Impact of the ΔF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure

Journal of Biological Chemistry

Volumn 280, Issue 2, 2005, Pages 1346-1353

  Lewis, Hal A ^a   Zhao, Xun ^a   Wang, Chi ^b   Sauder, J Michael ^a   Rooney, Isabelle ^a   Noland, Brian W ^a   Lorimer, Don ^a   Kearins, Margaret C ^a   Conners, Kris ^a   Condon, Brad ^a   Maloney, Peter C ^c   Guggino, William B ^a   Hunt, John F ^b   Emtage, Spencer ^a  

^a ELI LILLY AND COMPANY   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; ENZYMES; PROTEINS; SOLIDIFICATION; STABILITY; SURFACE TOPOGRAPHY;

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS (CFTR); FOLDING KINETICS; NUCLEOTIDE-BINDING DOMAINS (NBD); VITRO STABILITY;

CELLS;

ADENOSINE TRIPHOSPHATASE; PHENYLALANINE; TRANSMEMBRANE CONDUCTANCE REGULATOR; CFTR PROTEIN, HUMAN; NUCLEOTIDE;

ARTICLE; CRYSTAL STRUCTURE; IN VITRO STUDY; MUTATION; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CYSTIC FIBROSIS; GENE DELETION; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN DENATURATION; PROTEIN RENATURATION; PROTEIN TERTIARY STRUCTURE; SOLUBILITY;

AMINO ACID SEQUENCE; BINDING SITES; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEOTIDES; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN RENATURATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE DELETION; SOLUBILITY;

EID: 19944432524     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410968200     Document Type: Article

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