Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells

Breast Cancer Research and Treatment

Volumn 130, Issue 1, 2011, Pages 73-83

  Phuong, Nguyen Thi Thuy ^a   Kim, Sang Kyum ^b   Lim, Sung Chul ^a   Kim, Hyung Sik ^c   Kim, Tae Hyung ^c   Lee, Kwang Yeol ^d   Ahn, Sang Gun ^a   Yoon, Jung Hoon ^a   Kang, Keon Wook ^a  

^a Chosun University   (South Korea)

^b Chungnam National University   (South Korea)

^c Pusan National University   (South Korea)

^d Chonnam National University   (South Korea)

Author keywords

Methylation; PTEN; S adenosylmethionine; Tamoxifen resistance

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AFIMOXIFENE; DNA METHYLTRANSFERASE 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; S ADENOSYLMETHIONINE; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL CELL; BREAST CANCER; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN METHYLATION; PROTEIN PHOSPHORYLATION; PTEN GENE; TUMOR GENE; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, HORMONAL; APOPTOSIS; AZACITIDINE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; PROMOTER REGIONS, GENETIC; PTEN PHOSPHOHYDROLASE; S-ADENOSYLMETHIONINE; TAMOXIFEN; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 82455192395     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-1304-2     Document Type: Article

References (63)

1. Mueller SO, Clark JA, Mvers PH, Korach KS (2002) Mammary gland development in adult mice requires epithelial and stromal estrogen receptor alpha. Endocrinol 143:2357-2365 (Pubitemid 34521582)
2. Petrangeli E, Lubrano C, Ortolani F et al (1994) Estrogen receptors: new perspectives in breast cancer management. J Steroid Biochem Mol Biol 49:327-331 (Pubitemid 24240618)
3. Rose C, Thorpe SM, Andersen KW, Pedersen BV, Mouridsen HT, Blichert-Toft M, Rasmussen BB (1985) Beneficial effect of adjuvant tamoxifen therapy in primary breast cancer patients with high oestrogen receptor values. Lancet 1:16-19 (Pubitemid 15160544)
4. Eiermann W, Paepke S, Appfelstaedt J, Llombart-Cussac A, Eremin J, Vinholes J, Mauriac L, Ellis M, Lassus M, Chaudri-Ross HA, Dugan M, Borgs M (2001) Preoperative treatment of postmenopausal breast cancer patients with letrozole: a randomized double-blind multicenter study. Ann Oncol 12:1527-1532 (Pubitemid 34065880)
5. Clemons M, Danson S, Howell A (2002) Tamoxifen ("Nolvadex"): a review. Cancer Treat Rev 28:165-180
6. Ali S, Coombes RC (2002) Endocrine-responsive breast cancer cell and strategies for combating resistance. Nat Rev Cancer 2:101-112 (Pubitemid 37328797)
7. Osborne CK, Fuqua SA (1994) Mechanism of tamoxifen resistance. Breast Cancer Res Treat 32:49-55
8. Knowlden JM, Hutcheson IR, Jones HE, Madden T, Gee JM, Harper ME, Barrow D, Wakeling AE, Nicholson RI (2003) Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediated an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinol 144:1032-1044 (Pubitemid 36262870)
9. Choi HK, Yang JW, Roh SH, Han CY, Kang KW (2007) Induction of multidrug resistance associated protein 2 in tamoxifen-resistant breast cancer cells. Endocr Relat Cancer 14:293-303 (Pubitemid 47242630)
10. Lu SC, Mato JM (2005) Role of methionine adenosyltransferase and SAMe in alcohol-associated liver cancer. Alcohol 35:227-234 (Pubitemid 41085801)
11. Mato JM, Alvarez L, Ortiz P, Pajares MA (1997) S-adenosylmethionine synthesis: molecular mechanism and clinical implications. Pharmacol Ther 73:265-280 (Pubitemid 27224439)
12. Mato JM, Lu SC (2007) Role of S-adenosyl-L-methionine in liver health and injury. Hepatology 45:1306-1312 (Pubitemid 46775795)
13. Lu SC, Mato JM (2008) S-Adenosylmethionine in cell growth, apoptosis and liver cancer. J Gastroenterol Hepatol 23:S73-S77 (Pubitemid 351389035)
14. Mudd SH, Poole JR (1975) Labile methyl balances for normal humans of various dietary regimens. Metabolism 24:721-735
15. Tobena R, Horikawa S, Calvo V, Alemany S (1996) Interleukin-2 induces-S-adenosyl-L-methionine synthetase gene expression during T lymphocyte activation. Biochem J 319:929-933 (Pubitemid 26386999)
16. Ansorena E, García-Trevijano ER, Martínez-Chantar ML, Huang ZZ, Chen L, Mato JM, Iraburu M, Lu SC, Avila MA (2002) S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells. Hepatology 35(2):274-280 (Pubitemid 34106365)
17. Zhao Y, Li JS, Guo MZ, Feng BS, Zhang JP (2010) Inhibitory effect of S-adenosylmethionine on the growth of human gastric cancer cells in vivo and in vitro. Chin J Cancer 29:752-760
18. Chen H, Xia M, Lin M, Yang H, Kuhlenkamp J, Li T, Sodir NM, Chen YH, Josef-Lenz H, Laird PW, Clarke S, Mato JM, Lu SC (2007) Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology 133:207-218 (Pubitemid 47039238)
19. Luzhna L, Kovalchuk O (2010) Modulation of DNA methylation levels sensitizes doxorubicin-resistant breast adenocarcinoma cells to radiation-induced apoptosis. Biochem Biophys Res Commun 392:113-117
20. Jaenisch R, Bird A (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33:245-254 (Pubitemid 36278835)
21. Pecorino L (2005) Molecular biology of cancer. Chap 3: Regulation of gene expression. Oxford University Press, New York
22. Vanyushin BF, Tkacheva SG, Belozersky AN (1970) Rare bases in animal DNA. Nature 225:948-949
23. Antequera F, Bird A (1993) Number of CpG islands and genes in human and mouse. Proc Natl Acad Sci USA 90:11995-11999 (Pubitemid 24008767)
24. Bird AP (1995) Gene number, noise reduction and biological complexity. Trends Genet 11:94-100
25. Yang H, Huang ZZ, Wang J, Lu SC (2001) The role of c-Myb and Sp1 in the upregulation of methionine adenosyltransferase 2A gene expression in human hepatocelluar carcinoma. FASEB J 15:1507-1516 (Pubitemid 32673380)
26. Rhee I, Bachman KE, Park BH, Jair KW et al (2002) DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nat 416:552-556 (Pubitemid 34288859)
27. Dahia PL (2000) PTEN, a unique tumor suppressor gene. Endocr Relat Cancer 7:115-129 (Pubitemid 30609989)
28. Fresno Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, Gonzalez-Baron M (2004) PI3K/AKT signalling pathway and cancer. Cancer Treat Rev 30:193-204
29. Samuels Y, Ericson K (2006) Oncogenic PI3K and its role in cancer. Curr Opin Oncol 18:77-82 (Pubitemid 43740454)
30. Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP, Mak TW (1998) Negative regulation of PKB/AKT-dependent cell survival by the tumor suppressor PTEN. Cell 95:29-39 (Pubitemid 28458022)
31. Salvesen HB, MacDonald N, Ryan A, Jacobs IJ, Lynch ED, Akslen LA, Das S (2001) PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma. Int J Cancer 91:22-26
32. Mir Mohammad Sadegh A, Marini A, Nambiar S, Hassan M, Tannapfel A, Ruzicka T, Hengge UR (2006) Epigenetic silencing of the PTEN gene in melanoma. Cancer Res 66:6546-6552 (Pubitemid 44085609)
33. Soria JC, Lee HY, Khuri FR et al (2002) Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation. Clin Cancer Res 8:1178-1184 (Pubitemid 34517656)
34. Roman-Gomez J, Jimenez-Velasco A, Torres A et al (2004) Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia. Blood 104:2492-2498 (Pubitemid 39331852)
35. Wiencke JK, Zheng S, Stokoe D et al (2007) Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma. Neuro Oncol 9:271-279 (Pubitemid 47169659)
36. Cairns P, Okami K, King P, Bonacum J, Ahrendt S, Wu L, Mao L, Jen J, Sidransky D (1997) Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res 57:4997-5000 (Pubitemid 27498107)
37. Kang GH, Lee S, Kim WH, Lee HW, Kim JC, Rhyu MG, Ro JY (2002) Epstein-Barr viruspositive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol 160:787-794 (Pubitemid 34224568)
38. Furuta J, Umebayashi Y, Miyamoto K, Kikuchi K, Otsuka F, Sugimura T, Ushijima T (2004) Promoter methylation profiling of 30 genes in human malignant melanoma. Cancer Sci 95:962-968 (Pubitemid 40089588)
39. Hou P, Ji M, Xing M (2008) Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/Akt signaling pathway in thyroid tumors. Cancer 113:2440-2447
40. Khan S, Kumagai T, Vora J, Bose N, Sehgal I, Koeffler PH, Bose S (2004) Pten promoter is methylated in a proportion invasive breast cancer. Int J Cancer 112:407-410 (Pubitemid 39390604)
41. Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S, Morikawa T, Nakaya T, Sakatani T, Takada K, Fukayama M (2009) Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermythylation of PTEN gene in gastric carcinoma. Cancer Res 69:2766-2774
42. She QB, Nagao I, Hayakawa T, Tsuge H (1994) A simple HPLC method for the determination of S-adenosylmethionine and S-adenosylhomocysteine in rat tissues: the effect of vitamin B6 deficiency on these concentrations in rat liver. Biochem Biophys Res Commun 205:1748-1754
43. Ahn MY, Chung HY, Choi WS, Lee BM, Yoon S, Kim HS (2010) Anti-tumor effect of apicidin on Ishikawa human endometrial cancer cells both in vitro and in vivo by blocking histone deacetylase 3 and 4. Int J Oncol 36:125-131
44. Sowinska A, Jagodzinski PP (2007) RNA interference-mediated knockdown of DNMT1 and DNMT3b induces CXCL12 expression in MCF-7 breast cancer and AsPC1 pancreatic carcinoma cell lines. Cancer Lett 355:153-159 (Pubitemid 47212611)
45. Frogne T, Jepsen JS, Larsen SS, Fog CK, Brockdorff BL, Lykkesfeldt AE (2005) Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth. Endocr Relat Cancer 12:599-614 (Pubitemid 41482995)
46. Sabnis G, Goloubeva O, Jelovac D, Schayowitz A, Brodie A (2007) Inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens. Clin Cancer Res 13:2751-2757 (Pubitemid 46788044)
47. Das PM, Singal R (2004) DNA methylation and cancer. J Clin Oncol 22:4632-4642 (Pubitemid 41185132)
48. Yang X, Yan Y, Davidson NE (2001) DNA methylation in breast cancer. Endocr Relat Cancer 8:115-127 (Pubitemid 32641353)
49. Altundag O, Altundag K, Gunduz M (2004) DNA methylation inhibitor, procainamide, may decrease the tamoxifen resistance by inducing overexpression of the estrogen receptor beta in breast cancer patients. Med Hypotheses 63:684-687 (Pubitemid 39485840)
50. Finkelstein J, Martin J (2000) Homocystein. Int J Biochem Cell Biol 32:385-389
51. Champe PC, Harvey RA (2008) Biochemistry. Lippincott's illustrated reviews, 4th edn. Lippincott Williams and Wilkins, Hagerstown
52. Kim SK, Yang JW, Kim MR, Roh SH, Kim HG, Lee KY, Jeong HG, Kang KW (2008) Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells. Free Rad Biol Med 45:537-546
53. Fry MJ (2001) Phosphoinositide 3-kinase signaling in breast cancer: how big a role might it play? Breast Cancer Res 3:304-312 (Pubitemid 32851160)
54. Ahmad S, Singh N, Glazer RI (1999) Role of Akt1 in 17bestradiol-and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells. Biochem Pharmacol 58:425-430 (Pubitemid 29281541)
55. Jordan NJ, Gee JM, Barrow D, Wakeling AE, Nicholson RI (2004) Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells. Breast Cancer Res Treat 87:167-180 (Pubitemid 39237793)
56. Kandel ES, Hay N (1999) The regulation and activities of the multifunctional serine/threonine kinase akt/PKB. Exp Cell Res 253:210-229
57. El-Deiry WS, Nelkin BD, Celano P, Yen RW, Falco JP, Hamilton SR, Baylin SB (1991) High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer. Proc Natl Acad Sci USA 88:3470-3474 (Pubitemid 21916643)
58. De Marzo AM, Marchi VL, Yang ES, Veeraswamy R, Lin X, Nelson WG (1999) Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis. Cancer Res 59:3855-3860 (Pubitemid 29393539)
59. Issa JP, Vertino PM, Wu J, Sazawal S, Celano P, Nelkin BD, Hamilton SR, Baylin SB (1993) Increased cytosine DNA-methyltransferase activity during colon cancer progression. J Natl Cancer Inst 85:1235-1240 (Pubitemid 23223530)
60. Ramchandani S, MacLeod AR, Pinard M, von Hofe E, Szyf M (1997) Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide. Proc Natl Acad Sci USA 94:684-689 (Pubitemid 27053694)
61. Sahin M, Sahin E, Gumuslu S, Erdogan A, Gultekin M (2010) DNA methylation or histone modification status in metastasis and angiogenesis-related genes: a new hypothesis on usage of DNMT inhibitors and S-adenosylmethionine for genome stability. Cancer Metastasis Rev 29:655-676
62. Satini V, Kantarjian HM, Issa JP (2001) Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann Intern Med 134:573-586 (Pubitemid 32245319)
63. Cui M, Wen Z, Chen J, Yang Z, Zhang H (2010) 5-Aza-2'- deoxycytidine is a potent inhibitor of DNA methyltransferase 3B and induces apoptosis in human endometrial cancer cell lines with the up-regulation of hMLH1. Med Oncol 27:278-285