Probing conformational rescue induced by a chemical corrector of F508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) mutant

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 24714-24725

  Yu, Wilson ^a,c   Chiaw, Patrick Kim ^a,b   Bear, Christine E ^a,b,c  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APICAL SURFACES; CHLORIDE CHANNELS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; ENDOPLASMIC RETICULUM; EPITHELIAL CELLS; FULL-LENGTH PROTEINS; HIGH THROUGHPUT; IN-CHANNELS; MODIFIED PROTEASE; MUTANT PROTEINS; NUCLEOTIDE-BINDING DOMAIN; PARTIAL FUNCTIONS; PROTEIN CONFORMATION; SMALL MOLECULES; WILD TYPES;

AMINO ACIDS; CELL MEMBRANES; CHLORINE COMPOUNDS; DEFECTS; FETAL MONITORING; GENES; PROTEINS;

CONFORMATIONS;

MEMBRANE PROTEIN; NUCLEOTIDE BINDING DOMAIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CYSTIC FIBROSIS; ENDOPLASMIC RETICULUM; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING;

AMINOPHENOLS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ENDOPLASMIC RETICULUM; HEK293 CELLS; HUMANS; MUTATION; PIPERAZINES; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; QUINAZOLINES; QUINOLONES;

EID: 79960114415     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.239699     Document Type: Article

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