Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay

RNA

Volumn 14, Issue 3, 2008, Pages 563-576

  Silva, Ana Luísa ^a   Ribeiro, Patrícia ^a   Inácio, Ângela ^a   Liebhaber, Stephen A ^b   Romão, Luísa ^a  

^a NATIONAL INSTITUTE OF HEALTH DR RICARDO JORGE   (Portugal)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

50 54 nt boundary rule; Mammalian nonsense mediated mRNA decay (NMD); Poly(A) binding protein; Short open reading frame (ORF); Translation

Indexed keywords

CYTOPLASMIC POLY A BINDING PROTEIN 1; MESSENGER RNA; POLYADENYLIC ACID BINDING PROTEIN; UNCLASSIFIED DRUG; GLOBIN; MESSENGER RIBONUCLEOPROTEIN; RIBONUCLEOPROTEIN; SMALL INTERFERING RNA; TRANSACTIVATOR PROTEIN; UPF1 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; EXON; HUMAN; HUMAN CELL; MAMMAL CELL; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; RNA DEGRADATION; RNA STABILITY; RNA TRANSLATION; STOP CODON; BIOLOGICAL MODEL; GENETIC TRANSFECTION; GENETICS; HELA CELL; METABOLISM; MOLECULAR GENETICS; PROTEIN SYNTHESIS; SITE DIRECTED MUTAGENESIS;

MAMMALIA;

BASE SEQUENCE; CODON, NONSENSE; GLOBINS; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLY(A)-BINDING PROTEIN I; PROTEIN BIOSYNTHESIS; RIBONUCLEOPROTEINS; RNA STABILITY; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANS-ACTIVATORS; TRANSFECTION;

EID: 40449131535     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.815108     Document Type: Article

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