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Volumn 223, Issue 1, 2011, Pages 64-71

New insights in sarcoma oncogenesis: A comprehensive analysis of a large series of 160 soft tissue sarcomas with complex genomics

Author keywords

CGH; DKK1; leiomyosarcoma; PTEN; RB1; transcriptome; undifferentiated sarcoma

Indexed keywords

DICKKOPF 1 PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; HISTONE DEACETYLASE 4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LRRFIP1 PROTEIN; MYOCARDIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN; PROTEIN P130; RETINOBLASTOMA PROTEIN; T CELL FACTOR PROTEIN; TRANSCRIPTOME; TRIO PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 78650000822     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2787     Document Type: Article
Times cited : (103)

References (47)
  • 4
    • 0036873839 scopus 로고    scopus 로고
    • A subgroup of malignant fibrous histiocytomas is associated with genetic changes similar to those of well-differentiated liposarcomas
    • Chibon F, Mariani O, Derré J, et al., A subgroup of malignant fibrous histiocytomas is associated with genetic changes similar to those of well-differentiated liposarcomas. Cancer Genet Cytogenet 2002; 139: 24-29.
    • (2002) Cancer Genet Cytogenet , vol.139 , pp. 24-29
    • Chibon, F.1    Mariani, O.2    Derré, J.3
  • 5
    • 0037343252 scopus 로고    scopus 로고
    • Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: A review of 25 cases initially diagnosed as malignant fibrous histiocytoma
    • Coindre JM, Mariani O, Chibon F, et al., Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma. Mod Pathol 2003; 16: 256-262.
    • (2003) Mod Pathol , vol.16 , pp. 256-262
    • Coindre, J.M.1    Mariani, O.2    Chibon, F.3
  • 6
    • 0034745677 scopus 로고    scopus 로고
    • Leiomyosarcomas and most malignant fibrous histiocytomas share very similar comparative genomic hybridization imbalances: An analysis of a series of 27 leiomyosarcomas
    • Derré J, Lagacé R, Nicolas A, et al., Leiomyosarcomas and most malignant fibrous histiocytomas share very similar comparative genomic hybridization imbalances: an analysis of a series of 27 leiomyosarcomas. Lab Invest 2001; 81: 211-215.
    • (2001) Lab Invest , vol.81 , pp. 211-215
    • Derré, J.1    Lagacé, R.2    Nicolas, A.3
  • 7
    • 33645087651 scopus 로고    scopus 로고
    • The evolving classification of soft tissue tumours: An update based on the new WHO classification
    • Fletcher CD,. The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology 2006; 48: 3-12.
    • (2006) Histopathology , vol.48 , pp. 3-12
    • Fletcher, C.D.1
  • 8
    • 0024121611 scopus 로고
    • Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology
    • Weichselbaum RR, Beckett M, Diamond A,. Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology. Proc Natl Acad Sci U S A 1988; 85: 2106-2109.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 2106-2109
    • Weichselbaum, R.R.1    Beckett, M.2    Diamond, A.3
  • 9
    • 0033709408 scopus 로고    scopus 로고
    • The RB1 gene is the target of chromosome 13 deletions in malignant fibrous histiocytoma
    • Chibon F, Mairal A, Fréneaux P, et al., The RB1 gene is the target of chromosome 13 deletions in malignant fibrous histiocytoma. Cancer Res 2000; 60: 6339-6345.
    • (2000) Cancer Res , vol.60 , pp. 6339-6345
    • Chibon, F.1    Mairal, A.2    Fréneaux, P.3
  • 10
    • 34250013899 scopus 로고    scopus 로고
    • The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
    • Hernando E, Charytonowicz E, Dudas ME, et al., The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas. Nature Med 2007; 13: 748-753.
    • (2007) Nature Med , vol.13 , pp. 748-753
    • Hernando, E.1    Charytonowicz, E.2    Dudas, M.E.3
  • 11
    • 0032556910 scopus 로고    scopus 로고
    • Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
    • Glinka A, Wu W, Delius H, et al., Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 1998; 391: 357-362.
    • (1998) Nature , vol.391 , pp. 357-362
    • Glinka, A.1    Wu, W.2    Delius, H.3
  • 12
    • 36049042525 scopus 로고    scopus 로고
    • Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway
    • Matushansky I, Hernando E, Socci ND, et al., Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway. J Clin Invest 2007; 117: 3248-3257.
    • (2007) J Clin Invest , vol.117 , pp. 3248-3257
    • Matushansky, I.1    Hernando, E.2    Socci, N.D.3
  • 13
    • 0021366779 scopus 로고
    • Soft-tissue sarcomas of adults; Study of pathological prognostic variables and definition of a histopathological grading system
    • Trojani M, Contesso G, Coindre JM, et al., Soft-tissue sarcomas of adults; study of pathological prognostic variables and definition of a histopathological grading system. Int J Cancer 1984; 33: 37-42.
    • (1984) Int J Cancer , vol.33 , pp. 37-42
    • Trojani, M.1    Contesso, G.2    Coindre, J.M.3
  • 14
    • 0031023138 scopus 로고    scopus 로고
    • Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma
    • Guillou L, Coindre JM, Bonichon F, et al., Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group grading systems in a population of 410 adult patients with soft tissue sarcoma. J Clin Oncol 1997; 15: 350-362.
    • (1997) J Clin Oncol , vol.15 , pp. 350-362
    • Guillou, L.1    Coindre, J.M.2    Bonichon, F.3
  • 15
    • 0035873187 scopus 로고    scopus 로고
    • Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: A study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group
    • Coindre JM, Terrier P, Guillou L, et al., Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas: a study of 1240 patients from the French Federation of Cancer Centers Sarcoma Group. Cancer 2001; 91: 1914-1926.
    • (2001) Cancer , vol.91 , pp. 1914-1926
    • Coindre, J.M.1    Terrier, P.2    Guillou, L.3
  • 16
    • 65549111844 scopus 로고    scopus 로고
    • Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas
    • Pérot G, Derré J, Coindre JM, et al., Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas. Cancer Res 2009; 69: 2269-2278.
    • (2009) Cancer Res , vol.69 , pp. 2269-2278
    • Pérot, G.1    Derré, J.2    Coindre, J.M.3
  • 17
    • 10844290766 scopus 로고    scopus 로고
    • A model based background adjustment for oligonucleotide expression arrays
    • Wu Z, Irizarry RA, Gentleman R, et al., A model based background adjustment for oligonucleotide expression arrays. J Am Stat Assoc 2004; 99: 909-917.
    • (2004) J Am Stat Assoc , vol.99 , pp. 909-917
    • Wu, Z.1    Irizarry, R.A.2    Gentleman, R.3
  • 18
    • 0026960116 scopus 로고
    • Correspondence analysis in medical research
    • Greenacre M,. Correspondence analysis in medical research. Stat Methods Med Res 1992; 1: 97-117.
    • (1992) Stat Methods Med Res , vol.1 , pp. 97-117
    • Greenacre, M.1
  • 19
    • 34250208031 scopus 로고    scopus 로고
    • Identification of typical medullary breast carcinoma as a genomic sub-group of basal-like carcinomas, a heterogeneous new molecular entity
    • Vincent-Salomon A, Gruel N, Lucchesi C, et al., Identification of typical medullary breast carcinoma as a genomic sub-group of basal-like carcinomas, a heterogeneous new molecular entity. Breast Cancer Res 2007; 9: R24.
    • (2007) Breast Cancer Res , vol.9
    • Vincent-Salomon, A.1    Gruel, N.2    Lucchesi, C.3
  • 20
    • 33748673977 scopus 로고    scopus 로고
    • VAMP: Visualization and analysis of array-CGH, transcriptome and other molecular profiles
    • La Rosa P, Viara E, Hupé P, et al., VAMP: visualization and analysis of array-CGH, transcriptome and other molecular profiles. Bioinformatics 2006; 22: 2066-2073.
    • (2006) Bioinformatics , vol.22 , pp. 2066-2073
    • La Rosa, P.1    Viara, E.2    Hupé, P.3
  • 21
    • 0037379178 scopus 로고    scopus 로고
    • Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation
    • Du KL, Ip HS, Li J, et al., Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Mol Cell Biol. 2003; 23: 2425-2437.
    • (2003) Mol Cell Biol. , vol.23 , pp. 2425-2437
    • Du, K.L.1    Ip, H.S.2    Li, J.3
  • 22
    • 26244440041 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta inhibits myocardin-dependent transcription and hypertrophy induction through site-specific phosphorylation
    • Badorff C, Seeger FH, Zeiher AM, et al., Glycogen synthase kinase 3beta inhibits myocardin-dependent transcription and hypertrophy induction through site-specific phosphorylation. Circ Res 2005; 97: 645-654.
    • (2005) Circ Res , vol.97 , pp. 645-654
    • Badorff, C.1    Seeger, F.H.2    Zeiher, A.M.3
  • 23
    • 44849108031 scopus 로고    scopus 로고
    • Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling
    • Guo Y, Xie J, Rubin E, et al., Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. Cancer Res 2008; 68: 3350-3360.
    • (2008) Cancer Res , vol.68 , pp. 3350-3360
    • Guo, Y.1    Xie, J.2    Rubin, E.3
  • 24
    • 34848863333 scopus 로고    scopus 로고
    • Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation
    • Glenisson W, Castronovo V, Waltregny D,. Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation. Biochim Biophys Acta 2007; 1773: 1572-1582.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 1572-1582
    • Glenisson, W.1    Castronovo, V.2    Waltregny, D.3
  • 25
    • 33847053935 scopus 로고    scopus 로고
    • Platelet-derived growth factor-BB represses smooth muscle cell marker genes via changes in binding of MKL factors and histone deacetylases to their promoters
    • Yoshida T, Gan Q, Shang Y, et al., Platelet-derived growth factor-BB represses smooth muscle cell marker genes via changes in binding of MKL factors and histone deacetylases to their promoters. Am J Physiol Cell Physiol 2007; 292: C886-C895.
    • (2007) Am J Physiol Cell Physiol , vol.292
    • Yoshida, T.1    Gan, Q.2    Shang, Y.3
  • 26
    • 0346333095 scopus 로고    scopus 로고
    • The tumour suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumour necrosis factor
    • Regamey A, Hohl D, Liu JW, et al., The tumour suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumour necrosis factor. J Exp Med 2003; 198: 1959-1964.
    • (2003) J Exp Med , vol.198 , pp. 1959-1964
    • Regamey, A.1    Hohl, D.2    Liu, J.W.3
  • 27
    • 26444603837 scopus 로고    scopus 로고
    • GCF2/LRRFIP1 represses tumour necrosis factor alpha expression
    • Suriano AR, Sanford AN, Kim N, et al., GCF2/LRRFIP1 represses tumour necrosis factor alpha expression. Mol Cell Biol 2005; 25: 9073-9081.
    • (2005) Mol Cell Biol , vol.25 , pp. 9073-9081
    • Suriano, A.R.1    Sanford, A.N.2    Kim, N.3
  • 28
    • 33746799441 scopus 로고    scopus 로고
    • Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas
    • Adamowicz M, Radlwimmer B, Rieker RJ, et al., Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas. Genes Chromosomes Cancer 2006; 45: 829-838.
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 829-838
    • Adamowicz, M.1    Radlwimmer, B.2    Rieker, R.J.3
  • 29
    • 33644841931 scopus 로고    scopus 로고
    • Genetic alterations in urothelial bladder carcinoma: An updated review
    • Mhawech-Fauceglia P, Cheney RT, Schwaller J,. Genetic alterations in urothelial bladder carcinoma: an updated review. Cancer 2006; 106: 1205-1216.
    • (2006) Cancer , vol.106 , pp. 1205-1216
    • Mhawech-Fauceglia, P.1    Cheney, R.T.2    Schwaller, J.3
  • 30
    • 33847663898 scopus 로고    scopus 로고
    • Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer
    • Kloth JN, Oosting J, van Wezel T, et al., Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex genetic alterations in cervical cancer. BMC Genomics 2007; 8: 53-66.
    • (2007) BMC Genomics , vol.8 , pp. 53-66
    • Kloth, J.N.1    Oosting, J.2    Van Wezel, T.3
  • 31
    • 0032518914 scopus 로고    scopus 로고
    • The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo
    • Bellanger JM, Lazaro JB, Diriong S, et al., The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo. Oncogene 1998; 16: 147-152.
    • (1998) Oncogene , vol.16 , pp. 147-152
    • Bellanger, J.M.1    Lazaro, J.B.2    Diriong, S.3
  • 32
    • 0033662155 scopus 로고    scopus 로고
    • The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin
    • Bellanger JM, Astier C, Sardet C, et al., The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin. Nature Cell Biol 2000; 2: 888-892.
    • (2000) Nature Cell Biol , vol.2 , pp. 888-892
    • Bellanger, J.M.1    Astier, C.2    Sardet, C.3
  • 33
    • 0034053503 scopus 로고    scopus 로고
    • TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG
    • Blangy A, Vignal E, Schmidt S, et al., TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG. J Cell Sci 2000; 113: 729-739.
    • (2000) J Cell Sci , vol.113 , pp. 729-739
    • Blangy, A.1    Vignal, E.2    Schmidt, S.3
  • 34
    • 67649814136 scopus 로고    scopus 로고
    • PI3K/PTEN signaling in angiogenesis and tumourigenesis
    • Jiang BH, Liu LZ,. PI3K/PTEN signaling in angiogenesis and tumourigenesis. Adv Cancer Res 2009; 102: 19-65.
    • (2009) Adv Cancer Res , vol.102 , pp. 19-65
    • Jiang, B.H.1    Liu, L.Z.2
  • 35
    • 0034718483 scopus 로고    scopus 로고
    • Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control
    • Classon M, Salama S, Gorka C, et al., Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control. Proc Natl Acad Sci U S A 2000; 97: 10820-10825.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 10820-10825
    • Classon, M.1    Salama, S.2    Gorka, C.3
  • 36
    • 33748061967 scopus 로고    scopus 로고
    • PRb2/p130: A new candidate for retinoblastoma tumour formation
    • De Falco G, Giordano A,. pRb2/p130: a new candidate for retinoblastoma tumour formation. Oncogene 2006; 25: 5333-5340.
    • (2006) Oncogene , vol.25 , pp. 5333-5340
    • De Falco, G.1    Giordano, A.2
  • 37
    • 66149083996 scopus 로고    scopus 로고
    • High incidence of allelic loss at 16q12.2 region spanning RBL2/p130 gene in retinoblastoma
    • Priya K, Jada SR, Quah BL, et al., High incidence of allelic loss at 16q12.2 region spanning RBL2/p130 gene in retinoblastoma. Cancer Biol Ther 2009; 8: 714-717.
    • (2009) Cancer Biol Ther , vol.8 , pp. 714-717
    • Priya, K.1    Jada, S.R.2    Quah, B.L.3
  • 38
    • 55249100796 scopus 로고    scopus 로고
    • Does comparative genomic hybridization reveal distinct differences in DNA copy number sequence patterns between leiomyosarcoma and malignant fibrous histiocytoma?
    • Larramendy ML, Gentilec M, Soloneskib S, et al., Does comparative genomic hybridization reveal distinct differences in DNA copy number sequence patterns between leiomyosarcoma and malignant fibrous histiocytoma? Cancer Genet Cytogenet 2008; 187: 1-11.
    • (2008) Cancer Genet Cytogenet , vol.187 , pp. 1-11
    • Larramendy, M.L.1    Gentilec, M.2    Soloneskib, S.3
  • 39
    • 0037070754 scopus 로고    scopus 로고
    • Molecular characterization of soft tissue tumours: A gene expression study
    • Nielsen TO, West RB, Linn SC, et al., Molecular characterization of soft tissue tumours: a gene expression study. Lancet 2002; 359: 1301-1307.
    • (2002) Lancet , vol.359 , pp. 1301-1307
    • Nielsen, T.O.1    West, R.B.2    Linn, S.C.3
  • 40
    • 0037463287 scopus 로고    scopus 로고
    • Molecular classification of synovial sarcomas, leiomyosarcomas and malignant fibrous histiocytomas by gene expression profiling
    • Lee YF, John M, Edwards S, et al., Molecular classification of synovial sarcomas, leiomyosarcomas and malignant fibrous histiocytomas by gene expression profiling. Br J Cancer 2003; 88: 510-515.
    • (2003) Br J Cancer , vol.88 , pp. 510-515
    • Lee, Y.F.1    John, M.2    Edwards, S.3
  • 41
    • 27144523169 scopus 로고    scopus 로고
    • Gene expression profiling of human sarcomas: Insights into sarcoma biology
    • Baird K, Davis S, Antonescu CR, et al., Gene expression profiling of human sarcomas: insights into sarcoma biology. Cancer Res 2005; 65: 9226-9235.
    • (2005) Cancer Res , vol.65 , pp. 9226-9235
    • Baird, K.1    Davis, S.2    Antonescu, C.R.3
  • 42
    • 34047129837 scopus 로고    scopus 로고
    • Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: Hypoxia-induced transcription profile signifies metastatic potential
    • Francis P, Namlos HM, Muller C, et al., Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential. BMC Genomics 2007; 8: 73.
    • (2007) BMC Genomics , vol.8 , pp. 73
    • Francis, P.1    Namlos, H.M.2    Muller, C.3
  • 43
    • 34250680520 scopus 로고    scopus 로고
    • Gene expression analysis of soft tissue sarcomas: Characterization and reclassification of malignant fibrous histiocytoma
    • Nakayama R, Nemoto T, Takahashi H, et al., Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma. Mod Pathol 2007; 20: 749-759.
    • (2007) Mod Pathol , vol.20 , pp. 749-759
    • Nakayama, R.1    Nemoto, T.2    Takahashi, H.3
  • 44
    • 76849102318 scopus 로고    scopus 로고
    • Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling
    • Beck AH, Lee CH, Witten DM, et al., Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling. Oncogene 2010; 29: 845-854.
    • (2010) Oncogene , vol.29 , pp. 845-854
    • Beck, A.H.1    Lee, C.H.2    Witten, D.M.3
  • 45
    • 66549088451 scopus 로고    scopus 로고
    • Indistinguishable genomic profiles and shared prognostic markers in undifferentiated pleomorphic sarcoma and leiomyosarcoma: Different sides of a single coin?
    • Carneiro A, Francis P, Bendahl PA, et al., Indistinguishable genomic profiles and shared prognostic markers in undifferentiated pleomorphic sarcoma and leiomyosarcoma: different sides of a single coin? Lab Invest 2009; 89: 668-675.
    • (2009) Lab Invest , vol.89 , pp. 668-675
    • Carneiro, A.1    Francis, P.2    Bendahl, P.A.3
  • 46
    • 77954535843 scopus 로고    scopus 로고
    • Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity
    • Chibon F, Lagarde P, Salas S, et al., Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity. Nature Med 2010; 16: 781-787.
    • (2010) Nature Med , vol.16 , pp. 781-787
    • Chibon, F.1    Lagarde, P.2    Salas, S.3
  • 47
    • 40849083276 scopus 로고    scopus 로고
    • Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
    • Qiang YW, Barlogie B, Rudikoff S, et al., Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma. Bone 2008; 42: 669-680.
    • (2008) Bone , vol.42 , pp. 669-680
    • Qiang, Y.W.1    Barlogie, B.2    Rudikoff, S.3


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