Involvement of miR-21 in resistance to daunorubicin by regulating PTEN expression in the leukaemia K562 cell line

FEBS Letters

Volumn 585, Issue 2, 2011, Pages 402-408

  Bai, Haitao ^a   Xu, Rang ^a   Cao, Zhongwei ^a   Wei, Daolin ^a   Wang, Chun ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Daunorubicin; Drug resistance; Leukaemia; miR 21; PI3K Akt; PTEN

Indexed keywords

DAUNORUBICIN; MICRORNA 21; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B;

ARTICLE; CANCER RESISTANCE; CELL STRAIN K 562; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; ENZYME REGULATION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA STABILITY; UPREGULATION;

ANTINEOPLASTIC AGENTS; DAUNORUBICIN; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; K562 CELLS; LEUKEMIA; MICRORNAS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE;

EID: 78651347241     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.12.027     Document Type: Article

References (49)

1. G. Minotti, P. Menna, E. Salvatorelli, G. Cairo, and L. Gianni Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity Pharmacol. Rev. 56 2004 185 229 (Pubitemid 38720829)
2. G.N. Hortobágyi Anthracyclines in the treatment of cancer. An overview Drugs 54 1997 1 7
3. B. Löwenberg, G.J. Ossenkoppele, W. van Putten, H.C. Schouten, C. Graux, A. Ferrant, P. Sonneveld, J. Maertens, M. Jongen-Lavrencic, M. von Lilienfeld-Toal, B.J. Biemond, E. Vellenga, M. van Marwijk Kooy, L.F. Verdonck, J. Beck, H. Döhner, A. Gratwohl, T. Pabst, and G. Verhoef High-dose daunorubicin in older patients with acute myeloid leukemia N. Engl. J. Med. 361 2009 1235 1248
4. S.A. Johnson, and D.S. Richardson Anthracyclines in haematology: pharmacokinetics and clinical studies Blood Rev. 12 1998 52 71
5. C.P. Michael The chemotherapy source book (fourth edition) 2008 Lippincott Williams & wilkins Philadelphia, PA pp. 779
6. Y. Huang, P. Anderle, K.J. Bussey, C. Barbacioru, U. Shankavaram, Z. Dai, W.C. Reinhold, A. Papp, J.N. Weinstein, and W. Sadee Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance Cancer Res. 64 2004 4294 4301 (Pubitemid 38802436)
7. D.P. McLornan, M.F. McMullin, D.B. Johnston, and P. Longley Molecular mechanisms of drug resistance in acute myeloid leukemia Expert Opin. Drug Metab. Toxicol. 3 2007 363 377 (Pubitemid 47316029)
8. L. He, and G.J. Hannon MicroRNAs: small RNAs with a big role in gene regulation Nat. Rev. Genet. 5 2004 522 531 (Pubitemid 38868508)
9. C.M. Croce, and G.A. Calin MiRNAs, cancer, and stem cell division Cell 122 2005 6 7 (Pubitemid 40977933)
10. P.E. Blower, J.H. Chung, J.S. Verducci, S. Lin, J.K. Park, Z.Y. Dai, C.G. Liu, T.D. Schmittgen, W.C. Reinhold, C.M. Croce, J.N. Weinstein, and W. Sadee MicroRNAs modulate the chemosensitivity of tumor cells Mol. Cancer Ther. 7 2008 1 9
11. A.M. Krichevsky, and G. Gabriely MiR-21: a small multi-faceted RNA J. Cell Mol. Med. 13 2009 39 53
12. C. Chen, D.A. Ridzon, A.J. Broomer, Z. Zhou, D.H. Lee, J.T. Nguyen, M. Barbisin, N.L. Xu, V.R. Mahuvakar, M.R. Andersen, K.Q. Lao, K.J. Livak, and K.J. Guegler Real-time quantification of microRNAs by stem-loop RT-PCR Nucleic Acids Res. 33 2005 e179 (Pubitemid 41806407)
13. G.A. Calin, M. Ferracin, A. Cimmino, G. Di Leva, M. Shimizu, S.E. Wojcik, M.V. Iorio, R. Visone, N.I. Sever, M. Fabbri, R. Iuliano, T. Palumbo, F. Pichiorri, C. Roldo, R. Garzon, C. Sevignani, L. Rassenti, H. Alder, S. Volinia, C.G. Liu, T.J. Kipps, M. Negrini, and C.M. Croce A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia N. Engl. J. Med. 353 2005 1793 1801 (Pubitemid 41549891)
14. F. Meng, R. Henson, M. Lang, H. Wehbe, S. Maheshwari, J.T. Mendell, J. Jiang, T.D. Schmittgen, and T. Patel Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines Gastroenterology 130 2006 2113 2129 (Pubitemid 43816961)
15. Y. Li, X. Zhu, J. Gu, D. Dong, J. Yao, C. Lin, K. Huang, and J. Fei Anti-miR-21 oligonucleotide sensitizes leukemic K562 cells to arsenic trioxide by inducing apoptosis Cancer Sci. 101 2010 948 954
16. Gu, J., Zhu, X., Li, Y., Dong, D., Yao, J., Lin, C., Huang, K., Hu, H., and Fei, J. (2010) miRNA-21 regulates arsenic-induced anti-leukemia activity in myelogenous cell lines. Med. Oncol. [Epub ahead of print].
17. H. Hu, Y. Li, J. Gu, X. Zhu, D. Dong, J. Yao, C. Lin, and J. Fei Antisense oligonucleotide against miR-21 inhibits migration and induces apoptosis in leukemic K562 cells Leuk. Lymphoma 51 2010 694 701
18. L.S. Steelman, P.M. Navolanic, M.L. Sokolosky, J.R. Taylor, B.D. Lehmann, W.H. Chappell, S.L. Abrams, E.W.T. Wong, K.M. Stadelman, D.M. Terrian, N.R. Leslie, A.M. Martelli, F. Stivala, M. Libra, R.A. Franklin, and J.A. McCubrey Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors Oncogene 27 2008 4086 4095 (Pubitemid 351931994)
19. I.K. Mellinghoff, T.F. Cloughesy, and P.S. Mischel PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors Clin. Cancer Res. 13 2007 378 381 (Pubitemid 46225339)
20. M.V. Iorio, M. Ferracin, C.G. Liu, A. Veronese, R. Spizzo, S. Sabbioni, E. Magri, M. Pedriali, M. Fabbri, M. Campiglio, S. Ménard, J.P. Palazzo, A. Rosenberg, P. Musiani, S. Volinia, I. Nenci, G.A. Calin, P. Querzoli, M. Negrini, and C.M. Croce MicroRNA gene expression deregulation in human breast cancer Cancer Res. 65 2005 7065 7070 (Pubitemid 41161233)
21. E. Giovannetti, N. Funel, G.J. Peters, M. Del Chiaro, L.A. Erozenci, E. Vasile, L.G. Leon, L.E. Pollina, A. Groen, A. Falcone, R. Danesi, D. Campani, H.M. Verheul, and U. Boggi MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity Cancer Res. 70 2010 4528 4538
22. P.P. Medina, M. Nolde, and F.J. Slack OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma Nature 467 2010 86 90
23. J.A. Chan, A.M. Krichevsky, and K.S. Kosik MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells Cancer Res. 65 2005 6029 6033 (Pubitemid 40994386)
24. S. Volinia, G.A. Calin, C.G. Liu, S. Ambs, A. Cimmino, F. Petrocca, R. Visone, M. Iorio, C. Roldo, M. Ferracin, R.L. Prueitt, N. Yanaihara, G. Lanza, A. Scarpa, A. Vecchione, M. Negrini, C.C. Harris, and C.M. Croce A microRNA expression signature of human solid tumors defines cancer gene targets Proc. Natl. Acad. Sci. USA 103 2006 2257 2261 (Pubitemid 43271657)
25. L.Y. Bourguignon, C.C. Spevak, G. Wong, W. Xia, and E. Gilad Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells J. Biol. Chem. 284 2009 26533 26546
26. L. Shi, J. Chen, J. Yang, T. Pan, S. Zhang, and Z. Wang MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity Brain Res. 1352 2010 255 264
27. Y. Li, W. Li, Y. Yang, Y. Lu, C. He, G. Hu, H. Liu, J. Chen, J. He, and H. Yu MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme Brain Res. 1286 2009 13 18
28. I.A. Asangani, S.A. Rasheed, D.A. Nikolova, J.H. Leupold, N.H. Colburn, S. Post, and H. Allgayer MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer Oncogene 27 2008 2128 2136 (Pubitemid 351485639)
29. T. Li, D. Li, J. Sha, P. Sun, and Y. Huang MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells Biochem. Biophys. Res. Commun. 383 2009 280 285
30. Y.J. Kim, S.J. Hwang, Y.C. Bae, and J.S. Jung MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue Stem cells 27 2009 3093 3102
31. S. Zhu, M.L. Si, H. Wu, and Y.Y. Mo MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1) J. Biol. Chem. 282 2007 14328 14336 (Pubitemid 47100416)
32. F. Meng, R. Henson, H. Wehbe-Janek, K. Ghoshal, S.T. Jacob, and T. Patel MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer Gastroenterology 133 2007 647 658 (Pubitemid 47187346)
33. D.J. Rossi, and I.L. Weissman Pten, tumorigenesis, and stem cell self-renewal Cell 125 2006 229 231
34. L.S. Steelman, S.L. Abrams, J. Whelan, F.E. Bertrand, D.E. Ludwig, J. Bäsecke, M. Libra, F. Stivala, M. Milella, A. Tafuri, P. Lunghi, A. Bonati, A.M. Martelli, and J.A. McCubrey Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia Leukemia 22 2008 686 707 (Pubitemid 351565618)
35. G. Tabellini, A. Cappellini, P.L. Tazzari, A.M. Fala F. Billi, L. Manzoli, L. Cocco, and A.M. Martelli Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells J. Cell Physiol. 202 2005 623 634 (Pubitemid 40041333)
36. M. Zhou, L. Gu, H.W. Findley, R. Jiang, and W.G. Woods PTEN reverses MDM2 mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells Cancer Res. 63 2003 6357 6362 (Pubitemid 37255184)
37. S. Banerjee Mustafi, P.K. Chakraborty, and S. Raha Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70 PLoS One 5 2010 e8719
38. S. Dong, S. Kang, S. Lonial, H.J. Khoury, J. Viallet, and J. Chen Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, rapamycin and Bcl-2 inhibitor GX15-070 Leukemia 22 2008 572 577 (Pubitemid 351386727)
39. Q.Y. Zhang, J.H. Mao, P. Liu, Q.H. Huang, J. Lu, Y.Y. Xie, L. Weng, Y. Zhang, Q. Chen, S.J. Chen, and Z. Chen A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia Proc. Natl. Acad. Sci. USA 106 2009 3378 3383
40. G. Marfe, M. Tafani, M. Indelicato, P. Sinibaldi-Salimei, V. Reali, B. Pucci, M. Fini, and M.A. Russo Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction J. Cell Biochem. 106 2009 643 650
41. C. Xiao, L. Srinivasan, D.P. Calado, H.C. Patterson, B. Zhang, J. Wang, J.M. Henderson, J.L. Kutok, and K. Rajewsky Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes Nat. Immunol. 9 2008 405 414 (Pubitemid 351405110)
42. J.T. Huse, C. Brennan, D. Hambardzumyan, B. Wee, J. Pena, S.H. Rouhanifard, C. Sohn-Lee, C. le Sage, R. Agami, T. Tuschl, and E.C. Holland The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo Genes Dev. 23 2009 1327 1337
43. M. Kato, S. Putta, M. Wang, H. Yuan, L. Lanting, I. Nair, A. Gunn, Y. Nakagawa, H. Shimano, I. Todorov, J.J. Rossi, and R. Natarajan TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN Nat. Cell Biol. 11 2009 881 889
44. H. Yang, W. Kong, L. He, J.J. Zhao, J.D. O'Donnell, J. Wang, R.M. Wenham, D. Coppola, P.A. Kruk, S.V. Nicosia, and J.Q. Cheng MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN Cancer Res. 68 2008 425 433 (Pubitemid 351380068)
45. M. Garofalo, G. Di Leva, G. Romano, G. Nuovo, S.S. Suh, A. Ngankeu, C. Taccioli, F. Pichiorri, H. Alder, P. Secchiero, P. Gasparini, A. Gonelli, S. Costinean, M. Acunzo, G. Condorelli, and C.M. Croce MiR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation Cancer Cell. 16 2009 498 509
46. E.M. Small, J.R. O'Rourke, V. Moresi, L.B. Sutherland, J. McAnally, R.D. Gerard, J.A. Richardson, and E.N. Olson Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486 Proc. Natl. Acad. Sci. USA 107 2010 4218 4223
47. N. Bar, and R. Dikstein MiR-22 forms a regulatory loop in PTEN/AKT pathway and modulates signaling kinetics PLoS One. 5 2010 e10859
48. X.B. Shi, L. Xue, J. Yang, A.H. Ma, J. Zhao, M. Xu, C.G. Tepper, C.P. Evans, H.J. Kung, and R.W. deVere White An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells Proc. Natl. Acad. Sci. USA 104 2007 19983 19988
49. N. Felli, L. Fontana, E. Pelosi, R. Botta, D. Bonci, F. Facchiano, F. Liuzzi, V. Lulli, O. Morsilli, S. Santoro, M. Valtieri, G.A. Calin, C.G. Liu, A. Sorrentino, C.M. Croce, and C. Peschle MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation Proc. Natl. Acad. Sci. USA 102 2005 18081 18086 (Pubitemid 41798505)