Diminished self-chaperoning activity of the ΔF508 mutant of CFTR results in protein misfolding

PLoS Computational Biology

Volumn 4, Issue 2, 2008, Pages

  Serohijos, Adrian W R ^a   Hegedus, Tamás ^b   Riordan, John R ^b   Dokholyan, Nikolay V ^b  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIODEGRADATION; KINETICS; PROTEINS;

APICAL MEMBRANES; ATP-BINDING CASSETTE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; EPITHELIAL CELLS; FOLDING KINETICS; FOLDINGS; MISFOLDING; PROTEIN MISFOLDING; WILD TYPES;

MOLECULAR DYNAMICS;

ABC TRANSPORTER; CHAPERONE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ARTICLE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MOUSE; KINETICS; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN FOLDING; THERMODYNAMICS; AMINO ACID SUBSTITUTION; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; GENETICS; MUTATION; PROTEIN DENATURATION; STRUCTURE ACTIVITY RELATION; ULTRASTRUCTURE;

AMINO ACID SUBSTITUTION; COMPUTER SIMULATION; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CHAPERONES; MUTATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40149102264     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000008     Document Type: Article

References (26)