Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: Mechanistic implications of spinal glia and proinflammatory cytokines

Pain

Volumn 104, Issue 3, 2003, Pages 655-664

  Raghavendra, Vasudeva ^a   Tanga, Flobert ^a   Rutkowski, Maria D ^a   DeLeo, Joyce A ^a  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

Author keywords

Peripheral nerve injury; Proinflammatory cytokine; Propentofylline; Rat; Spinal glia

Indexed keywords

CYTOKINE; MORPHINE; PROPENTOFYLLINE; ANALGESIC AGENT; MESSENGER RNA; XANTHINE DERIVATIVE;

ALLODYNIA; ANALGESIC ACTIVITY; ANESTHESIA MECHANISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHRONICITY; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFICACY; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPERALGESIA; IMMUNOCYTOCHEMISTRY; MALE; MEDICAL ASSESSMENT; MONONEUROPATHY; NERVE TRANSECTION; NEUROIMMUNOLOGY; NEUROPATHIC PAIN; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL GANGLION; ANIMAL; BIOSYNTHESIS; DOSE RESPONSE; DRUG EFFECT; GENETICS; GLIA; INJURY; METABOLISM; PAIN THRESHOLD; PHYSIOLOGY; SPINAL NERVE; SPRAGUE DAWLEY RAT;

ANALGESICS; ANIMALS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERALGESIA; MALE; MORPHINE; NEUROGLIA; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SPINAL NERVES; XANTHINES;

EID: 0037567958     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(03)00138-6     Document Type: Article

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