Workshop on Molecular and Cellular Gerontology, Serpiano, Switzerland, 18-22 September 1999

EMBO Journal

Volumn 19, Issue 9, 2000, Pages 1929-1934

  Brack, Christine ^a   Lithgow, Gordon ^b   Osiewacz, Heinz ^c   Toussaint, Olivier ^d  

^a UNIVERSITY OF BASEL   (Switzerland)

^b School of Biological Sciences   (United Kingdom)

^c GOETHE UNIVERSITY   (Germany)

^d UNIVERSITY OF NAMUR   (Belgium)

Author keywords

Age related disease; Ageing; Model systems; Molecular gerontology; Oxidative stress

Indexed keywords

MITOCHONDRIAL DNA;

AGING; CELL REGENERATION; CONFERENCE PAPER; HUMAN; HUMAN CELL; NERVE DEGENERATION; OXIDATIVE STRESS; PRIORITY JOURNAL; SENESCENCE; ALZHEIMER DISEASE; ANIMAL; BRAIN; CELL AGING; CYTOLOGY; DNA REPAIR; GENETICS; IMMUNOLOGY; LONGEVITY; MITOCHONDRION; PATHOPHYSIOLOGY; PHYSIOLOGY; STRESS; YEAST;

AGING; ALZHEIMER DISEASE; ANIMALS; BRAIN; CELL AGING; DNA REPAIR; DNA, MITOCHONDRIAL; HUMANS; LONGEVITY; MITOCHONDRIA; OXIDATIVE STRESS; STRESS; YEASTS;

EID: 0034595212     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (54)

1. Ball, M.J. and West, M.J. (1998) Aging in the human brain: a clarion call to stay the course. Neurobiol. Aging, 19, 1.
2. Brack, C. Ackermann, R., Shikama, N. and Thüring, E. (1996) Drosophila as a model system for molecular gerontology. In Rattan, S.I.S. and Toussaint, O. (eds), Molecular Gerontology. Research Status and Perspectives. Plenum Press, New York, NY, pp. 151-176.
3. Bürkle, A. (1999) Poly (ADP-ribosyl)ation, genetic instability and aging. In Bohr, V.A., Clark, B.F.C. and Stevnsner, T. (eds), Molecular Biology of Aging. Alfred Benzon Symposium, 44, Munksgaard, Copenhagen, Denmark, pp. 104-111.
4. Calhoun, M.E., Wiederhold, K.H., Abramowski, D., Phinney, A.L., Probst, A., Sturchler-Pierrat, C., Staufenbiel, M., Sommer, B. and Jucker, M. (1998) Neuron loss in APP transgenic mice. Nature, 395, 755-756.
5. De Benedictis, G. (1996) Genes and longevity. Aging (Milano), 8, 367-369.
6. De Benedictis, G. et al. (1999) Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J., 13, 1532-1536.
7. De Laat, W.L., Jaspers, N.G. and Hoeijmakers, J.H. (1999) Molecular mechanism of nucleotide excision repair. Genes Dev., 13, 768-785.
8. Derventzi, A., Gonos, E.S. and Rattan, S.I.S. (1996) Ageing and cancer: a struggle of tendencies. In Rattan, S.I.S. and Toussaint, O. (eds) Molecular Gerontology. Research Status and Perspectives. Plenum Press, New York, NY, pp. 15-24.
9. Dumont, P., Burton, M., Chen, Q.M., Gonos, E.S., Frippiat, C., Mazarati, J., Eliaers, F., Remacle, J. and Toussaint, O. (2000) Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblasts. Free Radic. Biol. Med., 28, 361-373.
10. Esposito, L.A., Melov, S., Panov, A., Cottrell, B.A. and Wallace, D.C. (1999) Mitochondrial disease in mouse results in increased oxidative stress. Proc. Natl Acad. Sci. USA, 96, 4820-4825.
11. Finch, C.E. and Kirkwood, T.B.L. (1999) Chance, Development and Ageing. Oxford, UK.
12. Franceschi, C. and Ottaviani, E. (1997) Stress, inflammation and natural immunity in the aging process: a new theory. Aging (Milano), 9, 4 Suppl., 30-31.
13. Franceschi, C., Passeri, M., De Benedictis, G. and Motta, L. (1998) Immunosenescence. Aging (Milano), 10, 153-154.
14. Grubeck-Loebenstein, B. and Wick, G. (1999) Proceedings of a symposium on 'Immunosenescence - A major cause of disease in the elderly: from molecules to patients'. Exp. Gerontol., 34, 407-411.
15. Grune, T., Reinheckel, T. and Davies, K.J. (1997) Degradation of oxidized proteins in mammalian cells. FASEB J., 11, 526-534.
16. Jazwinski, S.M. (1999) Longevity, genes and aging: A review provided by genetic model systems. Exp. Gerontol., 34, 1-6.
17. Kirchman, P.A., Kim, S., Lai, C.Y. and Jazwinski, S.M. (1999) Interorganellar signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics, 152, 179-190.
18. Kirkwood, T.B. (1988) Biological theories of aging: an overview. Aging (Milano), 10, 144-146.
19. Kirkwood, T.B. and Kowald, A. (1997) Network theory of aging. Exp. Gerontol., 32, 395-399.
20. Kovalenko, S.A., Kopsidas, G., Kelso, J., Rosenfeldt, F. and Linnane, A.W. (1998) Tissue-specific distribution of multiple mitochondrial DNA rearrangements during human aging. Ann. NY Acad. Sci., 854, 171-181.
21. Liao, V. and Butow, R.A. (1993) RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus. Cell, 72, 61-71.
22. Linnane, A.W., Kovalenko, S. and Gingold, E.B. (1998) The universality of bioenergetic disease. Age-associated cellular bioenergetic degradation and amelioration therapy. Ann. NY Acad. Sci., 854, 202-213.
23. Lithgow, G.J. (1998) Aging mechanisms from nematodes to mammals. Nutrition, 14, 522-524.
24. Lithgow, G.J. and Kirkwood, T.B. (1996) Mechanisms and evolution of aging. Science, 273, 80.
25. Martin, G.M, Austad, S.N. and Johnson, T.E. (1996) Genetic analysis of aging: role of oxidative damage and environmental stresses. Nature Genet., 13, 25-34.
26. Medrano, E.E., Haddad, M. and Xu, W. (1999) Signal transduction, the cell cycle and the role of melanins in melanocyte aging. In Bohr, V.A., Clark, B.F.C. and Stevnsner, T. (eds). Molecular Biology of Aging. Alfred Benzon Symposium, 44, Munksgaard, Copenhagen, Denmark, pp. 354-361.
27. Melov, S., Coskun, P.E. and Wallace, D.C. (1999a) Mouse models of mitochondrial disease, oxidative stress and senescence. Mutat. Res., 434, 233-242.
28. Melov, S., Schneider, J.A., Coskun, P.E., Bennett, D.A. and Wallace, D.C. (1999b) Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA. Neurobiol. Aging, 20, 565-571.
29. Murakami, S. and Johnson, T. (1998) Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-I gene. Curr. Biol., 8, 1091-1094.
30. Orgel, L.E. (1970) The maintenance of protein synthesis and its relevance to ageing. Proc. Natl Acad. Sci. USA, 67, 1476.
31. Osiewacz, H.D. (1997) Genetic regulation of ageing. J. Mol. Med., 75, 715-727.
32. Osiewacz, H.D. and Kimpel, E. (1999) Mitochondrial-nuclear interactions and lifespan control in fungi. Exp. Gerontol., 34, 901-909.
33. Partridge, L., Prowse, N. and Pignatelli, P. (1999) Another set of responses and correlated responses to selection on age at reproduction in Drosophila melanogaster. Proc. R. Soc. Lond. B Biol. Sci., 266, 255-261.
34. Petersen, S., Saretzki, G. and von Zglinicki, T. (1998) Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp. Cell Res., 239, 152-160.
35. Rattan, S.I.S. (1998) Repeated mild heat shock delays ageing in cultured human skin fibroblasts. Biochem. Mol. Biol. Int., 45, 753-759.
36. Roth, G.S. (1997) Age changes in signal transduction and gene expression. Mech. Ageing Dev., 98, 231-238.
37. Roth, G.S., Ingram, D.K. and Lane, M.A. (1999) Calorie restriction in primates: will it work and how will we know? J. Am. Geriatr. Soc., 47, 896-903.
38. Schächter, F. (1998) Causes, effects and constraints in the genetics of human longevity. Am. J. Hum. Genet., 62, 1008-1014.
39. Schächter, F., Cohen, D. and Kirkwood, T.B. (1993) Prospects for the genetics of human longevity. Hum. Genet., 91, 519-526.
40. Sgro, C.M. and Partridge, L. (1999) A delayed wave of death from reproduction in Drosophila. Science, 286, 2521-2524.
41. Stathakos, D., Kletsas, D. and Psarras, S. (1996) In Rattan, S.I.S. and Toussaint, O. (eds), Molecular Gerontology. Research Status and Perspectives. Plenum Press, New York, NY, pp. 111-130.
42. Sturchler-Pierrat, C. and Sommer, B. (1999) Transgenic animals in Alzheimer's disease research. Rev. Neurosci., 10, 15-24.
43. Sturchler-Pierrat, C. et al. (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc. Natl Acad. Sci. USA, 94, 13287-13292.
44. Toussaint, O. and Rattan, S.I.S. (1996) From molecular gerontology to healthy old age. In Rattan, S.I.S. and Toussaint, O. (eds), Molecular Gerontology. Research Status and Perspectives. Plenum Press, New York, NY, pp. 201-209.
45. Toussaint, O. and Remacle, J. (1996) Stress and energy metabolism in age-related processes. In Rattan, S.I.S. and Toussaint, O. (eds), Molecular Gerontology. Research Status and Perspectives. Plenum Press, NewYork, NY, pp. 87-110.
46. Toussaint, O., Osiewacs, H., Lithgow, G. and Brack, C. (2000) Molecular and Cellular Gerontology. Ann. NY Acad. Sci., in press.
47. Tower, J. (1996) Aging mechanisms in fruit files. BioEssays, 18, 799-807.
48. Van Leeuwen, F.W. et al. (1998a) Mutations in RNA: a first example of molecular misreading in Alzheimer's disease. Trends Neurosci., 21, 331-335.
49. Van Leeuwen, F.W., Burbach, J.P. and Hol, E.M. (1998b) Frameshift mutants of βamyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. Science, 279, 242-247.
50. Walker, G.A., Walker, D.W. and Lithgow, G.J. (1998) Genes that determine both thermotolerance and rate of aging in Caenorhabditis elegans. Ann. NY Acad. Sci., 851, 444-449.
51. Wallace, D.C. (1999) Mitochondrial diseases in man and mouse. Science, 283, 1482-1488.
52. Wallace, D.C., Brown, M.D. and Lott, M.T. (1999) Mitochondrial DNA variation in human evolution and disease. Gene, 238, 211-230.
53. West, M.J. (1990) Stereological studies of the hippocampus: a comparison of the hippocampal subdivisions of diverse species including hedgehogs, laboratory rodents, wild mice and men. Prog. Brain Res., 83, 13-36.
54. Wick, G., Perschinka, H. and Xu, Q. (1999) Autoimmunity and atherosclerosis. Am. Heart J., 138, 444-449.