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Volumn 131, Issue , 2015, Pages 325-358

Nonneuronal central mechanisms of pain: Glia and immune response

Author keywords

Microglia Astrocytes Glia Spinal cord Glial modulators Clinical trials

Indexed keywords

AZD 2423; MINOCYCLINE; PROPENTOFYLLINE;

EID: 84924598569     PISSN: 18771173     EISSN: 18780814     Source Type: Book Series    
DOI: 10.1016/bs.pmbts.2014.11.007     Document Type: Chapter
Times cited : (25)

References (167)
  • 1
    • 78149314205 scopus 로고    scopus 로고
    • Specification and morphogenesis of astrocytes
    • M.R. Freeman Specification and morphogenesis of astrocytes Science 330 6005 2010 774 778
    • (2010) Science , vol.330 , Issue.6005 , pp. 774-778
    • Freeman, M.R.1
  • 2
    • 78149322599 scopus 로고    scopus 로고
    • Changing face of microglia
    • M.B. Graeber Changing face of microglia Science 330 6005 2010 783 788
    • (2010) Science , vol.330 , Issue.6005 , pp. 783-788
    • Graeber, M.B.1
  • 3
    • 77649184973 scopus 로고    scopus 로고
    • Microglia: Biology and pathology
    • M.B. Graeber, and W.J. Streit Microglia: biology and pathology Acta Neuropathol 119 1 2010 89 105
    • (2010) Acta Neuropathol , vol.119 , Issue.1 , pp. 89-105
    • Graeber, M.B.1    Streit, W.J.2
  • 4
    • 27844473354 scopus 로고    scopus 로고
    • A dynamic view of the immunological synapse
    • M.L. Dustin A dynamic view of the immunological synapse Semin Immunol 17 6 2005 400 410
    • (2005) Semin Immunol , vol.17 , Issue.6 , pp. 400-410
    • Dustin, M.L.1
  • 5
    • 33646522699 scopus 로고    scopus 로고
    • Glia-derived d-serine controls NMDA receptor activity and synaptic memory
    • A. Panatier, D.T. Theodosis, and J.P. Mothet Glia-derived d-serine controls NMDA receptor activity and synaptic memory Cell 125 4 2006 775 784
    • (2006) Cell , vol.125 , Issue.4 , pp. 775-784
    • Panatier, A.1    Theodosis, D.T.2    Mothet, J.P.3
  • 6
    • 26444552361 scopus 로고    scopus 로고
    • Astrocytic purinergic signaling coordinates synaptic networks
    • O. Pascual, K.B. Casper, and C. Kubera Astrocytic purinergic signaling coordinates synaptic networks Science 310 5745 2005 113 116
    • (2005) Science , vol.310 , Issue.5745 , pp. 113-116
    • Pascual, O.1    Casper, K.B.2    Kubera, C.3
  • 7
    • 33646043440 scopus 로고    scopus 로고
    • The tetrapartite synapse: Path to CNS sensitization and chronic pain
    • J.A. De Leo, V.L. Tawfik, and M.L. LaCroix-Fralish The tetrapartite synapse: path to CNS sensitization and chronic pain Pain 122 1-2 2006 17 21
    • (2006) Pain , vol.122 , Issue.12 , pp. 17-21
    • De Leo, J.A.1    Tawfik, V.L.2    Lacroix-Fralish, M.L.3
  • 8
    • 0141533205 scopus 로고    scopus 로고
    • New roles for astrocytes: Redefining the functional architecture of the brain
    • M. Nedergaard, B. Ransom, and S.A. Goldman New roles for astrocytes: redefining the functional architecture of the brain Trends Neurosci 26 10 2003 523 530
    • (2003) Trends Neurosci , vol.26 , Issue.10 , pp. 523-530
    • Nedergaard, M.1    Ransom, B.2    Goldman, S.A.3
  • 9
    • 45849091466 scopus 로고    scopus 로고
    • A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain
    • A. Romero-Sandoval, N. Chai, N. Nutile-McMenemy, and J.A. Deleo A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain Brain Res 1219 2008 116 126
    • (2008) Brain Res , vol.1219 , pp. 116-126
    • Romero-Sandoval, A.1    Chai, N.2    Nutile-Mcmenemy, N.3    Deleo, J.A.4
  • 10
    • 46749129803 scopus 로고    scopus 로고
    • Neuroimmune interactions and pain: Focus on glial-modulating targets
    • E.A. Romero-Sandoval, R.J. Horvath, and J.A. DeLeo Neuroimmune interactions and pain: focus on glial-modulating targets Curr Opin Investig Drugs 9 7 2008 726 734
    • (2008) Curr Opin Investig Drugs , vol.9 , Issue.7 , pp. 726-734
    • Romero-Sandoval, E.A.1    Horvath, R.J.2    Deleo, J.A.3
  • 11
    • 59049101209 scopus 로고    scopus 로고
    • Gene transfer of GLT-1, a glial glutamate transporter, into the spinal cord by recombinant adenovirus attenuates inflammatory and neuropathic pain in rats
    • S. Maeda, A. Kawamoto, Y. Yatani, H. Shirakawa, T. Nakagawa, and S. Kaneko Gene transfer of GLT-1, a glial glutamate transporter, into the spinal cord by recombinant adenovirus attenuates inflammatory and neuropathic pain in rats Mol Pain 4 2008 65
    • (2008) Mol Pain , vol.4 , pp. 65
    • Maeda, S.1    Kawamoto, A.2    Yatani, Y.3    Shirakawa, H.4    Nakagawa, T.5    Kaneko, S.6
  • 12
    • 33747181927 scopus 로고    scopus 로고
    • Induction of astrocyte differentiation by propentofylline increases glutamate transporter expression in vitro: Heterogeneity of the quiescent phenotype
    • V.L. Tawfik, M.L. Lacroix-Fralish, K.K. Bercury, N. Nutile-McMenemy, B.T. Harris, and J.A. Deleo Induction of astrocyte differentiation by propentofylline increases glutamate transporter expression in vitro: heterogeneity of the quiescent phenotype Glia 54 3 2006 193 203
    • (2006) Glia , vol.54 , Issue.3 , pp. 193-203
    • Tawfik, V.L.1    Lacroix-Fralish, M.L.2    Bercury, K.K.3    Nutile-Mcmenemy, N.4    Harris, B.T.5    Deleo, J.A.6
  • 13
    • 41549147179 scopus 로고    scopus 로고
    • Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection
    • V.L. Tawfik, M.R. Regan, and C. Haenggeli Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection Neuroscience 152 4 2008 1086 1092
    • (2008) Neuroscience , vol.152 , Issue.4 , pp. 1086-1092
    • Tawfik, V.L.1    Regan, M.R.2    Haenggeli, C.3
  • 14
    • 65749105558 scopus 로고    scopus 로고
    • Plasticity in expression of the glutamate transporters GLT-1 and GLAST in spinal dorsal horn glial cells following partial sciatic nerve ligation
    • W.J. Xin, H.R. Weng, and P.M. Dougherty Plasticity in expression of the glutamate transporters GLT-1 and GLAST in spinal dorsal horn glial cells following partial sciatic nerve ligation Mol Pain 5 2009 15
    • (2009) Mol Pain , vol.5 , pp. 15
    • Xin, W.J.1    Weng, H.R.2    Dougherty, P.M.3
  • 15
    • 42249104400 scopus 로고    scopus 로고
    • + T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain
    • + T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain Eur J Immunol 38 2 2008 448 458
    • (2008) Eur J Immunol , vol.38 , Issue.2 , pp. 448-458
    • Cao, L.1    Deleo, J.A.2
  • 16
    • 70949108323 scopus 로고    scopus 로고
    • T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity
    • M. Costigan, A. Moss, and A. Latremoliere T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity J Neurosci 29 46 2009 14415 14422
    • (2009) J Neurosci , vol.29 , Issue.46 , pp. 14415-14422
    • Costigan, M.1    Moss, A.2    Latremoliere, A.3
  • 17
    • 0036844372 scopus 로고    scopus 로고
    • Focal peripheral nerve injury induces leukocyte trafficking into the central nervous system: Potential relationship to neuropathic pain
    • S.M. Sweitzer, W.F. Hickey, M.D. Rutkowski, J.L. Pahl, and J.A. DeLeo Focal peripheral nerve injury induces leukocyte trafficking into the central nervous system: potential relationship to neuropathic pain Pain 100 1-2 2002 163 170
    • (2002) Pain , vol.100 , Issue.12 , pp. 163-170
    • Sweitzer, S.M.1    Hickey, W.F.2    Rutkowski, M.D.3    Pahl, J.L.4    Deleo, J.A.5
  • 18
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • N.J. Abbott, L. Ronnback, and E. Hansson Astrocyte-endothelial interactions at the blood-brain barrier Nat Rev Neurosci 7 1 2006 41 53
    • (2006) Nat Rev Neurosci , vol.7 , Issue.1 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 19
    • 84455205524 scopus 로고    scopus 로고
    • The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence
    • J.I. Alvarez, A. Dodelet-Devillers, and H. Kebir The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence Science 334 6063 2011 1727 1731
    • (2011) Science , vol.334 , Issue.6063 , pp. 1727-1731
    • Alvarez, J.I.1    Dodelet-Devillers, A.2    Kebir, H.3
  • 20
    • 0033152442 scopus 로고    scopus 로고
    • Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice
    • T.G. Bush, N. Puvanachandra, and C.H. Horner Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice Neuron 23 2 1999 297 308
    • (1999) Neuron , vol.23 , Issue.2 , pp. 297-308
    • Bush, T.G.1    Puvanachandra, N.2    Horner, C.H.3
  • 21
    • 52049102033 scopus 로고    scopus 로고
    • T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: A novel astrocyte response mechanism to cellular injury
    • C. Barcia, N.S. Sanderson, and R.J. Barrett T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury PLoS ONE 3 8 2008 e2977
    • (2008) PLoS ONE , vol.3 , Issue.8 , pp. e2977
    • Barcia, C.1    Sanderson, N.S.2    Barrett, R.J.3
  • 22
    • 33748549010 scopus 로고    scopus 로고
    • In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain
    • C. Barcia, C.E. Thomas, and J.F. Curtin In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain J Exp Med 203 9 2006 2095 2107
    • (2006) J Exp Med , vol.203 , Issue.9 , pp. 2095-2107
    • Barcia, C.1    Thomas, C.E.2    Curtin, J.F.3
  • 23
    • 0029451821 scopus 로고
    • The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis
    • J. Bauer, I. Huitinga, W. Zhao, H. Lassmann, W.F. Hickey, and C.D. Dijkstra The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis Glia 15 4 1995 437 446
    • (1995) Glia , vol.15 , Issue.4 , pp. 437-446
    • Bauer, J.1    Huitinga, I.2    Zhao, W.3    Lassmann, H.4    Hickey, W.F.5    Dijkstra, C.D.6
  • 24
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • R.C. Paolicelli, G. Bolasco, and F. Pagani Synaptic pruning by microglia is necessary for normal brain development Science 333 6048 2011 1456 1458
    • (2011) Science , vol.333 , Issue.6048 , pp. 1456-1458
    • Paolicelli, R.C.1    Bolasco, G.2    Pagani, F.3
  • 25
    • 84860338445 scopus 로고    scopus 로고
    • The complement system: An unexpected role in synaptic pruning during development and disease
    • A.H. Stephan, B.A. Barres, and B. Stevens The complement system: an unexpected role in synaptic pruning during development and disease Annu Rev Neurosci 35 2012 369 389
    • (2012) Annu Rev Neurosci , vol.35 , pp. 369-389
    • Stephan, A.H.1    Barres, B.A.2    Stevens, B.3
  • 27
    • 35548969443 scopus 로고    scopus 로고
    • Glial regulation of the cerebral microvasculature
    • C. Iadecola, and M. Nedergaard Glial regulation of the cerebral microvasculature Nat Neurosci 10 11 2007 1369 1376
    • (2007) Nat Neurosci , vol.10 , Issue.11 , pp. 1369-1376
    • Iadecola, C.1    Nedergaard, M.2
  • 29
    • 84888637560 scopus 로고    scopus 로고
    • Glia and pain: Is chronic pain a gliopathy?
    • R.R. Ji, T. Berta, and M. Nedergaard Glia and pain: is chronic pain a gliopathy? Pain 154 suppl 1 2013 S10 S28
    • (2013) Pain , vol.154 , pp. S10-S28
    • Ji, R.R.1    Berta, T.2    Nedergaard, M.3
  • 30
    • 84858152101 scopus 로고    scopus 로고
    • The mechanisms of microgliosis and pain following peripheral nerve injury
    • M. Calvo, and D.L. Bennett The mechanisms of microgliosis and pain following peripheral nerve injury Exp Neurol 234 2 2012 271 282
    • (2012) Exp Neurol , vol.234 , Issue.2 , pp. 271-282
    • Calvo, M.1    Bennett, D.L.2
  • 31
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • B. Ajami, J.L. Bennett, C. Krieger, W. Tetzlaff, and F.M. Rossi Local self-renewal can sustain CNS microglia maintenance and function throughout adult life Nat Neurosci 10 12 2007 1538 1543
    • (2007) Nat Neurosci , vol.10 , Issue.12 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 32
    • 0034014321 scopus 로고    scopus 로고
    • Glial cell proliferation in the spinal cord after dorsal rhizotomy or sciatic nerve transection in the adult rat
    • L. Liu, M. Rudin, and E.N. Kozlova Glial cell proliferation in the spinal cord after dorsal rhizotomy or sciatic nerve transection in the adult rat Exp Brain Res 131 1 2000 64 73
    • (2000) Exp Brain Res , vol.131 , Issue.1 , pp. 64-73
    • Liu, L.1    Rudin, M.2    Kozlova, E.N.3
  • 33
    • 0036139877 scopus 로고    scopus 로고
    • Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains
    • E.A. Bushong, M.E. Martone, Y.Z. Jones, and M.H. Ellisman Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains J Neurosci 22 1 2002 183 192
    • (2002) J Neurosci , vol.22 , Issue.1 , pp. 183-192
    • Bushong, E.A.1    Martone, M.E.2    Jones, Y.Z.3    Ellisman, M.H.4
  • 34
    • 0037008429 scopus 로고    scopus 로고
    • Structural and quantitative analysis of astrocytes in the mouse hippocampus
    • K. Ogata, and T. Kosaka Structural and quantitative analysis of astrocytes in the mouse hippocampus Neuroscience 113 1 2002 221 233
    • (2002) Neuroscience , vol.113 , Issue.1 , pp. 221-233
    • Ogata, K.1    Kosaka, T.2
  • 35
    • 38849178118 scopus 로고    scopus 로고
    • Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain
    • S. Echeverry, X.Q. Shi, and J. Zhang Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain Pain 135 1-2 2008 37 47
    • (2008) Pain , vol.135 , Issue.12 , pp. 37-47
    • Echeverry, S.1    Shi, X.Q.2    Zhang, J.3
  • 36
    • 38049119409 scopus 로고    scopus 로고
    • P38 MAPK, microglial signaling, and neuropathic pain
    • R.R. Ji, and M.R. Suter p38 MAPK, microglial signaling, and neuropathic pain Mol Pain 3 2007 33
    • (2007) Mol Pain , vol.3 , pp. 33
    • Ji, R.R.1    Suter, M.R.2
  • 37
    • 84883199752 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in innate immunity
    • J.S. Arthur, and S.C. Ley Mitogen-activated protein kinases in innate immunity Nat Rev Immunol 13 9 2013 679 692
    • (2013) Nat Rev Immunol , vol.13 , Issue.9 , pp. 679-692
    • Arthur, J.S.1    Ley, S.C.2
  • 39
    • 4444273369 scopus 로고    scopus 로고
    • Peripheral and central p38 MAPK mediates capsaicin-induced hyperalgesia
    • S.M. Sweitzer, M.C. Peters, and J.Y. Ma Peripheral and central p38 MAPK mediates capsaicin-induced hyperalgesia Pain 111 3 2004 278 285
    • (2004) Pain , vol.111 , Issue.3 , pp. 278-285
    • Sweitzer, S.M.1    Peters, M.C.2    Ma, J.Y.3
  • 40
    • 0037705314 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    • S.X. Jin, Z.Y. Zhuang, C.J. Woolf, and R.R. Ji p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain J Neurosci 23 10 2003 4017 4022
    • (2003) J Neurosci , vol.23 , Issue.10 , pp. 4017-4022
    • Jin, S.X.1    Zhuang, Z.Y.2    Woolf, C.J.3    Ji, R.R.4
  • 41
    • 77955560673 scopus 로고    scopus 로고
    • Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK
    • K.M. Lee, S.M. Jeon, and H.J. Cho Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK Eur J Pain 14 7 2010 682.e1 682.e12
    • (2010) Eur J Pain , vol.14 , Issue.7 , pp. 682e1-682e12
    • Lee, K.M.1    Jeon, S.M.2    Cho, H.J.3
  • 42
    • 0141767048 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing
    • C.I. Svensson, M. Marsala, and A. Westerlund Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing J Neurochem 86 6 2003 1534 1544
    • (2003) J Neurochem , vol.86 , Issue.6 , pp. 1534-1544
    • Svensson, C.I.1    Marsala, M.2    Westerlund, A.3
  • 43
    • 58749098812 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia
    • Y.R. Wen, M.R. Suter, and R.R. Ji Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia Anesthesiology 110 1 2009 155 165
    • (2009) Anesthesiology , vol.110 , Issue.1 , pp. 155-165
    • Wen, Y.R.1    Suter, M.R.2    Ji, R.R.3
  • 44
    • 65249114367 scopus 로고    scopus 로고
    • JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
    • Y.J. Gao, L. Zhang, and O.A. Samad JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain J Neurosci 29 13 2009 4096 4108
    • (2009) J Neurosci , vol.29 , Issue.13 , pp. 4096-4108
    • Gao, Y.J.1    Zhang, L.2    Samad, O.A.3
  • 45
    • 34447502253 scopus 로고    scopus 로고
    • Possible role of spinal astrocytes in maintaining chronic pain sensitization: Review of current evidence with focus on bFGF/JNK pathway
    • R.R. Ji, Y. Kawasaki, Z.Y. Zhuang, Y.R. Wen, and I. Decosterd Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway Neuron Glia Biol 2 4 2006 259 269
    • (2006) Neuron Glia Biol , vol.2 , Issue.4 , pp. 259-269
    • Ji, R.R.1    Kawasaki, Y.2    Zhuang, Z.Y.3    Wen, Y.R.4    Decosterd, I.5
  • 46
    • 48249124939 scopus 로고    scopus 로고
    • Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury
    • H. Katsura, K. Obata, and K. Miyoshi Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury Glia 56 7 2008 723 733
    • (2008) Glia , vol.56 , Issue.7 , pp. 723-733
    • Katsura, H.1    Obata, K.2    Miyoshi, K.3
  • 47
    • 33645460235 scopus 로고    scopus 로고
    • A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: Respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    • Z.Y. Zhuang, Y.R. Wen, and D.R. Zhang A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance J Neurosci 26 13 2006 3551 3560
    • (2006) J Neurosci , vol.26 , Issue.13 , pp. 3551-3560
    • Zhuang, Z.Y.1    Wen, Y.R.2    Zhang, D.R.3
  • 48
    • 4644312225 scopus 로고    scopus 로고
    • Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    • Y. Kawasaki, T. Kohno, and Z.Y. Zhuang Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization J Neurosci 24 38 2004 8310 8321
    • (2004) J Neurosci , vol.24 , Issue.38 , pp. 8310-8321
    • Kawasaki, Y.1    Kohno, T.2    Zhuang, Z.Y.3
  • 49
    • 40449126196 scopus 로고    scopus 로고
    • Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain
    • Y. Kawasaki, Z.Z. Xu, and X. Wang Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain Nat Med 14 3 2008 331 336
    • (2008) Nat Med , vol.14 , Issue.3 , pp. 331-336
    • Kawasaki, Y.1    Xu, Z.Z.2    Wang, X.3
  • 50
    • 77952237425 scopus 로고    scopus 로고
    • Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions
    • [591p following 597]
    • Z.Z. Xu, L. Zhang, and T. Liu Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions Nat Med 16 5 2010 592 597 [591p following 597]
    • (2010) Nat Med , vol.16 , Issue.5 , pp. 592-597
    • Xu, Z.Z.1    Zhang, L.2    Liu, T.3
  • 51
    • 80455174056 scopus 로고    scopus 로고
    • Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury
    • P. Anand, R. Shenoy, and J.E. Palmer Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury Eur J Pain 15 10 2011 1040 1048
    • (2011) Eur J Pain , vol.15 , Issue.10 , pp. 1040-1048
    • Anand, P.1    Shenoy, R.2    Palmer, J.E.3
  • 52
    • 84860290270 scopus 로고    scopus 로고
    • Novel p38alpha mitogen-activated protein kinase inhibitor shows analgesic efficacy in acute postsurgical dental pain
    • S.E. Tong, S.E. Daniels, P. Black, S. Chang, A. Protter, and P.J. Desjardins Novel p38alpha mitogen-activated protein kinase inhibitor shows analgesic efficacy in acute postsurgical dental pain J Clin Pharmacol 52 5 2012 717 728
    • (2012) J Clin Pharmacol , vol.52 , Issue.5 , pp. 717-728
    • Tong, S.E.1    Daniels, S.E.2    Black, P.3    Chang, S.4    Protter, A.5    Desjardins, P.J.6
  • 53
    • 84880623225 scopus 로고    scopus 로고
    • Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1beta and ERK signaling in the spinal cord of mice
    • T. Berta, Y.C. Liu, Z.Z. Xu, and R.R. Ji Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1beta and ERK signaling in the spinal cord of mice Neuroscience 247 2013 376 385
    • (2013) Neuroscience , vol.247 , pp. 376-385
    • Berta, T.1    Liu, Y.C.2    Xu, Z.Z.3    Ji, R.R.4
  • 54
    • 84886639648 scopus 로고    scopus 로고
    • Traumatic scratch injury in astrocytes triggers calcium influx to activate the JNK/c-Jun/AP-1 pathway and switch on GFAP expression
    • K. Gao, C.R. Wang, and F. Jiang Traumatic scratch injury in astrocytes triggers calcium influx to activate the JNK/c-Jun/AP-1 pathway and switch on GFAP expression Glia 61 12 2013 2063 2077
    • (2013) Glia , vol.61 , Issue.12 , pp. 2063-2077
    • Gao, K.1    Wang, C.R.2    Jiang, F.3
  • 55
    • 78649348355 scopus 로고    scopus 로고
    • Spinal injection of TNF-alpha-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1
    • Y.J. Gao, L. Zhang, and R.R. Ji Spinal injection of TNF-alpha-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1 Glia 58 15 2010 1871 1880
    • (2010) Glia , vol.58 , Issue.15 , pp. 1871-1880
    • Gao, Y.J.1    Zhang, L.2    Ji, R.R.3
  • 56
    • 79956128999 scopus 로고    scopus 로고
    • IL-1beta in the trigeminal subnucleus caudalis contributes to extra-territorial allodynia/hyperalgesia following a trigeminal nerve injury
    • K. Takahashi, M. Watanabe, and Y. Suekawa IL-1beta in the trigeminal subnucleus caudalis contributes to extra-territorial allodynia/hyperalgesia following a trigeminal nerve injury Eur J Pain 15 5 2011 467.e1 467.e14
    • (2011) Eur J Pain , vol.15 , Issue.5 , pp. 467e1-467e14
    • Takahashi, K.1    Watanabe, M.2    Suekawa, Y.3
  • 57
    • 45549090676 scopus 로고    scopus 로고
    • Cytokine mechanisms of central sensitization: Distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord
    • Y. Kawasaki, L. Zhang, J.K. Cheng, and R.R. Ji Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord J Neurosci 28 20 2008 5189 5194
    • (2008) J Neurosci , vol.28 , Issue.20 , pp. 5189-5194
    • Kawasaki, Y.1    Zhang, L.2    Cheng, J.K.3    Ji, R.R.4
  • 58
    • 23244449557 scopus 로고    scopus 로고
    • Inhibition of p38 mitogen-activated protein kinase attenuates interleukin-1beta-induced thermal hyperalgesia and inducible nitric oxide synthase expression in the spinal cord
    • C.S. Sung, Z.H. Wen, and W.K. Chang Inhibition of p38 mitogen-activated protein kinase attenuates interleukin-1beta-induced thermal hyperalgesia and inducible nitric oxide synthase expression in the spinal cord J Neurochem 94 3 2005 742 752
    • (2005) J Neurochem , vol.94 , Issue.3 , pp. 742-752
    • Sung, C.S.1    Wen, Z.H.2    Chang, W.K.3
  • 59
    • 17444408199 scopus 로고    scopus 로고
    • Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38
    • C.I. Svensson, M. Schafers, T.L. Jones, H. Powell, and L.S. Sorkin Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38 Neurosci Lett 379 3 2005 209 213
    • (2005) Neurosci Lett , vol.379 , Issue.3 , pp. 209-213
    • Svensson, C.I.1    Schafers, M.2    Jones, T.L.3    Powell, H.4    Sorkin, L.S.5
  • 61
    • 78651498932 scopus 로고    scopus 로고
    • TNF-alpha contributes to spinal cord synaptic plasticity and inflammatory pain: Distinct role of TNF receptor subtypes 1 and 2
    • L. Zhang, T. Berta, Z.Z. Xu, T. Liu, J.Y. Park, and R.R. Ji TNF-alpha contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2 Pain 152 2 2011 419 427
    • (2011) Pain , vol.152 , Issue.2 , pp. 419-427
    • Zhang, L.1    Berta, T.2    Xu, Z.Z.3    Liu, T.4    Park, J.Y.5    Ji, R.R.6
  • 62
    • 77955574425 scopus 로고    scopus 로고
    • Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: Contribution of spinal cord CX3CR1, p38 and IL-1 signaling
    • H.L. Willemen, N. Eijkelkamp, and H. Wang Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling Pain 150 3 2010 550 560
    • (2010) Pain , vol.150 , Issue.3 , pp. 550-560
    • Willemen, H.L.1    Eijkelkamp, N.2    Wang, H.3
  • 63
    • 30744439794 scopus 로고    scopus 로고
    • BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    • J.A. Coull, S. Beggs, and D. Boudreau BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain Nature 438 7070 2005 1017 1021
    • (2005) Nature , vol.438 , Issue.7070 , pp. 1017-1021
    • Coull, J.A.1    Beggs, S.2    Boudreau, D.3
  • 64
    • 0033594738 scopus 로고    scopus 로고
    • Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat
    • S.M. Sweitzer, R.W. Colburn, M. Rutkowski, and J.A. DeLeo Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat Brain Res 829 1-2 1999 209 221
    • (1999) Brain Res , vol.829 , Issue.12 , pp. 209-221
    • Sweitzer, S.M.1    Colburn, R.W.2    Rutkowski, M.3    Deleo, J.A.4
  • 65
    • 0030859754 scopus 로고    scopus 로고
    • Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat
    • R.W. Colburn, J.A. DeLeo, A.J. Rickman, M.P. Yeager, P. Kwon, and W.F. Hickey Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat J Neuroimmunol 79 2 1997 163 175
    • (1997) J Neuroimmunol , vol.79 , Issue.2 , pp. 163-175
    • Colburn, R.W.1    Deleo, J.A.2    Rickman, A.J.3    Yeager, M.P.4    Kwon, P.5    Hickey, W.F.6
  • 66
    • 0027944898 scopus 로고
    • GFAP expression in lumbar spinal cord of naive and neuropathic rats treated with MK-801
    • C.J. Garrison, P.M. Dougherty, and S.M. Carlton GFAP expression in lumbar spinal cord of naive and neuropathic rats treated with MK-801 Exp Neurol 129 2 1994 237 243
    • (1994) Exp Neurol , vol.129 , Issue.2 , pp. 237-243
    • Garrison, C.J.1    Dougherty, P.M.2    Carlton, S.M.3
  • 67
    • 79954423670 scopus 로고    scopus 로고
    • Effects of local lidocaine treatment before and after median nerve injury on mechanical hypersensitivity and microglia activation in rat cuneate nucleus
    • S.C. Lin, J.H. Yeh, C.L. Chen, S.H. Chou, and Y.J. Tsai Effects of local lidocaine treatment before and after median nerve injury on mechanical hypersensitivity and microglia activation in rat cuneate nucleus Eur J Pain 15 4 2011 359 367
    • (2011) Eur J Pain , vol.15 , Issue.4 , pp. 359-367
    • Lin, S.C.1    Yeh, J.H.2    Chen, C.L.3    Chou, S.H.4    Tsai, Y.J.5
  • 68
    • 0036509936 scopus 로고    scopus 로고
    • Expression of functional NK-1 receptors in murine microglia
    • A. Rasley, K.L. Bost, J.K. Olson, S.D. Miller, and I. Marriott Expression of functional NK-1 receptors in murine microglia Glia 37 3 2002 258 267
    • (2002) Glia , vol.37 , Issue.3 , pp. 258-267
    • Rasley, A.1    Bost, K.L.2    Olson, J.K.3    Miller, S.D.4    Marriott, I.5
  • 69
    • 34249795149 scopus 로고    scopus 로고
    • Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain
    • W. Guo, H. Wang, and M. Watanabe Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain J Neurosci 27 22 2007 6006 6018
    • (2007) J Neurosci , vol.27 , Issue.22 , pp. 6006-6018
    • Guo, W.1    Wang, H.2    Watanabe, M.3
  • 70
    • 0031259777 scopus 로고    scopus 로고
    • Functional characterization of substance P receptors on cultured human spinal cord astrocytes: Synergism of substance P with cytokines in inducing interleukin-6 and prostaglandin E2 production
    • C. Palma, L. Minghetti, and M. Astolfi Functional characterization of substance P receptors on cultured human spinal cord astrocytes: synergism of substance P with cytokines in inducing interleukin-6 and prostaglandin E2 production Glia 21 2 1997 183 193
    • (1997) Glia , vol.21 , Issue.2 , pp. 183-193
    • Palma, C.1    Minghetti, L.2    Astolfi, M.3
  • 71
    • 0034720177 scopus 로고    scopus 로고
    • Allodynia and hyperalgesia evoked by sciatic mononeuropathy in NKI receptor knockout mice
    • L. Martinez-Caro, and J.M. Laird Allodynia and hyperalgesia evoked by sciatic mononeuropathy in NKI receptor knockout mice Neuroreport 11 6 2000 1213 1217
    • (2000) Neuroreport , vol.11 , Issue.6 , pp. 1213-1217
    • Martinez-Caro, L.1    Laird, J.M.2
  • 72
    • 0042968804 scopus 로고    scopus 로고
    • P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
    • M. Tsuda, Y. Shigemoto-Mogami, and S. Koizumi P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury Nature 424 6950 2003 778 783
    • (2003) Nature , vol.424 , Issue.6950 , pp. 778-783
    • Tsuda, M.1    Shigemoto-Mogami, Y.2    Koizumi, S.3
  • 73
    • 78651427914 scopus 로고    scopus 로고
    • Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses
    • Y.X. Chu, Y. Zhang, Y.Q. Zhang, and Z.Q. Zhao Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses Brain Behav Immun 24 7 2010 1176 1189
    • (2010) Brain Behav Immun , vol.24 , Issue.7 , pp. 1176-1189
    • Chu, Y.X.1    Zhang, Y.2    Zhang, Y.Q.3    Zhao, Z.Q.4
  • 74
    • 74949123761 scopus 로고    scopus 로고
    • P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide
    • A.K. Clark, A.A. Staniland, F. Marchand, T.K. Kaan, S.B. McMahon, and M. Malcangio P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide J Neurosci 30 2 2010 573 582
    • (2010) J Neurosci , vol.30 , Issue.2 , pp. 573-582
    • Clark, A.K.1    Staniland, A.A.2    Marchand, F.3    Kaan, T.K.4    McMahon, S.B.5    Malcangio, M.6
  • 75
    • 44949147139 scopus 로고    scopus 로고
    • P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury
    • H. Tozaki-Saitoh, M. Tsuda, H. Miyata, K. Ueda, S. Kohsaka, and K. Inoue P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury J Neurosci 28 19 2008 4949 4956
    • (2008) J Neurosci , vol.28 , Issue.19 , pp. 4949-4956
    • Tozaki-Saitoh, H.1    Tsuda, M.2    Miyata, H.3    Ueda, K.4    Kohsaka, S.5    Inoue, K.6
  • 76
    • 56149096976 scopus 로고    scopus 로고
    • Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain
    • L. Ulmann, J.P. Hatcher, and J.P. Hughes Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain J Neurosci 28 44 2008 11263 11268
    • (2008) J Neurosci , vol.28 , Issue.44 , pp. 11263-11268
    • Ulmann, L.1    Hatcher, J.P.2    Hughes, J.P.3
  • 77
    • 4544252839 scopus 로고    scopus 로고
    • Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions
    • G.M. Verge, E.D. Milligan, S.F. Maier, L.R. Watkins, G.S. Naeve, and A.C. Foster Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions Eur J Neurosci 20 5 2004 1150 1160
    • (2004) Eur J Neurosci , vol.20 , Issue.5 , pp. 1150-1160
    • Verge, G.M.1    Milligan, E.D.2    Maier, S.F.3    Watkins, L.R.4    Naeve, G.S.5    Foster, A.C.6
  • 78
    • 66149186748 scopus 로고    scopus 로고
    • The liberation of fractalkine in the dorsal horn requires microglial cathepsin S
    • A.K. Clark, P.K. Yip, and M. Malcangio The liberation of fractalkine in the dorsal horn requires microglial cathepsin S J Neurosci 29 21 2009 6945 6954
    • (2009) J Neurosci , vol.29 , Issue.21 , pp. 6945-6954
    • Clark, A.K.1    Yip, P.K.2    Malcangio, M.3
  • 79
    • 34249717859 scopus 로고    scopus 로고
    • Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine
    • Z.Y. Zhuang, Y. Kawasaki, P.H. Tan, Y.R. Wen, J. Huang, and R.R. Ji Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine Brain Behav Immun 21 5 2007 642 651
    • (2007) Brain Behav Immun , vol.21 , Issue.5 , pp. 642-651
    • Zhuang, Z.Y.1    Kawasaki, Y.2    Tan, P.H.3    Wen, Y.R.4    Huang, J.5    Ji, R.R.6
  • 80
    • 60949105934 scopus 로고    scopus 로고
    • CCL2 is a key mediator of microglia activation in neuropathic pain states
    • M.A. Thacker, A.K. Clark, and T. Bishop CCL2 is a key mediator of microglia activation in neuropathic pain states Eur J Pain 13 3 2009 263 272
    • (2009) Eur J Pain , vol.13 , Issue.3 , pp. 263-272
    • Thacker, M.A.1    Clark, A.K.2    Bishop, T.3
  • 81
    • 17644414137 scopus 로고    scopus 로고
    • The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy
    • F.Y. Tanga, N. Nutile-McMenemy, and J.A. DeLeo The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy Proc Natl Acad Sci U S A 102 16 2005 5856 5861
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.16 , pp. 5856-5861
    • Tanga, F.Y.1    Nutile-Mcmenemy, N.2    Deleo, J.A.3
  • 82
    • 84862776778 scopus 로고    scopus 로고
    • Emerging role of Toll-like receptors in the control of pain and itch
    • T. Liu, Y.J. Gao, and R.R. Ji Emerging role of Toll-like receptors in the control of pain and itch Neurosci Bull 28 2 2012 131 144
    • (2012) Neurosci Bull , vol.28 , Issue.2 , pp. 131-144
    • Liu, T.1    Gao, Y.J.2    Ji, R.R.3
  • 83
    • 78650250592 scopus 로고    scopus 로고
    • Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFkappaB signaling, MAPK, and Jak1/Stat1 pathways
    • R. Gorina, M. Font-Nieves, L. Marquez-Kisinousky, T. Santalucia, and A.M. Planas Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFkappaB signaling, MAPK, and Jak1/Stat1 pathways Glia 59 2 2011 242 255
    • (2011) Glia , vol.59 , Issue.2 , pp. 242-255
    • Gorina, R.1    Font-Nieves, M.2    Marquez-Kisinousky, L.3    Santalucia, T.4    Planas, A.M.5
  • 84
    • 78650160059 scopus 로고    scopus 로고
    • Lipopolysaccharide from Porphyromonas gingivalis sensitizes capsaicin-sensitive nociceptors
    • C.C. Ferraz, M.A. Henry, K.M. Hargreaves, and A. Diogenes Lipopolysaccharide from Porphyromonas gingivalis sensitizes capsaicin-sensitive nociceptors J Endod 37 1 2011 45 48
    • (2011) J Endod , vol.37 , Issue.1 , pp. 45-48
    • Ferraz, C.C.1    Henry, M.A.2    Hargreaves, K.M.3    Diogenes, A.4
  • 85
    • 33644986066 scopus 로고    scopus 로고
    • Trigeminal nociceptors express TLR-4 and CD14: A mechanism for pain due to infection
    • R. Wadachi, and K.M. Hargreaves Trigeminal nociceptors express TLR-4 and CD14: a mechanism for pain due to infection J Dent Res 85 1 2006 49 53
    • (2006) J Dent Res , vol.85 , Issue.1 , pp. 49-53
    • Wadachi, R.1    Hargreaves, K.M.2
  • 86
    • 77955096497 scopus 로고    scopus 로고
    • Release of prostaglandin E(2) and nitric oxide from spinal microglia is dependent on activation of p38 mitogen-activated protein kinase
    • T. Matsui, C.I. Svensson, Y. Hirata, K. Mizobata, X.Y. Hua, and T.L. Yaksh Release of prostaglandin E(2) and nitric oxide from spinal microglia is dependent on activation of p38 mitogen-activated protein kinase Anesth Analg 111 2 2010 554 560
    • (2010) Anesth Analg , vol.111 , Issue.2 , pp. 554-560
    • Matsui, T.1    Svensson, C.I.2    Hirata, Y.3    Mizobata, K.4    Hua, X.Y.5    Yaksh, T.L.6
  • 87
    • 79956058346 scopus 로고    scopus 로고
    • LPS sensitizes TRPV1 via activation of TLR4 in trigeminal sensory neurons
    • A. Diogenes, C.C. Ferraz, A.N. Akopian, M.A. Henry, and K.M. Hargreaves LPS sensitizes TRPV1 via activation of TLR4 in trigeminal sensory neurons J Dent Res 90 6 2011 759 764
    • (2011) J Dent Res , vol.90 , Issue.6 , pp. 759-764
    • Diogenes, A.1    Ferraz, C.C.2    Akopian, A.N.3    Henry, M.A.4    Hargreaves, K.M.5
  • 88
    • 80054947020 scopus 로고    scopus 로고
    • Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice
    • R.E. Sorge, M.L. LaCroix-Fralish, and A.H. Tuttle Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice J Neurosci 31 43 2011 15450 15454
    • (2011) J Neurosci , vol.31 , Issue.43 , pp. 15450-15454
    • Sorge, R.E.1    Lacroix-Fralish, M.L.2    Tuttle, A.H.3
  • 89
    • 51349166320 scopus 로고    scopus 로고
    • Glial TLR4 receptor as new target to treat neuropathic pain: Efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice
    • I. Bettoni, F. Comelli, and C. Rossini Glial TLR4 receptor as new target to treat neuropathic pain: efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice Glia 56 12 2008 1312 1319
    • (2008) Glia , vol.56 , Issue.12 , pp. 1312-1319
    • Bettoni, I.1    Comelli, F.2    Rossini, C.3
  • 90
    • 84875124740 scopus 로고    scopus 로고
    • Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: The ACCESS randomized trial
    • S.M. Opal, P.F. Laterre, and B. Francois Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial JAMA 309 11 2013 1154 1162
    • (2013) JAMA , vol.309 , Issue.11 , pp. 1154-1162
    • Opal, S.M.1    Laterre, P.F.2    Francois, B.3
  • 91
    • 0028027868 scopus 로고
    • The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat
    • S.T. Meller, C. Dykstra, D. Grzybycki, S. Murphy, and G.F. Gebhart The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat Neuropharmacology 33 11 1994 1471 1478
    • (1994) Neuropharmacology , vol.33 , Issue.11 , pp. 1471-1478
    • Meller, S.T.1    Dykstra, C.2    Grzybycki, D.3    Murphy, S.4    Gebhart, G.F.5
  • 92
    • 33845945382 scopus 로고    scopus 로고
    • Norman Cousins Lecture. Glia as the "bad guys": Implications for improving clinical pain control and the clinical utility of opioids
    • L.R. Watkins, M.R. Hutchinson, and A. Ledeboer Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids Brain Behav Immun 21 2 2007 131 146
    • (2007) Brain Behav Immun , vol.21 , Issue.2 , pp. 131-146
    • Watkins, L.R.1    Hutchinson, M.R.2    Ledeboer, A.3
  • 93
    • 79958004172 scopus 로고    scopus 로고
    • The prospects of minocycline in multiple sclerosis
    • X. Chen, X. Ma, Y. Jiang, R. Pi, Y. Liu, and L. Ma The prospects of minocycline in multiple sclerosis J Neuroimmunol 235 1-2 2011 1 8
    • (2011) J Neuroimmunol , vol.235 , Issue.12 , pp. 1-8
    • Chen, X.1    Ma, X.2    Jiang, Y.3    Pi, R.4    Liu, Y.5    Ma, L.6
  • 95
    • 77957579033 scopus 로고    scopus 로고
    • Propentofylline: Glial modulation, neuroprotection, and alleviation of chronic pain
    • S. Sweitzer, and J. De Leo Propentofylline: glial modulation, neuroprotection, and alleviation of chronic pain Handb Exp Pharmacol 200 2011 235 250
    • (2011) Handb Exp Pharmacol , vol.200 , pp. 235-250
    • Sweitzer, S.1    De Leo, J.2
  • 96
    • 34447529270 scopus 로고    scopus 로고
    • Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes
    • A. Ledeboer, M.R. Hutchinson, L.R. Watkins, and K.W. Johnson Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes Expert Opin Investig Drugs 16 7 2007 935 950
    • (2007) Expert Opin Investig Drugs , vol.16 , Issue.7 , pp. 935-950
    • Ledeboer, A.1    Hutchinson, M.R.2    Watkins, L.R.3    Johnson, K.W.4
  • 97
    • 17044417657 scopus 로고    scopus 로고
    • Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
    • A. Ledeboer, E.M. Sloane, and E.D. Milligan Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation Pain 115 1-2 2005 71 83
    • (2005) Pain , vol.115 , Issue.12 , pp. 71-83
    • Ledeboer, A.1    Sloane, E.M.2    Milligan, E.D.3
  • 98
    • 0037622717 scopus 로고    scopus 로고
    • Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
    • V. Raghavendra, F. Tanga, and J.A. DeLeo Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy J Pharmacol Exp Ther 306 2 2003 624 630
    • (2003) J Pharmacol Exp Ther , vol.306 , Issue.2 , pp. 624-630
    • Raghavendra, V.1    Tanga, F.2    Deleo, J.A.3
  • 99
    • 69549122426 scopus 로고    scopus 로고
    • Spinal microglial expression and mechanical hypersensitivity in a postoperative pain model: Comparison with a neuropathic pain model
    • N. Ito, H. Obata, and S. Saito Spinal microglial expression and mechanical hypersensitivity in a postoperative pain model: comparison with a neuropathic pain model Anesthesiology 111 3 2009 640 648
    • (2009) Anesthesiology , vol.111 , Issue.3 , pp. 640-648
    • Ito, N.1    Obata, H.2    Saito, S.3
  • 100
    • 32844472905 scopus 로고    scopus 로고
    • Systemic administration of minocycline inhibits formalin-induced inflammatory pain in rat
    • I.H. Cho, Y.M. Chung, and C.K. Park Systemic administration of minocycline inhibits formalin-induced inflammatory pain in rat Brain Res 1072 1 2006 208 214
    • (2006) Brain Res , vol.1072 , Issue.1 , pp. 208-214
    • Cho, I.H.1    Chung, Y.M.2    Park, C.K.3
  • 101
    • 35348890230 scopus 로고    scopus 로고
    • Characterization of the antinociceptive and anti-inflammatory activities of doxycycline and minocycline in different experimental models
    • L.F. Bastos, L.A. Merlo, L.T. Rocha, and M.M. Coelho Characterization of the antinociceptive and anti-inflammatory activities of doxycycline and minocycline in different experimental models Eur J Pharmacol 576 1-3 2007 171 179
    • (2007) Eur J Pharmacol , vol.576 , Issue.13 , pp. 171-179
    • Bastos, L.F.1    Merlo, L.A.2    Rocha, L.T.3    Coelho, M.M.4
  • 102
    • 49849087142 scopus 로고    scopus 로고
    • The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats
    • J.P. Cata, H.R. Weng, and P.M. Dougherty The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats Brain Res 1229 2008 100 110
    • (2008) Brain Res , vol.1229 , pp. 100-110
    • Cata, J.P.1    Weng, H.R.2    Dougherty, P.M.3
  • 103
    • 78149281987 scopus 로고    scopus 로고
    • Minocycline attenuates mechanical allodynia and central sensitization following peripheral second-degree burn injury
    • Y.W. Chang, and S.G. Waxman Minocycline attenuates mechanical allodynia and central sensitization following peripheral second-degree burn injury J Pain 11 11 2010 1146 1154
    • (2010) J Pain , vol.11 , Issue.11 , pp. 1146-1154
    • Chang, Y.W.1    Waxman, S.G.2
  • 104
    • 79956200772 scopus 로고    scopus 로고
    • Minocycline attenuates the development of diabetic neuropathic pain: Possible anti-inflammatory and anti-oxidant mechanisms
    • K. Pabreja, K. Dua, S. Sharma, S.S. Padi, and S.K. Kulkarni Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms Eur J Pharmacol 661 1-3 2011 15 21
    • (2011) Eur J Pharmacol , vol.661 , Issue.13 , pp. 15-21
    • Pabreja, K.1    Dua, K.2    Sharma, S.3    Padi, S.S.4    Kulkarni, S.K.5
  • 105
    • 84862784235 scopus 로고    scopus 로고
    • Minocycline markedly reduces acute visceral nociception via inhibiting neuronal ERK phosphorylation
    • I.H. Cho, M.J. Lee, M. Jang, N.G. Gwak, K.Y. Lee, and H.S. Jung Minocycline markedly reduces acute visceral nociception via inhibiting neuronal ERK phosphorylation Mol Pain 8 2012 13
    • (2012) Mol Pain , vol.8 , pp. 13
    • Cho, I.H.1    Lee, M.J.2    Jang, M.3    Gwak, N.G.4    Lee, K.Y.5    Jung, H.S.6
  • 107
    • 33646439133 scopus 로고    scopus 로고
    • Activated microglia contribute to the maintenance of chronic pain after spinal cord injury
    • B.C. Hains, and S.G. Waxman Activated microglia contribute to the maintenance of chronic pain after spinal cord injury J Neurosci 26 16 2006 4308 4317
    • (2006) J Neurosci , vol.26 , Issue.16 , pp. 4308-4317
    • Hains, B.C.1    Waxman, S.G.2
  • 108
    • 28744435045 scopus 로고    scopus 로고
    • Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia
    • X.Y. Hua, C.I. Svensson, T. Matsui, B. Fitzsimmons, T.L. Yaksh, and M. Webb Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia Eur J Neurosci 22 10 2005 2431 2440
    • (2005) Eur J Neurosci , vol.22 , Issue.10 , pp. 2431-2440
    • Hua, X.Y.1    Svensson, C.I.2    Matsui, T.3    Fitzsimmons, B.4    Yaksh, T.L.5    Webb, M.6
  • 109
    • 36249012543 scopus 로고    scopus 로고
    • Minocycline decreases in vitro microglial motility, beta1-integrin, and Kv1.3 channel expression
    • N. Nutile-McMenemy, A. Elfenbein, and J.A. Deleo Minocycline decreases in vitro microglial motility, beta1-integrin, and Kv1.3 channel expression J Neurochem 103 5 2007 2035 2046
    • (2007) J Neurochem , vol.103 , Issue.5 , pp. 2035-2046
    • Nutile-Mcmenemy, N.1    Elfenbein, A.2    Deleo, J.A.3
  • 110
    • 84994571233 scopus 로고    scopus 로고
    • Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain
    • L. Guasti, D. Richardson, and M. Jhaveri Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain Mol Pain 5 2009 35
    • (2009) Mol Pain , vol.5 , pp. 35
    • Guasti, L.1    Richardson, D.2    Jhaveri, M.3
  • 111
    • 84880910366 scopus 로고    scopus 로고
    • Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression
    • G.W. Kay, and D.N. Palmer Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression J Neuroinflammation 10 2013 97
    • (2013) J Neuroinflammation , vol.10 , pp. 97
    • Kay, G.W.1    Palmer, D.N.2
  • 112
    • 34247600646 scopus 로고    scopus 로고
    • Effects of interleukin-1beta on spinal cord nociceptive transmission in intact and propentofylline-treated rats
    • O. Arriagada, L. Constandil, A. Hernandez, R. Barra, R. Soto-Moyano, and C. Laurido Effects of interleukin-1beta on spinal cord nociceptive transmission in intact and propentofylline-treated rats Int J Neurosci 117 5 2007 617 625
    • (2007) Int J Neurosci , vol.117 , Issue.5 , pp. 617-625
    • Arriagada, O.1    Constandil, L.2    Hernandez, A.3    Barra, R.4    Soto-Moyano, R.5    Laurido, C.6
  • 113
    • 49049093990 scopus 로고    scopus 로고
    • Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat
    • Y.S. Gwak, E.D. Crown, G.C. Unabia, and C.E. Hulsebosch Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat Pain 138 2 2008 410 422
    • (2008) Pain , vol.138 , Issue.2 , pp. 410-422
    • Gwak, Y.S.1    Crown, E.D.2    Unabia, G.C.3    Hulsebosch, C.E.4
  • 114
    • 0035857748 scopus 로고    scopus 로고
    • Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain
    • S. Sweitzer, D. Martin, and J.A. DeLeo Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain Neuroscience 103 2 2001 529 539
    • (2001) Neuroscience , vol.103 , Issue.2 , pp. 529-539
    • Sweitzer, S.1    Martin, D.2    Deleo, J.A.3
  • 115
    • 0035018058 scopus 로고    scopus 로고
    • Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain
    • S.M. Sweitzer, P. Schubert, and J.A. DeLeo Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain J Pharmacol Exp Ther 297 3 2001 1210 1217
    • (2001) J Pharmacol Exp Ther , vol.297 , Issue.3 , pp. 1210-1217
    • Sweitzer, S.M.1    Schubert, P.2    Deleo, J.A.3
  • 116
    • 33845961213 scopus 로고    scopus 로고
    • Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury
    • V.L. Tawfik, N. Nutile-McMenemy, M.L. Lacroix-Fralish, and J.A. Deleo Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury Brain Behav Immun 21 2 2007 238 246
    • (2007) Brain Behav Immun , vol.21 , Issue.2 , pp. 238-246
    • Tawfik, V.L.1    Nutile-Mcmenemy, N.2    Lacroix-Fralish, M.L.3    Deleo, J.A.4
  • 117
    • 33646271360 scopus 로고    scopus 로고
    • Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat
    • S.M. Sweitzer, J.L. Pahl, and J.A. DeLeo Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat Neurosci Lett 400 3 2006 258 261
    • (2006) Neurosci Lett , vol.400 , Issue.3 , pp. 258-261
    • Sweitzer, S.M.1    Pahl, J.L.2    Deleo, J.A.3
  • 118
    • 0842286586 scopus 로고    scopus 로고
    • Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats
    • V. Raghavendra, F.Y. Tanga, and J.A. DeLeo Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats Neuropsychopharmacology 29 2 2004 327 334
    • (2004) Neuropsychopharmacology , vol.29 , Issue.2 , pp. 327-334
    • Raghavendra, V.1    Tanga, F.Y.2    Deleo, J.A.3
  • 119
    • 0037567958 scopus 로고    scopus 로고
    • Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: Mechanistic implications of spinal glia and proinflammatory cytokines
    • V. Raghavendra, F. Tanga, M.D. Rutkowski, and J.A. DeLeo Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines Pain 104 3 2003 655 664
    • (2003) Pain , vol.104 , Issue.3 , pp. 655-664
    • Raghavendra, V.1    Tanga, F.2    Rutkowski, M.D.3    Deleo, J.A.4
  • 120
    • 0034613224 scopus 로고    scopus 로고
    • Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: Possible immune modulation in neuropathic pain
    • J.L. Arruda, S. Sweitzer, M.D. Rutkowski, and J.A. DeLeo Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain Brain Res 879 1-2 2000 216 225
    • (2000) Brain Res , vol.879 , Issue.12 , pp. 216-225
    • Arruda, J.L.1    Sweitzer, S.2    Rutkowski, M.D.3    Deleo, J.A.4
  • 121
    • 28344444842 scopus 로고    scopus 로고
    • Activation of p38 and p42/44 MAP kinase in neuropathic pain: Involvement of VPAC2 and NK2 receptors and mediation by spinal glia
    • E.M. Garry, A. Delaney, and G. Blackburn-Munro Activation of p38 and p42/44 MAP kinase in neuropathic pain: involvement of VPAC2 and NK2 receptors and mediation by spinal glia Mol Cell Neurosci 30 4 2005 523 537
    • (2005) Mol Cell Neurosci , vol.30 , Issue.4 , pp. 523-537
    • Garry, E.M.1    Delaney, A.2    Blackburn-Munro, G.3
  • 122
    • 0031800045 scopus 로고    scopus 로고
    • Cyclic AMP-elevating agents prevent oligodendroglial excitotoxicity
    • A. Yoshioka, Y. Shimizu, G. Hirose, H. Kitasato, and D. Pleasure Cyclic AMP-elevating agents prevent oligodendroglial excitotoxicity J Neurochem 70 6 1998 2416 2423
    • (1998) J Neurochem , vol.70 , Issue.6 , pp. 2416-2423
    • Yoshioka, A.1    Shimizu, Y.2    Hirose, G.3    Kitasato, H.4    Pleasure, D.5
  • 123
    • 0033532995 scopus 로고    scopus 로고
    • Ibudilast suppresses TNFalpha production by glial cells functioning mainly as type III phosphodiesterase inhibitor in the CNS
    • A. Suzumura, A. Ito, M. Yoshikawa, and M. Sawada Ibudilast suppresses TNFalpha production by glial cells functioning mainly as type III phosphodiesterase inhibitor in the CNS Brain Res 837 1-2 1999 203 212
    • (1999) Brain Res , vol.837 , Issue.12 , pp. 203-212
    • Suzumura, A.1    Ito, A.2    Yoshikawa, M.3    Sawada, M.4
  • 124
    • 0029990733 scopus 로고    scopus 로고
    • Ibudilast protects against neuronal damage induced by glutamate in cultured hippocampal neurons
    • Y. Tominaga, Y. Nakamura, K. Tsuji, T. Shibata, and K. Kataoka Ibudilast protects against neuronal damage induced by glutamate in cultured hippocampal neurons Clin Exp Pharmacol Physiol 23 6-7 1996 519 523
    • (1996) Clin Exp Pharmacol Physiol , vol.23 , Issue.67 , pp. 519-523
    • Tominaga, Y.1    Nakamura, Y.2    Tsuji, K.3    Shibata, T.4    Kataoka, K.5
  • 125
    • 1242284201 scopus 로고    scopus 로고
    • Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia
    • T. Mizuno, T. Kurotani, and Y. Komatsu Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia Neuropharmacology 46 3 2004 404 411
    • (2004) Neuropharmacology , vol.46 , Issue.3 , pp. 404-411
    • Mizuno, T.1    Kurotani, T.2    Komatsu, Y.3
  • 126
    • 79954523511 scopus 로고    scopus 로고
    • Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells
    • M. Kiebala, and S.B. Maggirwar Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells PLoS ONE 6 4 2011 e18633
    • (2011) PLoS ONE , vol.6 , Issue.4 , pp. e18633
    • Kiebala, M.1    Maggirwar, S.B.2
  • 127
    • 84897954674 scopus 로고    scopus 로고
    • Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain
    • A. Ellis, J. Wieseler, and J. Favret Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain J Pain 15 4 2014 407 421
    • (2014) J Pain , vol.15 , Issue.4 , pp. 407-421
    • Ellis, A.1    Wieseler, J.2    Favret, J.3
  • 128
    • 34447515697 scopus 로고    scopus 로고
    • The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain
    • A. Ledeboer, T. Liu, and J.A. Shumilla The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain Neuron Glia Biol 2 4 2006 279 291
    • (2006) Neuron Glia Biol , vol.2 , Issue.4 , pp. 279-291
    • Ledeboer, A.1    Liu, T.2    Shumilla, J.A.3
  • 129
    • 84896402659 scopus 로고    scopus 로고
    • CSF levels of YKL-40 are increased in MS and replaces with immunosuppressive treatment
    • C. Malmestrom, M. Axelsson, J. Lycke, H. Zetterberg, K. Blennow, and B. Olsson CSF levels of YKL-40 are increased in MS and replaces with immunosuppressive treatment J Neuroimmunol 269 1-2 2014 87 89
    • (2014) J Neuroimmunol , vol.269 , Issue.12 , pp. 87-89
    • Malmestrom, C.1    Axelsson, M.2    Lycke, J.3    Zetterberg, H.4    Blennow, K.5    Olsson, B.6
  • 130
    • 84874623590 scopus 로고    scopus 로고
    • Effects of natalizumab treatment on the cerebrospinal fluid proteome of multiple sclerosis patients
    • M.P. Stoop, V. Singh, and C. Stingl Effects of natalizumab treatment on the cerebrospinal fluid proteome of multiple sclerosis patients J Proteome Res 12 3 2013 1101 1107
    • (2013) J Proteome Res , vol.12 , Issue.3 , pp. 1101-1107
    • Stoop, M.P.1    Singh, V.2    Stingl, C.3
  • 131
    • 84912071947 scopus 로고    scopus 로고
    • Traumatic white matter injury and glial activation: From basic science to clinics
    • Z. Kou, and P.J. Vandevord Traumatic white matter injury and glial activation: from basic science to clinics Glia 62 11 2014 1831 1855
    • (2014) Glia , vol.62 , Issue.11 , pp. 1831-1855
    • Kou, Z.1    Vandevord, P.J.2
  • 132
    • 84861531178 scopus 로고    scopus 로고
    • Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention
    • L. Papa, L.M. Lewis, and J.L. Falk Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention Ann Emerg Med 59 6 2012 471 483
    • (2012) Ann Emerg Med , vol.59 , Issue.6 , pp. 471-483
    • Papa, L.1    Lewis, L.M.2    Falk, J.L.3
  • 133
    • 63449104335 scopus 로고    scopus 로고
    • Profiling of dynamically changed gene expression in dorsal root ganglia post peripheral nerve injury and a critical role of injury-induced glial fibrillary acidic protein in maintenance of pain behaviors [corrected]
    • D.S. Kim, K.W. Figueroa, K.W. Li, A. Boroujerdi, T. Yolo, and Z.D. Luo Profiling of dynamically changed gene expression in dorsal root ganglia post peripheral nerve injury and a critical role of injury-induced glial fibrillary acidic protein in maintenance of pain behaviors [corrected] Pain 143 1-2 2009 114 122
    • (2009) Pain , vol.143 , Issue.12 , pp. 114-122
    • Kim, D.S.1    Figueroa, K.W.2    Li, K.W.3    Boroujerdi, A.4    Yolo, T.5    Luo, Z.D.6
  • 134
    • 0036850086 scopus 로고    scopus 로고
    • Visualising microglial activation in vivo
    • R.B. Banati Visualising microglial activation in vivo Glia 40 2 2002 206 217
    • (2002) Glia , vol.40 , Issue.2 , pp. 206-217
    • Banati, R.B.1
  • 135
    • 0036556421 scopus 로고    scopus 로고
    • Brain plasticity and microglia: Is transsynaptic glial activation in the thalamus after limb denervation linked to cortical plasticity and central sensitisation?
    • R.B. Banati Brain plasticity and microglia: is transsynaptic glial activation in the thalamus after limb denervation linked to cortical plasticity and central sensitisation? J Physiol Paris 96 3-4 2002 289 299
    • (2002) J Physiol Paris , vol.96 , Issue.34 , pp. 289-299
    • Banati, R.B.1
  • 136
    • 0035900348 scopus 로고    scopus 로고
    • Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury
    • R.B. Banati, A. Cagnin, and D.J. Brooks Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury Neuroreport 12 16 2001 3439 3442
    • (2001) Neuroreport , vol.12 , Issue.16 , pp. 3439-3442
    • Banati, R.B.1    Cagnin, A.2    Brooks, D.J.3
  • 137
    • 84894552855 scopus 로고    scopus 로고
    • Microglia activation in multiple sclerosis black holes predicts outcome in progressive patients: An in vivo [(11)C](R)-PK11195-PET pilot study
    • P. Giannetti, M. Politis, and P. Su Microglia activation in multiple sclerosis black holes predicts outcome in progressive patients: an in vivo [(11)C](R)-PK11195-PET pilot study Neurobiol Dis 65 2014 203 210
    • (2014) Neurobiol Dis , vol.65 , pp. 203-210
    • Giannetti, P.1    Politis, M.2    Su, P.3
  • 138
    • 84903166821 scopus 로고    scopus 로고
    • Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: An 11C-(R)-PK11195 PET study
    • Y. Nakatomi, K. Mizuno, and A. Ishii Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an 11C-(R)-PK11195 PET study J Nucl Med 55 6 2014 945 950
    • (2014) J Nucl Med , vol.55 , Issue.6 , pp. 945-950
    • Nakatomi, Y.1    Mizuno, K.2    Ishii, A.3
  • 139
    • 84875912433 scopus 로고    scopus 로고
    • Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - A PET study in control subjects
    • A. Jucaite, Z. Cselenyi, and A. Arvidsson Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects EJNMMI Res 2 2012 15
    • (2012) EJNMMI Res , vol.2 , pp. 15
    • Jucaite, A.1    Cselenyi, Z.2    Arvidsson, A.3
  • 140
    • 84856769108 scopus 로고    scopus 로고
    • Evidence of central inflammation in fibromyalgia-increased cerebrospinal fluid interleukin-8 levels
    • D. Kadetoff, J. Lampa, M. Westman, M. Andersson, and E. Kosek Evidence of central inflammation in fibromyalgia-increased cerebrospinal fluid interleukin-8 levels J Neuroimmunol 242 1-2 2012 33 38
    • (2012) J Neuroimmunol , vol.242 , Issue.12 , pp. 33-38
    • Kadetoff, D.1    Lampa, J.2    Westman, M.3    Andersson, M.4    Kosek, E.5
  • 141
    • 77649182701 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor is increased in cerebrospinal fluid but decreased in blood during long-term pain
    • C. Lundborg, M. Hahn-Zoric, B. Biber, and E. Hansson Glial cell line-derived neurotrophic factor is increased in cerebrospinal fluid but decreased in blood during long-term pain J Neuroimmunol 220 1-2 2010 108 113
    • (2010) J Neuroimmunol , vol.220 , Issue.12 , pp. 108-113
    • Lundborg, C.1    Hahn-Zoric, M.2    Biber, B.3    Hansson, E.4
  • 142
    • 10744225509 scopus 로고    scopus 로고
    • Cerebrospinal fluid interleukin 8 concentrations and the subsequent development of postherpetic neuralgia
    • N. Kotani, R. Kudo, and Y. Sakurai Cerebrospinal fluid interleukin 8 concentrations and the subsequent development of postherpetic neuralgia Am J Med 116 5 2004 318 324
    • (2004) Am J Med , vol.116 , Issue.5 , pp. 318-324
    • Kotani, N.1    Kudo, R.2    Sakurai, Y.3
  • 143
    • 0032798282 scopus 로고    scopus 로고
    • Comparative therapeutic evaluation of intrathecal versus epidural methylprednisolone for long-term analgesia in patients with intractable postherpetic neuralgia
    • A. Kikuchi, N. Kotani, T. Sato, K. Takamura, I. Sakai, and A. Matsuki Comparative therapeutic evaluation of intrathecal versus epidural methylprednisolone for long-term analgesia in patients with intractable postherpetic neuralgia Reg Anesth Pain Med 24 4 1999 287 293
    • (1999) Reg Anesth Pain Med , vol.24 , Issue.4 , pp. 287-293
    • Kikuchi, A.1    Kotani, N.2    Sato, T.3    Takamura, K.4    Sakai, I.5    Matsuki, A.6
  • 144
    • 38849152403 scopus 로고    scopus 로고
    • CD40-CD40 ligand interactions in human microglia induce CXCL8 (interleukin-8) secretion by a mechanism dependent on activation of ERK1/2 and nuclear translocation of nuclear factor-kappaB (NFkappaB) and activator protein-1 (AP-1)
    • T.G. D'Aversa, E.A. Eugenin, and J.W. Berman CD40-CD40 ligand interactions in human microglia induce CXCL8 (interleukin-8) secretion by a mechanism dependent on activation of ERK1/2 and nuclear translocation of nuclear factor-kappaB (NFkappaB) and activator protein-1 (AP-1) J Neurosci Res 86 3 2008 630 639
    • (2008) J Neurosci Res , vol.86 , Issue.3 , pp. 630-639
    • D'Aversa, T.G.1    Eugenin, E.A.2    Berman, J.W.3
  • 145
    • 84864857081 scopus 로고    scopus 로고
    • Chronic-pain-associated astrocytic reaction in the spinal cord dorsal horn of human immunodeficiency virus-infected patients
    • Y. Shi, B.B. Gelman, J.G. Lisinicchia, and S.J. Tang Chronic-pain-associated astrocytic reaction in the spinal cord dorsal horn of human immunodeficiency virus-infected patients J Neurosci 32 32 2012 10833 10840
    • (2012) J Neurosci , vol.32 , Issue.32 , pp. 10833-10840
    • Shi, Y.1    Gelman, B.B.2    Lisinicchia, J.G.3    Tang, S.J.4
  • 146
  • 147
    • 84903708844 scopus 로고    scopus 로고
    • Gp120 in the pathogenesis of human immunodeficiency virus-associated pain
    • S.B. Yuan, Y. Shi, and J. Chen Gp120 in the pathogenesis of human immunodeficiency virus-associated pain Ann Neurol 75 6 2014 837 850
    • (2014) Ann Neurol , vol.75 , Issue.6 , pp. 837-850
    • Yuan, S.B.1    Shi, Y.2    Chen, J.3
  • 148
    • 34249658983 scopus 로고    scopus 로고
    • Changes in immune and glial markers in the CSF of patients with Complex Regional Pain Syndrome
    • G.M. Alexander, M.J. Perreault, E.R. Reichenberger, and R.J. Schwartzman Changes in immune and glial markers in the CSF of patients with Complex Regional Pain Syndrome Brain Behav Immun 21 5 2007 668 676
    • (2007) Brain Behav Immun , vol.21 , Issue.5 , pp. 668-676
    • Alexander, G.M.1    Perreault, M.J.2    Reichenberger, E.R.3    Schwartzman, R.J.4
  • 150
    • 56949106793 scopus 로고    scopus 로고
    • Spinal cord histopathological alterations in a patient with longstanding complex regional pain syndrome
    • L. Del Valle, R.J. Schwartzman, and G. Alexander Spinal cord histopathological alterations in a patient with longstanding complex regional pain syndrome Brain Behav Immun 23 1 2009 85 91
    • (2009) Brain Behav Immun , vol.23 , Issue.1 , pp. 85-91
    • Del Valle, L.1    Schwartzman, R.J.2    Alexander, G.3
  • 151
    • 41949109975 scopus 로고    scopus 로고
    • Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients
    • M.M. Backonja, C.L. Coe, D.A. Muller, and K. Schell Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients J Neuroimmunol 195 1-2 2008 157 163
    • (2008) J Neuroimmunol , vol.195 , Issue.12 , pp. 157-163
    • Backonja, M.M.1    Coe, C.L.2    Muller, D.A.3    Schell, K.4
  • 152
    • 84864524213 scopus 로고    scopus 로고
    • Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice
    • J. Lampa, M. Westman, and D. Kadetoff Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice Proc Natl Acad Sci U S A 109 31 2012 12728 12733
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.31 , pp. 12728-12733
    • Lampa, J.1    Westman, M.2    Kadetoff, D.3
  • 153
    • 84884689173 scopus 로고    scopus 로고
    • Cerebrospinal fluid of postherpetic neuralgia patients induced interleukin-6 release in human glial cell-line T98G
    • A.S. Tay, E.H. Liu, and T.L. Lee Cerebrospinal fluid of postherpetic neuralgia patients induced interleukin-6 release in human glial cell-line T98G Neurochem Int 63 5 2013 517 521
    • (2013) Neurochem Int , vol.63 , Issue.5 , pp. 517-521
    • Tay, A.S.1    Liu, E.H.2    Lee, T.L.3
  • 154
    • 63849175251 scopus 로고    scopus 로고
    • Uniquely hominid features of adult human astrocytes
    • N.A. Oberheim, T. Takano, and X. Han Uniquely hominid features of adult human astrocytes J Neurosci 29 10 2009 3276 3287
    • (2009) J Neurosci , vol.29 , Issue.10 , pp. 3276-3287
    • Oberheim, N.A.1    Takano, T.2    Han, X.3
  • 155
  • 156
    • 84892603003 scopus 로고    scopus 로고
    • Morphometric characterization of microglial phenotypes in human cerebral cortex
    • S.G. Torres-Platas, S. Comeau, and A. Rachalski Morphometric characterization of microglial phenotypes in human cerebral cortex J Neuroinflammation 11 2014 12
    • (2014) J Neuroinflammation , vol.11 , pp. 12
    • Torres-Platas, S.G.1    Comeau, S.2    Rachalski, A.3
  • 157
    • 84858157952 scopus 로고    scopus 로고
    • Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages
    • R.P. Landry, V.L. Jacobs, E.A. Romero-Sandoval, and J.A. DeLeo Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages Exp Neurol 234 2 2012 340 350
    • (2012) Exp Neurol , vol.234 , Issue.2 , pp. 340-350
    • Landry, R.P.1    Jacobs, V.L.2    Romero-Sandoval, E.A.3    Deleo, J.A.4
  • 158
    • 75749146196 scopus 로고    scopus 로고
    • Minocycline 1-year therapy in multiple-system-atrophy: Effect on clinical symptoms and [(11)C] (R)-PK11195 PET (MEMSA-trial)
    • R. Dodel, A. Spottke, and A. Gerhard Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms and [(11)C] (R)-PK11195 PET (MEMSA-trial) Mov Disord 25 1 2010 97 107
    • (2010) Mov Disord , vol.25 , Issue.1 , pp. 97-107
    • Dodel, R.1    Spottke, A.2    Gerhard, A.3
  • 159
    • 77956416346 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy reveals neuroprotection by oral minocycline in a nonhuman primate model of accelerated NeuroAIDS
    • E.M. Ratai, J.P. Bombardier, and C.G. Joo Proton magnetic resonance spectroscopy reveals neuroprotection by oral minocycline in a nonhuman primate model of accelerated NeuroAIDS PLoS ONE 5 5 2010 e10523
    • (2010) PLoS ONE , vol.5 , Issue.5 , pp. e10523
    • Ratai, E.M.1    Bombardier, J.P.2    Joo, C.G.3
  • 160
    • 84879782710 scopus 로고    scopus 로고
    • The efficacy of a glial inhibitor, minocycline, for preventing persistent pain after lumbar discectomy: A randomized, double-blind, controlled study
    • V. Martinez, B. Szekely, and J. Lemarie The efficacy of a glial inhibitor, minocycline, for preventing persistent pain after lumbar discectomy: a randomized, double-blind, controlled study Pain 154 8 2013 1197 1203
    • (2013) Pain , vol.154 , Issue.8 , pp. 1197-1203
    • Martinez, V.1    Szekely, B.2    Lemarie, J.3
  • 161
    • 84878020881 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia
    • J. Kalliomaki, N. Attal, and B. Jonzon A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia Pain 154 5 2013 761 767
    • (2013) Pain , vol.154 , Issue.5 , pp. 761-767
    • Kalliomaki, J.1    Attal, N.2    Jonzon, B.3
  • 162
    • 36148960127 scopus 로고    scopus 로고
    • Efficacy of minocycline in patients with amyotrophic lateral sclerosis: A phase III randomised trial
    • P.H. Gordon, D.H. Moore, and R.G. Miller Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial Lancet Neurol 6 12 2007 1045 1053
    • (2007) Lancet Neurol , vol.6 , Issue.12 , pp. 1045-1053
    • Gordon, P.H.1    Moore, D.H.2    Miller, R.G.3
  • 163
    • 81855163349 scopus 로고    scopus 로고
    • Changes in expression of mRNA for interleukin-8 and effects of interleukin-8 receptor inhibitor in the spinal dorsal horn in a rat model of lumbar disc herniation
    • S.J. Kim, S.M. Park, and Y.W. Cho Changes in expression of mRNA for interleukin-8 and effects of interleukin-8 receptor inhibitor in the spinal dorsal horn in a rat model of lumbar disc herniation Spine 36 25 2011 2139 2146
    • (2011) Spine , vol.36 , Issue.25 , pp. 2139-2146
    • Kim, S.J.1    Park, S.M.2    Cho, Y.W.3
  • 164
    • 1542317072 scopus 로고    scopus 로고
    • Reactive astrocytes protect tissue and preserve function after spinal cord injury
    • J.R. Faulkner, J.E. Herrmann, M.J. Woo, K.E. Tansey, N.B. Doan, and M.V. Sofroniew Reactive astrocytes protect tissue and preserve function after spinal cord injury J Neurosci 24 9 2004 2143 2155
    • (2004) J Neurosci , vol.24 , Issue.9 , pp. 2143-2155
    • Faulkner, J.R.1    Herrmann, J.E.2    Woo, M.J.3    Tansey, K.E.4    Doan, N.B.5    Sofroniew, M.V.6
  • 165
    • 84894582125 scopus 로고    scopus 로고
    • Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury
    • D.P. Stirling, K. Cummins, M. Mishra, W. Teo, V.W. Yong, and P. Stys Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury Brain J Neurol 137 pt 3 2014 707 723
    • (2014) Brain J Neurol , vol.137 , Issue.PART 3 , pp. 707-723
    • Stirling, D.P.1    Cummins, K.2    Mishra, M.3    Teo, W.4    Yong, V.W.5    Stys, P.6
  • 166
    • 41149137558 scopus 로고    scopus 로고
    • Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury
    • A. Romero-Sandoval, N. Nutile-McMenemy, and J.A. DeLeo Spinal microglial and perivascular cell cannabinoid receptor type 2 activation reduces behavioral hypersensitivity without tolerance after peripheral nerve injury Anesthesiology 108 4 2008 722 734
    • (2008) Anesthesiology , vol.108 , Issue.4 , pp. 722-734
    • Romero-Sandoval, A.1    Nutile-Mcmenemy, N.2    Deleo, J.A.3
  • 167
    • 84862179426 scopus 로고    scopus 로고
    • Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain
    • C. Ndong, R.P. Landry, J.A. DeLeo, and E.A. Romero-Sandoval Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain Mol Pain 8 2012 34
    • (2012) Mol Pain , vol.8 , pp. 34
    • Ndong, C.1    Landry, R.P.2    Deleo, J.A.3    Romero-Sandoval, E.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.