Ibudilast suppresses TNFα production by glial cells functioning mainly as type III phosphodiesterase inhibitor in the CNS

Brain Research

Volumn 837, Issue 1-2, 1999, Pages 203-212

  Suzumura, Akio ^a   Ito, Atsushi ^a   Yoshikawa, Minka ^a   Sawada, Makoto ^b  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

Astrocyte; Cytokine; Microglia; Multiple sclerosis; Phosphodiesterase inhibitor; TNF

Indexed keywords

IBUDILAST; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYTOKINE; PYRIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; ASTROCYTE; ENZYME INHIBITION; MACROGLIA; MALE; MOUSE; MULTIPLE SCLEROSIS; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; BRAIN; C57BL MOUSE; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; GLIA; METABOLISM; MICROGLIA; NEWBORN; RAT; WISTAR RAT;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BRAIN; CELLS, CULTURED; CYTOKINES; GENE EXPRESSION REGULATION; MALE; MICE; MICE, INBRED C57BL; MICROGLIA; NEUROGLIA; PHOSPHODIESTERASE INHIBITORS; PYRIDINES; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033532995     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01666-2     Document Type: Article

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