Phase 1 and pharmacodynamic trial of everolimus in combination with cetuximab in patients with advanced cancer

Cancer

Volumn 120, Issue 1, 2014, Pages 77-85

  Ciunci, Christine A ^a   Perini, Rodolfo F ^a   Avadhani, Anjali N ^a   Kang, Hyunseon C ^a   Sun, Weijing ^a   Redlinger, Maryann ^a   Harlacker, Kathleen ^a   Flaherty, Keith T ^a   Giantonio, Bruce J ^a   Rosen, Mark A ^a   Divgi, Chaitanya R ^a   Song, Hee Kwon ^a   Englander, Sarah ^a   Troxel, Andrea ^b   Schnall, Mitchell ^a   O'Dwyer, Peter J ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

antiangiogenic; cetuximab; everolimus; pharmacodynamic; phase 1

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CETUXIMAB; EVEROLIMUS; FLUORODEOXYGLUCOSE F 18; GADODIAMIDE; MAMMALIAN TARGET OF RAPAMYCIN;

ADULT; ADVANCED CANCER; AGED; ALLERGIC REACTION; ANEMIA; ANOREXIA; ANTIANGIOGENIC ACTIVITY; ANUS CANCER; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CLINICAL ARTICLE; COLON CANCER; COLORECTAL CANCER; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DEHYDRATION; DIARRHEA; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPNEA; ESOPHAGUS CANCER; FATIGUE; FEMALE; HEAD AND NECK CANCER; HEADACHE; HUMAN; HYPERBILIRUBINEMIA; HYPERGLYCEMIA; HYPERSENSITIVITY; HYPOALBUMINEMIA; HYPOCALCEMIA; HYPOKALEMIA; HYPOMAGNESEMIA; HYPOPHOSPHATEMIA; LOADING DRUG DOSE; MALE; METABOLIC INHIBITION; MUCOSA INFLAMMATION; NAUSEA; NEUTROPENIA; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OVARY CANCER; PANCREAS CANCER; PET SCANNER; PHARMACODYNAMICS; PHASE 1 CLINICAL TRIAL; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RANDOMIZED CONTROLLED TRIAL; RASH; SKIN TOXICITY; STOMATITIS; THROMBOCYTOPENIA; UNSPECIFIED SIDE EFFECT; VOMITING;

ANTIANGIOGENIC; CETUXIMAB; EVEROLIMUS; PHARMACODYNAMIC; PHASE 1;

ADULT; AGED; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; RADIOPHARMACEUTICALS; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84890794963     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.28294     Document Type: Article

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