Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization

Journal of Neuroscience

Volumn 24, Issue 38, 2004, Pages 8310-8321

  Kawasaki, Yasuhiko ^a   Kohno, Tatsuro ^b   Zhuang, Zhi Ye ^a   Brenner, Gary J ^b   Wang, Haibin ^b   Van Der Meer, Catrien ^b   Befort, Katia ^b   Woolf, Clifford J ^b   Ji, Ru Rong ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

C fiber; Capsaicin; CREB; Dorsal horn; ERK; Pain; Spinal cord slices

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CAPSAICIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IONOTROPIC RECEPTOR; KAINIC ACID; METABOTROPIC RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE INHIBITOR; N METHYL DEXTRO ASPARTIC ACID; NEUROKININ 1 RECEPTOR; PRODYNORPHIN; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE C; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ADOLESCENT; ALLODYNIA; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; ELECTROSTIMULATION; ENZYME ACTIVATION; ENZYME INHIBITION; MALE; NERVE FIBER C; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR INTRINSIC ACTIVITY; SPINAL CORD DORSAL HORN;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CAPSAICIN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ELECTRIC STIMULATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HYPERALGESIA; MALE; N-METHYLASPARTATE; NERVE FIBERS, UNMYELINATED; ORGAN CULTURE TECHNIQUES; PAIN MEASUREMENT; PHOSPHORYLATION; POSTERIOR HORN CELLS; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUTAMATE; SRC-FAMILY KINASES; STIMULATION, CHEMICAL; SUBSTANCE P;

EID: 4644312225     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2396-04.2004     Document Type: Article

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