Role of cellular senescence in lifestyle-related disease

Circulation Journal

Volumn 74, Issue 12, 2010, Pages 2527-2533

  Minamino, Tohru ^a,b  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Atherosclerosis; Heart failure; Insulin resistance; p53; Telomeres

Indexed keywords

ANGIOTENSIN II; CHECKPOINT KINASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; INSULIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; TELOMERASE; TELOMERE BINDING PROTEIN;

ADIPOSE TISSUE CELL; APOPTOSIS; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR RISK; CELL AGING; CELL DIVISION; CELL PROLIFERATION; CELL REGENERATION; CELLULAR STRESS RESPONSE; DIABETES MELLITUS; DNA DAMAGE; DNA REPAIR; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; HEART FAILURE; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HEMODYNAMIC STRESS; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIFESPAN; LIFESTYLE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PROTEIN SYNTHESIS INHIBITION; REVIEW; SMOOTH MUSCLE FIBER; TELOMERE; TUMOR SUPPRESSOR GENE;

AGE FACTORS; AGING; ANIMALS; CARDIOVASCULAR DISEASES; CELL AGING; DIABETES MELLITUS; DNA REPAIR; HUMANS; LIFE STYLE; MODELS, BIOLOGICAL; RISK FACTORS; TELOMERE;

EID: 78649710391     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-10-0916     Document Type: Review

References (71)

1. Campisi J. The biology of replicative senescence. Eur J Cancer 1997; 33: 703-709.
2. Bringold F, Serrano M. Tumor suppressors and oncogenes in cellular senescence. Exp Gerontol 2000; 35: 317-329.
3. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995; 92: 9363-9367.
4. Kumazaki T, Kobayashi M, Mitsui Y. Enhanced expression of fibronectin during in vivo cellular aging of human vascular endothelial cells and skin fibroblasts. Exp Cell Res 1993; 205: 396-402.
5. Bennett M.R, Macdonald K, Chan S.W, Boyle J.J, Weissberg P.L., Cooperative interactions between RB and P53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques. Circ Res 1998; 82: 704 -712.
6. Burrig KF. The endothelium of advanced arteriosclerotic plaques in humans. Arterioscler Thromb 1991; 11: 1678-1689.
7. Ross R, Wight TN, Strandness E, Thiele B. Human atherosclerosis. I: Cell constitution and characteristics of advanced lesions of the superficial femoral artery. Am J Pathol 1984; 114: 79-93.
8. Fenton M, Barker S, Kurz DJ, Erusalimsky JD. Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries. Arterioscler Thromb Vasc Biol 2001; 21: 220-226.
9. Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I. Endothelial cell senescence in human atherosclerosis: Role of telomere in endothelial dysfunction. Circulation 2002; 105: 1541 -1544.
10. Minamino T, Yoshida T, Tateno K, Miyauchi H, Zou Y, Toko H, et al. Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis. Circulation 2003; 108: 2264-2269.
11. Minamino T, Miyauchi H, Yoshida T, Tateno K, Kunieda T, Komuro I. Vascular cell senescence and vascular aging. J Mol Cell Cardiol 2004; 36: 175-183.
12. Vanhoutte PM. Endothelial dysfunction: The first step toward coronary arteriosclerosis. Circ J 2009; 73: 595-601.
13. Blasco M.A. Telomeres and human disease: Ageing, cancer and beyond. Nat Rev Genet 2005; 6: 611-622.
14. a). Mol Cell 2004; 14: 501-513.
15. d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003; 426: 194-198.
16. Takai H, Smogorzewska A, de Lange T. DNA damage foci at dysfunctional telomeres. Curr Biol 2003; 13: 1549-1556.
17. Herbig U, Ferreira M, Condel L, Carey D, Sedivy JM. Cellular senescence in aging primates. Science 2006; 311: 1257.
18. Chang E, Harley C.B. Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci USA 1995; 92: 11190-11194.
19. Aviv H, Khan MY, Skurnick J, Okuda K, Kimura M, Gardner J, et al. Age dependent aneuploidy and telomere length of the human vascular endothelium. Atherosclerosis 2001; 159: 281-287.
20. Ogami M, Ikura Y, Ohsawa M, Matsuo T, Kayo S, Yoshimi N, et al. Telomere shortening in human coronary artery diseases. Arterioscler Thromb Vasc Biol 2004; 24: 546-550.
21. Voghel G, Thorin-Trescases N, Farhat N, Nguyen A, Villeneuve L, Mamarbachi AM, et al. Cellular senescence in endothelial cells from atherosclerotic patients is accelerated by oxidative stress associated with cardiovascular risk factors. Mech Ageing Dev 2007; 128: 662-671.
22. Minamino T, Kourembanas S. Mechanisms of telomerase induction during vascular smooth muscle cell proliferation. Circ Res 2001; 89: 237-243.
23. Minamino T, Mitsialis SA, Kourembanas S. Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol Cell Biol 2001; 21: 3336-3342.
24. Matsushita H, Chang E, Glassford AJ, Cooke JP, Chiu CP, Tsao PS. eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization. Circ Res 2001; 89: 793-798.
25. Yang J, Chang E, Cherry AM, Bangs CD, Oei Y, Bodnar A, et al. Human endothelial cell life extension by telomerase expression. J Biol Chem 1999; 274: 26141-26148.
26. Yang J, Nagavarapu U, Relloma K, Sjaastad MD, Moss WC, Passaniti A, et al. Telomerized human microvasculature is functional in vivo. Nat Biotechnol 2001; 19: 219-224.
27. Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997; 91: 25-34.
28. Lee HW, Blasco MA, Gottlieb GJ, Horner JW 2nd, Greider CW, DePinho RA. Essential role of mouse telomerase in highly proliferative organs. Nature 1998; 392: 569-574.
29. Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, et al. Longevity, stress response, and cancer in aging telomerasedeficient mice. Cell 1999; 96: 701-712.
30. Franco S, Segura I, Riese HH, Blasco MA. Decreased B16F10 melanoma growth and impaired vascularization in telomerase-deficient mice with critically short telomeres. Cancer Res 2002; 62: 552-559.
31. Poch E, Carbonell P, Franco S, Diez-Juan A, Blasco MA, Andres V. Short telomeres protect from diet-induced atherosclerosis in apolipoprotein E-null mice. Faseb J 2004; 18: 418-420.
32. Perez-Rivero G, Ruiz-Torres MP, Rivas-Elena JV, Jerkic M, Diez-Marques ML, Lopez-Novoa JM, et al. Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production. Circulation 2006; 114: 309-317.
33. Najjar SS, Scuteri A, Lakatta EG. Arterial aging: Is it an immutable cardiovascular risk factor? Hypertension 2005; 46: 454-462.
34. Kunieda T, Minamino T, Nishi J, Tateno K, Oyama T, Katsuno T, et al. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 2006; 114: 953-960.
35. Matthews C, Gorenne I, Scott S, Figg N, Kirkpatrick P, Ritchie A, et al. Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: Effects of telomerase and oxidative stress. Circ Res 2006; 99: 156-164.
36. Kurz DJ, Decary S, Hong Y, Trivier E, Akhmedov A, Erusalimsky JD. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci 2004; 117: 2417-2426.
37. Voghel G, Thorin-Trescases N, Farhat N, Mamarbachi A.M, Villeneuve L, Fortier A, et al. Chronic treatment with N-acetylcystein delays cellular senescence in endothelial cells isolated from a subgroup of atherosclerotic patients. Mech Ageing Dev 2008; 129: 261-270.
38. Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J. Aging and genome maintenance: Lessons from the mouse? Science 2003; 299: 1355-1359.
39. Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, et al. P53 mutant mice that display early ageing-associated phenotypes. Nature 2002; 415: 45-53.
40. Maier B, Gluba W, Bernier B, Turner T, Mohammad K, Guise T, et al. Modulation of mammalian life span by the short isoform of P53. Genes Dev 2004; 18: 306-319.
41. Cao L, Li W, Kim S, Brodie SG, Deng CX. Senescence, aging, and malignant transformation mediated by P53 in mice lacking the Brca1 full-length isoform. Genes Dev 2003; 17: 201-213.
42. Olivetti G, Giordano G, Corradi D, Melissari M, Lagrasta C, Gambert SR, et al. Gender differences and aging: Effects on the human heart. J Am Coll Cardiol 1995; 26: 1068-1079.
43. Kajstura J, Leri A, Finato N, Di Loreto C, Beltrami CA, Anversa P. Myocyte proliferation in end-stage cardiac failure in humans. Proc Natl Acad Sci USA 1998; 95: 8801-8805.
44. Beltrami AP, Urbanek K, Kajstura J, Yan SM, Finato N, Bussani R, et al. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 2001; 344: 1750-1757.
45. Kajstura J, Pertoldi B, Leri A, Beltrami CA, Deptala A, Darzynkiewicz Z, et al. Telomere shortening is an in vivo marker of myocyte replication and aging. Am J Pathol 2000; 156: 813-819.
46. Oh H, Wang SC, Prahash A, Sano M, Moravec CS, Taffet GE, et al. Telomere attrition and Chk2 activation in human heart failure. Proc Natl Acad Sci USA 2003; 100: 5378-5383.
47. Leri A, Franco S, Zacheo A, Barlucchi L, Chimenti S, Limana F, et al. Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with P53 upregulation. EMBO J 2003; 22: 131-139.
48. Oh H, Taffet GE, Youker KA, Entman ML, Overbeek PA, Michael LH, et al. Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival. Proc Natl Acad Sci USA 2001; 98: 10308-10313.
49. Urbanek K, Quaini F, Tasca G, Torella D, Castaldo C, Nadal- Ginard B, et al. Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci USA 2003; 100: 10440-10445.
50. Urbanek K, Torella D, Sheikh F, De Angelis A, Nurzynska D, Silvestri F, et al. Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci USA 2005; 102: 8692-8697.
51. Hsieh PC, Segers VF, Davis ME, MacGillivray C, Gannon J, Molkentin JD, et al. Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med 2007; 13: 970-974.
52. Hosoda T, Kajstura J, Leri A, Anversa P. Mechanisms of myocardial regeneration. Circ J 2010; 74: 13-17.
53. Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi I, et al. Cardiac stem cell and myocyte aging, heart failure, and insulinlike growth factor-1 overexpression. Circ Res 2004; 94: 514-524.
54. Chimenti C, Kajstura J, Torella D, Urbanek K, Heleniak H, Colussi C, et al. Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure. Circ Res 2003; 93: 604-613.
55. Rota M, LeCapitaine N, Hosoda T, Boni A, De Angelis A, Padin- Iruegas M.E, et al. Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene. Circ Res 2006; 99: 42-52.
56. Urbanek K, Rota M, Cascapera S, Bearzi C, Nascimbene A, De Angelis A, et al. Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ Res 2005; 97: 663-673.
57. Gonzalez A, Rota M, Nurzynska D, Misao Y, Tillmanns J, Ojaimi C, et al. Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan. Circ Res 2008; 102: 597-606.
58. Frey N, Olson E.N. Cardiac hypertrophy: The good, the bad, and the ugly. Annu Rev Physiol 2003; 65: 45-79.
59. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 1990; 322: 1561-1566.
60. Ferrari R, Ceconi C, Campo G, Cangiano E, Cavazza C, Secchiero P, et al. Mechanisms of remodelling: A question of life (stem cell production) and death (myocyte apoptosis). Circ J 2009; 73: 1973-1982.
61. Misra A, Mann DL. Treatment of heart failure beyond practice guidelines: Role of cardiac remodeling. Circ J 2008; 72(Suppl A): A-1-A-7.
62. Fiordaliso F, Leri A, Cesselli D, Limana F, Safai B, Nadal-Ginard B, et al. Hyperglycemia activates P53 and P53-regulated genes leading to myocyte cell death. Diabetes 2001; 50: 2363-2375.
63. Kajstura J, Fiordaliso F, Andreoli AM, Li B, Chimenti S, Medow MS, et al. IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress. Diabetes 2001; 50: 1414-1424.
64. Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T, et al. A crucial role for adipose tissue P53 in the regulation of insulin resistance. Nat Med 2009; 15: 1082-1087.
65. Kenyon C. The plasticity of aging: Insights from long-lived mutants. Cell 2005; 120: 449-460.
66. Hwangbo DS, Gershman B, Tu MP, Palmer M, Tatar M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 2004; 429: 562-566.
67. Giannakou ME, Goss M, Junger MA, Hafen E, Leevers SJ, Partridge L. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 2004; 305: 361.
68. Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003; 299: 572-574.
69. Bluher M, Michael MD, Peroni OD, Ueki K, Carter N, Kahn BB, et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 2002; 3: 25-38.
70. Libina N, Berman JR, Kenyon C. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 2003; 115: 489-502.
71. Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, et al. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004; 114: 1299-1307.