Synonymous codon usage affects the expression of wild type and f508del CFTR

Journal of Molecular Biology

Volumn 427, Issue 6, 2015, Pages 1464-1479

  Shah, Kalpit ^a   Cheng, Yi ^a   Hahn, Brian ^a   Bridges, Robert ^a   Bradbury, Neil A ^a   Mueller, David M ^a  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

CFTR; CFTR F508del; nonsense mediated decay; protein folding; synonymous codon usage

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DNA; MESSENGER RNA; CFTR PROTEIN, HUMAN; CHLORIDE; CODON;

ARTICLE; CODON USAGE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; EXON; HALF LIFE TIME; HEK293 CELL LINE; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; NONSENSE MEDIATED MRNA DECAY; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; WILD TYPE; CELL MEMBRANE; CHEMISTRY; CODON; FLUORESCENT ANTIBODY TECHNIQUE; GENE DELETION; GENETICS; METABOLISM; MUTATION; NORTHERN BLOTTING; PROTEIN FOLDING; PROTEIN TRANSPORT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA STABILITY; WESTERN BLOTTING;

BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL MEMBRANE; CHLORIDES; CODON; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; FLUORESCENT ANTIBODY TECHNIQUE; HEK293 CELLS; HUMANS; MUTATION; OPEN READING FRAMES; PROTEIN FOLDING; PROTEIN TRANSPORT; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA STABILITY; RNA, MESSENGER; SEQUENCE DELETION;

EID: 84924063047     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2015.02.003     Document Type: Article

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