Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

Cell Biology International

Volumn 32, Issue 9, 2008, Pages 1031-1043

  Puig, Pierre Emmanuel ^a,b   Guilly, Marie Noëlle ^c   Bouchot, André ^b   Droin, Nathalie ^a,b   Cathelin, Dominique ^a,b   Bouyer, Florence ^a,b   Favier, Laure ^a   Ghiringhelli, François ^a,b   Kroemer, Guido ^d   Solary, Eric ^a,b   Martin, François ^a,b   Chauffert, Bruno ^a,b,e  

^a Chu   (France)

^b UNIVERSITÉ DE BOURGOGNE   (France)

^c INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^d INSTITUT GUSTAVE ROUSSY   (France)

^e Centre de Lutte Contre le Cancer GF Leclerc   (France)

Author keywords

Cancer; Chemotherapy; Endoreduplication; Mitotic catastrophe; Polyploidy; Resistance

Indexed keywords

CISPLATIN; DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CELL PROLIFERATION; CELL SELECTION; CELL SURVIVAL; CHROMOSOME ABERRATION; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA SYNTHESIS; DRUG MEGADOSE; ENDOREDUPLICATION; GENE DUPLICATION; IN VITRO STUDY; IN VIVO STUDY; MITOSIS; NONHUMAN; PHENOTYPE; POLYPLOIDY; RAT; TREATMENT RESPONSE; TUMOR CELL; TUMOR GROWTH;

ANIMALS; BROMODEOXYURIDINE; CELL AGING; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; COLONIC NEOPLASMS; DIPLOIDY; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; GENE DUPLICATION; MITOSIS; PHENOTYPE; POLYPLOIDY; RATS; TIME FACTORS; TUMOR ESCAPE;

ANIMALIA;

EID: 49749107218     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2008.04.021     Document Type: Article

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