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Volumn 15, Issue 1, 2014, Pages 17-24

Roles of PTEN (Phosphatase and Tensin Homolog) in gastric cancer development and progression

Author keywords

Chemoresistance; Gastric cancer; Gene therapy; Inactivation; PTEN

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, HUMAN; TUMOR MARKER;

EID: 84894051794     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.1.17     Document Type: Review
Times cited : (66)

References (89)
  • 1
    • 84858248352 scopus 로고    scopus 로고
    • Genetic Changes in the PTEN Gene and their Association with Breast Cancer in Pakistan
    • Baig RM, Mahjabeen I, Sabir M, et al (2011). Genetic Changes in the PTEN Gene and their Association with Breast Cancer in Pakistan. Asian Pacific J Cancer Prev, 12, 2773-8.
    • (2011) Asian Pacific J Cancer Prev , vol.12 , pp. 2773-2778
    • Baig, R.M.1    Mahjabeen, I.2    Sabir, M.3
  • 2
    • 84875982084 scopus 로고    scopus 로고
    • PTEN expression and suppression of proliferation are associated with Cdx2 overexpression in gastric cancercells
    • Bai ZG, Ye YJ, Shen DH, et al (2013). PTEN expression and suppression of proliferation are associated with Cdx2 overexpression in gastric cancercells. Int J Oncol, 42, 1682-91.
    • (2013) Int J Oncol , vol.42 , pp. 1682-1691
    • Bai, Z.G.1    Ye, Y.J.2    Shen, D.H.3
  • 3
    • 0000227612 scopus 로고    scopus 로고
    • PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis
    • Besson A, Robbins SM, Yong VW(1999). PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis. Eur J Biochem, 263, 605-11.
    • (1999) Eur J Biochem , vol.263 , pp. 605-611
    • Besson, A.1    Robbins, S.M.2    Yong, V.W.3
  • 4
    • 0037431435 scopus 로고    scopus 로고
    • Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK-3CA amplification in gastric carcinoma
    • Byun DS, Cho K, Ryu BK, et al (2003). Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK-3CA amplification in gastric carcinoma. Int J Cancer, 104, 318-27.
    • (2003) Int J Cancer , vol.104 , pp. 318-327
    • Byun, D.S.1    Cho, K.2    Ryu, B.K.3
  • 5
    • 84877254190 scopus 로고    scopus 로고
    • Integrated genomic characterization of endometrial carcinoma
    • Cancer Genome Atlas Research Network.
    • Cancer Genome Atlas Research Network, Kandoth C, Schultz N, et al (2013). Integrated genomic characterization of endometrial carcinoma. Nature, 497, 67-73.
    • (2013) Nature , vol.497 , pp. 67-73
    • Kandoth, C.1    Schultz, N.2
  • 6
    • 0033119571 scopus 로고    scopus 로고
    • Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3'-kinase and Akt/protein kinase B
    • Carson JP, Kulik G, Weber MJ (1999). Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3'-kinase and Akt/protein kinase B. Cancer Res, 59, 1449-53.
    • (1999) Cancer Res , vol.59 , pp. 1449-1453
    • Carson, J.P.1    Kulik, G.2    Weber, M.J.3
  • 7
    • 0033118646 scopus 로고    scopus 로고
    • Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract
    • Chang JG, Chen YJ, Perng LI, et al (1999). Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract. Eur J Cancer, 35, 647-51.
    • (1999) Eur J Cancer , vol.35 , pp. 647-651
    • Chang, J.G.1    Chen, Y.J.2    Perng, L.I.3
  • 8
    • 79961168175 scopus 로고    scopus 로고
    • Methylation of an intronic region regulates miR-199a in testicular tumor malignancy
    • Cheung HH, Davis AJ, Lee TL, et al (2011). Methylation of an intronic region regulates miR-199a in testicular tumor malignancy. Oncogene, 30, 3404-15.
    • (2011) Oncogene , vol.30 , pp. 3404-3415
    • Cheung, H.H.1    Davis, A.J.2    Lee, T.L.3
  • 9
    • 84890571260 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase pathway aberrations in gastric and colorectal cancer: Meta-analysis, co-occurrence and ethnic variation
    • Chong ML, Loh M, Thakkar B, et al (2013). Phosphatidylinositol-3-kinase pathway aberrations in gastric and colorectal cancer: Meta-analysis, co-occurrence and ethnic variation. Int J Cancer, 134, 1232-8.
    • (2013) Int J Cancer , vol.134 , pp. 1232-1238
    • Chong, M.L.1    Loh, M.2    Thakkar, B.3
  • 10
    • 77955429106 scopus 로고    scopus 로고
    • MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN
    • Chun-Zhi Z, Lei H, An-Ling Z, et al (2010). MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN. BMC Cancer, 10, 367.
    • (2010) BMC Cancer , vol.10 , pp. 367
    • Chun-Zhi, Z.1    Lei, H.2    An-Ling, Z.3
  • 11
    • 84862649725 scopus 로고    scopus 로고
    • The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms
    • Ciuffreda L, Di Sanza C, Cesta Incani U, et al (2012). The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms. J Mol Med (Berl), 90, 667-79.
    • (2012) J Mol Med (Berl) , vol.90 , pp. 667-679
    • Ciuffreda, L.1    Di Sanza, C.2    Cesta Incani, U.3
  • 12
    • 0035575312 scopus 로고    scopus 로고
    • Matrix metalloproteinases and cancer
    • Cox G, O'Byrne KJ (2001). Matrix metalloproteinases and cancer. Anticancer Res, 21, 4207-19.
    • (2001) Anticancer Res , vol.21 , pp. 4207-4219
    • Cox, G.1    O'Byrne, K.J.2
  • 13
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA(1995). Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature, 378, 785-9.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 14
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of Bad couples survival Signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, et al (1997). Akt phosphorylation of Bad couples survival Signals to the cell-intrinsic death machinery. Cell, 91, 231-41.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3
  • 15
    • 84862777035 scopus 로고    scopus 로고
    • A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets
    • Deng N, Goh LK, Wang H, et al (2012). A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets. Gut, 61, 673-84.
    • (2012) Gut , vol.61 , pp. 673-684
    • Deng, N.1    Goh, L.K.2    Wang, H.3
  • 16
    • 0032533225 scopus 로고    scopus 로고
    • Gl ycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular lvocalization
    • Diehl JA, Cheng M, Roussel MF, Sherr CJ (1998). Gl ycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular lvocalization. Genes & Development, 12, 3499-511.
    • (1998) Genes & Development , vol.12 , pp. 3499-3511
    • Diehl, J.A.1    Cheng, M.2    Roussel, M.F.3    Sherr, C.J.4
  • 17
    • 77957352037 scopus 로고    scopus 로고
    • PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab responseand survival in patients with HER2-positive metastatic breast cancer
    • Esteva FJ, Guo H, Zhang S, et al. PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab responseand survival in patients with HER2-positive metastatic breast cancer. Am J Pathol, 177, 1647-56.
    • Am J Pathol , vol.177 , pp. 1647-1656
    • Esteva, F.J.1    Guo, H.2    Zhang, S.3
  • 18
    • 33646705667 scopus 로고    scopus 로고
    • Regulation of the PTEN phosphatase
    • Gericke A, Munson M, Ross AH (2006). Regulation of the PTEN phosphatase. Gene, 374, 1-9.
    • (2006) Gene , vol.374 , pp. 1-9
    • Gericke, A.1    Munson, M.2    Ross, A.H.3
  • 19
    • 84871551022 scopus 로고    scopus 로고
    • Gastric cancer epidemiology and risk factors
    • Guggenheim DE, Shah MA (2013). Gastric cancer epidemiology and risk factors. J Surg Oncol, 107, 230-6.
    • (2013) J Surg Oncol , vol.107 , pp. 230-236
    • Guggenheim, D.E.1    Shah, M.A.2
  • 20
    • 0032583122 scopus 로고    scopus 로고
    • Tumor Suppressor PTEN inhibits integrin-and Growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways
    • Gu J, Tamura M, Yamada KM (1998). Tumor Suppressor PTEN inhibits integrin-and Growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J Cell Biol, 143, 1375-83.
    • (1998) J Cell Biol , vol.143 , pp. 1375-1383
    • Gu, J.1    Tamura, M.2    Yamada, K.M.3
  • 21
    • 63849206509 scopus 로고    scopus 로고
    • Differential expression of microRNA species in human gastric cancer versus non-tumorous Tissues
    • Guo J, Miao Y, Xiao B, et al (2009). Differential expression of microRNA species in human gastric cancer versus non-tumorous Tissues. J Gastroenterol Hepatol, 24, 652-7.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 652-657
    • Guo, J.1    Miao, Y.2    Xiao, B.3
  • 22
    • 84884204791 scopus 로고    scopus 로고
    • Roles of pro-angiogenic and anti-angiogenic factors as well as matrix metalloproteinases in healing of NSAID-induced small intestinal ulcers in rats
    • Gyenge M, Amagase K, Kunimi S, Matsuoka R, Takeuchi K (2013). Roles of pro-angiogenic and anti-angiogenic factors as well as matrix metalloproteinases in healing of NSAID-induced small intestinal ulcers in rats. Life Sci, 93, 441-7.
    • (2013) Life Sci , vol.93 , pp. 441-447
    • Gyenge, M.1    Amagase, K.2    Kunimi, S.3    Matsuoka, R.4    Takeuchi, K.5
  • 23
    • 18744381273 scopus 로고    scopus 로고
    • Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene
    • Hang Y, Zheng YC, Cao Y, Li QS, Sui YJ (2005). Suppression of gastric cancer growth by adenovirus-mediated transfer of the PTEN gene. World J Gastroenterol, 11, 2224-9.
    • (2005) World J Gastroenterol , vol.11 , pp. 2224-2229
    • Hang, Y.1    Zheng, Y.C.2    Cao, Y.3    Li, Q.S.4    Sui, Y.J.5
  • 24
    • 34347405744 scopus 로고    scopus 로고
    • Biological implication of PTEN gene expression in human gastric cancer and related molecular mechanisms
    • He RF, Hu ZL, Wen JF (2007). Biological implication of PTEN gene expression in human gastric cancer and related molecular mechanisms. Zhonghua Binglixue Zazhi, 36, 324-8.
    • (2007) Zhonghua Binglixue Zazhi , vol.36 , pp. 324-328
    • He, R.F.1    Hu, Z.L.2    Wen, J.F.3
  • 25
    • 66149101689 scopus 로고    scopus 로고
    • Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma
    • Hino R, Uozaki H, Murakami N, et al (2009). Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma. Cancer Res, 69, 2766-74.
    • (2009) Cancer Res , vol.69 , pp. 2766-2774
    • Hino, R.1    Uozaki, H.2    Murakami, N.3
  • 26
    • 41349096445 scopus 로고    scopus 로고
    • Gene regulation by transcription factors and microRNAs
    • Hobert O (2008). Gene regulation by transcription factors and microRNAs. Science, 319, 1785-6.
    • (2008) Science , vol.319 , pp. 1785-1786
    • Hobert, O.1
  • 27
    • 0037192768 scopus 로고    scopus 로고
    • PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects
    • Huang J, Kontos CD (2002). PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects. J Biol Chem, 277, 10760-6.
    • (2002) J Biol Chem , vol.277 , pp. 10760-10766
    • Huang, J.1    Kontos, C.D.2
  • 28
    • 27744440723 scopus 로고    scopus 로고
    • PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells
    • Hwang PH, Kim SY, Lee JC, et al (2005). PTEN/MMAC1 enhances the growth inhibition by anticancer drugs with downregulation of IGF-II expression in gastric cancer cells. Exp Mol Med, 37, 391-8.
    • (2005) Exp Mol Med , vol.37 , pp. 391-398
    • Hwang, P.H.1    Kim, S.Y.2    Lee, J.C.3
  • 29
    • 0035935261 scopus 로고    scopus 로고
    • Suppression of tumorigenicity and metastasis in B16F10 cells by PTEN/MMAC1/TEP1 gene
    • Hwang PH, Yi HK, Kim DS, et al (2001). Suppression of tumorigenicity and metastasis in B16F10 cells by PTEN/MMAC1/TEP1 gene. Cancer Lett, 172, 83-91.
    • (2001) Cancer Lett , vol.172 , pp. 83-91
    • Hwang, P.H.1    Yi, H.K.2    Kim, D.S.3
  • 31
    • 0036127525 scopus 로고    scopus 로고
    • Promoter methylation and silencing of PTEN in gastric carcinoma
    • Kang YH, Lee HS, Kim WH (2002). Promoter methylation and silencing of PTEN in gastric carcinoma. Lab Invest, 82, 285-91.
    • (2002) Lab Invest , vol.82 , pp. 285-291
    • Kang, Y.H.1    Lee, H.S.2    Kim, W.H.3
  • 32
    • 84855341519 scopus 로고    scopus 로고
    • The apoptotic effects of the flavonoid N101-2 in human cervical cancer cells
    • Kim JH, Kang JW, Kim MS, et al (2012). The apoptotic effects of the flavonoid N101-2 in human cervical cancer cells. Toxicol In Vitro, 26, 67-73.
    • (2012) Toxicol In Vitro , vol.26 , pp. 67-73
    • Kim, J.H.1    Kang, J.W.2    Kim, M.S.3
  • 33
    • 79959403545 scopus 로고    scopus 로고
    • Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells
    • Kim JS, Xu X, Li H, et al (2011). Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells. Mol Cell Biol, 31, 2756-71.
    • (2011) Mol Cell Biol , vol.31 , pp. 2756-2771
    • Kim, J.S.1    Xu, X.2    Li, H.3
  • 34
    • 0033146396 scopus 로고    scopus 로고
    • Correlation between expression of matrix metalloproteinas-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9) and angiogenesis in colorectal adenocarcinoma
    • Kim TS, Kim YB (1999). Correlation between expression of matrix metalloproteinas-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9) and angiogenesis in colorectal adenocarcinoma. J Korean Med Sci, 14, 263-70.
    • (1999) J Korean Med Sci , vol.14 , pp. 263-270
    • Kim, T.S.1    Kim, Y.B.2
  • 35
    • 0030960657 scopus 로고    scopus 로고
    • Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease
    • Krajewska M, Wang HG, Krajewski S, et al (1997). Immunohistochemical analysis of in vivo patterns of expression of CPP32 (Caspase-3), a cell death protease. Cancer Res, 57, 1605-13.
    • (1997) Cancer Res , vol.57 , pp. 1605-1613
    • Krajewska, M.1    Wang, H.G.2    Krajewski, S.3
  • 36
    • 79958789619 scopus 로고    scopus 로고
    • E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via b-catenin-Egr1-mediated PTEN expression
    • Lau MT, Klausen C, Leung PC(2011). E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via b-catenin-Egr1-mediated PTEN expression. Oncogene, 30, 2753-66.
    • (2011) Oncogene , vol.30 , pp. 2753-2766
    • Lau, M.T.1    Klausen, C.2    Leung, P.C.3
  • 37
    • 8544230666 scopus 로고    scopus 로고
    • Phosphatidylinositol 3?-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresi-stance in advanced prostate cancer cells
    • Lee Jr JT, Steelman LS, McCubrey JA (2004). Phosphatidylinositol 3?-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresi-stance in advanced prostate cancer cells. Cancer Res, 64, 8397-404.
    • (2004) Cancer Res , vol.64 , pp. 8397-8404
    • Lee Jr., J.T.1    Steelman, L.S.2    McCubrey, J.A.3
  • 38
    • 0031001041 scopus 로고    scopus 로고
    • TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
    • Li DM, Sun H(1997). TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res, 57, 2124-9.
    • (1997) Cancer Res , vol.57 , pp. 2124-2129
    • Li, D.M.1    Sun, H.2
  • 39
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, et al (1997). PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science, 275, 1943-7.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 40
    • 27744437224 scopus 로고    scopus 로고
    • Molecular study of the tumour suppressor gene PTEN in gastric adenocarcinoma in Brazil
    • Lima EM, Araújo JJ, Harada ML,et al (2005). Molecular study of the tumour suppressor gene PTEN in gastric adenocarcinoma in Brazil. Clin Exp Med, 5, 129-32.
    • (2005) Clin Exp Med , vol.5 , pp. 129-132
    • Lima, E.M.1    Araújo, J.J.2    Harada, M.L.3
  • 41
    • 84867253682 scopus 로고    scopus 로고
    • Immunohistochemical expression of mTOR negatively correlates with PTEN expression in gastric carcinoma
    • Li M, Sun H, Song L, et al (2012). Immunohistochemical expression of mTOR negatively correlates with PTEN expression in gastric carcinoma. Oncol Lett, 4,1213-8.
    • (2012) Oncol Lett , vol.4 , pp. 1213-1218
    • Li, M.1    Sun, H.2    Song, L.3
  • 42
    • 84884567714 scopus 로고    scopus 로고
    • High-expression of DJ-1 and loss of PTEN associated with tumor metastasis and correlated with poor prognosis of gastric carcinoma
    • Li Y, Cui J, Zhang CH, et al (2013). High-expression of DJ-1 and loss of PTEN associated with tumor metastasis and correlated with poor prognosis of gastric carcinoma. Int J Med Sci, 10, 1689-97.
    • (2013) Int J Med Sci , vol.10 , pp. 1689-1697
    • Li, Y.1    Cui, J.2    Zhang, C.H.3
  • 43
    • 12344273281 scopus 로고    scopus 로고
    • Loss of heterozygosity on 10q23.3 and mutation of tumor suppressor gene PTEN in gastric cancer and precancerous lesions
    • Li YL, Tian Z, Wu DY, Fu BY, Xin Y (2005). Loss of heterozygosity on 10q23.3 and mutation of tumor suppressor gene PTEN in gastric cancer and precancerous lesions. World J Gastroenterol, 11, 285-8.
    • (2005) World J Gastroenterol , vol.11 , pp. 285-288
    • Li, Y.L.1    Tian, Z.2    Wu, D.Y.3    Fu, B.Y.4    Xin, Y.5
  • 44
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid Second messenger, phosphatidylinositol 3, 4, 5-trisphosphate
    • Maehama T, Dixon JE (1998). The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid Second messenger, phosphatidylinositol 3, 4, 5-trisphosphate. J Biol Chem, 273, 13375-8.
    • (1998) J Biol Chem , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 45
    • 0034912744 scopus 로고    scopus 로고
    • PTEN and myotubularin: novel phosphoinositide phosphatases
    • Maehama T, Taylor GS, Dixon JE (2001). PTEN and myotubularin: novel phosphoinositide phosphatases. Annu Rev Biochem, 70, 247-79.
    • (2001) Annu Rev Biochem , vol.70 , pp. 247-279
    • Maehama, T.1    Taylor, G.S.2    Dixon, J.E.3
  • 46
    • 79960271775 scopus 로고    scopus 로고
    • Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR Pathway
    • Martelli AM, Evangelisti C, Chappell W, et al (2011). Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR Pathway. Leukemia, 25,1064-79.
    • (2011) Leukemia , vol.25 , pp. 1064-1079
    • Martelli, A.M.1    Evangelisti, C.2    Chappell, W.3
  • 47
    • 84862822127 scopus 로고    scopus 로고
    • ShRNA-mediated knockdown of Bmi-1 inhibit lung adenocarcinoma cell migration and Metastasis
    • Meng X, Wang Y, Zheng X, et al (2012). ShRNA-mediated knockdown of Bmi-1 inhibit lung adenocarcinoma cell migration and Metastasis. Lung Cancer, 77, 24-30.
    • (2012) Lung Cancer , vol.77 , pp. 24-30
    • Meng, X.1    Wang, Y.2    Zheng, X.3
  • 48
    • 84873695296 scopus 로고    scopus 로고
    • PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line
    • Moon SH, Kim DK, Cha Y, et al (2013). PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line. Int J Oncol, 42, 921-8.
    • (2013) Int J Oncol , vol.42 , pp. 921-928
    • Moon, S.H.1    Kim, D.K.2    Cha, Y.3
  • 49
    • 26444503696 scopus 로고    scopus 로고
    • Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer
    • Oki E, Baba H, Tokunaga E, et al (2005). Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer. Int J Cancer, 117, 376-80.
    • (2005) Int J Cancer , vol.117 , pp. 376-380
    • Oki, E.1    Baba, H.2    Tokunaga, E.3
  • 50
    • 33646923255 scopus 로고    scopus 로고
    • Impact of loss of heterozygosity of encoding phosphate and tensin homolog on the prognosis of gastric cancer
    • Oki E, Kakeji Y, Baba H, et al (2006). Impact of loss of heterozygosity of encoding phosphate and tensin homolog on the prognosis of gastric cancer. J Gastroenterol Hepatol, 21, 814-8.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 814-818
    • Oki, E.1    Kakeji, Y.2    Baba, H.3
  • 51
    • 0035873953 scopus 로고    scopus 로고
    • Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN
    • Patel L, Pass I, Coxon P, et al (2001). Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN. Curr Biol, 11,764-8.
    • (2001) Curr Biol , vol.11 , pp. 764-768
    • Patel, L.1    Pass, I.2    Coxon, P.3
  • 52
    • 84874599503 scopus 로고    scopus 로고
    • Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression
    • Patel R, Gao M, Ahmad I, et al (2013). Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. J Clin Invest, 123, 1157-75.
    • (2013) J Clin Invest , vol.123 , pp. 1157-1175
    • Patel, R.1    Gao, M.2    Ahmad, I.3
  • 53
    • 58849102128 scopus 로고    scopus 로고
    • phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
    • Rahdar M, Inoue T, Meyer T, et al (2009). phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. ProcNatl Acad Sci USA, 106, 480-5.
    • (2009) ProcNatl Acad Sci USA , vol.106 , pp. 480-485
    • Rahdar, M.1    Inoue, T.2    Meyer, T.3
  • 54
    • 84861028929 scopus 로고    scopus 로고
    • PTEN gene: a model for genetic diseases in dermatology
    • Romano C, Schepis C (2012). PTEN gene: a model for genetic diseases in dermatology. Sci World J, 2012, 252457.
    • (2012) Sci World J , vol.2012 , pp. 252457
    • Romano, C.1    Schepis, C.2
  • 55
    • 79954992390 scopus 로고    scopus 로고
    • Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt
    • Sakamaki J, Daitoku H, Ueno K, et al (2011). Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt. Proc Natl Acad Sci USA, 108, 6085-90.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 6085-6090
    • Sakamaki, J.1    Daitoku, H.2    Ueno, K.3
  • 56
    • 18244406326 scopus 로고    scopus 로고
    • Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer
    • Sato K, Tamura G, Tsuchiya T, et al (2002). Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer. Virchows Arch, 440,160-5.
    • (2002) Virchows Arch , vol.440 , pp. 160-165
    • Sato, K.1    Tamura, G.2    Tsuchiya, T.3
  • 58
    • 0035929596 scopus 로고    scopus 로고
    • The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival
    • Schwartzbauer G, Robbins J (2001). The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. J Biol Chem, 276, 35786-93.
    • (2001) J Biol Chem , vol.276 , pp. 35786-35793
    • Schwartzbauer, G.1    Robbins, J.2
  • 59
    • 33845999615 scopus 로고    scopus 로고
    • Essential role for nuclear PTEN in Maintaining chromosomal integrity
    • Shen WH, Balajee AS, Wang J, et al (2007). Essential role for nuclear PTEN in Maintaining chromosomal integrity. Cell, 128, 157-70.
    • (2007) Cell , vol.128 , pp. 157-170
    • Shen, W.H.1    Balajee, A.S.2    Wang, J.3
  • 60
    • 78651482046 scopus 로고    scopus 로고
    • Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner
    • Song MS, Carracedo A, Salmena L, et al (2011). Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell, 144, 187-99.
    • (2011) Cell , vol.144 , pp. 187-199
    • Song, M.S.1    Carracedo, A.2    Salmena, L.3
  • 61
    • 0034854091 scopus 로고    scopus 로고
    • Regulation of PTEN transcription by p53
    • Stambolic V, MacPherson D, Sas D, et al (2001). Regulation of PTEN transcription by p53. Mol Cell, 8, 317-25.
    • (2001) Mol Cell , vol.8 , pp. 317-325
    • Stambolic, V.1    MacPherson, D.2    Sas, D.3
  • 62
    • 17144436629 scopus 로고    scopus 로고
    • Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    • Steck PA, Pershouse MA, Jasser SA, et al (1997). Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet, 15, 356-62.
    • (1997) Nat Genet , vol.15 , pp. 356-362
    • Steck, P.A.1    Pershouse, M.A.2    Jasser, S.A.3
  • 63
    • 38349030742 scopus 로고    scopus 로고
    • New insights into PTEN
    • Tamguney T, Stokoe D (2007). New insights into PTEN. J Cell Sci, 120, 4071-9.
    • (2007) J Cell Sci , vol.120 , pp. 4071-4079
    • Tamguney, T.1    Stokoe, D.2
  • 64
    • 0032486198 scopus 로고    scopus 로고
    • Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
    • Tamura M, Gu J, Matsumoto K, et al (1998). Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science, 280, 1614-7.
    • (1998) Science , vol.280 , pp. 1614-1617
    • Tamura, M.1    Gu, J.2    Matsumoto, K.3
  • 65
    • 0033556443 scopus 로고    scopus 로고
    • Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas
    • Tamura M, Gu J, Takino T, Yamada KM (1999). Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. Cancer Res, 59, 442-9.
    • (1999) Cancer Res , vol.59 , pp. 442-449
    • Tamura, M.1    Gu, J.2    Takino, T.3    Yamada, K.M.4
  • 66
    • 84894068391 scopus 로고    scopus 로고
    • Four microRNAs promote prostate cell proliferation with regulation of PTEN and its downstream signals in vitro
    • Tian L, Fang YX, Xue JL, Chen JZ (2013). Four microRNAs promote prostate cell proliferation with regulation of PTEN and its downstream signals in vitro. PLoS One, 8, e75885.
    • (2013) PLoS One , vol.8
    • Tian, L.1    Fang, Y.X.2    Xue, J.L.3    Chen, J.Z.4
  • 67
    • 0035847102 scopus 로고    scopus 로고
    • The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation
    • Torres J, Pulido R (2001). The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J Biol Chem, 276, 993-8.
    • (2001) J Biol Chem , vol.276 , pp. 993-998
    • Torres, J.1    Pulido, R.2
  • 68
    • 33845977965 scopus 로고    scopus 로고
    • Ubiquitination regulates PTEN nuclear import and tumor suppression
    • Trotman LC, Wang X, Alimonti A, et al (2007). Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell, 128, 141-56.
    • (2007) Cell , vol.128 , pp. 141-156
    • Trotman, L.C.1    Wang, X.2    Alimonti, A.3
  • 69
    • 0033946740 scopus 로고    scopus 로고
    • Phosphory-lation of the PTEN tail regulates protein stability and function
    • Vazquez F, Ramaswamy S, Nakamura N, Sellers WR (2000). Phosphory-lation of the PTEN tail regulates protein stability and function. Mol Cell Biol, 20, 5010-8.
    • (2000) Mol Cell Biol , vol.20 , pp. 5010-5018
    • Vazquez, F.1    Ramaswamy, S.2    Nakamura, N.3    Sellers, W.R.4
  • 70
    • 0035199914 scopus 로고    scopus 로고
    • The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling
    • Virolle T, Adamson ED, Baron V, et al (2001). The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nat Cell Biol, 3, 1124-8.
    • (2001) Nat Cell Biol , vol.3 , pp. 1124-1128
    • Virolle, T.1    Adamson, E.D.2    Baron, V.3
  • 72
    • 0036206130 scopus 로고    scopus 로고
    • Protean PTEN: form and function
    • Waite KA, Eng C (2002). Protean PTEN: form and function. Am J Hum Genet, 70, 829-44.
    • (2002) Am J Hum Genet , vol.70 , pp. 829-844
    • Waite, K.A.1    Eng, C.2
  • 73
    • 0038459116 scopus 로고    scopus 로고
    • Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas
    • Wang JY, Huang TJ, Chen FM, et al (2003). Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas. Virchows Arch, 442, 437-43.
    • (2003) Virchows Arch , vol.442 , pp. 437-443
    • Wang, J.Y.1    Huang, T.J.2    Chen, F.M.3
  • 74
    • 33845991111 scopus 로고    scopus 로고
    • NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN
    • Wang X, Trotman LC, Koppie T, et al (2007). NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell, 128, 129-39.
    • (2007) Cell , vol.128 , pp. 129-139
    • Wang, X.1    Trotman, L.C.2    Koppie, T.3
  • 75
    • 79961088478 scopus 로고    scopus 로고
    • MicroRNA-21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN
    • Wang ZX, Lu BB, Wang H, Cheng ZX, Yin YMM (2011). MicroRNA-21 modulates chemosensitivity of breast cancer cells to doxorubicin by targeting PTEN. Arch Med Res, 42, 281-90.
    • (2011) Arch Med Res , vol.42 , pp. 281-290
    • Wang, Z.X.1    Lu, B.B.2    Wang, H.3    Cheng, Z.X.4    Yin, Y.M.M.5
  • 76
    • 0033536225 scopus 로고    scopus 로고
    • PTEN genetransfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis
    • Wick W, Furnari FB, Naumann U, Cavenee WK, Weller M (1999). PTEN genetransfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. Oncogene, 18, 3936-43.
    • (1999) Oncogene , vol.18 , pp. 3936-3943
    • Wick, W.1    Furnari, F.B.2    Naumann, U.3    Cavenee, W.K.4    Weller, M.5
  • 77
    • 85047688996 scopus 로고    scopus 로고
    • Genetic Variants in the PI3K/PTEN/AKT/mTOR Pathway Predict Platinum-based Chemotherapy Response of Advanced Non-small Cell Lung Cancers in a Chinese Population
    • Xu JL, Wang ZW, Hu LM, et al (2012). Genetic Variants in the PI3K/PTEN/AKT/mTOR Pathway Predict Platinum-based Chemotherapy Response of Advanced Non-small Cell Lung Cancers in a Chinese Population. Asian Pacific J Cancer Prev, 13, 2157-62.
    • (2012) Asian Pacific J Cancer Prev , vol.13 , pp. 2157-2162
    • Xu, J.L.1    Wang, Z.W.2    Hu, L.M.3
  • 78
    • 0028809209 scopus 로고
    • Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
    • Yang E, Zha J, Jockel J, et al (1995). Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell, 80, 285-91.
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockel, J.3
  • 79
    • 0037439234 scopus 로고    scopus 로고
    • PTEN encoding product: a marker for tumorigenesis and progression of gastric carcinoma
    • Yang L, Kuang LG, Zheng HC, et al (2003). PTEN encoding product: a marker for tumorigenesis and progression of gastric carcinoma. World J Gastroenterol, 9, 35-9.
    • (2003) World J Gastroenterol , vol.9 , pp. 35-39
    • Yang, L.1    Kuang, L.G.2    Zheng, H.C.3
  • 80
    • 84879826452 scopus 로고    scopus 로고
    • MiR-214 regulate gastric cancer cell proliferation, migration and invasion by targeting PTEN
    • Yang TS, Yang XH, Wang XD, et al (2013). MiR-214 regulate gastric cancer cell proliferation, migration and invasion by targeting PTEN. Cancer Cell Int, 13, 68.
    • (2013) Cancer Cell Int , vol.13 , pp. 68
    • Yang, T.S.1    Yang, X.H.2    Wang, X.D.3
  • 81
    • 84873907094 scopus 로고    scopus 로고
    • Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?
    • Yang Z, Yuan XG, Chen J, Lu NH (2012). Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis? World J Gastroenterol, 18, 6345-8.
    • (2012) World J Gastroenterol , vol.18 , pp. 6345-6348
    • Yang, Z.1    Yuan, X.G.2    Chen, J.3    Lu, N.H.4
  • 82
    • 84873123369 scopus 로고    scopus 로고
    • Reduced expression of PTEN and increased PTEN phosphorylation at residue Ser380 in gastric cancer tissues: a novel mechanism of PTEN inactivation
    • Yang Z, Yuan XG, Chen J, et al (2013). Reduced expression of PTEN and increased PTEN phosphorylation at residue Ser380 in gastric cancer tissues: a novel mechanism of PTEN inactivation. Clin Res Hepatol Gastroenterol, 37, 72-9.
    • (2013) Clin Res Hepatol Gastroenterol , vol.37 , pp. 72-79
    • Yang, Z.1    Yuan, X.G.2    Chen, J.3
  • 83
    • 84868019147 scopus 로고    scopus 로고
    • Expression of PI3K/AKT pathway in gastric cancer and its blockade suppresses tumor growth and metastasis
    • Ye B, Jiang LL, Xu HT, Zhou DW, Li ZS (2012). Expression of PI3K/AKT pathway in gastric cancer and its blockade suppresses tumor growth and metastasis. Int J Immunopathol Pharmacol, 25, 627-36.
    • (2012) Int J Immunopathol Pharmacol , vol.25 , pp. 627-636
    • Ye, B.1    Jiang, L.L.2    Xu, H.T.3    Zhou, D.W.4    Li, Z.S.5
  • 84
    • 84865186402 scopus 로고    scopus 로고
    • microRNA expression signature of gastric cancer cells relative to normal gastric mucosa
    • Yu BQ, Su LP, Li JF, et al (2012). microRNA expression signature of gastric cancer cells relative to normal gastric mucosa. Mol Med Rep, 6, 821-6.
    • (2012) Mol Med Rep , vol.6 , pp. 821-826
    • Yu, B.Q.1    Su, L.P.2    Li, J.F.3
  • 85
    • 36849015047 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death
    • Yu HG, Ai YW, Yu LL, et al (2008). Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death. Int J Cancer, 122, 433-43.
    • (2008) Int J Cancer , vol.122 , pp. 433-443
    • Yu, H.G.1    Ai, Y.W.2    Yu, L.L.3
  • 86
    • 79953745096 scopus 로고    scopus 로고
    • Combating trastuzmab resistance by targeting SRC, a common node down-stream of multiple resistance pathways
    • Zhang S, Huang WC, Li P, et al (2011). Combating trastuzmab resistance by targeting SRC, a common node down-stream of multiple resistance pathways. Nat Med, 17, 461-9.
    • (2011) Nat Med , vol.17 , pp. 461-469
    • Zhang, S.1    Huang, W.C.2    Li, P.3
  • 87
    • 79959251756 scopus 로고    scopus 로고
    • Combination of hsa-miR-375 and hsa-miR-142-5p as a predictor for recurrence risk in gastric cancer patients Following surgical resection
    • Zhang X, Yan Z, Zhang J, et al (2011). Combination of hsa-miR-375 and hsa-miR-142-5p as a predictor for recurrence risk in gastric cancer patients Following surgical resection. Ann Oncol, 22, 2257-66.
    • (2011) Ann Oncol , vol.22 , pp. 2257-2266
    • Zhang, X.1    Yan, Z.2    Zhang, J.3
  • 88
    • 0042629744 scopus 로고    scopus 로고
    • Expression of PTEN-encoding product in different stages of carcinogenesis and progression of gastric Carcinoma
    • Zheng HC, Chen Y, Kuang LG, et al (2003). Expression of PTEN-encoding product in different stages of carcinogenesis and progression of gastric Carcinoma. ZhonghuaZhongliu Zazhi, 25, 13-6.
    • (2003) ZhonghuaZhongliu Zazhi , vol.25 , pp. 13-16
    • Zheng, H.C.1    Chen, Y.2    Kuang, L.G.3
  • 89
    • 0344014119 scopus 로고    scopus 로고
    • Role of PTEN and MMP-7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma
    • Zheng HC, Sun JM, Li XH, et al (2003). Role of PTEN and MMP-7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma. Pathol Int, 53, 659-66.
    • (2003) Pathol Int , vol.53 , pp. 659-666
    • Zheng, H.C.1    Sun, J.M.2    Li, X.H.3


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