Phase i study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome

Investigational New Drugs

Volumn 31, Issue 5, 2013, Pages 1217-1227

  Gojo, Ivana ^a,d   Perl, Alexander ^b   Luger, Selina ^b   Baer, Maria R ^a   Norsworthy, Kelly J ^a   Bauer, Kenneth S ^a,c   Tidwell, Michael ^a   Fleckinger, Stephanie ^a   Carroll, Martin ^b   Sausville, Edward A ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Acute leukemia; Akt inhibition; Perifosine; UCN 01

Indexed keywords

7 HYDROXYSTAUROSPORINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; PERIFOSINE; PROTEIN KINASE B; PROTEIN S6;

ABDOMINAL PAIN; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ADVANCED CANCER; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANEMIA; ANOREXIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHILL; CLINICAL ARTICLE; CONSTIPATION; DIARRHEA; DIZZINESS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG SAFETY; DYSPNEA; ENZYME INHIBITION; FATIGUE; FEMALE; FEVER; FLOW CYTOMETRY; HEART TAMPONADE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPERKALEMIA; HYPOALBUMINEMIA; HYPOCALCEMIA; HYPOKALEMIA; HYPOTENSION; LETHARGY; LEUKEMIA RELAPSE; LEUKOPENIA; LOADING DRUG DOSE; MALE; MAXIMUM TOLERATED DOSE; MONONUCLEAR CELL; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; MYALGIA; MYELODYSPLASTIC SYNDROME; NAUSEA; PERICARDIAL EFFUSION; PHARMACODYNAMICS; PHASE 1 CLINICAL TRIAL; PNEUMONIA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REFRACTORY ANEMIA WITH EXCESS BLASTS; RIGOR; SEPSIS; SIDE EFFECT; STEADY STATE; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; TREATMENT RESPONSE; VOMITING; WEAKNESS; WEIGHT REDUCTION; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; LEUKEMIA; LEUKOCYTES, MONONUCLEAR; MALE; MAXIMUM TOLERATED DOSE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; PHOSPHORYLCHOLINE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; STAUROSPORINE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84884818193     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-013-9937-8     Document Type: Article

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