Propentofylline: Glial modulation, neuroprotection, and alleviation of chronic pain

Handbook of Experimental Pharmacology

Volumn 200, Issue , 2011, Pages 235-250

  Sweitzer, Sarah ^a   De Leo, Joyce ^b  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Astrocytes; Cytokines; Glia; Microglia; Neuropathic pain; Opioids; Tolerance

Indexed keywords

CD11B ANTIGEN; CYCLIC AMP; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MINOCYCLINE; MORPHINE; OPIATE; PENTOBARBITAL; PLACEBO; PROPENTOFYLLINE; TUMOR NECROSIS FACTOR ALPHA; VESICULAR GLUTAMATE TRANSPORTER 1;

ALLODYNIA; ALZHEIMER DISEASE; ANALGESIA; BEHAVIOR DISORDER; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CEREBROVASCULAR ACCIDENT; CHRONIC PAIN; DEGENERATIVE DISEASE; DEMENTIA; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; DRUG STRUCTURE; FOOD DRUG INTERACTION; GABAERGIC TRANSMISSION; HUMAN; HYPERALGESIA; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MORPHINE TOLERANCE; NERVE CELL DIFFERENTIATION; NEUROMODULATION; NEUROPATHIC PAIN; NEUROPROTECTION; NONHUMAN; PAIN; PHENOTYPE; POSTHERPETIC NEURALGIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; UNSPECIFIED SIDE EFFECT; WESTERN BLOTTING;

ANIMALS; CHRONIC DISEASE; DRUG TOLERANCE; HUMANS; MORPHINE; NEUROGLIA; NEUROPROTECTIVE AGENTS; PAIN; XANTHINES;

EID: 77957579033     PISSN: 01712004     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-13443-2_8     Document Type: Review

References (46)

1. Arriagada O, Constandil L, Hernandez A, Barra R, Soto-Moyano R, Laurido C (2007) Effects of interleukin-1beta on spinal cord nociceptive transmission in intact and propentofylline-treated rats. Int J Neurosci 117(5):617-625
2. Arruda JL, Sweitzer S, Rutkowski MD, DeLeo JA (2000) Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain. Brain Res 879 (1-2): 216-225
3. Binns BC, Huang Y, Goettl VM, Hackshaw KV, Stephens RL Jr (2005) Glutamate uptake is attenuated in spinal deep dorsal and ventral horn in the rat spinal nerve ligation model. Brain Res 1041(1):38-47
4. Cata JP, Weng HR, Chen JH, Dougherty PM (2006) Altered discharges of spinal wide dynamic range neurons and down-regulation of glutamate transporter expression in rats with paclitaxelinduced hyperalgesia. Neuroscience 138(1):329-338
5. Colburn RW, DeLeo JA, Rickman AJ, Yeager MP, Kwon P, Hickey WF (1997) Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat. J Neuroimmunol 79(2):163-175
6. Colburn RW, Rickman AJ, DeLeo JA (1999) The effect of site and type of nerve injury on spinal glial activation and neuropathic pain behavior. Exp Neurol 157(2):289-304
7. DeLeo J, Toth L, Schubert P, Rudolphi K, Kreutzberg GW (1987) Ischemia-induced neuronal cell death, calcium accumulation, and glial response in the hippocampus of the Mongolian gerbil and protection by propentofylline (HWA 285). J Cereb Blood Flow Metab 7(6):745-751
8. DeLeo J, Schubert P, Kreutzberg GW (1988a) Propentofylline (HWA 285) protects hippocampal neurons of Mongolian gerbils against ischemic damage in the presence of an adenosine antagonist. Neurosci Lett 84(3):307-311
9. DeLeo J, Schubert P, Kreutzberg GW (1988b) Protection against ischemic brain damage using propentofylline in gerbils. Stroke 19(12):1535-1539
10. Dorazil-Dudzik M, Mika J, Schafer MK, Li Y, Obara I, Wordliczek J, Przewlocka B (2004) The effects of local pentoxifylline and propentofylline treatment on formalin-induced pain and tumor necrosis factor-alpha messenger RNA levels in the inflamed tissue of the rat paw. Anesth Analg 98(6):1566-1573
11. Fredholm BB, Lindstrom K (1986) The xanthine derivative 1-(5'-oxohexyl)-3-methyl-7-propyl xanthine (HWA 285) enhances the actions of adenosine. Acta Pharmacol Toxicol (Copenh) 58(3):187-192
12. Garrison CJ, Dougherty PM, Kajander KC, Carlton SM (1991) Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury. Brain Res 565(1):1-7
13. Garrison CJ, Dougherty PM, Carlton SM (1994) GFAP expression in lumbar spinal cord of naive and neuropathic rats treated with MK-801. Exp Neurol 129(2):237-243
14. Garry EM, Delaney A, Blackburn-Munro G, Dickinson T, Moss A, Nakalembe I, Robertson DC, Rosie R, Robberecht P, Mitchell R, Fleetwood-Walker SM (2005) Activation of p38 and p42/44 MAP kinase in neuropathic pain: involvement of VPAC2 and NK2 receptors and mediation by spinal glia. Mol Cell Neurosci 30(4):523-537
15. Grome J, Stefanovich V (1985) Differential effects of xanthine derivatives on local cerebral blood flow and glucose utilization in the conscious rat. In: Stefanovich V, Rudolphi R, Schubert P (eds) Adenosine: receptors and modulation of cell function. IRL, Oxford, pp 453-460
16. Gwak YS, Hulsebosch CE (2009) Remote astrocytic and microglial activation modulates neuronal hyperexcitability and below-level neuropathic pain after spinal injury in rat. Neuroscience 161(3):895-903
17. Gwak YS, Crown ED, Unabia GC, Hulsebosch CE (2008) Propentofylline attenuates allodynia, glial activation and modulates GABAergic tone after spinal cord injury in the rat. Pain 138(2):410-422
18. Hashizume H, DeLeo JA, Colburn RW, Weinstein JN (2000) Spinal glial activation and cytokine expression after lumbar root injury in the rat. Spine 25(10):1206-1217
19. Holdridge SV, Armstrong SA, Taylor AM, Cahill CM (2007) Behavioural and morphological evidence for the involvement of glial cell activation in delta opioid receptor function: implications for the development of opioid tolerance. Mol Pain 3:7
20. Kuzumaki N, Narita M, Narita M, Hareyama N, Niikura K, Nagumo Y, Nozaki H, Amano T, Suzuki T (2007) Chronic pain-induced astrocyte activation in the cingulate cortex with no change in neural or glial differentiation from neural stem cells in mice. Neurosci Lett 415(1):22-27
21. Meller ST, Dykstra C, Grzybycki D, Murphy S, Gebhart GF (1994) The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat. Neuropharmacology 33(11):1471-1478
22. Miyashita K, Nakajima T, Ishikawa A, Miyatake T (1992) An adenosine uptake blocker, propentofylline, reduces glutamate release in gerbil hippocampus following transient forebrain ischemia. Neurochem Res 17(2):147-150
23. Nagata K, Ogawa T, Omosu M, Fujimoto K, Hayashi S (1985) In vitro and in vivo inhibitory effects of propentofylline on cyclic AMP phosphodiesterase activity. Arzneimittelforschung 35(7):1034-1036
24. Narita M, Suzuki M, Narita M, Niikura K, Nakamura A, Miyatake M, Yajima Y, Suzuki T (2006) mu-Opioid receptor internalization-dependent and-independent mechanisms of the development of tolerance to mu-opioid receptor agonists: comparison between etorphine and morphine. Neuroscience 138(2):609-619
25. Raghavendra V, Tanga F, DeLeo JA (2003a) Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy. J Pharmacol Exp Ther 306(2):624-630
26. Raghavendra V, Tanga F, Rutkowski MD, DeLeo JA (2003b) Anti-hyperalgesic and morphinesparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines. Pain 104(3):655-664
27. Raghavendra V, Tanga FY, DeLeo JA (2004) Attenuation of morphine tolerance, withdrawalinduced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats. Neuropsychopharmacology 29(2):327-334
28. Schubert P, Rudolphi K (1998) Interfering with the pathologic activation of microglial cells and astrocytes in dementia. Alzheimer Dis Assoc Disord 12 (Suppl 2): S21-S28
29. Schubert P, Ogata T, Rudolphi K, Marchini C, McRae A, Ferroni S (1997) Supportof homeostatic glial cell signaling: a novel therapeutic approach by propentofylline. Ann N Y Acad Sci 826:337-347
30. Schubert P, Ogata T, Miyazaki H, Marchini C, Ferroni S, Rudolphi K (1998) Pathological immuno-reactions of glial cells in Alzheimer's disease and possible sites of interference. J Neural Transm Suppl 54:167-174
31. Shumilla JA, Samuels I, Johnson KW, Forsayeth JR (2005) Systemic administration of propentofylline does not attenuate morphine tolerance in non-injured rodents. Neurosci Lett 384(3):344-348
32. Si QS, Nakamura Y, Schubert P, Rudolphi K, Kataoka K (1996) Adenosine and propentofylline inhibit the proliferation of cultured microglial cells. Exp Neurol 137(2):345-349
33. Si Q, Nakamura Y, Ogata T, Kataoka K, Schubert P (1998) Differential regulation of microglial activation by propentofylline via cAMP signaling. Brain Res 812 (1-2): 97-104
34. Sung B, Lim G, Mao J (2003) Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats. J Neurosci 23(7):2899-2910
35. Sweitzer SM, Colburn RW, Rutkowski M, DeLeo JA (1999) Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat. Brain Res 829 (1-2): 209-221
36. Sweitzer S, Martin D, DeLeo JA (2001a) Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain. Neuroscience 103(2):529-539
37. Sweitzer SM, Schubert P, DeLeo JA (2001b) Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. J Pharmacol Exp Ther 297(3):1210-1217
38. Sweitzer SM, Pahl JL, DeLeo JA (2006) Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat. Neurosci Lett 400(3):258-261
39. Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, Iwama H, Nishikawa T, Ichihara N, Kikuchi T, Okuyama S, Kawashima N, Hori S, Takimoto M, Wada K (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276(5319):1699-1702
40. Tawfik VL, Nutile-McMenemy N, Lacroix-Fralish ML, Deleo JA (2007) Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury. Brain Behav Immun 21(2):238-246
41. Tawfik VL, Regan MR, Haenggeli C, Lacroix-Fralish ML, Nutile-McMenemy N, Perez N, Rothstein JD, DeLeo JA (2008) Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection. Neuroscience 152(4):1086-1092
42. Tawfik VL, LaCroix-Fralish ML, Bercury KK, Nutile-McMenemy N, Harris BT, DeLeo JA (2006) Induction of astrocyte differentiation by propentyfylline increases glutamate transporter expression in vitro: Heterogeneity of the quiescent phenotype. Glia 54(3):193-203
43. Watkins LR, Martin D, Ulrich P, Tracey KJ, Maier SF (1997) Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat. Pain 71(3):225-235
44. Weng HR, Aravindan N, Cata JP, Chen JH, Shaw AD, Dougherty PM (2005) Spinal glial glutamate transporters downregulate in rats with taxol-induced hyperalgesia. Neurosci Lett 386(1):18-22
45. Wu YP, McRae A, Rudolphi K, Ling EA (1999) Propentofylline attenuates microglial reaction in the rat spinal cord induced by middle cerebral artery occlusion. Neurosci Lett 260(1):17-20
46. Wu HE, Thompson J, Sun HS, Terashvili M, Tseng LF (2005) Antianalgesia: stereoselective action of dextro-morphine over levo-morphine on glia in the mouse spinal cord. J Pharmacol Exp Ther 314(3):1101-1108