Mutational analysis of p53 and PTEN in soft tissue sarcoma

Molecular Medicine Reports

Volumn 5, Issue 2, 2012, Pages 457-461

  Yin, Liang ^a   Liu, Chun Xia ^a   Nong, Wei Xia ^a   Chen, Yun Zhao ^a   Qi, Yan ^a   Li, Hong An ^a   Hu, Wen Hao ^a   Sun, Kan ^a   Li, Feng ^a  

^a SHIHEZI UNIVERSITY   (China)

Author keywords

Mutation; p53; PTEN; Soft tissue sarcoma

Indexed keywords

ARGININE; ASPARAGINE; DNA; GLUTAMINE; LYSINE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53;

ADOLESCENT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; CARCINOGENESIS; CODON; CONTROLLED STUDY; DNA SEQUENCE; EXON; FEMALE; GENE MUTATION; GENETIC SCREENING; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MUTATIONAL ANALYSIS; PATHOGENESIS; POINT MUTATION; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE; RECIPROCAL CHROMOSOME TRANSLOCATION; SINGLE STRAND CONFORMATION POLYMORPHISM; SOFT TISSUE SARCOMA;

ADOLESCENT; AGED; AMINO ACID SUBSTITUTION; DNA MUTATIONAL ANALYSIS; EXONS; FEMALE; HUMANS; MALE; MUTATION, MISSENSE; POINT MUTATION; PTEN PHOSPHOHYDROLASE; SARCOMA; SEQUENCE ANALYSIS, DNA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84862907926     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.660     Document Type: Article

References (31)

1. Levine AJ: p53, the cellular gatekeeper for growth and division. Cell 88: 323-331, 1997.
2. Bates S and Vousden KH: Mechanisms of p53-mediated apoptosis. Cell Mol Life Sci 55: 28-37, 1999. (Pubitemid 29077852)
3. Greenblatt MS, Hollstein M and Harris CC: Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54: 4855-4878, 1994. (Pubitemid 24289415)
4. Hollstein M, Sidransky D, Vogelstein B and Harris CC: p53 mutations in human cancers. Science 253: 49-53, 1991. (Pubitemid 21917115)
5. Latres E, Drobnjak M, Pollack D, et al: Chromosome 17 abnormalities and TP53 mutations in adult soft tissue sarcomas. Am J Pathol 145: 345-355, 1994. (Pubitemid 24245835)
6. Myers MP, Stolarov JP, Eng C, et al: PTEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci USA 94: 9052-9057, 1997.
7. Li J, Yen C, Liaw D, et al: PTEN, a putative protein tyrosinephosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943-1947, 1997. (Pubitemid 27148818)
8. Eng C: PTEN: one gene, many syndromes. Hum Mutat 22: 183-198, 2003.
9. Derre J, Lagace R, Nicolas A, et al: Leiomyosarcomas and most malignant fibrous histiocytomas share very similar comparative genomic hybridization imbalances: an analysis of a series of 27 leiomyosarcomas. Lab Invest 81: 211-215, 2001. (Pubitemid 32176385)
10. Mandahl N, Fletcher CDM, Dal Cin P, et al: Comparative cytogenetic study of spindle cell and pleomorphic leiomyosarcomas of soft tissues: a report from the CHAMP study group. Cancer Genet Cytogenet 116: 66-73, 2000.
11. Fletcher CDM, Unni KK and Mertens F (eds). World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Soft Tissue and Bone. IARCPress, Lyon, pp1-420, 2002.
12. Mertens F, Panagopoulos I and Mandahl N: Genomic characteristics of soft tissue sarcomas. Virchows Arch 456: 129-139, 2010.
13. Kurose K, Gilley K, Matsumoto S, Watson PH, Zhou XP and Eng C: Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Genet 32: 355-357, 2002. (Pubitemid 35266108)
14. Stambolic V, MacPherson D, Sas D, et al: Regulation of PTEN transcription by p53. Mol Cell 8: 317-325, 2001. (Pubitemid 32831549)
15. Wang J, Ouyang W, Li J, et al: Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor κB induced by UV radiation. Cancer Res 65: 6601-6611, 2005.
16. Chang CJ, Mulholland DJ, Valamehr B, et al: PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression. Mol Cell Biol 28: 3281-3289, 2008. (Pubitemid 351657092)
17. Chen Z, Trotman LC, Shaffer D, et al: Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436: 725-730, 2005. (Pubitemid 41117277)
18. Puzio-Kuter AM, Castillo-Martin M, Kinkade CW, et al: Inactivation of p53 and Pten promotes invasive bladder cancer. Genes Dev 23: 675-680, 2009.
19. Sambrook J and David WR: Molecular Cloning: A Laboratory Manual. 3rd edition. Cold Spring Harbor Laboratory Press, New York, NY pp461-485, 2001.
20. Risinger JI, Hayes AK, Barrett JC, et al: PTEN/MMAC1 mutations in endometrial cancers. Cancer Res 57: 4736-4738, 1997.
21. Guo CY, Xu XF, Liu SF, et al: PCR-SSCP-DNA sequencing method in detecting PTEN gene mutation and its significance in human gastric cancer. World J Gastroenterol 14: 3804-3811, 2008.
22. Saito T, Oda Y, Kawaguchik T, et al: PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations. Int J Cancer 104: 175-178, 2003. (Pubitemid 36249792)
23. Pollock R, Lang A, Ge T, Sun D, Tan M and Yu D: Wild-type p53 and a p53 temperature-sensitive mutant suppress human soft tissue sarcoma by enhancing cell cycle control. Clin Cancer Res 4: 1985-1994, 1998. (Pubitemid 28369185)
24. Zhang L, Yu D, Hu M, et al: Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. Cancer Res 60: 3655-3661, 2000. (Pubitemid 30482190)
25. Schneider-Stock R, Onnasch D, Haeckel C, Mellin W, Franke DS and Roessner A: Prognostic significance of p53 gene mutations and p53 protein expression in synovial sarcomas. Virchows Arch 435: 407-412, 1999. (Pubitemid 29472199)
26. Yoo J, Lee HK, Kang CS, Park WS, Lee JY and Shim SI: p53 gene mutations and p53 protein expression in human soft tissue sarcomas. Arch Pathol Lab Med 121: 395-399, 1997. (Pubitemid 27184994)
27. Chang B, Pang LJ, Li F, et al: PAX-FKHR fusion genes and AChR-γ in Chinese patients with rhabdomyosarcoma: diagnosis using formalin-fixed archival tissues. Int J Surg Pathol 17: 6-15, 2009.
28. Merlino G and Helman LJ: Rhabdomyosarcoma - working out the pathways. Oncogene 18: 5340-5348, 1999. (Pubitemid 29462370)
29. Zhu Y, Wang DY, Sugimura H, et al: Mutation analysis of tumor suppressor gene PTEN in bone and soft tissue tumors. Natl Med J China 81: 715-718, 2001.
30. Sjoling A, Samuelson E, Adamovic T, et al: Recurrent allelic imbalance at the rat Pten locus in DMBA-induced fibrosarcomas. Genes Chromosomes Cancer 36: 70-79, 2003. (Pubitemid 36077383)
31. Li Y, Guessous F, Kwon S and Kumar M: PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations. Cancer Res 68: 1723-1731, 2008. (Pubitemid 351416557)