Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling

Journal of Cellular and Molecular Medicine

Volumn 14, Issue 1-2, 2010, Pages 357-367

  Blazkova, Hana ^a   Krejcikova, Katerina ^a   Moudry, Pavel ^a   Frisan, Teresa ^b   Hodny, Zdenek ^a   Bartek, Jiri ^a,c  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b KAROLINSKA INSTITUTE   (Sweden)

^c DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

Bacterial toxins; Cellular senescence; Cytokines; DNA damage response; Genetic instability

Indexed keywords

BACTERIAL TOXIN; CYCLIN DEPENDENT KINASE; CYTOKINE; CYTOLETHAL DISTENDING TOXIN;

ARTICLE; CELL AGING; CELL CYCLE; DNA DAMAGE; DRUG ANTAGONISM; DRUG EFFECT; HAEMOPHILUS DUCREYI; HUMAN; METABOLISM; PHENOTYPE; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

BACTERIAL TOXINS; CELL AGING; CELL CYCLE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASES; CYTOKINES; DNA DAMAGE; HAEMOPHILUS DUCREYI; HUMANS; PHENOTYPE; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); HAEMOPHILUS DUCREYI; MAMMALIA; NEGIBACTERIA;

EID: 77951958808     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00862.x     Document Type: Article

References (54)

1. Cope LD, Lumbley S, Latimer JL. A diffusible cytotoxin of Haemophilus ducreyi. Proc Natl Acad Sci USA. 1997, 94:4056-61.
2. Johnson WM, Lior H. A new heat-labile cytolethal distending toxin (CLDT) produced by Escherichia coli isolates from clinical material. Microb Pathog. 1988, 4:103-13.
3. Okuda J, Fukumoto M, Takeda Y. Examination of diarrheagenicity of cytolethal distending toxin: suckling mouse response to the products of the cdtABC genes of Shigella dysenteriae. Infect Immun. 1997, 65:428-33.
4. Pickett CL, Pesci EC, Cottle DL. Prevalence of cytolethal distending toxin production in Campylobacter jejuni and relatedness of Campylobacter sp. cdtB gene. Infect Immun. 1996, 64:2070-8.
5. Scott DA, Kaper JB. Cloning and sequencing of the genes encoding Escherichia coli cytolethal distending toxin. Infect Immun. 1994, 62:244-51.
6. Young VB, Knox KA, Schauer DB. Cytolethal distending toxin sequence and activity in the enterohepatic pathogen Helicobacter hepaticus. Infect Immun. 2000, 68:184-91.
7. Sugai M, Kawamoto T, Peres SY. The cell cycle-specific growth-inhibitory factor produced by Actinobacillus actinomycetemcomitans is a cytolethal distending toxin. Infect Immun. 1998, 66:5008-19.
8. Lara-Tejero M, Galan JE. A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein. Science. 2000, 290:354-7.
9. Elwell CA, Dreyfus LA. DNase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest. Mol Microbiol. 2000, 37:952-63.
10. Li LQ, Sharipo A, Chaves-Olarte E. The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells. Cellular Microbiology. 2002, 4:87-99.
11. Comayras C, Tasca C, Peres SY. Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation. Infect Immun. 1997, 65:5088-95.
12. Sert V, Cans C, Tasca C. The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks. Oncogene. 1999, 18:6296-304.
13. Cortes-Bratti X, Karlsson C, Lagergard T. The haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways. J Biol Chem. 2001, 276:5296-302.
14. Shenker BJ, McKay T, Datar S. Actinobacillus actinomycetemcomitans immunosuppressive protein is a member of the family of cytolethal distending toxins capable of causing a G2 arrest in human T cells. J Immunol. 1999, 162:4773-80.
15. Hassane DC, Lee RB, Pickett CL. Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells. Infect Immun. 2003, 71:541-5.
16. Cortes-Bratti X, Frisan T, Thelestam M. The cytolethal distending toxins induce DNA damage and cell cycle arrest. Toxicon. 2001, 39:1729-36.
17. Bartkova J, Horejsi Z, Koed K. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature. 2005, 434:864-70.
18. Gorgoulis VG, Vassiliou LV, Karakaidos P. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature. 2005, 434:907-13.
19. Halazonetis TD, Gorgoulis VG, Bartek J. An oncogene-induced DNA damage model for cancer development. Science. 2008, 319:1352-5.
20. Di Micco R, Fumagalli M, Cicalese A. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature. 2006, 444:638-42.
21. Bartkova J, Rezaei N, Liontos M. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature. 2006, 444:633-7.
22. Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007, 8:729-40.
23. Acosta JC, O'Loghlen A, Banito A. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell. 2008, 133:1006-18.
24. Kuilman T, Michaloglou C, Vredeveld LC. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell. 2008, 133:1019-31.
25. Bartek J, Hodny Z, Lukas J. Cytokine loops driving senescence. Nat Cell Biol. 2008, 10:887-9.
26. Danesh J. Estimating the contribution of Helicobacter pylori to gastric cancer. Br J Cancer. 2000, 83:970.
27. Giesecke J. International association between Helicobacter pylori and gastric cancer. Lancet. 1993, 342:120-1.
28. Frisan T, Cortes-Bratti X, Chaves-Olarte E. The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA. Cell Microbiol. 2003, 5:695-707.
29. Guerra L, Teter K, Lilley BN. Cellular internalization of cytolethal distending toxin: a new end to a known pathway. Cellular Microbiology. 2005, 7:921-34.
30. Purven M, Lagergard T. Haemophilus ducreyi, a cytotoxin-producing bacterium. Infect Immun. 1992, 60:1156-62.
31. Mailand N, Falck J, Lukas C. Rapid destruction of human Cdc25A in response to DNA damage. Science. 2000, 288:1425-9.
32. Thullberg M, Welcker M, Bartkova J. Monoclonal antibody probes for p21WAF1/CIP1 and the INK4 family of cyclin-dependent kinase inhibitors. Hybridoma. 2000, 19:63-72.
33. Dimri GP, Lee X, Basile G. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA. 1995, 92:9363-7.
34. Serrano M, Lin AW, McCurrach ME. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 1997, 88:593-602.
35. Alby F, Mazars R, de Rycke J. Study of the cytolethal distending toxin (CDT)-activated cell cycle checkpoint. Involvement of the CHK2 kinase. FEBS Lett. 2001, 491:261-5.
36. DiTullio RA, Mochan TA, Venere M. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol. 2002, 4:998-1002.
37. De Rycke J, Sert V, Comayras C. Sequence of lethal events in HeLa cells exposed to the G2 blocking cytolethal distending toxin. Eur J Cell Biol. 2000, 79:192-201.
38. Gary RK, Kindell SM. Quantitative assay of senescence-associated [beta]-galactosidase activity in mammalian cell extracts. Analytical Biochemistry. 2005, 343:329-34.
39. Pearson M, Carbone R, Sebastiani C. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature. 2000, 406:207-10.
40. Ferbeyre G, de Stanchina E, Querido E. PML is induced by oncogenic ras and promotes premature senescence. Genes Dev. 2000, 14:2015-27.
41. Langley E, Pearson M, Faretta M. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 2002, 21:2383-96.
42. Janderova-Rossmeislova L, Novakova Z, Vlasakova J. PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells. J Struct Biol. 2007, 159:56-70.
43. Kuilman T, Peeper DS. Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer. 2009, 9:81-94.
44. Minamino T, Yoshida T, Tateno K. Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis. Circulation. 2003, 108:2264-9.
45. Coppe JP, Patil CK, Rodier F. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008, 6:2853-68.
46. Hickey TE, McVeigh AL, Scott DA. Campylobacter jejuni cytolethal distending toxin mediates release of interleukin-8 from intestinal epithelial cells. Infect Immun. 2000, 68:6535-41.
47. Zheng J, Meng J, Zhao S. Campylobacter-induced interleukin-8 secretion in polarized human intestinal epithelial cells requires Campylobacter-secreted cytolethal distending toxin- and Toll-like receptor-mediated activation of NF-kappaB. Infect Immun. 2008, 76:4498-508.
48. Jiang H, Su Z-Z, Lin JJ. The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. Proc Natl Acad Sci USA. 1996, 93:9160-5.
49. Xie Y, Sheng W, Xiang J. Recombinant human IL-24 suppresses lung carcinoma cell growth via induction of cell apoptosis and inhibition of tumor angiogenesis. Cancer Biother Radiopharm. 2008, 23:310-20.
50. Dent P, Yacoub A, Grant S. MDA-7/IL-24 regulates proliferation, invasion and tumor cell radiosensitivity: a new cancer therapy?. J Cell Biochem. 2005, 95:712-9.
51. Inoue S, Shanker M, Miyahara R. MDA-7/IL-24-based cancer gene therapy: translation from the laboratory to the clinic. Curr Gene Ther. 2006, 6:73-91.
52. Carson CT, Orazio NI, Lee DV. Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection. EMBO J. 2009, 28:652-62.
53. Ge Z, Rogers AB, Feng Y. Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis. Cell Microbiol. 2007, 9:2070-80.
54. Lax AJ. Opinion: Bacterial toxins and cancer-a case to answer?. Nat Rev Microbiol. 2005, 3:343-9.