Current clinical regulation of PI3K/PTEN/Akt/mTOR signalling in treatment of human cancer

Journal of Cancer Research and Clinical Oncology

Volumn 141, Issue 4, 2015, Pages 671-689

  Lim, Hui Jun ^a   Crowe, Philip ^a   Yang, Jia Lin ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Cancers; PI3K mTOR inhibitors; PTEN expression; Targeted therapy

Indexed keywords

BIOLOGICAL MARKER; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; ENZYME INHIBITOR; MTOR PROTEIN, HUMAN; PTEN PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER RESISTANCE; CANCER THERAPY; CARCINOGENESIS; EPIGENETICS; GENE MUTATION; HEMATOLOGIC MALIGNANCY; HUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; SOLID TUMOR; TRANSCRIPTION REGULATION; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR SUPPRESSOR GENE; UPREGULATION; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CLINICAL TRIAL (TOPIC); DRUG EFFECTS; METABOLISM; NEOPLASMS;

CLINICAL TRIALS AS TOPIC; ENZYME INHIBITORS; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84924763751     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-014-1803-3     Document Type: Review

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