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Volumn 6, Issue 6, 2011, Pages 650-659

Codon usage: Nature's roadmap to expression and folding of proteins

Author keywords

Codon usage; Protein folding; Translation

Indexed keywords

BIOLOGICAL PRODUCTS; CODON USAGE; CODON USAGE BIAS; GENE EXPRESSION LEVELS; HIGH QUALITY; MULTISTEP PROCESS; POST-TRANSLATIONAL MODIFICATIONS; PROTEIN EXPRESSIONS; PROTEIN TRANSLATION; ROADMAP; TARGET GENES; TRANSLATION;

EID: 79957798888     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201000332     Document Type: Review
Times cited : (172)

References (108)
  • 1
    • 31144465926 scopus 로고    scopus 로고
    • Hearing silence: Non-neutral evolution at synonymous sites in mammals.
    • Chamary, J. V., Parmley, J. L., Hurst, L. D., Hearing silence: Non-neutral evolution at synonymous sites in mammals. Nat. Rev. Genet. 2006, 7, 98-108.
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 98-108
    • Chamary, J.V.1    Parmley, J.L.2    Hurst, L.D.3
  • 2
    • 51649118422 scopus 로고    scopus 로고
    • Folding at the rhythm of the rare codon beat.
    • Marin, M., Folding at the rhythm of the rare codon beat. Biotechnol. J. 2008, 3, 1047-1057.
    • (2008) Biotechnol. J. , vol.3 , pp. 1047-1057
    • Marin, M.1
  • 3
    • 78049403925 scopus 로고    scopus 로고
    • Synonymous codon usage influences the local protein structure observed.
    • Saunders, R., Deane, C. M., Synonymous codon usage influences the local protein structure observed. Nucleic Acids Res. 2010, 38, 6719-6728.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 6719-6728
    • Saunders, R.1    Deane, C.M.2
  • 4
    • 78650304100 scopus 로고    scopus 로고
    • Synonymous but not the same: The causes and consequences of codon bias.
    • Plotkin, J. B., Kudla, G., Synonymous but not the same: The causes and consequences of codon bias. Nat. Rev. Genet. 2011, 12, 32-42.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 32-42
    • Plotkin, J.B.1    Kudla, G.2
  • 5
    • 0025338172 scopus 로고
    • Is genetic code redundancy related to retention of structural information in both DNA strands?
    • Zull, J. E., Smith, S. K., Is genetic code redundancy related to retention of structural information in both DNA strands? Trends Biochem. Sci. 1990, 15, 257-261.
    • (1990) Trends Biochem. Sci. , vol.15 , pp. 257-261
    • Zull, J.E.1    Smith, S.K.2
  • 6
    • 0019824131 scopus 로고
    • Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: A proposal for a synonymous codon choice that is optimal for the E. coli translational system.
    • Ikemura, T., Correlation between the abundance of Escherichia coli transfer RNAs and the occurrence of the respective codons in its protein genes: A proposal for a synonymous codon choice that is optimal for the E. coli translational system. J. Mol. Biol. 1981, 151, 389-409.
    • (1981) J. Mol. Biol. , vol.151 , pp. 389-409
    • Ikemura, T.1
  • 7
    • 0021958933 scopus 로고
    • Codon usage and tRNA content in unicellular and multicellular organisms.
    • Ikemura, T., Codon usage and tRNA content in unicellular and multicellular organisms. Mol. Biol. Evol. 1985, 2, 13-34.
    • (1985) Mol. Biol. Evol. , vol.2 , pp. 13-34
    • Ikemura, T.1
  • 8
    • 0023126266 scopus 로고
    • Coevolution of codon usage and transfer RNA abundance.
    • Bulmer, M., Coevolution of codon usage and transfer RNA abundance. Nature 1987, 325, 728-730.
    • (1987) Nature , vol.325 , pp. 728-730
    • Bulmer, M.1
  • 9
    • 0030564828 scopus 로고    scopus 로고
    • Co-variation of tRNA abundance and codon usage in Escherichia coli at different growth rates.
    • Dong, H., Nilsson, L., Kurland, C. G., Co-variation of tRNA abundance and codon usage in Escherichia coli at different growth rates. J. Mol. Biol. 1996, 260, 649-663.
    • (1996) J. Mol. Biol. , vol.260 , pp. 649-663
    • Dong, H.1    Nilsson, L.2    Kurland, C.G.3
  • 10
    • 0348013051 scopus 로고    scopus 로고
    • Hierarchy of sequence-dependent features associated with prokaryotic translation.
    • Lithwick, G., Margalit, H., Hierarchy of sequence-dependent features associated with prokaryotic translation. Genome Res. 2003, 13, 2665-2673.
    • (2003) Genome Res. , vol.13 , pp. 2665-2673
    • Lithwick, G.1    Margalit, H.2
  • 11
    • 0021370660 scopus 로고
    • Costs of accuracy determined by a maximal growth rate constraint.
    • Ehrenberg, M., Kurland, C. G., Costs of accuracy determined by a maximal growth rate constraint. Q. Rev. Biophys. 1984, 17, 45-82.
    • (1984) Q. Rev. Biophys. , vol.17 , pp. 45-82
    • Ehrenberg, M.1    Kurland, C.G.2
  • 12
    • 8744310123 scopus 로고    scopus 로고
    • Codon usage bias from tRNA's point of view: Redundancy, specialization, and efficient decoding for translation optimization.
    • Rocha, E. P., Codon usage bias from tRNA's point of view: Redundancy, specialization, and efficient decoding for translation optimization. Genome Res. 2004, 14, 2279-2286.
    • (2004) Genome Res. , vol.14 , pp. 2279-2286
    • Rocha, E.P.1
  • 13
    • 77951570815 scopus 로고    scopus 로고
    • Forces that influence the evolution of codon bias.
    • Sharp, P. M., Emery, L. R., Zeng, K., Forces that influence the evolution of codon bias. Philos. Trans. R. Soc., B 2010, 365, 1203-1212.
    • (2010) Philos. Trans. R. Soc., B , vol.365 , pp. 1203-1212
    • Sharp, P.M.1    Emery, L.R.2    Zeng, K.3
  • 14
    • 0036889468 scopus 로고    scopus 로고
    • Evolution of synonymous codon usage in metazoans.
    • Duret, L., Evolution of synonymous codon usage in metazoans. Curr. Opin. Genet. Dev. 2002, 12, 640-649.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 640-649
    • Duret, L.1
  • 15
    • 0034237669 scopus 로고    scopus 로고
    • tRNA gene number and codon usage in the C. elegans genome are co-adapted for optimal translation of highly expressed genes.
    • Duret, L., tRNA gene number and codon usage in the C. elegans genome are co-adapted for optimal translation of highly expressed genes. Trends Genet. 2000, 16, 287-289.
    • (2000) Trends Genet. , vol.16 , pp. 287-289
    • Duret, L.1
  • 16
    • 4344647504 scopus 로고    scopus 로고
    • Tissue-specific codon usage and the expression of human genes.
    • Plotkin, J. B., Robins, H., Levine, A. J., Tissue-specific codon usage and the expression of human genes. Proc. Natl. Acad. Sci. USA 2004, 101, 12588-12591.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 12588-12591
    • Plotkin, J.B.1    Robins, H.2    Levine, A.J.3
  • 17
    • 33244484877 scopus 로고    scopus 로고
    • No evidence for tissue-specific adaptation of synonymous codon usage in humans.
    • Semon, M., Lobry, J. R., Duret, L., No evidence for tissue-specific adaptation of synonymous codon usage in humans. Mol. Biol. Evol. 2006, 23, 523-529.
    • (2006) Mol. Biol. Evol. , vol.23 , pp. 523-529
    • Semon, M.1    Lobry, J.R.2    Duret, L.3
  • 18
    • 68249130936 scopus 로고    scopus 로고
    • Clustering of codons with rare cognate tRNAs in human genes suggests an extra level of expression regulation.
    • Parmley, J. L., Huynen, M. A., Clustering of codons with rare cognate tRNAs in human genes suggests an extra level of expression regulation. PLoS Genet. 2009, 5, e1000548.
    • (2009) PLoS Genet. , vol.5
    • Parmley, J.L.1    Huynen, M.A.2
  • 19
    • 77953283586 scopus 로고    scopus 로고
    • Translation efficiency in humans: Tissue specificity, global optimization and differences between developmental stages.
    • Waldman, Y. Y., Tuller, T., Shlomi, T., Sharan, R., Ruppin, E., Translation efficiency in humans: Tissue specificity, global optimization and differences between developmental stages. Nucleic Acids Res. 2010, 38, 2964-2974.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 2964-2974
    • Waldman, Y.Y.1    Tuller, T.2    Shlomi, T.3    Sharan, R.4    Ruppin, E.5
  • 20
    • 0020262659 scopus 로고
    • Codon usage and transfer RNA contents: Organism-specific codon-choice patterns in reference to the isoacceptor contents.
    • Ikemura, T., Ozeki, H., Codon usage and transfer RNA contents: Organism-specific codon-choice patterns in reference to the isoacceptor contents. Cold Spring Harbor Symp. Quant. Biol. 1983, 47, 1087-1097.
    • (1983) Cold Spring Harbor Symp. Quant. Biol. , vol.47 , pp. 1087-1097
    • Ikemura, T.1    Ozeki, H.2
  • 21
    • 0020024572 scopus 로고
    • Codon selection in yeast.
    • Bennetzen, J. L., Hall, B. D., Codon selection in yeast. J. Biol. Chem. 1982, 257, 3026-3031.
    • (1982) J. Biol. Chem. , vol.257 , pp. 3026-3031
    • Bennetzen, J.L.1    Hall, B.D.2
  • 23
    • 0020363515 scopus 로고
    • Preferential codon usage in prokaryotic genes: The optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes.
    • Grosjean, H., Fiers, W., Preferential codon usage in prokaryotic genes: The optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes. Gene 1982, 18, 199-209.
    • (1982) Gene , vol.18 , pp. 199-209
    • Grosjean, H.1    Fiers, W.2
  • 24
    • 0020491327 scopus 로고
    • Codon usage in bacteria: Correlation with gene expressivity.
    • Gouy, M., Gautier, C., Codon usage in bacteria: Correlation with gene expressivity. Nucleic Acids Res. 1982, 10, 7055-7074.
    • (1982) Nucleic Acids Res. , vol.10 , pp. 7055-7074
    • Gouy, M.1    Gautier, C.2
  • 26
    • 0023650543 scopus 로고
    • The codon Adaptation Index-a measure of directional synonymous codon usage bias, and its potential applications.
    • Sharp, P. M., Li, W. H., The codon Adaptation Index-a measure of directional synonymous codon usage bias, and its potential applications. Nucleic Acids Res. 1987, 15, 1281-1295.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 1281-1295
    • Sharp, P.M.1    Li, W.H.2
  • 27
    • 0242391986 scopus 로고    scopus 로고
    • Codon adaptation index as a measure of dominating codon bias.
    • Carbone, A., Zinovyev, A., Kepes, F., Codon adaptation index as a measure of dominating codon bias. Bioinformatics 2003, 19, 2005-2015.
    • (2003) Bioinformatics , vol.19 , pp. 2005-2015
    • Carbone, A.1    Zinovyev, A.2    Kepes, F.3
  • 28
    • 0031586223 scopus 로고    scopus 로고
    • Growth rate-optimised tRNA abundance and codon usage.
    • Berg, O. G., Kurland, C. G., Growth rate-optimised tRNA abundance and codon usage. J. Mol. Biol. 1997, 270, 544-550.
    • (1997) J. Mol. Biol. , vol.270 , pp. 544-550
    • Berg, O.G.1    Kurland, C.G.2
  • 29
    • 0030731696 scopus 로고    scopus 로고
    • Codon usage bias and tRNA abundance in Drosophila.
    • Moriyama, E. N., Powell, J. R., Codon usage bias and tRNA abundance in Drosophila. J. Mol. Evol. 1997, 45, 514-523.
    • (1997) J. Mol. Evol. , vol.45 , pp. 514-523
    • Moriyama, E.N.1    Powell, J.R.2
  • 30
    • 0030861159 scopus 로고    scopus 로고
    • Evolution of codon usage bias in Drosophila.
    • Powell, J. R., Moriyama, E. N., Evolution of codon usage bias in Drosophila. Proc. Natl. Acad. Sci. USA 1997, 94, 7784-7790.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 7784-7790
    • Powell, J.R.1    Moriyama, E.N.2
  • 31
    • 0028359705 scopus 로고
    • Codon usage in Caenorhabditis elegans: Delineation of translational selection and mutational biases.
    • Stenico, M., Lloyd, A. T., Sharp, P. M., Codon usage in Caenorhabditis elegans: Delineation of translational selection and mutational biases. Nucleic Acids Res. 1994, 22, 2437-2446.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 2437-2446
    • Stenico, M.1    Lloyd, A.T.2    Sharp, P.M.3
  • 32
    • 0344653653 scopus 로고    scopus 로고
    • Codon usage and gene function are related in sequences of Arabidopsis thaliana.
    • Chiapello, H., Lisacek, F., Caboche, M., Henaut, A., Codon usage and gene function are related in sequences of Arabidopsis thaliana. Gene 1998, 209, GC1-GC38.
    • (1998) Gene , vol.209
    • Chiapello, H.1    Lisacek, F.2    Caboche, M.3    Henaut, A.4
  • 34
    • 13444291526 scopus 로고    scopus 로고
    • Codon bias as a factor in regulating expression via translation rate in the human genome.
    • Lavner, Y., Kotlar, D., Codon bias as a factor in regulating expression via translation rate in the human genome. Gene 2005, 345, 127-138.
    • (2005) Gene , vol.345 , pp. 127-138
    • Lavner, Y.1    Kotlar, D.2
  • 35
    • 0033991967 scopus 로고    scopus 로고
    • Isochores and the evolutionary genomics of vertebrates.
    • Bernardi, G., Isochores and the evolutionary genomics of vertebrates. Gene 2000, 241, 3-17.
    • (2000) Gene , vol.241 , pp. 3-17
    • Bernardi, G.1
  • 36
    • 30744432134 scopus 로고    scopus 로고
    • Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals.
    • Chamary, J. V., Hurst, L. D., Evidence for selection on synonymous mutations affecting stability of mRNA secondary structure in mammals. GenomeBiology 2005, 6, R75.
    • (2005) GenomeBiology , vol.6
    • Chamary, J.V.1    Hurst, L.D.2
  • 37
    • 0035220937 scopus 로고    scopus 로고
    • A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomes.
    • Knight, R. D., Freeland, S. J., Landweber, L. F., A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomes. GenomeBiology 2001, 2, research0010-research001013.
    • (2001) GenomeBiology , vol.2
    • Knight, R.D.1    Freeland, S.J.2    Landweber, L.F.3
  • 38
    • 78149419366 scopus 로고    scopus 로고
    • A general model of codon bias due to GC mutational bias.
    • Palidwor, G. A., Perkins, T. J., Xia, X., A general model of codon bias due to GC mutational bias. PLoS One 2010, 5, e13431.
    • (2010) PLoS One , vol.5
    • Palidwor, G.A.1    Perkins, T.J.2    Xia, X.3
  • 39
    • 0024365911 scopus 로고
    • mRNA secondary structure in an open reading frame reduces translation efficiency in Bacillus subtilis.
    • Kubo, M., Imanaka, T., mRNA secondary structure in an open reading frame reduces translation efficiency in Bacillus subtilis. J. Bacteriol. 1989, 171, 4080-4082.
    • (1989) J. Bacteriol. , vol.171 , pp. 4080-4082
    • Kubo, M.1    Imanaka, T.2
  • 40
    • 0025166089 scopus 로고
    • Secondary structure of the ribosome binding site determines translational efficiency: A quantitative analysis.
    • de Smit, M. H., van Duin, J., Secondary structure of the ribosome binding site determines translational efficiency: A quantitative analysis. Proc. Natl. Acad. Sci. USA 1990, 87, 7668-7672.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7668-7672
    • de Smit, M.H.1    van Duin, J.2
  • 41
    • 77951715627 scopus 로고    scopus 로고
    • An evolutionarily conserved mechanism for controlling the efficiency of protein translation.
    • Tuller, T., Carmi, A., Vestsigian, K., Navon, S. et al., An evolutionarily conserved mechanism for controlling the efficiency of protein translation. Cell 2010, 141, 344-354.
    • (2010) Cell , vol.141 , pp. 344-354
    • Tuller, T.1    Carmi, A.2    Vestsigian, K.3    Navon, S.4
  • 42
    • 77649198142 scopus 로고    scopus 로고
    • A universal trend of reduced mRNA stability near the translation-initiation site in prokaryotes and eukaryotes.
    • Gu, W., Zhou, T., Wilke, C. O., A universal trend of reduced mRNA stability near the translation-initiation site in prokaryotes and eukaryotes. PLoS Comput. Biol. 2010, 6, e1000664.
    • (2010) PLoS Comput. Biol. , vol.6
    • Gu, W.1    Zhou, T.2    Wilke, C.O.3
  • 43
    • 77957240693 scopus 로고    scopus 로고
    • Multifactorial determinants of protein expression in prokaryotic open reading frames.
    • Allert, M., Cox, J. C., Hellinga, H. W., Multifactorial determinants of protein expression in prokaryotic open reading frames. J. Mol. Biol. 2010, 402, 905-918.
    • (2010) J. Mol. Biol. , vol.402 , pp. 905-918
    • Allert, M.1    Cox, J.C.2    Hellinga, H.W.3
  • 44
    • 64849114915 scopus 로고    scopus 로고
    • Coding-sequence determinants of gene expression in Escherichia coli.
    • Kudla, G., Murray, A. W., Tollervey, D., Plotkin, J. B., Coding-sequence determinants of gene expression in Escherichia coli. Science 2009, 324, 255-258.
    • (2009) Science , vol.324 , pp. 255-258
    • Kudla, G.1    Murray, A.W.2    Tollervey, D.3    Plotkin, J.B.4
  • 45
    • 78349248644 scopus 로고    scopus 로고
    • On relevance of codon usage to expression of synthetic and natural genes in Escherichia coli.
    • Supek, F., Smuc, T., On relevance of codon usage to expression of synthetic and natural genes in Escherichia coli. Genetics 2010, 185, 1129-1134.
    • (2010) Genetics , vol.185 , pp. 1129-1134
    • Supek, F.1    Smuc, T.2
  • 46
    • 0023659927 scopus 로고
    • The efficiency of folding of some proteins is increased by controlled rates of translation in vivo. A hypothesis.
    • Purvis, I. J., Bettany, A. J., Santiago, T. C., Coggins, J. R. et al., The efficiency of folding of some proteins is increased by controlled rates of translation in vivo. A hypothesis. J. Mol. Biol. 1987, 193, 413-417.
    • (1987) J. Mol. Biol. , vol.193 , pp. 413-417
    • Purvis, I.J.1    Bettany, A.J.2    Santiago, T.C.3    Coggins, J.R.4
  • 47
    • 0029908504 scopus 로고    scopus 로고
    • Protein secondary structural types are differentially coded on messenger RNA.
    • Thanaraj, T. A., Argos, P., Protein secondary structural types are differentially coded on messenger RNA. Protein Sci. 1996, 5, 1973-1983.
    • (1996) Protein Sci. , vol.5 , pp. 1973-1983
    • Thanaraj, T.A.1    Argos, P.2
  • 48
    • 0024117032 scopus 로고
    • Ribosome pausing and stacking during translation of a eukaryotic mRNA.
    • Wolin, S. L., Walter, P., Ribosome pausing and stacking during translation of a eukaryotic mRNA. EMBO J. 1988, 7, 3559-3569.
    • (1988) EMBO J. , vol.7 , pp. 3559-3569
    • Wolin, S.L.1    Walter, P.2
  • 50
    • 0032699491 scopus 로고    scopus 로고
    • Synonymous codon substitutions affect ribosome traffic and protein folding during in vitro translation.
    • Komar, A. A., Lesnik, T., Reiss, C., Synonymous codon substitutions affect ribosome traffic and protein folding during in vitro translation. FEBS Lett. 1999, 462, 387-391.
    • (1999) FEBS Lett. , vol.462 , pp. 387-391
    • Komar, A.A.1    Lesnik, T.2    Reiss, C.3
  • 51
    • 0029870925 scopus 로고    scopus 로고
    • Programmed translational frameshifting.
    • Farabaugh, P. J., Programmed translational frameshifting. Microbiol. Rev. 1996, 60, 103-134.
    • (1996) Microbiol. Rev. , vol.60 , pp. 103-134
    • Farabaugh, P.J.1
  • 52
    • 34247876224 scopus 로고    scopus 로고
    • Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: Close to 300 cases reveal remarkable diversity despite underlying conservation.
    • Ivanov, I. P., Atkins, J. F., Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: Close to 300 cases reveal remarkable diversity despite underlying conservation. Nucleic Acids Res. 2007, 35, 1842-1858.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 1842-1858
    • Ivanov, I.P.1    Atkins, J.F.2
  • 53
    • 33846504706 scopus 로고    scopus 로고
    • A "silent" polymorphism in the MDR1 gene changes substrate specificity.
    • Kimchi-Sarfaty, C., Oh, J. M., Kim, I. W., Sauna, Z. E. et al., A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science 2007, 315, 525-528.
    • (2007) Science , vol.315 , pp. 525-528
    • Kimchi-Sarfaty, C.1    Oh, J.M.2    Kim, I.W.3    Sauna, Z.E.4
  • 54
    • 41149155366 scopus 로고    scopus 로고
    • Following translation by single ribosomes one codon at a time.
    • Wen, J. D., Lancaster, L., Hodges, C., Zeri, A. C. et al., Following translation by single ribosomes one codon at a time. Nature 2008, 452, 598-603.
    • (2008) Nature , vol.452 , pp. 598-603
    • Wen, J.D.1    Lancaster, L.2    Hodges, C.3    Zeri, A.C.4
  • 55
    • 58149199728 scopus 로고    scopus 로고
    • A pause for thought along the co-translational folding pathway.
    • Komar, A. A., A pause for thought along the co-translational folding pathway. Trends Biochem. Sci. 2009, 34, 16-24.
    • (2009) Trends Biochem. Sci. , vol.34 , pp. 16-24
    • Komar, A.A.1
  • 56
    • 53449087888 scopus 로고    scopus 로고
    • Rare codon priority and its position specificity at the 5' of the gene modulates heterologous protein expression in Escherichia coli.
    • Thangadurai, C., Suthakaran, P., Barfal, P., Anandaraj, B. et al., Rare codon priority and its position specificity at the 5' of the gene modulates heterologous protein expression in Escherichia coli. Biochem. Biophys. Res. Commun. 2008, 376, 647-652.
    • (2008) Biochem. Biophys. Res. Commun. , vol.376 , pp. 647-652
    • Thangadurai, C.1    Suthakaran, P.2    Barfal, P.3    Anandaraj, B.4
  • 57
    • 14644396660 scopus 로고    scopus 로고
    • Selective charging of tRNA isoacceptors induced by amino-acid starvation.
    • Dittmar, K. A., Sorensen, M. A., Elf, J., Ehrenberg, M., Pan, T., Selective charging of tRNA isoacceptors induced by amino-acid starvation. EMBO Rep. 2005, 6, 151-157.
    • (2005) EMBO Rep. , vol.6 , pp. 151-157
    • Dittmar, K.A.1    Sorensen, M.A.2    Elf, J.3    Ehrenberg, M.4    Pan, T.5
  • 58
    • 62549134121 scopus 로고    scopus 로고
    • Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling.
    • Ingolia, N. T., Ghaemmaghami, S., Newman, J. R., Weissman, J. S., Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. Science 2009, 324, 218-223.
    • (2009) Science , vol.324 , pp. 218-223
    • Ingolia, N.T.1    Ghaemmaghami, S.2    Newman, J.R.3    Weissman, J.S.4
  • 59
    • 77951722801 scopus 로고    scopus 로고
    • How the sequence of a gene can tune its translation.
    • Fredrick, K., Ibba, M., How the sequence of a gene can tune its translation. Cell 2010, 141, 227-229.
    • (2010) Cell , vol.141 , pp. 227-229
    • Fredrick, K.1    Ibba, M.2
  • 60
    • 77949456534 scopus 로고    scopus 로고
    • Increased incidence of rare codon clusters at 5' and 3' gene termini: Implications for function.
    • Clarke, T. F., Clark, P. L., Increased incidence of rare codon clusters at 5' and 3' gene termini: Implications for function. BMC Genomics 2010, 11, 118.
    • (2010) BMC Genomics , vol.11 , pp. 118
    • Clarke, T.F.1    Clark, P.L.2
  • 61
    • 19944369747 scopus 로고    scopus 로고
    • The clinical-grade 42-kilodalton fragment of merozoite surface protein 1 of Plasmodium falciparum strain FVO expressed in Escherichia coli protects Aotus nancymai against challenge with homologous erythrocytic-stage parasites.
    • Darko, C. A., Angov, E., Collins, W. E., Bergmann-Leitner, E. S. et al., The clinical-grade 42-kilodalton fragment of merozoite surface protein 1 of Plasmodium falciparum strain FVO expressed in Escherichia coli protects Aotus nancymai against challenge with homologous erythrocytic-stage parasites. Infect. Immun. 2005, 73, 287-297.
    • (2005) Infect. Immun. , vol.73 , pp. 287-297
    • Darko, C.A.1    Angov, E.2    Collins, W.E.3    Bergmann-Leitner, E.S.4
  • 62
    • 48249093081 scopus 로고    scopus 로고
    • Heterologous protein expression is enhanced by harmonizing the codon usage frequencies of the target gene with those of the expression host.
    • Angov, E., Hillier, C. J., Kincaid, R. L., Lyon, J. A., Heterologous protein expression is enhanced by harmonizing the codon usage frequencies of the target gene with those of the expression host. PLoS One 2008, 3, e2189.
    • (2008) PLoS One , vol.3
    • Angov, E.1    Hillier, C.J.2    Kincaid, R.L.3    Lyon, J.A.4
  • 63
    • 79952470599 scopus 로고    scopus 로고
    • Adjustment of codon usage frequencies by codon harmonization improves protein expression and folding.
    • Angov, E., Legler, P. M., Mease, R. M., Adjustment of codon usage frequencies by codon harmonization improves protein expression and folding. Methods Mol. Biol. 2011, 705, 1-13.
    • (2011) Methods Mol. Biol. , vol.705 , pp. 1-13
    • Angov, E.1    Legler, P.M.2    Mease, R.M.3
  • 64
    • 33947572539 scopus 로고    scopus 로고
    • Protein folding information in nucleic acids which is not present in the genetic code.
    • Biro, J. C., Protein folding information in nucleic acids which is not present in the genetic code. Ann. N. Y. Acad. Sci. 2006, 1091, 399-411.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1091 , pp. 399-411
    • Biro, J.C.1
  • 65
    • 33846519298 scopus 로고    scopus 로고
    • A single-nucleotide synonymous mutation in the gag gene controlling human immunodeficiency virus type 1 virion production.
    • Hamano, T., Matsuo, K., Hibi, Y., Victoriano, A. F. et al., A single-nucleotide synonymous mutation in the gag gene controlling human immunodeficiency virus type 1 virion production. J. Virol. 2007, 81, 1528-1533.
    • (2007) J. Virol. , vol.81 , pp. 1528-1533
    • Hamano, T.1    Matsuo, K.2    Hibi, Y.3    Victoriano, A.F.4
  • 66
    • 35448992847 scopus 로고    scopus 로고
    • Silent polymorphisms speak: How they affect pharmacogenomics and the treatment of cancer.
    • Sauna, Z. E., Kimchi-Sarfaty, C., Ambudkar, S. V., Gottesman, M. M., Silent polymorphisms speak: How they affect pharmacogenomics and the treatment of cancer. Cancer Res. 2007, 67, 9609-9612.
    • (2007) Cancer Res. , vol.67 , pp. 9609-9612
    • Sauna, Z.E.1    Kimchi-Sarfaty, C.2    Ambudkar, S.V.3    Gottesman, M.M.4
  • 67
    • 34548726841 scopus 로고    scopus 로고
    • Silent SNPs: Impact on gene function and phenotype.
    • Komar, A. A., Silent SNPs: Impact on gene function and phenotype. Pharmacogenomics 2007, 8, 1075-1080.
    • (2007) Pharmacogenomics , vol.8 , pp. 1075-1080
    • Komar, A.A.1
  • 68
    • 33846588874 scopus 로고    scopus 로고
    • Genetics. SNPs, silent but not invisible.
    • Komar, A. A., Genetics. SNPs, silent but not invisible. Science 2007, 315, 466-467.
    • (2007) Science , vol.315 , pp. 466-467
    • Komar, A.A.1
  • 69
    • 62049083910 scopus 로고    scopus 로고
    • Transient ribosomal attenuation coordinates protein synthesis and co-translational folding.
    • Zhang, G., Hubalewska, M., Ignatova, Z., Transient ribosomal attenuation coordinates protein synthesis and co-translational folding. Nat. Struct. Mol. Biol. 2009, 16, 274-280.
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 274-280
    • Zhang, G.1    Hubalewska, M.2    Ignatova, Z.3
  • 70
    • 70350344794 scopus 로고    scopus 로고
    • Analysis of synonymous codon usage patterns in different plant mitochondrial genomes.
    • Zhou, M., Li, X., Analysis of synonymous codon usage patterns in different plant mitochondrial genomes. Mol. Biol. Rep. 2009, 36, 2039-2046.
    • (2009) Mol. Biol. Rep. , vol.36 , pp. 2039-2046
    • Zhou, M.1    Li, X.2
  • 71
    • 0029828233 scopus 로고    scopus 로고
    • Strategies for achieving high-level expression of genes in Escherichia coli.
    • Makrides, S. C., Strategies for achieving high-level expression of genes in Escherichia coli. Microbiol. Rev. 1996, 60, 512-538.
    • (1996) Microbiol. Rev. , vol.60 , pp. 512-538
    • Makrides, S.C.1
  • 73
    • 0028804911 scopus 로고
    • Effects of rare codon clusters on high-level expression of heterologous proteins in Escherichia coli.
    • Kane, J. F., Effects of rare codon clusters on high-level expression of heterologous proteins in Escherichia coli. Curr. Opin. Biotechnol. 1995, 6, 494-500.
    • (1995) Curr. Opin. Biotechnol. , vol.6 , pp. 494-500
    • Kane, J.F.1
  • 74
    • 0028907431 scopus 로고
    • Consecutive low-usage leucine codons block translation only when near the 5' end of a message in Escherichia coli.
    • Goldman, E., Rosenberg, A. H., Zubay, G., Studier, F. W., Consecutive low-usage leucine codons block translation only when near the 5' end of a message in Escherichia coli. J. Mol. Biol. 1995, 245, 467-473.
    • (1995) J. Mol. Biol. , vol.245 , pp. 467-473
    • Goldman, E.1    Rosenberg, A.H.2    Zubay, G.3    Studier, F.W.4
  • 75
    • 1442289362 scopus 로고    scopus 로고
    • Enhanced expression of a recombinant malaria candidate vaccine in Escherichia coli by codon optimization.
    • Zhou, Z., Schnake, P., Xiao, L., Lal, A. A., Enhanced expression of a recombinant malaria candidate vaccine in Escherichia coli by codon optimization. Protein Expression Purif. 2004, 34, 87-94.
    • (2004) Protein Expression Purif. , vol.34 , pp. 87-94
    • Zhou, Z.1    Schnake, P.2    Xiao, L.3    Lal, A.A.4
  • 76
    • 10644255526 scopus 로고    scopus 로고
    • Advanced genetic strategies for recombinant protein expression in Escherichia coli.
    • Sorensen, H. P., Mortensen, K. K., Advanced genetic strategies for recombinant protein expression in Escherichia coli. J. Biotechnol. 2005, 115, 113-128.
    • (2005) J. Biotechnol. , vol.115 , pp. 113-128
    • Sorensen, H.P.1    Mortensen, K.K.2
  • 77
    • 0024825088 scopus 로고
    • High-level expression of recombinant genes in Escherichia coli is dependent on the availability of the dnaY gene product.
    • Brinkmann, U., Mattes, R. E., Buckel, P., High-level expression of recombinant genes in Escherichia coli is dependent on the availability of the dnaY gene product. Gene 1989, 85, 109-114.
    • (1989) Gene , vol.85 , pp. 109-114
    • Brinkmann, U.1    Mattes, R.E.2    Buckel, P.3
  • 78
    • 0034797685 scopus 로고    scopus 로고
    • A hybrid plasmid for expression of toxic malarial proteins in Escherichia coli.
    • Cinquin, O., Christopherson, R. I., Menz, R. I., A hybrid plasmid for expression of toxic malarial proteins in Escherichia coli. Mol. Biochem. Parasitol. 2001, 117, 245-247.
    • (2001) Mol. Biochem. Parasitol. , vol.117 , pp. 245-247
    • Cinquin, O.1    Christopherson, R.I.2    Menz, R.I.3
  • 79
    • 34247265994 scopus 로고    scopus 로고
    • Removing the regulatory N-terminal domain of cardiac troponin I diminishes incompatibility during bacterial expression.
    • Yu, Z. B., Jin, J. P., Removing the regulatory N-terminal domain of cardiac troponin I diminishes incompatibility during bacterial expression. Arch. Biochem. Biophys. 2007, 461, 138-145.
    • (2007) Arch. Biochem. Biophys. , vol.461 , pp. 138-145
    • Yu, Z.B.1    Jin, J.P.2
  • 80
    • 0027513392 scopus 로고
    • Effects of consecutive AGG codons on translation in Escherichia coli, demonstrated with a versatile codon test system.
    • Rosenberg, A. H., Goldman, E., Dunn, J. J., Studier, F. W., Zubay, G., Effects of consecutive AGG codons on translation in Escherichia coli, demonstrated with a versatile codon test system. J. Bacteriol. 1993, 175, 716-722.
    • (1993) J. Bacteriol. , vol.175 , pp. 716-722
    • Rosenberg, A.H.1    Goldman, E.2    Dunn, J.J.3    Studier, F.W.4    Zubay, G.5
  • 81
    • 0030018101 scopus 로고    scopus 로고
    • Ribosome-mediated translational pause and protein domain organization.
    • Thanaraj, T. A., Argos, P., Ribosome-mediated translational pause and protein domain organization. Protein Sci. 1996, 5, 1594-1612.
    • (1996) Protein Sci. , vol.5 , pp. 1594-1612
    • Thanaraj, T.A.1    Argos, P.2
  • 82
    • 16244415171 scopus 로고    scopus 로고
    • Process development and analysis of liver-stage antigen 1, a preerythrocyte-stage protein-based vaccine for Plasmodium falciparum.
    • Hillier, C. J., Ware, L. A., Barbosa, A., Angov, E. et al., Process development and analysis of liver-stage antigen 1, a preerythrocyte-stage protein-based vaccine for Plasmodium falciparum. Infect. Immun. 2005, 73, 2109-2115.
    • (2005) Infect. Immun. , vol.73 , pp. 2109-2115
    • Hillier, C.J.1    Ware, L.A.2    Barbosa, A.3    Angov, E.4
  • 83
    • 67749099938 scopus 로고    scopus 로고
    • A potent malaria transmission blocking vaccine based on codon harmonized full length Pfs48/45 expressed in Escherichia coli.
    • Chowdhury, D. R., Angov, E., Kariuki, T., Kumar, N., A potent malaria transmission blocking vaccine based on codon harmonized full length Pfs48/45 expressed in Escherichia coli. PLoS One 2009, 4, e6352.
    • (2009) PLoS One , vol.4
    • Chowdhury, D.R.1    Angov, E.2    Kariuki, T.3    Kumar, N.4
  • 84
    • 77956485238 scopus 로고    scopus 로고
    • Francis, D. M., Page, R., Strategies to optimize protein expression in E. coli. Current Protocols in Protein Science 2010, Chapter 5, Unit 5.24 21-29.
    • Francis, D. M., Page, R., Strategies to optimize protein expression in E. coli. Current Protocols in Protein Science 2010, Chapter 5, Unit 5.24, pp. 21-29.
  • 85
    • 77954040786 scopus 로고    scopus 로고
    • Secretory expression of human protein in the Yeast Pichia pastoris by controlled fermentor culture.
    • Murasugi, A., Secretory expression of human protein in the Yeast Pichia pastoris by controlled fermentor culture. Recent Pat. Biotechnol. 2010, 4, 153-166.
    • (2010) Recent Pat. Biotechnol. , vol.4 , pp. 153-166
    • Murasugi, A.1
  • 86
    • 77955962894 scopus 로고    scopus 로고
    • New baculovirus expression tools for recombinant protein complex production.
    • Trowitzsch, S., Bieniossek, C., Nie, Y., Garzoni, F., Berger, I., New baculovirus expression tools for recombinant protein complex production. J. Struct. Biol. 2010, 172, 45-54.
    • (2010) J. Struct. Biol. , vol.172 , pp. 45-54
    • Trowitzsch, S.1    Bieniossek, C.2    Nie, Y.3    Garzoni, F.4    Berger, I.5
  • 87
    • 77249147339 scopus 로고    scopus 로고
    • Engineering of protein secretion in yeast: Strategies and impact on protein production.
    • Idiris, A., Tohda, H., Kumagai, H., Takegawa, K., Engineering of protein secretion in yeast: Strategies and impact on protein production. Appl. Microbiol. Biotechnol. 2010, 86, 403-417.
    • (2010) Appl. Microbiol. Biotechnol. , vol.86 , pp. 403-417
    • Idiris, A.1    Tohda, H.2    Kumagai, H.3    Takegawa, K.4
  • 88
    • 77954863747 scopus 로고    scopus 로고
    • Production of heterologous proteins in plants: Strategies for optimal expression.
    • Desai, P. N., Shrivastava, N., Padh, H., Production of heterologous proteins in plants: Strategies for optimal expression. Biotechnol. Adv. 2010, 28, 427-435.
    • (2010) Biotechnol. Adv. , vol.28 , pp. 427-435
    • Desai, P.N.1    Shrivastava, N.2    Padh, H.3
  • 89
    • 40849137678 scopus 로고    scopus 로고
    • Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study.
    • Burgess-Brown, N. A., Sharma, S., Sobott, F., Loenarz, C. et al., Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study. Protein Expression Purif. 2008, 59, 94-102.
    • (2008) Protein Expression Purif. , vol.59 , pp. 94-102
    • Burgess-Brown, N.A.1    Sharma, S.2    Sobott, F.3    Loenarz, C.4
  • 90
    • 38549143777 scopus 로고    scopus 로고
    • Production of active eukaryotic proteins through bacterial expression systems: A review of the existing biotechnology strategies.
    • Sahdev, S., Khattar, S. K., Saini, K. S., Production of active eukaryotic proteins through bacterial expression systems: A review of the existing biotechnology strategies. Mol. Cell. Biochem. 2008, 307, 249-264.
    • (2008) Mol. Cell. Biochem. , vol.307 , pp. 249-264
    • Sahdev, S.1    Khattar, S.K.2    Saini, K.S.3
  • 91
    • 33751419975 scopus 로고    scopus 로고
    • Strategies to maximize heterologous protein expression in Escherichia coli with minimal cost.
    • Peti, W., Page, R., Strategies to maximize heterologous protein expression in Escherichia coli with minimal cost. Protein Expression Purif. 2007, 51, 1-10.
    • (2007) Protein Expression Purif. , vol.51 , pp. 1-10
    • Peti, W.1    Page, R.2
  • 92
    • 33747666218 scopus 로고    scopus 로고
    • Overview of bacterial expression systems for heterologous protein production: From molecular and biochemical fundamentals to commercial systems.
    • Terpe, K., Overview of bacterial expression systems for heterologous protein production: From molecular and biochemical fundamentals to commercial systems. Appl. Microbiol. Biotechnol. 2006, 72, 211-222.
    • (2006) Appl. Microbiol. Biotechnol. , vol.72 , pp. 211-222
    • Terpe, K.1
  • 93
    • 0037407668 scopus 로고    scopus 로고
    • Structural insight into the role of the ribosomal tunnel in cellular regulation.
    • Berisio, R., Schluenzen, F., Harms, J., Bashan, A. et al., Structural insight into the role of the ribosomal tunnel in cellular regulation. Nat. Struct. Biol. 2003, 10, 366-370.
    • (2003) Nat. Struct. Biol. , vol.10 , pp. 366-370
    • Berisio, R.1    Schluenzen, F.2    Harms, J.3    Bashan, A.4
  • 94
    • 0021764898 scopus 로고
    • Translation is a non-uniform process. Effect of tRNA availability on the rate of elongation of nascent polypeptide chains.
    • Varenne, S., Buc, J., Lloubes, R., Lazdunski, C., Translation is a non-uniform process. Effect of tRNA availability on the rate of elongation of nascent polypeptide chains. J. Mol. Biol. 1984, 180, 549-576.
    • (1984) J. Mol. Biol. , vol.180 , pp. 549-576
    • Varenne, S.1    Buc, J.2    Lloubes, R.3    Lazdunski, C.4
  • 95
    • 28544449949 scopus 로고    scopus 로고
    • Folding zones inside the ribosomal exit tunnel.
    • Lu, J., Deutsch, C., Folding zones inside the ribosomal exit tunnel. Nat. Struct. Mol. Biol. 2005, 12, 1123-1129.
    • (2005) Nat. Struct. Mol. Biol. , vol.12 , pp. 1123-1129
    • Lu, J.1    Deutsch, C.2
  • 96
    • 66849109240 scopus 로고    scopus 로고
    • The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins.
    • Kramer, G., Boehringer, D., Ban, N., Bukau, B., The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins. Nat. Struct. Mol. Biol. 2009, 16, 589-597.
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 589-597
    • Kramer, G.1    Boehringer, D.2    Ban, N.3    Bukau, B.4
  • 97
    • 34547569922 scopus 로고    scopus 로고
    • Mapping the electrostatic potential within the ribosomal exit tunnel.
    • Lu, J., Kobertz, W. R., Deutsch, C., Mapping the electrostatic potential within the ribosomal exit tunnel. J. Mol. Biol. 2007, 371, 1378-1391.
    • (2007) J. Mol. Biol. , vol.371 , pp. 1378-1391
    • Lu, J.1    Kobertz, W.R.2    Deutsch, C.3
  • 98
    • 54249096045 scopus 로고    scopus 로고
    • Electrostatics in the ribosomal tunnel modulate chain elongation rates.
    • Lu, J., Deutsch, C., Electrostatics in the ribosomal tunnel modulate chain elongation rates. J. Mol. Biol. 2008, 384, 73-86.
    • (2008) J. Mol. Biol. , vol.384 , pp. 73-86
    • Lu, J.1    Deutsch, C.2
  • 99
    • 2142639387 scopus 로고    scopus 로고
    • Analyzing and enhancing mRNA translational efficiency in an Escherichia coli in vitro expression system.
    • Voges, D., Watzele, M., Nemetz, C., Wizemann, S., Buchberger, B., Analyzing and enhancing mRNA translational efficiency in an Escherichia coli in vitro expression system. Biochem. Biophys. Res. Commun. 2004, 318, 601-614.
    • (2004) Biochem. Biophys. Res. Commun. , vol.318 , pp. 601-614
    • Voges, D.1    Watzele, M.2    Nemetz, C.3    Wizemann, S.4    Buchberger, B.5
  • 100
    • 65649112893 scopus 로고    scopus 로고
    • Gene composer: Database software for protein construct design, codon engineering, and gene synthesis.
    • Lorimer, D., Raymond, A., Walchli, J., Mixon, M. et al., Gene composer: Database software for protein construct design, codon engineering, and gene synthesis. BMC Biotechnol. 2009, 9, 36.
    • (2009) BMC Biotechnol. , vol.9 , pp. 36
    • Lorimer, D.1    Raymond, A.2    Walchli, J.3    Mixon, M.4
  • 101
    • 48949116363 scopus 로고    scopus 로고
    • GASCO: Genetic algorithm simulation for codon optimization.
    • Sandhu, K. S., Pandey, S., Maiti, S., Pillai, B., GASCO: Genetic algorithm simulation for codon optimization. In Silico Biol. 2008, 8, 187-192.
    • (2008) In Silico Biol. , vol.8 , pp. 187-192
    • Sandhu, K.S.1    Pandey, S.2    Maiti, S.3    Pillai, B.4
  • 102
    • 49049117997 scopus 로고    scopus 로고
    • Optimizing the codon usage of synthetic gene with QPSO algorithm.
    • Cai, Y., Sun, J., Wang, J., Ding, Y. et al., Optimizing the codon usage of synthetic gene with QPSO algorithm. J. Theor. Biol. 2008, 254, 123-127.
    • (2008) J. Theor. Biol. , vol.254 , pp. 123-127
    • Cai, Y.1    Sun, J.2    Wang, J.3    Ding, Y.4
  • 103
    • 34547579086 scopus 로고    scopus 로고
    • OPTIMIZER: A web server for optimizing the codon usage of DNA squences.
    • Puigbo, P., Guzman, E., Romeu, A., Carcia-Vallve, S., OPTIMIZER: A web server for optimizing the codon usage of DNA squences. Nucleic Acids Res. 2007, 35, W126-W131.
    • (2007) Nucleic Acids Res. , vol.35
    • Puigbo, P.1    Guzman, E.2    Romeu, A.3    Carcia-Vallve, S.4
  • 105
    • 33646582374 scopus 로고    scopus 로고
    • The synthetic gene designer: A flexible web platform to explore sequence manipulation for heterologous expression.
    • Wu, G., Bashir-Bello, N., Freeland, S. J., The synthetic gene designer: A flexible web platform to explore sequence manipulation for heterologous expression. Protein Expression Purif. 2006, 47, 441-445.
    • (2006) Protein Expression Purif. , vol.47 , pp. 441-445
    • Wu, G.1    Bashir-Bello, N.2    Freeland, S.J.3
  • 106
    • 23144444226 scopus 로고    scopus 로고
    • JCat: A novel tool to adapt codon usage of a target gene to its potential expression host.
    • Grote, A., Hiller, K., Scheer, M., Munch, R. et al., JCat: A novel tool to adapt codon usage of a target gene to its potential expression host. Nucleic Acids Res. 2005, 33, W526-531.
    • (2005) Nucleic Acids Res. , vol.33
    • Grote, A.1    Hiller, K.2    Scheer, M.3    Munch, R.4
  • 107
    • 19644370646 scopus 로고    scopus 로고
    • GeMS: An advanced software package for designing synthetic genes.
    • Jayaraj, S., Reid, R., Santi, D. V., GeMS: An advanced software package for designing synthetic genes. Nucleic Acids Res. 2005, 33, 3011-3016.
    • (2005) Nucleic Acids Res. , vol.33 , pp. 3011-3016
    • Jayaraj, S.1    Reid, R.2    Santi, D.V.3
  • 108
    • 1842713354 scopus 로고    scopus 로고
    • UpGene: Application of a web-based DNA codon optimization algorithm.
    • Gao, W., Rzewski, A., Sun, H., Robbins, P. D., Gambotto, A., UpGene: Application of a web-based DNA codon optimization algorithm. Biotechnol. Prog. 2004, 20, 443-448.
    • (2004) Biotechnol. Prog. , vol.20 , pp. 443-448
    • Gao, W.1    Rzewski, A.2    Sun, H.3    Robbins, P.D.4    Gambotto, A.5


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