Changes in expression of mRNA for interleukin-8 and effects of interleukin-8 receptor inhibitor in the spinal dorsal horn in a rat model of lumbar disc herniation

Spine

Volumn 36, Issue 25, 2011, Pages 2139-2146

  Kim, Su Jeong ^a   Park, Sung Min ^b   Cho, Yun Woo ^c   Jung, Yong Jae ^c   Lee, Dong Gyu ^c   Jang, Sung Ho ^c   Park, Hea Woon ^d   Hwang, Se Jin ^e   Ahn, Sang Ho ^c  

^a Yeungnam University   (South Korea)

^b Namsan Hospital   (South Korea)

^c Yeungnam University College of Medicine   (South Korea)

^d Catholic University of Daegu   (South Korea)

^e Hanyang University   (South Korea)

Author keywords

CXCL8 inhibitor; disc herniation; ERK; IL 8; microglia; radicular pain

Indexed keywords

INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; REPARIXIN;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CELL ACTIVATION; COCCYGEAL BONE; CONTROLLED STUDY; GENE EXPRESSION; HYPERALGESIA; LUMBAR DISK HERNIA; MALE; MICROGLIA; NERVE ROOT; NONHUMAN; NUCLEUS PULPOSUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD DORSAL HORN; SPINAL GANGLION;

ANIMALS; CHEMOKINE CXCL1; DISEASE MODELS, ANIMAL; GANGLIA, SPINAL; GENE EXPRESSION; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-8; INTERVERTEBRAL DISC DISPLACEMENT; LUMBAR VERTEBRAE; MALE; PAIN; PAIN MEASUREMENT; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, INTERLEUKIN-8A; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD; SULFONAMIDES; TIME FACTORS;

EID: 81855163349     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e31821945a3     Document Type: Article

References (68)

1. Goupille P, Jayson MI, Valat JP, et al. The role of inflammation in disk herniation-associated radiculopathy. Semin Arthritis Rheum 1998; 28 : 60-71.
2. Goupille P, Mulleman D, Valat JP. Radiculopathy associated with disc herniation. Ann Rheum Dis 2006; 65 : 141-3.
3. Olmarker K, Rydevik B, Nordborg C. Autologous nucleus pulposus induces neurophysiologic and histologic changes in porcine cauda equina nerve roots. Spine (Phila Pa 1976) 1993; 18 : 1425-32.
4. Ahn SH, Cho YW, Ahn MW, et al. mRNA expression of cytokines and chemokines in herniated lumbar intervertebral discs. Spine (Phila Pa 1976) 2002; 27 : 911-17.
5. Brisby H, Olmarker K, Larsson K, et al. Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica. Eur Spine J 2002; 11 : 62-6.
6. Kawakami M, Tamaki T, Hayashi N, et al. Possible mechanism of painful radiculopathy in lumbar disc herniation. Clin Orthop Relat Res 1998 : 241-51.
7. Kawakami M, Tamaki T, Weinstein JN, et al. Pathomechanism of pain-related behavior produced by allografts of intervertebral disc in the rat. Spine (Phila Pa 1976) 1996; 21 : 2101-7.
8. Omarker K, Myers RR. Pathogenesis of sciatic pain: Role of herniated nucleus pulposus and deformation of spinal nerve root and dorsal root ganglion. Pain 1998; 78 : 99-105.
9. Igarashi T, Kikuchi S, Shubayev V, et al. 2000 Volvo Award winner in basic science studies: Exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats. Spine (Phila Pa 1976) 2000; 25 : 2975-80.
10. Kallakuri S, Takebayashi T, Ozaktay AC, et al. The effects of epiduralapplication of allografted nucleus pulposus in rats on cytokine expression, limb withdrawaland nerve root discharge. Eur Spine J 2005; 14 : 956-64.
11. Sweitzer S, Martin D, DeLeo JA. Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain. Neuroscience 2001; 103 : 529-39.
12. Takahashi H, Suguro T, Okazima Y, et al. Inflammatory cytokines in the herniated disc of the lumbar spine. Spine (Phila Pa 1976) 1996; 21 : 218-24.
13. Burke JG, Watson RW, McCormack D, et al. Spontaneous production of monocyte chemoattractant protein-1 and interleukin-8 by the human lumbar intervertebral disc. Spine (Phila Pa 1976) 2002; 27 : 1402-7.
14. Cuellar JM, Montesano PX, Carstens E. Role of TNF-alpha in sensitization of nociceptive dorsal horn neurons induced by application of nucleus pulposus to L5 dorsal root ganglion in rats. Pain 2004; 110 : 578-87.
15. Olmarker K, Nutu M, Storkson R. Changes in spontaneous behavior in rats exposed to experimental disc herniation are blocked by selective TNF-alpha inhibition. Spine (Phila Pa 1976) 2003; 28 : 1635-41; discussion 42.
16. Olmarker K, Rydevik B. Selective inhibition of tumor necrosis factor-alpha prevents nucleus pulposus-induced thrombus formation, intraneural edema, and reduction of nerve conduction velocity: Possible implications for future pharmacologic treatment strategies of sciatica. Spine (Phila Pa 1976) 2001; 26 : 863-9.
17. Ohtori S, Takahashi K, Aoki Y, et al. Spinal neural cyclooxygenase-2 mediates pain caused in a rat model of lumbar disk herniation. J Pain 2004; 5 : 385-91.
18. Adams DH, Lloyd AR. Chemokines: Leucocyte recruitment and activation cytokines. Lancet 1997; 349 : 490-5.
19. Luster AD. Chemokines-chemotactic cytokines that mediate inflammation. N Engl J Med 1998; 338 : 436-45.
20. Rollins BJ. Chemokines. Blood 1997; 90 : 909-28.
21. Abbadie C. Chemokines, chemokine receptors and pain. Trends Immunol 2005; 26 : 529-34.
22. Zlotnik A, Yoshie O. Chemokines: A new classification system and their role in immunity. Immunity 2000; 12 : 121-7.
23. Baggiolini M. Chemokines and leukocyte traffic. Nature 1998; 392 : 565-8.
24. Verge GM, Milligan ED, Maier SF, et al. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basaland neuropathic pain conditions. Eur J Neurosci 2004; 20 : 1150-60.
25. Lund BT, Ashikian N, Ta HQ, et al. Increased CXCL8 (IL-8) expression in multiple sclerosis. J Neuroimmunol 2004; 155 : 161-71.
26. Penna G, Mondaini N, Amuchastegui S, et al. Seminal plasma cytokines and chemokines in prostate inflammation: Interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia. Eur Urol 2007; 51 : 524-33; discussion 33.
27. Tanaka T, Minami M, Nakagawa T, et al. Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: Possible involvement in the development of neuropathic pain. Neurosci Res 2004; 48 : 463-9.
28. Milligan ED, Zapata V, Chacur M, et al. Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats. Eur J Neurosci 2004; 20 : 2294-302.
29. Ulrich JA, Liebenberg EC, Thuillier DU, et al. ISSLS prize winner: Repeated disc injury causes persistent inflammation. Spine (Phila Pa 1976) 2007; 32 : 2812-19.
30. Ito T, Ohtori S, Inoue G, et al. Glial phosphorylated p38 MAP kinase mediates pain in a rat model of lumbar disc herniation and induces motor dysfunction in a rat model of lumbar spinal canal stenosis. Spine (Phila Pa 1976) 2007; 32 : 159-67.
31. Hargreaves K, Dubner R, Brown F, et al. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988; 32 : 77-88.
32. Dirig DM, Salami A, Rathbun ML, et al. Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli. J Neurosci Methods 1997; 76 : 183-91.
33. Chaplan SR, Bach FW, Pogrel JW, et al. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994; 53 : 55-63.
34. Milligan ED, Hinde JL, Mehmert KK, et al. A method for increasing the viability of the external portion of lumbar catheters placed in the spinal subarachnoid space of rats. J Neurosci Methods 1999; 90 : 81-6.
35. Hylden JL, Wilcox GL. Intrathecal morphine in mice: A new technique. Eur J Pharmacol 1980; 67 : 313-16.
36. Hou SX, Tang JG, Chen HS, et al. Chronic inflammation and compression of the dorsal root contribute to sciatica induced by the intervertebral disc herniation in rats. Pain 2003; 105 : 255-64.
37. Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992; 50 : 355-63.
38. Seltzer Z, Dubner R, Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain 1990; 43 : 205-18.
39. Zhang JM, Li H, Brull SJ. Perfusion of the mechanically compressed lumbar ganglion with lidocaine reduces mechanical hyperalgesia and allodynia in the rat. J Neurophysiol 2000; 84 : 798-805.
40. Koltzenburg M, Wall PD, McMahon SB. Does the right side know what the left is doing? Trends Neurosci 1999; 22 : 122-7.
41. Colburn RW, Rickman AJ, DeLeo JA. The effect of site and type of nerve injury on spinal glialactivation and neuropathic pain behavior. Exp Neurol 1999; 157 : 289-304.
42. Hashizume H, DeLeo JA, Colburn RW, et al. Spinal glialactivation and cytokine expression after lumbar root injury in the rat. Spine (Phila Pa 1976) 2000; 25 : 1206-17.
43. Ledeboer A, Sloane EM, Milligan ED, et al. Minocycline attenuates mechanicalallodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain 2005; 115 : 71-83.
44. McMahon SB, Cafferty WB, Marchand F. Immune and glial cell factors as pain mediators and modulators. Exp Neurol 2005; 192 : 444-62.
45. Twining CM, Sloane EM, Schoeniger DK, et al. Activation of the spinal cord complement cascade might contribute to mechanicalallodynia induced by three animal models of spinal sensitization. J Pain 2005; 6 : 174-83.
46. Watkins LR, Milligan ED, Maier SF. Spinal cord glia: New players in pain. Pain 2001; 93 : 201-5.
47. Marchand F, Perretti M, McMahon SB. Role of the immune system in chronic pain. Nat Rev Neurosci 2005; 6 : 521-32.
48. Tsuda M, Inoue K, Salter MW. Neuropathic pain and spinal microglia: A big problem from molecules in "small" glia. Trends Neurosci 2005; 28 : 101-7.
49. Watkins LR, Maier SF. Beyond neurons: Evidence that immune and glial cells contribute to pathological pain states. Physiol Rev 2002; 82 : 981-1011.
50. Watkins LR, Maier SF. Glia: A novel drug discovery target for clinical pain. Nat Rev Drug Discov 2003; 2 : 973-85.
51. Kawaguchi S, Yamashita T, Katahira G, et al. Chemokine profile of herniated intervertebral discs infiltrated with monocytes and macrophages. Spine (Phila Pa 1976) 2002; 27 : 1511-16.
52. Obata K, Tsujino H, Yamanaka H, et al. Expression of neurotrophic factors in the dorsal root ganglion in a rat model of lumbar disc herniation. Pain 2002; 99 : 121-32.
53. Onda A, Murata Y, Rydevik B, et al. Nerve growth factor content in dorsal root ganglion as related to changes in pain behavior in a rat model of experimental lumbar disc herniation. Spine (Phila Pa 1976) 2005; 30 : 188-93.
54. O'Hayre M, Salanga CL, Handel TM, et al. Chemokines and cancer: Migration, intracellular signalling and intercellular communication in the microenvironment. Biochem J 2008; 409 : 635-49.
55. Thacker MA, Clark AK, Bishop T, et al. CCL2 is a key mediator of microglia activation in neuropathic pain states. Eur J Pain 2009; 13 : 263-72.
56. Franciosi S, Choi HB, Kim SU, et al. IL-8 enhancement of amyloidbeta (Abeta 1-42)-induced expression and production of proinflammatory cytokines and COX-2 in cultured human microglia. J Neuroimmunol 2005; 159 : 66-74.
57. Garau A, Bertini R, Colotta F, et al. Neuroprotection with the CXCL8 inhibitor repertaxin in transient brain ischemia. Cytokine 2005; 30 : 125-31.
58. Sato J, Segami N, Nishimura M, et al. Expression of interleukin 8 in synovial tissues in patients with internal derangement of the temporomandibular joint and its relationship with clinical variables. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 103 : 467-74.
59. Bertini R, Allegretti M, Bizzarri C, et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injury. Proc Natl Acad Sci U S A 2004; 101 : 11791-6.
60. Casilli F, Bianchini A, Gloaguen I, et al. Inhibition of interleukin-8 (CXCL8/IL-8) responses by repertaxin, a new inhibitor of the chemokine receptors CXCR1 and CXCR2. Biochem Pharmacol 2005; 69 : 385-94.
61. Lewis TS, Shapiro PS, Ahn NG. Signal transduction through MAP kinase cascades. Adv Cancer Res 1998; 74 : 49-139.
62. Widmann C, Gibson S, Jarpe MB, et al. Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human. Physiol Rev 1999; 79 : 143-80.
63. Impey S, Obrietan K, Storm DR. Making new connections: Role of ERK/MAP kinase signaling in neuronal plasticity. Neuron 1999; 23 : 11-14.
64. Ji RR, Woolf CJ. Neuronal plasticity and signal transduction in nociceptive neurons: Implications for the initiation and maintenance of pathological pain. Neurobiol Dis 2001; 8 : 1-10.
65. Ji RR, Befort K, Brenner GJ, et al. ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci 2002; 22 : 478-85.
66. Kawasaki Y, Kohno T, Zhuang ZY, et al. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J Neurosci 2004; 24 : 8310-21.
67. Zhuang ZY, Gerner P, Woolf CJ, et al. ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanicalallodynia in this neuropathic pain model. Pain 2005; 114 : 149-59.
68. Obata K, Yamanaka H, Dai Y, et al. Differentialactivation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury. J Neurosci 2003; 23 : 4117-26.