Ibudilast protects against neuronal damage induced by glutamate in cultured hippocampal neurons

Clinical and Experimental Pharmacology and Physiology

Volumn 23, Issue 6-7, 1996, Pages 519-523

  Tominaga, Yasuhiro ^a   Nakamura, Yoichi ^a   Tsuji, Koji ^a   Shibata, Taiho ^a   Kataoka, Kiyoshi ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Ca2+ influx; cAMP; glutamate neurotoxicity; hippocampal neuron; lactate dehydrogenase release; neuronal death

Indexed keywords

CYCLIC AMP; GLUTAMIC ACID; IBUDILAST; LACTATE DEHYDROGENASE;

ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; DRUG EFFECT; EMBRYO; HIPPOCAMPUS; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; RAT;

EID: 0029990733     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1996.tb02772.x     Document Type: Article

References (26)

1. Olney JW. Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate. Science 1969; 164: 719-21.
2. Olney JW, Ho OL, Rhee V. Cytotoxic effects of acidic and sulfur-containing amino acids on the infant mouse central nervous system. Exp. Brain Res. 1971; 14: 61-76.
3. Rothman SM, Olney JW. Excitoxicity and NMDA receptor. Trends Neurosci. 1987; 10: 299-302.
4. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1988; 1: 623-34.
5. Benveniste H, Drejer J, Schousboe A, Diemer NH. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 1984; 43: 1369-74.
6. Mitani A, Kubo H, Iga K, Imon H, Kadoya F, Kataoka K. A new enzymatic cycling technique for glutamate determination in brain microdialysates. J. Neurochem. 1990; 54: 709-11.
7. Choi DW, Rothman SM. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu. Rev. Neurosci. 1990; 13: 171-82.
8. Choi DW, Maulucci-Gedde M, Kriegstein AR. Glutamate neurotoxicity in cortical cell culture. J. Neurosci. 1987; 7: 357-68.
9. Frandsen A, Schousboe A. Time and concentration dependency of the toxicity of excitatory amino acids on the cerebral neurons in primary culture. Neurochem. Int. 1987; 10: 583-91.
10. Rothman SM, Thurston JH, Hauhart RE. Delayed neurotoxicity of excitatory amino acids in vitro. Neuroscience 1987; 22: 471-80.
11. Finkbeiner S, Stevens CF. Applications of quantitative measurements for assessing glutamate neurotoxicity. Proc. Natl Acad. Sci. USA 1988; 85: 4071-4.
12. Regan RF, Choi DW. Glutamate neurotoxicity in spinal cord cell culture. Neuroscience 1991; 43: 585-91.
13. Ohashi M, Kito J, Nishino K. Mode of cerebral vasodilating action of KC-404 in isolated canine basilar artery. Arch. Int. Pharmacodyn. Ther. 1986; 280: 216-29.
14. Ohashi M, Yoshida K, Ichikawa Y, Nishino K. Anti-thrombotic effect of KC-404, a novel cerebral vasodilator. Gen. Pharmacol. 1986; 17: 385-9.
15. Ohashi M, Kanai R, Nishino K, Sato T. Antagonistic effect of KC-404, a new antiasthmatic agent, on leukotriene D4-induced contractile responses in isolated guinea pig smooth muscles. Prostaglandins 1986; 32: 875-88.
16. Etoh S, Ohashi M, Baba A, Iwata H. Inhibition by ibudilast of leukotriene D4-induced formation of inositol phosphates in guinea-pig lung. Br. J. Pharmacol. 1990; 100: 564-8.
17. Niwa M, Kohno K, Al-Essa LY, Kobayashi M, Nozaki M, Tsuromi K. Ibudilast, an anti-allergic and cerebral vasodilator, modulates Superoxide production in human neutrophils. Life Sci. 1995; 56: 107-15.
18. Hisayama T, Takayanagi I, Goromaru N, Okamoto Y. Potentiating effect of 3-isobutyryl-2-isopropylpyrazolo-[1,5a]-pyridine (KC-404), a new cerebral vasodilator with anti-platelet activity, on prostacyclin-induced increase of cyclic AMP content in platelets. Gen. Pharmacol. 1989; 20: 183-6.
19. Amano T, Ujihara H, Matsubayashi H et al. Dopamine-induced protection of striatal neurons against kainate receptor-mediated glutamate cytotoxicity in vitro. Brain Res. 1994; 655: 61-9.
20. Ogata T, Nakamura Y, Shibata T, Kataoka K. Release of excitatory amino acids from cultured hippocampal astrocytes induced by a hypoxic-hypoglycemia stimulation. J. Neurochem. 1992; 58: 1957-9.
21. Ogata T, Nakamura Y, Tsuji K, Shibata T, Kataoka K. Steroid hormones protect spinal cord neurons from glutamate toxicity. Neuroscience 1993; 55: 445-9.
22. Hatanaka H, Tsukui H, Nihonmatsu I. Developmental change in the nerve growth factor action from induction of choline acetyl-transferase to promotion of cell survival in cultured basal forebrain cholinergic neurons from postnatal rats. Dev. Brain Res. 1988; 39: 85-95.
23. Koh JY, Choi DW. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J. Neurosci. Meth. 1987; 20: 83-90.
24. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976; 72: 248-54.
25. Tsuji K, Nakamura Y, Ogata T, Shibata T, Kataoka K. Transient increase of cyclic AMP induced by glutamate in cultured neurons from rat spinal cord. J. Neurochem. 1995; 65: 1816-21.
26. Yanase H, Mitani A, Kataoka K. Ibudilast reduces intracellular calcium elevation induced by in vitro ischemia in gerbil hippocampal slices. Clin. Exp. Pharmacol. Physiol. 1996; 23 (in press).