Chronic oral administration of minocycline to sheep with ovine CLN6 neuronal ceroid lipofuscinosis maintains pharmacological concentrations in the brain but does not suppress neuroinflammation or disease progression

Journal of Neuroinflammation

Volumn 10, Issue , 2013, Pages

  Kay, Graham W ^a   Palmer, David N ^a  

^a LINCOLN UNIVERSITY   (New Zealand)

Author keywords

Anti inflammatory drugs; Batten disease; Cerebrospinal fluid; Cortical atrophy; CSF; HPLC; NCL; Neurodegeneration; Neuroinflammation; Ovine model

Indexed keywords

GAMMA GLUTAMYLTRANSFERASE; GLUTAMATE DEHYDROGENASE; MINOCYCLINE; ANTIINFECTIVE AGENT; GLIAL FIBRILLARY ACIDIC PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTOSIS; ASYMPTOMATIC DISEASE; BLINDNESS; BRAIN ATROPHY; BRAIN SIZE; CELL ACTIVATION; CELL LOSS; CONTROLLED STUDY; DISEASE COURSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG TRANSFORMATION; ENZYME ACTIVITY; HISTOPATHOLOGY; MALE; MICROGLIA; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEURONAL CEROID LIPOFUSCINOSIS; NEUROPROTECTION; NONHUMAN; SHEEP; ANIMAL; ATROPHY; BIOSYNTHESIS; BRAIN; CEREBROSPINAL FLUID; CHEMICALLY INDUCED DISORDER; DEGENERATIVE DISEASE; DRUG EFFECT; FEMALE; GENETICS; GLIA; GROWTH; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMAGE PROCESSING; INFLAMMATION; LIVER FUNCTION TEST; MACROPHAGE ACTIVATION; METABOLISM; PATHOLOGY;

ANIMALS; ANTI-BACTERIAL AGENTS; ATROPHY; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE PROGRESSION; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; GROWTH; IMAGE PROCESSING, COMPUTER-ASSISTED; INFLAMMATION; LIVER FUNCTION TESTS; MACROPHAGE ACTIVATION; MALE; MINOCYCLINE; NEURODEGENERATIVE DISEASES; NEUROGLIA; NEURONAL CEROID-LIPOFUSCINOSES; SHEEP;

EID: 84880910366     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-10-97     Document Type: Article

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