEINE KEIJINKAI HOSPITAL   (Japan)

^c HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Adjuvant therapy; Hypoxia inducible factor 1 ; Immunohistochemistry; Lymph node metastasis; Oesophageal squamous cell carcinoma

Indexed keywords

ANTINEOPLASTIC AGENT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MONOCLONAL ANTIBODY;

ADJUVANT THERAPY; ADULT; AGED; ARTICLE; CANCER INVASION; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; ESOPHAGUS CARCINOMA; FEMALE; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MULTIMODALITY CANCER THERAPY; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RISK FACTOR; SQUAMOUS CELL CARCINOMA; SURGICAL TECHNIQUE; SURVIVAL RATE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, NEOPLASM; CARCINOMA, SQUAMOUS CELL; ESOPHAGEAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOENZYME TECHNIQUES; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; SURVIVAL RATE; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0141956303     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601186     Document Type: Article

References (30)

1. Adham M, Baulieux J, Mornex F, de La Roche de Bransat E, Ducerf C, Souquet JC, Gerard JP (2000) Combined chemotherapy and radiotherapy followed by surgery in the treatment of patients with squamous cell carcinoma of the esophagus. Cancer 89: 946-954
2. Aebersold DM, Burri P, Beer KT, Laissue J, Greiner RH, Djonov V (2001) Expression of hypoxia-inducible factor-1α: A novel predictive and prognostic parameter in radiotherapy of oropharyngeal cancer. Cancer Res 61: 2911-2916
3. Ando N, Ozawa S, Kitagawa Y, Shinozawa Y, Kitajima M (2000) Improvement in the results of surgical treatment of advanced squamous oesophageal carcinoma during 15 consecutive years. Ann Surg 232: 225-232
4. Arany Z, Huang LE, Eckner R, Bhattacharya S, Jiang C, Goldberg MA, Bunn HF, Livingston DM (1996) An essential role for p300/CBP in the cellular response to hypoxia. Proc Acad Sci USA 93: 2969-2973
5. Collard JM, Otte JB, Fiasse RF, Laterre PF, De Knock M, Longueville J, Glineur D, Romagnoli R, Reynaert M, Kestens PJ (2001) Skeletonizing en bloc esophagectomy for cancer. Ann Surg 234: 25-32
6. Dang CV, Semenza GL (1999) Oncogenic alterations of metabolism. Trends Biochem Sci 24: 68-72
7. Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16: 4604-4613
8. Fyles AW, Milosevic M, Wong R, Kavanagh MC, Pintilie M, Sun A, Chapman W, Levin W, Manchul L, Keane TJ, Hill RP (1998) Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol 48: 149-156
9. Gatenby RA, Kessler HB, Rosenblum JS, Coia LR, Moldofsky PJ, Hartz WH, Broder GJ (1988) Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys 14: 831-838
10. 2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol 26: 45-50
11. Hoetzel A, Vagts DA, Loop T, Humar M, Bauer M, Pahl HL, Geiger KK, Pannen BH (2001) Effect of nitric oxide on shock-induced hepatic heme oxygenase-1 expression in the rat. Hepatology 33: 925-937
12. Jung F, Palmer LA, Zhou N, Johns RA (2000) Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes. Circ Res 86: 319-325
13. Kato H, Tachimori Y, Watanabe H, Igaki H, Nakanishi Y, Ochiai A (1996) Recurrent esophageal carcinoma after esophagectomy with three-field lymph node dissection. J Surg Oncol 61: 267-272
14. Koukourakis MI, Giatromanolaki A, Skarlatos J, Corti L, Blandamura S, Piazza M, Gatter KC, Harris AL (2001) Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early espohageal cancer and response to photodynamic therapy and radiotherapy. Cancer Res 61: 1830-1832
15. Kusumi S, Nhisimaki T, Watanabe H, Ajioka Y, Suzuki T, Hatakeyama K (2000) Significance of immunohistochemically demonstrated micrometastases to lymph nodes in esophageal cancer with histologically negative nodes. Surgery 127: 40-46
16. Li H, Ko HP, Whitlock JP (1996) Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF 1 alpha. J Biol Chem 271: 21262-21267
17. Matsubara T, Ueda M, Takahashi T, Nakajima T, Nishi M (1996) Localization of recurrent disease after extended lymph node dissection for carcinoma of the thoracic esophagus. J Am Coll Surg 182: 340-346
18. Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, Hankinson O, Pugh CW, Ratcliffe PJ (1997) Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor gowth. Proc Natl Acad Sci USA 94: 8104-8109
19. Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ (1999) The tumorsuppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275
20. Minchenko A, Leshchinsky I, Opentanoval I, Sang N, Srinivas V, Armstead V, Caro J (2002) Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3(PFKFB3) gene. Its possible role in the Warburg effect. J Biol Chem 277: 6183-6187
21. Moulder JE, Rockwell S (1987) Tumor hypoxia: its impact on cancer Therapy. Cancer Metast Rev 5: 313-341
22. Nordsmark M, Overgaad M, Overgaad J (1996) Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 41: 31-39
23. Ryan HE, Poloni M, McNulty W, Elson D, Gassmann M, Arbeit JM, Johnson RS (2000) Hypoxia-inducible Factor-1α is a positive factor in solid tumor growth. Cancer Res 60: 4010-4015
24. Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, Giallongo A (1996) Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A, gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 271: 2529-2537
25. Sobin LH, Wittekind CH (eds) (1997) UICC TNM Classification of Malignant Tumors, 5th edn. New York: John Wiley
26. Teicher BA (1994) Hypoxia and drug resistance. Cancer Metast Rev 13:139-168
27. Torres C, Turner JR, Wang HH, Richards W, Sugarbaker D, Shahsafaei A, Odze RD (1999) Pathologic prognosis factors in Barretts associated adenocarcinoma: a follow-up study of 96 patients. Cancer 85: 520-528
28. 2 tension. Proc Natl Acad Sci USA 92: 5510-5514
29. Wang GL, Semenza GL (1993) General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 90: 4304-4308
30. Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW (1999) Overexpression of Hypoxia-inducible Factor 1α in common human cancers and their metastases. Cancer Res 59: 5830-5835