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Volumn 29, Issue 11, 2014, Pages 2307-2322

The convergence of fracture repair and stem cells: Interplay of genes, aging, environmental factors and disease

Author keywords

aging; animal models; cell tissue signaling; cells of bone; genetically altered mice; injury fracture healing; orthopaedics; paracrine pathways; stem and progenitor cells

Indexed keywords

GROWTH FACTOR; HEAVY METAL; INTEGRIN; MICRORNA;

EID: 84923792299     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2373     Document Type: Review
Times cited : (110)

References (184)
  • 3
    • 34848921478 scopus 로고    scopus 로고
    • Definition and classification of fracture non-unions
    • (Suppl 2)
    • Frolke JP, Patka P., Definition and classification of fracture non-unions. Injury. 2007; 38 (Suppl 2): S19-22.
    • (2007) Injury. , vol.38 , pp. S19-S22
    • Frolke, J.P.1    Patka, P.2
  • 5
    • 33749990290 scopus 로고    scopus 로고
    • Effectiveness of completely round nails with both-ends-threaded locking screws for tibial shaft fractures
    • Lin J., Effectiveness of completely round nails with both-ends-threaded locking screws for tibial shaft fractures. J Trauma. 2006; 61 (4): 893-9.
    • (2006) J Trauma. , vol.61 , Issue.4 , pp. 893-899
    • Lin, J.1
  • 6
    • 0037119434 scopus 로고    scopus 로고
    • Transcriptional profiling of bone regeneration. Insight into the molecular complexity of wound repair
    • Hadjiargyrou M, Lombardo F, Zhao S, et al., Transcriptional profiling of bone regeneration. Insight into the molecular complexity of wound repair. J Biol Chem. 2002; 277 (33): 30177-82.
    • (2002) J Biol Chem. , vol.277 , Issue.33 , pp. 30177-30182
    • Hadjiargyrou, M.1    Lombardo, F.2    Zhao, S.3
  • 7
    • 74949130829 scopus 로고    scopus 로고
    • The control of fracture healing and its therapeutic targeting: Improving upon nature
    • Komatsu DE, Warden SJ., The control of fracture healing and its therapeutic targeting: improving upon nature. J Cell Biochem. 2010; 109 (2): 302-11.
    • (2010) J Cell Biochem. , vol.109 , Issue.2 , pp. 302-311
    • Komatsu, D.E.1    Warden, S.J.2
  • 8
    • 49149121741 scopus 로고    scopus 로고
    • Circulating endothelial/skeletal progenitor cells for bone regeneration and healing
    • Matsumoto T, Kuroda R, Mifune Y, et al., Circulating endothelial/skeletal progenitor cells for bone regeneration and healing. Bone. 2008; 43 (3): 434-9.
    • (2008) Bone , vol.43 , Issue.3 , pp. 434-439
    • Matsumoto, T.1    Kuroda, R.2    Mifune, Y.3
  • 9
    • 84879097640 scopus 로고    scopus 로고
    • The role of muscle in bone repair: The cells, signals, and tissue responses to injury
    • Shah K, Majeed Z, Jonason J, O'Keefe RJ., The role of muscle in bone repair: the cells, signals, and tissue responses to injury. Curr Osteoporos Rep. 2013; 11 (2): 130-5.
    • (2013) Curr Osteoporos Rep. , vol.11 , Issue.2 , pp. 130-135
    • Shah, K.1    Majeed, Z.2    Jonason, J.3    O'Keefe, R.J.4
  • 10
    • 38849099826 scopus 로고    scopus 로고
    • Circulating cells with osteogenic potential are physiologically mobilized into the fracture healing site in the parabiotic mice model
    • Kumagai K, Vasanji A, Drazba JA, Butler RS, Muschler GF., Circulating cells with osteogenic potential are physiologically mobilized into the fracture healing site in the parabiotic mice model. J Orthop Res. 2008; 26 (2): 165-75.
    • (2008) J Orthop Res. , vol.26 , Issue.2 , pp. 165-175
    • Kumagai, K.1    Vasanji, A.2    Drazba, J.A.3    Butler, R.S.4    Muschler, G.F.5
  • 11
    • 34547224256 scopus 로고    scopus 로고
    • Circulating connective tissue precursors: Extreme rarity in humans and chondrogenic potential in Guinea pigs
    • Kuznetsov SA, Mankani MH, Leet AI, Ziran N, Gronthos S, Robey PG., Circulating connective tissue precursors: extreme rarity in humans and chondrogenic potential in guinea pigs. Stem Cells. 2007; 25 (7): 1830-9.
    • (2007) Stem Cells. , vol.25 , Issue.7 , pp. 1830-1839
    • Kuznetsov, S.A.1    Mankani, M.H.2    Leet, A.I.3    Ziran, N.4    Gronthos, S.5    Robey, P.G.6
  • 12
    • 84907915679 scopus 로고    scopus 로고
    • No evidence for circulating mesenchymal stem cells in patients with organ injury
    • Oct 1;
    • Hoogduijn MJ, Verstegen MM, Engela AU, et al., No evidence for circulating mesenchymal stem cells in patients with organ injury. Stem Cells Dev. 2014 Oct 1; 23 (19): 2328-35.
    • (2014) Stem Cells Dev. , vol.23 , Issue.19 , pp. 2328-2335
    • Hoogduijn, M.J.1    Verstegen, M.M.2    Engela, A.U.3
  • 13
    • 58649117944 scopus 로고    scopus 로고
    • Skeletal cell fate decisions within periosteum and bone marrow during bone regeneration
    • Colnot C., Skeletal cell fate decisions within periosteum and bone marrow during bone regeneration. J Bone Miner Res. 2009; 24 (2): 274-82.
    • (2009) J Bone Miner Res. , vol.24 , Issue.2 , pp. 274-282
    • Colnot, C.1
  • 14
    • 84857920401 scopus 로고    scopus 로고
    • Fracture healing under healthy and inflammatory conditions
    • Claes L, Recknagel S, Ignatius A., Fracture healing under healthy and inflammatory conditions. Nat Rev Rheumatol. 2012; 8 (3): 133-43.
    • (2012) Nat Rev Rheumatol. , vol.8 , Issue.3 , pp. 133-143
    • Claes, L.1    Recknagel, S.2    Ignatius, A.3
  • 15
    • 66349123284 scopus 로고    scopus 로고
    • Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing
    • Taylor DK, Meganck JA, Terkhorn S, et al., Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing. J Bone Miner Res. 2009; 24 (6): 1043-54.
    • (2009) J Bone Miner Res. , vol.24 , Issue.6 , pp. 1043-1054
    • Taylor, D.K.1    Meganck, J.A.2    Terkhorn, S.3
  • 16
    • 84864269916 scopus 로고    scopus 로고
    • Substrate stiffness and oxygen as regulators of stem cell differentiation during skeletal tissue regeneration: A mechanobiological model
    • Burke DP, Kelly DJ., Substrate stiffness and oxygen as regulators of stem cell differentiation during skeletal tissue regeneration: a mechanobiological model. PLoS One. 2012; 7 (7): e40737.
    • (2012) PLoS One. , vol.7 , Issue.7 , pp. e40737
    • Burke, D.P.1    Kelly, D.J.2
  • 17
    • 34247259929 scopus 로고    scopus 로고
    • Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency
    • Komatsu DE, Bosch-Marce M, Semenza GL, Hadjiargyrou M., Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency. J Bone Miner Res. 2007; 22 (3): 366-74.
    • (2007) J Bone Miner Res. , vol.22 , Issue.3 , pp. 366-374
    • Komatsu, D.E.1    Bosch-Marce, M.2    Semenza, G.L.3    Hadjiargyrou, M.4
  • 18
    • 1642333512 scopus 로고    scopus 로고
    • Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair
    • Komatsu DE, Hadjiargyrou M., Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair. Bone. 2004; 34 (4): 680-8.
    • (2004) Bone , vol.34 , Issue.4 , pp. 680-688
    • Komatsu, D.E.1    Hadjiargyrou, M.2
  • 19
    • 38649128127 scopus 로고    scopus 로고
    • Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration
    • Wan C, Gilbert SR, Wang Y, et al., Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration. Proc Natl Acad Sci U S A. 2008; 105 (2): 686-91.
    • (2008) Proc Natl Acad Sci U S A. , vol.105 , Issue.2 , pp. 686-691
    • Wan, C.1    Gilbert, S.R.2    Wang, Y.3
  • 20
    • 77953028993 scopus 로고    scopus 로고
    • Healing of non-displaced fractures produced by fatigue loading of the mouse ulna
    • Martinez MD, Schmid GJ, McKenzie JA, Ornitz DM, Silva MJ., Healing of non-displaced fractures produced by fatigue loading of the mouse ulna. Bone. 2010; 46 (6): 1604-12.
    • (2010) Bone , vol.46 , Issue.6 , pp. 1604-1612
    • Martinez, M.D.1    Schmid, G.J.2    McKenzie, J.A.3    Ornitz, D.M.4    Silva, M.J.5
  • 21
    • 77955569142 scopus 로고    scopus 로고
    • Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels
    • Maes C, Kobayashi T, Selig MK, et al., Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels. Dev Cell. 2010; 19 (2): 329-44.
    • (2010) Dev Cell. , vol.19 , Issue.2 , pp. 329-344
    • Maes, C.1    Kobayashi, T.2    Selig, M.K.3
  • 22
    • 33846804313 scopus 로고    scopus 로고
    • Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice
    • Kosaki N, Takaishi H, Kamekura S, et al., Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice. Biochem Biophys Res Commun. 2007; 354 (4): 846-51.
    • (2007) Biochem Biophys Res Commun. , vol.354 , Issue.4 , pp. 846-851
    • Kosaki, N.1    Takaishi, H.2    Kamekura, S.3
  • 23
    • 84882903351 scopus 로고    scopus 로고
    • The role of oxygen as a regulator of stem cell fate during fracture repair in TSP2-null mice
    • Burke D, Dishowitz M, Sweetwyne M, Miedel E, Hankenson KD, Kelly DJ., The role of oxygen as a regulator of stem cell fate during fracture repair in TSP2-null mice. J Orthop Res. 2013; 31 (10): 1585-96.
    • (2013) J Orthop Res. , vol.31 , Issue.10 , pp. 1585-1596
    • Burke, D.1    Dishowitz, M.2    Sweetwyne, M.3    Miedel, E.4    Hankenson, K.D.5    Kelly, D.J.6
  • 25
    • 84867897196 scopus 로고    scopus 로고
    • The role of oxygen during fracture healing
    • Lu C, Saless N, Wang X, et al., The role of oxygen during fracture healing. Bone. 2013; 52 (1): 220-9.
    • (2013) Bone , vol.52 , Issue.1 , pp. 220-229
    • Lu, C.1    Saless, N.2    Wang, X.3
  • 26
    • 62149148156 scopus 로고    scopus 로고
    • Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration
    • Goessling W, North TE, Loewer S, et al., Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 2009; 136 (6): 1136-47.
    • (2009) Cell. , vol.136 , Issue.6 , pp. 1136-1147
    • Goessling, W.1    North, T.E.2    Loewer, S.3
  • 27
    • 84873608154 scopus 로고    scopus 로고
    • Mechanisms that regulate stem cell aging and life span
    • Signer RA, Morrison SJ., Mechanisms that regulate stem cell aging and life span. Cell Stem Cell. 2013; 12 (2): 152-65.
    • (2013) Cell Stem Cell. , vol.12 , Issue.2 , pp. 152-165
    • Signer, R.A.1    Morrison, S.J.2
  • 28
    • 0014261390 scopus 로고
    • Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues
    • Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP., Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation. 1968; 6 (2): 230-47.
    • (1968) Transplantation. , vol.6 , Issue.2 , pp. 230-247
    • Friedenstein, A.J.1    Petrakova, K.V.2    Kurolesova, A.I.3    Frolova, G.P.4
  • 30
    • 0020420825 scopus 로고
    • The role of bone marrow in bone morphogenetic protein-induced repair of femoral massive diaphyseal defects
    • Nov-Dec;
    • Takagi K, Urist MR., The role of bone marrow in bone morphogenetic protein-induced repair of femoral massive diaphyseal defects. Clin Orthop Relat Res. 1982 Nov-Dec; (171): 224-31.
    • (1982) Clin Orthop Relat Res. , Issue.171 , pp. 224-231
    • Takagi, K.1    Urist, M.R.2
  • 31
    • 0022478005 scopus 로고
    • Percutaneous bone marrow grafting of fractures and bony defects. An experimental study in rabbits
    • Jul;
    • Paley D, Young MC, Wiley AM, Fornasier VL, Jackson RW., Percutaneous bone marrow grafting of fractures and bony defects. An experimental study in rabbits. Clin Orthop Relat Res. 1986 Jul; (208): 300-12.
    • (1986) Clin Orthop Relat Res. , Issue.208 , pp. 300-312
    • Paley, D.1    Young, M.C.2    Wiley, A.M.3    Fornasier, V.L.4    Jackson, R.W.5
  • 32
    • 0026318653 scopus 로고
    • Autogeneic bone marrow and porous biphasic calcium phosphate ceramic for segmental bone defects in the canine ulna
    • May;
    • Grundel RE, Chapman MW, Yee T, Moore DC., Autogeneic bone marrow and porous biphasic calcium phosphate ceramic for segmental bone defects in the canine ulna. Clin Orthop Relat Res. 1991 May; (266): 244-58.
    • (1991) Clin Orthop Relat Res. , Issue.266 , pp. 244-258
    • Grundel, R.E.1    Chapman, M.W.2    Yee, T.3    Moore, D.C.4
  • 33
    • 0029659155 scopus 로고    scopus 로고
    • Qualitative and quantitative analysis of orthotopic bone regeneration by marrow
    • Werntz JR, Lane JM, Burstein AH, Justin R, Klein R, Tomin E., Qualitative and quantitative analysis of orthotopic bone regeneration by marrow. J Orthop Res. 1996; 14 (1): 85-93.
    • (1996) J Orthop Res. , vol.14 , Issue.1 , pp. 85-93
    • Werntz, J.R.1    Lane, J.M.2    Burstein, A.H.3    Justin, R.4    Klein, R.5    Tomin, E.6
  • 34
    • 0030907440 scopus 로고    scopus 로고
    • Culture expanded canine mesenchymal stem cells possess osteochondrogenic potential in vivo and in vitro
    • Kadiyala S, Young RG, Thiede MA, Bruder SP., Culture expanded canine mesenchymal stem cells possess osteochondrogenic potential in vivo and in vitro. Cell Transplant. 1997; 6 (2): 125-34.
    • (1997) Cell Transplant. , vol.6 , Issue.2 , pp. 125-134
    • Kadiyala, S.1    Young, R.G.2    Thiede, M.A.3    Bruder, S.P.4
  • 35
    • 0032029899 scopus 로고    scopus 로고
    • Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells
    • Bruder SP, Kurth AA, Shea M, Hayes WC, Jaiswal N, Kadiyala S., Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells. J Orthop Res. 1998; 16 (2): 155-62.
    • (1998) J Orthop Res. , vol.16 , Issue.2 , pp. 155-162
    • Bruder, S.P.1    Kurth, A.A.2    Shea, M.3    Hayes, W.C.4    Jaiswal, N.5    Kadiyala, S.6
  • 36
    • 0026356843 scopus 로고
    • Autologous marrow injection as a substitute for operative grafting of tibial nonunions
    • Connolly JF, Guse R, Tiedeman J, Dehne R., Autologous marrow injection as a substitute for operative grafting of tibial nonunions. Clin Orthop Relat Res. 1991; (266): 259-70.
    • (1991) Clin Orthop Relat Res. , Issue.266 , pp. 259-270
    • Connolly, J.F.1    Guse, R.2    Tiedeman, J.3    Dehne, R.4
  • 37
    • 0027753808 scopus 로고
    • Percutaneous autogenous bone marrow grafting in 20 cases of ununited fracture
    • Garg NK, Gaur S, Sharma S., Percutaneous autogenous bone marrow grafting in 20 cases of ununited fracture. Acta Orthop Scand. 1993; 64 (6): 671-2.
    • (1993) Acta Orthop Scand. , vol.64 , Issue.6 , pp. 671-672
    • Garg, N.K.1    Gaur, S.2    Sharma, S.3
  • 38
    • 0027683390 scopus 로고
    • Autologous marrow injection in the treatment of delayed and non-union in long bones
    • Sim R, Liang TS, Tay BK., Autologous marrow injection in the treatment of delayed and non-union in long bones. Singapore Med J. 1993; 34 (5): 412-7.
    • (1993) Singapore Med J. , vol.34 , Issue.5 , pp. 412-417
    • Sim, R.1    Liang, T.S.2    Tay, B.K.3
  • 39
    • 70350046985 scopus 로고    scopus 로고
    • Mesenchymal stem cell concentration and bone repair: Potential pitfalls from bench to bedside
    • Cuomo AV, Virk M, Petrigliano F, Morgan EF, Lieberman JR., Mesenchymal stem cell concentration and bone repair: potential pitfalls from bench to bedside. J Bone Joint Surg Am. 2009; 91 (5): 1073-83.
    • (2009) J Bone Joint Surg Am. , vol.91 , Issue.5 , pp. 1073-1083
    • Cuomo, A.V.1    Virk, M.2    Petrigliano, F.3    Morgan, E.F.4    Lieberman, J.R.5
  • 41
    • 84862777340 scopus 로고    scopus 로고
    • Mobilization of bone marrow mesenchymal stem cells in vivo augments bone healing in a mouse model of segmental bone defect
    • Kumar S, Ponnazhagan S., Mobilization of bone marrow mesenchymal stem cells in vivo augments bone healing in a mouse model of segmental bone defect. Bone. 2012; 50 (4): 1012-8.
    • (2012) Bone , vol.50 , Issue.4 , pp. 1012-1018
    • Kumar, S.1    Ponnazhagan, S.2
  • 42
    • 84881113549 scopus 로고    scopus 로고
    • Mobilization of endogenous stem cell populations enhances fracture healing in a murine femoral fracture model
    • Toupadakis CA, Granick JL, Sagy M, et al., Mobilization of endogenous stem cell populations enhances fracture healing in a murine femoral fracture model. Cytotherapy. 2013; 15 (9): 1136-47.
    • (2013) Cytotherapy. , vol.15 , Issue.9 , pp. 1136-1147
    • Toupadakis, C.A.1    Granick, J.L.2    Sagy, M.3
  • 43
    • 62249191413 scopus 로고    scopus 로고
    • Stem cell-mediated accelerated bone healing observed with in vivo molecular and small animal imaging technologies in a model of skeletal injury
    • Lee SW, Padmanabhan P, Ray P, et al., Stem cell-mediated accelerated bone healing observed with in vivo molecular and small animal imaging technologies in a model of skeletal injury. J Orthop Res. 2009; 27 (3): 295-302.
    • (2009) J Orthop Res. , vol.27 , Issue.3 , pp. 295-302
    • Lee, S.W.1    Padmanabhan, P.2    Ray, P.3
  • 44
    • 77952012256 scopus 로고    scopus 로고
    • Mesenchymal stem cells expressing osteogenic and angiogenic factors synergistically enhance bone formation in a mouse model of segmental bone defect
    • Kumar S, Wan C, Ramaswamy G, Clemens TL, Ponnazhagan S., Mesenchymal stem cells expressing osteogenic and angiogenic factors synergistically enhance bone formation in a mouse model of segmental bone defect. Mol Ther. 2010; 18 (5): 1026-34.
    • (2010) Mol Ther. , vol.18 , Issue.5 , pp. 1026-1034
    • Kumar, S.1    Wan, C.2    Ramaswamy, G.3    Clemens, T.L.4    Ponnazhagan, S.5
  • 45
    • 69249162221 scopus 로고    scopus 로고
    • Regenerative effects of transplanted mesenchymal stem cells in fracture healing
    • Granero-Molto F, Weis JA, Miga MI, et al., Regenerative effects of transplanted mesenchymal stem cells in fracture healing. Stem Cells. 2009; 27 (8): 1887-98.
    • (2009) Stem Cells. , vol.27 , Issue.8 , pp. 1887-1898
    • Granero-Molto, F.1    Weis, J.A.2    Miga, M.I.3
  • 46
    • 77954755705 scopus 로고    scopus 로고
    • Endothelial progenitor cells promote fracture healing in a segmental bone defect model
    • Atesok K, Li R, Stewart DJ, Schemitsch EH., Endothelial progenitor cells promote fracture healing in a segmental bone defect model. J Orthop Res. 2010; 28 (8): 1007-14.
    • (2010) J Orthop Res. , vol.28 , Issue.8 , pp. 1007-1014
    • Atesok, K.1    Li, R.2    Stewart, D.J.3    Schemitsch, E.H.4
  • 47
    • 77956218260 scopus 로고    scopus 로고
    • Human adipose derived stromal cells heal critical size mouse calvarial defects
    • Levi B, James AW, Nelson ER, et al., Human adipose derived stromal cells heal critical size mouse calvarial defects. PLoS One. 2010; 5 (6): e11177.
    • (2010) PLoS One. , vol.5 , Issue.6 , pp. e11177
    • Levi, B.1    James, A.W.2    Nelson, E.R.3
  • 48
    • 84859912590 scopus 로고    scopus 로고
    • Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification
    • Wosczyna MN, Biswas AA, Cogswell CA, Goldhamer DJ., Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification. J Bone Miner Res. 2012; 27 (5): 1004-7.
    • (2012) J Bone Miner Res. , vol.27 , Issue.5 , pp. 1004-1007
    • Wosczyna, M.N.1    Biswas, A.A.2    Cogswell, C.A.3    Goldhamer, D.J.4
  • 49
    • 46149102685 scopus 로고    scopus 로고
    • Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles
    • Cerletti M, Jurga S, Witczak CA, et al., Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles. Cell. 2008; 134 (1): 37-47.
    • (2008) Cell. , vol.134 , Issue.1 , pp. 37-47
    • Cerletti, M.1    Jurga, S.2    Witczak, C.A.3
  • 50
    • 74949112463 scopus 로고    scopus 로고
    • Repairing skeletal muscle: Regenerative potential of skeletal muscle stem cells
    • Tedesco FS, Dellavalle A, Diaz-Manera J, Messina G, Cossu G., Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells. J Clin Invest. 2010; 120 (1): 11-9.
    • (2010) J Clin Invest. , vol.120 , Issue.1 , pp. 11-19
    • Tedesco, F.S.1    Dellavalle, A.2    Diaz-Manera, J.3    Messina, G.4    Cossu, G.5
  • 51
    • 77951473740 scopus 로고    scopus 로고
    • Inefficient skeletal muscle repair in inhibitor of differentiation knockout mice suggests a crucial role for BMP signaling during adult muscle regeneration
    • Clever JL, Sakai Y, Wang RA, Schneider DB., Inefficient skeletal muscle repair in inhibitor of differentiation knockout mice suggests a crucial role for BMP signaling during adult muscle regeneration. Am J Physiol Cell Physiol. 2010; 298 (5): C1087-99.
    • (2010) Am J Physiol Cell Physiol. , vol.298 , Issue.5 , pp. C1087-C1099
    • Clever, J.L.1    Sakai, Y.2    Wang, R.A.3    Schneider, D.B.4
  • 52
    • 79951534491 scopus 로고    scopus 로고
    • Origin of muscle satellite cells in the Xenopus embryo
    • Daughters RS, Chen Y, Slack JM., Origin of muscle satellite cells in the Xenopus embryo. Development. 2011; 138 (5): 821-30.
    • (2011) Development. , vol.138 , Issue.5 , pp. 821-830
    • Daughters, R.S.1    Chen, Y.2    Slack, J.M.3
  • 53
    • 84867676626 scopus 로고    scopus 로고
    • The aged niche disrupts muscle stem cell quiescence
    • Chakkalakal JV, Jones KM, Basson MA, Brack AS., The aged niche disrupts muscle stem cell quiescence. Nature. 2012; 490 (7420): 355-60.
    • (2012) Nature. , vol.490 , Issue.7420 , pp. 355-360
    • Chakkalakal, J.V.1    Jones, K.M.2    Basson, M.A.3    Brack, A.S.4
  • 54
    • 84894251134 scopus 로고    scopus 로고
    • Ageing: Genetic rejuvenation of old muscle
    • Li M, Izpisua Belmonte JC., Ageing: genetic rejuvenation of old muscle. Nature. 2014; 506 (7488): 304-5.
    • (2014) Nature. , vol.506 , Issue.7488 , pp. 304-305
    • Li, M.1    Izpisua Belmonte, J.C.2
  • 55
    • 84900323323 scopus 로고    scopus 로고
    • Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle
    • Sinha M, Jang YC, Oh J, et al., Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science. 2014; 344 (6184): 649-52.
    • (2014) Science. , vol.344 , Issue.6184 , pp. 649-652
    • Sinha, M.1    Jang, Y.C.2    Oh, J.3
  • 56
    • 84870036897 scopus 로고    scopus 로고
    • Cell-autonomous Notch activity maintains the temporal specification potential of skeletal muscle stem cells
    • Mourikis P, Gopalakrishnan S, Sambasivan R, Tajbakhsh S., Cell-autonomous Notch activity maintains the temporal specification potential of skeletal muscle stem cells. Development. 2012; 139 (24): 4536-48.
    • (2012) Development. , vol.139 , Issue.24 , pp. 4536-4548
    • Mourikis, P.1    Gopalakrishnan, S.2    Sambasivan, R.3    Tajbakhsh, S.4
  • 58
    • 79952177539 scopus 로고    scopus 로고
    • Enhancement of bone morphogenetic protein-2-induced ectopic bone formation by transforming growth factor-beta1
    • Tachi K, Takami M, Sato H, et al., Enhancement of bone morphogenetic protein-2-induced ectopic bone formation by transforming growth factor-beta1. Tissue Eng Part A. 2011; 17 (5-6): 597-606.
    • (2011) Tissue Eng Part A. , vol.17 , Issue.56 , pp. 597-606
    • Tachi, K.1    Takami, M.2    Sato, H.3
  • 59
    • 84055213708 scopus 로고    scopus 로고
    • Myogenic progenitors contribute to open but not closed fracture repair
    • Liu R, Birke O, Morse A, et al., Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskelet Disord. 2011; 12: 288.
    • (2011) BMC Musculoskelet Disord. , vol.12 , pp. 288
    • Liu, R.1    Birke, O.2    Morse, A.3
  • 60
    • 84896851309 scopus 로고    scopus 로고
    • Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH1-3
    • Yukata K, Xie C, Li TF, et al., Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH1-3. treatment. Bone. 2014; 62: 79-89.
    • (2014) Treatment. Bone. , vol.62 , pp. 79-89
    • Yukata, K.1    Xie, C.2    Li, T.F.3
  • 61
    • 84899082536 scopus 로고    scopus 로고
    • Analysis of αsMA-labeled progenitor cell commitment identifies Notch signaling as an important pathway in fracture healing
    • Matthews BG, Grcevic D, Wang L, et al., Analysis of αSMA-labeled progenitor cell commitment identifies Notch signaling as an important pathway in fracture healing. J Bone Miner Res. 2014; 29 (5): 1283-94.
    • (2014) J Bone Miner Res , vol.29 , Issue.5 , pp. 1283-1294
    • Matthews, B.G.1    Grcevic, D.2    Wang, L.3
  • 62
    • 28144436728 scopus 로고    scopus 로고
    • Periosteal progenitor cell fate in segmental cortical bone graft transplantations: Implications for functional tissue engineering
    • Zhang X, Xie C, Lin AS, et al., Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering. J Bone Miner Res. 2005; 20 (12): 2124-37.
    • (2005) J Bone Miner Res. , vol.20 , Issue.12 , pp. 2124-2137
    • Zhang, X.1    Xie, C.2    Lin, A.S.3
  • 63
    • 84879422083 scopus 로고    scopus 로고
    • Effects of radiation and surgery on healing of femoral fractures in a rat model
    • Nicholls F, Janic K, Filomeno P, Willett T, Grynpas M, Ferguson P., Effects of radiation and surgery on healing of femoral fractures in a rat model. J Orthop Res. 2013; 31 (8): 1323-31.
    • (2013) J Orthop Res. , vol.31 , Issue.8 , pp. 1323-1331
    • Nicholls, F.1    Janic, K.2    Filomeno, P.3    Willett, T.4    Grynpas, M.5    Ferguson, P.6
  • 64
    • 84859919522 scopus 로고    scopus 로고
    • Therapeutic effect of local administration of low-dose simvastatin-conjugated gelatin hydrogel for fracture healing
    • Fukui T, Ii M, Shoji T, et al., Therapeutic effect of local administration of low-dose simvastatin-conjugated gelatin hydrogel for fracture healing. J Bone Miner Res. 2012; 27 (5): 1118-31.
    • (2012) J Bone Miner Res. , vol.27 , Issue.5 , pp. 1118-1131
    • Fukui, T.1    Ii, M.2    Shoji, T.3
  • 65
    • 78650203492 scopus 로고    scopus 로고
    • Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: Implication for postnatal bone repair
    • Wang Q, Huang C, Zeng F, Xue M, Zhang X., Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair. Am J Pathol. 2010; 177 (6): 3100-11.
    • (2010) Am J Pathol. , vol.177 , Issue.6 , pp. 3100-3111
    • Wang, Q.1    Huang, C.2    Zeng, F.3    Xue, M.4    Zhang, X.5
  • 66
    • 77952966866 scopus 로고    scopus 로고
    • RBMP represses Wnt signaling and influences skeletal progenitor cell fate specification during bone repair
    • Minear S, Leucht P, Miller S, Helms JA., rBMP represses Wnt signaling and influences skeletal progenitor cell fate specification during bone repair. J Bone Miner Res. 2010; 25 (6): 1196-207.
    • (2010) J Bone Miner Res. , vol.25 , Issue.6 , pp. 1196-1207
    • Minear, S.1    Leucht, P.2    Miller, S.3    Helms, J.A.4
  • 67
    • 33751506452 scopus 로고    scopus 로고
    • BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing
    • Tsuji K, Bandyopadhyay A, Harfe BD, et al., BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet. 2006; 38 (12): 1424-9.
    • (2006) Nat Genet. , vol.38 , Issue.12 , pp. 1424-1429
    • Tsuji, K.1    Bandyopadhyay, A.2    Harfe, B.D.3
  • 68
    • 84883225977 scopus 로고    scopus 로고
    • The effect of mesenchymal stem cells delivered via hydrogel-based tissue engineered periosteum on bone allograft healing
    • Hoffman MD, Xie C, Zhang X, Benoit DS., The effect of mesenchymal stem cells delivered via hydrogel-based tissue engineered periosteum on bone allograft healing. Biomaterials. 2013; 34 (35): 8887-98.
    • (2013) Biomaterials. , vol.34 , Issue.35 , pp. 8887-8898
    • Hoffman, M.D.1    Xie, C.2    Zhang, X.3    Benoit, D.S.4
  • 69
    • 79952392109 scopus 로고    scopus 로고
    • Comparative study between tissue-engineered periosteum and structural allograft in rabbit critical-sized radial defect model
    • Zhao L, Zhao J, Wang S, Wang J, Liu J., Comparative study between tissue-engineered periosteum and structural allograft in rabbit critical-sized radial defect model. J Biomed Mater Res B Appl Biomater. 2011; 97 (1): 1-9.
    • (2011) J Biomed Mater Res B Appl Biomater. , vol.97 , Issue.1 , pp. 1-9
    • Zhao, L.1    Zhao, J.2    Wang, S.3    Wang, J.4    Liu, J.5
  • 70
    • 0034953367 scopus 로고    scopus 로고
    • Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling
    • Gerstenfeld LC, Cho TJ, Kon T, et al., Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling. Cells Tissues Organs. 2001; 169 (3): 285-94.
    • (2001) Cells Tissues Organs. , vol.169 , Issue.3 , pp. 285-294
    • Gerstenfeld, L.C.1    Cho, T.J.2    Kon, T.3
  • 71
    • 57049122815 scopus 로고    scopus 로고
    • COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing
    • Xie C, Ming X, Wang Q, et al., COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing. Bone. 2008; 43 (6): 1075-83.
    • (2008) Bone , vol.43 , Issue.6 , pp. 1075-1083
    • Xie, C.1    Ming, X.2    Wang, Q.3
  • 72
    • 68449103187 scopus 로고    scopus 로고
    • -/- mice via activation of prostaglandin E2 receptor subtype 4
    • -/- mice via activation of prostaglandin E2 receptor subtype 4. Am J Pathol. 2009; 175 (2): 772-85.
    • (2009) Am J Pathol. , vol.175 , Issue.2 , pp. 772-785
    • Xie, C.1    Liang, B.2    Xue, M.3
  • 73
    • 34249729416 scopus 로고    scopus 로고
    • Prostaglandin e receptors
    • Sugimoto Y, Narumiya S., Prostaglandin E receptors. J Biol Chem. 2007; 282 (16): 11613-7.
    • (2007) J Biol Chem. , vol.282 , Issue.16 , pp. 11613-11617
    • Sugimoto, Y.1    Narumiya, S.2
  • 74
    • 58649121014 scopus 로고    scopus 로고
    • Reduced COX-2 expression in aged mice is associated with impaired fracture healing
    • Naik AA, Xie C, Zuscik MJ, et al., Reduced COX-2 expression in aged mice is associated with impaired fracture healing. J Bone Miner Res. 2009; 24 (2): 251-64.
    • (2009) J Bone Miner Res. , vol.24 , Issue.2 , pp. 251-264
    • Naik, A.A.1    Xie, C.2    Zuscik, M.J.3
  • 75
    • 79953056654 scopus 로고    scopus 로고
    • EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair
    • Zhang M, Ho HC, Sheu TJ, et al., EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair. J Bone Miner Res. 2011; 26 (4): 792-802.
    • (2011) J Bone Miner Res. , vol.26 , Issue.4 , pp. 792-802
    • Zhang, M.1    Ho, H.C.2    Sheu, T.J.3
  • 77
    • 73949157583 scopus 로고    scopus 로고
    • Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair
    • Tsuji K, Cox K, Gamer L, Graf D, Economides A, Rosen V., Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair. J Orthop Res. 2010; 28 (3): 384-9.
    • (2010) J Orthop Res. , vol.28 , Issue.3 , pp. 384-389
    • Tsuji, K.1    Cox, K.2    Gamer, L.3    Graf, D.4    Economides, A.5    Rosen, V.6
  • 78
    • 0036899744 scopus 로고    scopus 로고
    • BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: A prospective, controlled, randomized study of four hundred and fifty patients
    • Govender S, Csimma C, Genant HK, et al., BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am. 2002; 84-A (12): 2123-34.
    • (2002) J Bone Joint Surg Am. , vol.84 , Issue.12 , pp. 2123-2134
    • Govender, S.1    Csimma, C.2    Genant, H.K.3
  • 80
    • 33744824348 scopus 로고    scopus 로고
    • Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation
    • Zhong N, Gersch RP, Hadjiargyrou M., Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation. Bone. 2006; 39 (1): 5-16.
    • (2006) Bone , vol.39 , Issue.1 , pp. 5-16
    • Zhong, N.1    Gersch, R.P.2    Hadjiargyrou, M.3
  • 81
    • 40149087343 scopus 로고    scopus 로고
    • Beta-catenin-dependent Wnt signaling in mandibular bone regeneration
    • (Suppl 1)
    • Leucht P, Kim JB, Helms JA., Beta-catenin-dependent Wnt signaling in mandibular bone regeneration. J Bone Joint Surg Am. 2008; 90 (Suppl 1): 3-8.
    • (2008) J Bone Joint Surg Am. , vol.90 , pp. 3-8
    • Leucht, P.1    Kim, J.B.2    Helms, J.A.3
  • 82
    • 83855162879 scopus 로고    scopus 로고
    • Inhibition of beta-catenin signaling in chondrocytes induces delayed fracture healing in mice
    • Huang Y, Zhang X, Du K, et al., Inhibition of beta-catenin signaling in chondrocytes induces delayed fracture healing in mice. J Orthop Res. 2012; 30 (2): 304-10.
    • (2012) J Orthop Res. , vol.30 , Issue.2 , pp. 304-310
    • Huang, Y.1    Zhang, X.2    Du, K.3
  • 84
    • 84888846084 scopus 로고    scopus 로고
    • Sclerostin deficient mice rapidly heal bone defects by activating beta-catenin and increasing intramembranous ossification
    • McGee-Lawrence ME, Ryan ZC, Carpio LR, Kakar S, Westendorf JJ, Kumar R., Sclerostin deficient mice rapidly heal bone defects by activating beta-catenin and increasing intramembranous ossification. Biochem Biophys Res Commun. 2013; 441 (4): 886-90.
    • (2013) Biochem Biophys Res Commun. , vol.441 , Issue.4 , pp. 886-890
    • McGee-Lawrence, M.E.1    Ryan, Z.C.2    Carpio, L.R.3    Kakar, S.4    Westendorf, J.J.5    Kumar, R.6
  • 85
    • 84887053589 scopus 로고    scopus 로고
    • Acceleration of bone development and regeneration through the Wnt/beta-catenin signaling pathway in mice heterozygously deficient for GSK-3beta
    • Arioka M, Takahashi-Yanaga F, Sasaki M, et al., Acceleration of bone development and regeneration through the Wnt/beta-catenin signaling pathway in mice heterozygously deficient for GSK-3beta. Biochem Biophys Res Commun. 2013; 440 (4): 677-82.
    • (2013) Biochem Biophys Res Commun. , vol.440 , Issue.4 , pp. 677-682
    • Arioka, M.1    Takahashi-Yanaga, F.2    Sasaki, M.3
  • 86
    • 77952989890 scopus 로고    scopus 로고
    • Wnt proteins promote bone regeneration
    • Minear S, Leucht P, Jiang J, et al., Wnt proteins promote bone regeneration. Sci Transl Med. 2010; 2 (29): 29-30.
    • (2010) Sci Transl Med. , vol.2 , Issue.29 , pp. 29-30
    • Minear, S.1    Leucht, P.2    Jiang, J.3
  • 87
    • 84883812680 scopus 로고    scopus 로고
    • Human stem cell osteoblastogenesis mediated by novel glycogen synthase kinase 3 inhibitors induces bone formation and a unique bone turnover biomarker profile in rats
    • Gilmour PS, O'Shea PJ, Fagura M, et al., Human stem cell osteoblastogenesis mediated by novel glycogen synthase kinase 3 inhibitors induces bone formation and a unique bone turnover biomarker profile in rats. Toxicol Appl Pharmacol. 2013; 272 (2): 399-407.
    • (2013) Toxicol Appl Pharmacol. , vol.272 , Issue.2 , pp. 399-407
    • Gilmour, P.S.1    O'Shea, P.J.2    Fagura, M.3
  • 88
    • 81855184668 scopus 로고    scopus 로고
    • Determinants of serum sclerostin in healthy pre- and postmenopausal women
    • Ardawi MS, Al-Kadi HA, Rouzi AA, Qari MH., Determinants of serum sclerostin in healthy pre- and postmenopausal women. J Bone Miner Res. 2011; 26 (12): 2812-22.
    • (2011) J Bone Miner Res. , vol.26 , Issue.12 , pp. 2812-2822
    • Ardawi, M.S.1    Al-Kadi, H.A.2    Rouzi, A.A.3    Qari, M.H.4
  • 89
    • 34547604106 scopus 로고    scopus 로고
    • Beta-catenin signaling plays a disparate role in different phases of fracture repair: Implications for therapy to improve bone healing
    • Chen Y, Whetstone HC, Lin AC, et al., Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. PLoS Med. 2007; 4 (7): e249.
    • (2007) PLoS Med. , vol.4 , Issue.7 , pp. e249
    • Chen, Y.1    Whetstone, H.C.2    Lin, A.C.3
  • 90
    • 65549129938 scopus 로고    scopus 로고
    • Secreted frizzled related protein 1 is a target to improve fracture healing
    • Gaur T, Wixted JJ, Hussain S, et al., Secreted frizzled related protein 1 is a target to improve fracture healing. J Cell Physiol. 2009; 220 (1): 174-81.
    • (2009) J Cell Physiol. , vol.220 , Issue.1 , pp. 174-181
    • Gaur, T.1    Wixted, J.J.2    Hussain, S.3
  • 91
    • 2442481882 scopus 로고    scopus 로고
    • Impairment of bone healing by insulin receptor substrate-1 deficiency
    • Shimoaka T, Kamekura S, Chikuda H, et al., Impairment of bone healing by insulin receptor substrate-1 deficiency. J Biol Chem. 2004; 279 (15): 15314-22.
    • (2004) J Biol Chem. , vol.279 , Issue.15 , pp. 15314-15322
    • Shimoaka, T.1    Kamekura, S.2    Chikuda, H.3
  • 92
    • 84860849772 scopus 로고    scopus 로고
    • A2B adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo
    • Carroll SH, Wigner NA, Kulkarni N, Johnston-Cox H, Gerstenfeld LC, Ravid K., A2B adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo. J Biol Chem. 2012; 287 (19): 15718-27.
    • (2012) J Biol Chem. , vol.287 , Issue.19 , pp. 15718-15727
    • Carroll, S.H.1    Wigner, N.A.2    Kulkarni, N.3    Johnston-Cox, H.4    Gerstenfeld, L.C.5    Ravid, K.6
  • 93
    • 21644439556 scopus 로고    scopus 로고
    • Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PT H(1-34)
    • Wang L, Quarles LD, Spurney RF., Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PT H(1-34). J Bone Miner Res. 2004; 19 (10): 1661-70.
    • (2004) J Bone Miner Res. , vol.19 , Issue.10 , pp. 1661-1670
    • Wang, L.1    Quarles, L.D.2    Spurney, R.F.3
  • 94
    • 0036092313 scopus 로고    scopus 로고
    • Diminished callus size and cartilage synthesis in alpha 1 beta 1 integrin-deficient mice during bone fracture healing
    • Ekholm E, Hankenson KD, Uusitalo H, et al., Diminished callus size and cartilage synthesis in alpha 1 beta 1 integrin-deficient mice during bone fracture healing. Am J Pathol. 2002; 160 (5): 1779-85.
    • (2002) Am J Pathol. , vol.160 , Issue.5 , pp. 1779-1785
    • Ekholm, E.1    Hankenson, K.D.2    Uusitalo, H.3
  • 95
    • 79959509852 scopus 로고    scopus 로고
    • Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment
    • Saeed H, Abdallah BM, Ditzel N, et al., Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment. J Bone Miner Res. 2011; 26 (7): 1494-505.
    • (2011) J Bone Miner Res. , vol.26 , Issue.7 , pp. 1494-1505
    • Saeed, H.1    Abdallah, B.M.2    Ditzel, N.3
  • 97
    • 79951812916 scopus 로고    scopus 로고
    • Telomere dysfunction induces metabolic and mitochondrial compromise
    • Sahin E, Colla S, Liesa M, et al., Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 2011; 470 (7334): 359-65.
    • (2011) Nature. , vol.470 , Issue.7334 , pp. 359-365
    • Sahin, E.1    Colla, S.2    Liesa, M.3
  • 98
    • 77955842046 scopus 로고    scopus 로고
    • The role of telomeres and telomerase in stem cell aging
    • Flores I, Blasco MA., The role of telomeres and telomerase in stem cell aging. FEBS Lett. 2010; 584 (17): 3826-30.
    • (2010) FEBS Lett. , vol.584 , Issue.17 , pp. 3826-3830
    • Flores, I.1    Blasco, M.A.2
  • 99
    • 84860456242 scopus 로고    scopus 로고
    • Removal of shelterin reveals the telomere end-protection problem
    • Sfeir A, de Lange T., Removal of shelterin reveals the telomere end-protection problem. Science. 2012; 336 (6081): 593-7.
    • (2012) Science. , vol.336 , Issue.6081 , pp. 593-597
    • Sfeir, A.1    De Lange, T.2
  • 100
    • 78349270933 scopus 로고    scopus 로고
    • Role of shelterin in cancer and aging
    • Martinez P, Blasco MA., Role of shelterin in cancer and aging. Aging Cell. 2010; 9 (5): 653-66.
    • (2010) Aging Cell. , vol.9 , Issue.5 , pp. 653-666
    • Martinez, P.1    Blasco, M.A.2
  • 101
    • 84867304481 scopus 로고    scopus 로고
    • The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures
    • Barefield C, Karlseder J., The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures. Nucleic Acids Res. 2012; 40 (15): 7358-67.
    • (2012) Nucleic Acids Res. , vol.40 , Issue.15 , pp. 7358-7367
    • Barefield, C.1    Karlseder, J.2
  • 102
    • 84887541042 scopus 로고    scopus 로고
    • Genomic characterization of the inherited bone marrow failure syndromes
    • Khincha PP, Savage SA., Genomic characterization of the inherited bone marrow failure syndromes. Semin Hematol. 2013; 50 (4): 333-47.
    • (2013) Semin Hematol. , vol.50 , Issue.4 , pp. 333-347
    • Khincha, P.P.1    Savage, S.A.2
  • 103
    • 79953692083 scopus 로고    scopus 로고
    • Sequence analysis of the shelterin telomere protection complex genes in dyskeratosis congenita
    • Savage SA, Giri N, Jessop L, et al., Sequence analysis of the shelterin telomere protection complex genes in dyskeratosis congenita. J Med Genet. 2011; 48 (4): 285-8.
    • (2011) J Med Genet. , vol.48 , Issue.4 , pp. 285-288
    • Savage, S.A.1    Giri, N.2    Jessop, L.3
  • 104
    • 48749086322 scopus 로고    scopus 로고
    • Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells
    • Breault DT, Min IM, Carlone DL, et al., Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc Natl Acad Sci U S A. 2008; 105 (30): 10420-5.
    • (2008) Proc Natl Acad Sci U S A. , vol.105 , Issue.30 , pp. 10420-10425
    • Breault, D.T.1    Min, I.M.2    Carlone, D.L.3
  • 105
    • 40349085766 scopus 로고    scopus 로고
    • The longest telomeres: A general signature of adult stem cell compartments
    • Flores I, Canela A, Vera E, Tejera A, Cotsarelis G, Blasco MA., The longest telomeres: a general signature of adult stem cell compartments. Genes Dev. 2008; 22 (5): 654-67.
    • (2008) Genes Dev. , vol.22 , Issue.5 , pp. 654-667
    • Flores, I.1    Canela, A.2    Vera, E.3    Tejera, A.4    Cotsarelis, G.5    Blasco, M.A.6
  • 106
    • 70349559751 scopus 로고    scopus 로고
    • P53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
    • Begus-Nahrmann Y, Lechel A, Obenauf AC, et al., p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nat Genet. 2009; 41 (10): 1138-43.
    • (2009) Nat Genet. , vol.41 , Issue.10 , pp. 1138-1143
    • Begus-Nahrmann, Y.1    Lechel, A.2    Obenauf, A.C.3
  • 107
    • 1542781658 scopus 로고    scopus 로고
    • Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence
    • Pelicci PG., Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence ? J Clin Invest. 2004; 113 (1): 4-7.
    • (2004) J Clin Invest. , vol.113 , Issue.1 , pp. 4-7
    • Pelicci, P.G.1
  • 108
    • 84884412859 scopus 로고    scopus 로고
    • Usp16 contributes to somatic stem-cell defects in Down's syndrome
    • Adorno M, Sikandar S, Mitra SS, et al., Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature. 2013; 501 (7467): 380-4.
    • (2013) Nature. , vol.501 , Issue.7467 , pp. 380-384
    • Adorno, M.1    Sikandar, S.2    Mitra, S.S.3
  • 109
    • 33845892109 scopus 로고    scopus 로고
    • Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
    • Choudhury AR, Ju Z, Djojosubroto MW, et al., Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet. 2007; 39 (1): 99-105.
    • (2007) Nat Genet. , vol.39 , Issue.1 , pp. 99-105
    • Choudhury, A.R.1    Ju, Z.2    Djojosubroto, M.W.3
  • 110
    • 33749172559 scopus 로고    scopus 로고
    • Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
    • Janzen V, Forkert R, Fleming HE, et al., Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature. 2006; 443 (7110): 421-6.
    • (2006) Nature. , vol.443 , Issue.7110 , pp. 421-426
    • Janzen, V.1    Forkert, R.2    Fleming, H.E.3
  • 111
    • 63349092825 scopus 로고    scopus 로고
    • A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres
    • Flores I, Blasco MA., A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres. PLoS One. 2009; 4 (3): e4934.
    • (2009) PLoS One. , vol.4 , Issue.3 , pp. e4934
    • Flores, I.1    Blasco, M.A.2
  • 113
    • 77950265945 scopus 로고    scopus 로고
    • Linking functional decline of telomeres, mitochondria and stem cells during ageing
    • Sahin E, Depinho RA., Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature. 2010; 464 (7288): 520-8.
    • (2010) Nature. , vol.464 , Issue.7288 , pp. 520-528
    • Sahin, E.1    Depinho, R.A.2
  • 114
    • 49649090009 scopus 로고    scopus 로고
    • Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease
    • Jiang H, Schiffer E, Song Z, et al., Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proc Natl Acad Sci U S A. 2008; 105 (32): 11299-304.
    • (2008) Proc Natl Acad Sci U S A. , vol.105 , Issue.32 , pp. 11299-11304
    • Jiang, H.1    Schiffer, E.2    Song, Z.3
  • 115
    • 33847027624 scopus 로고    scopus 로고
    • Genes with greater up-regulation in the fracture callus of older rats with delayed healing
    • Meyer MH, Meyer RA Jr., Genes with greater up-regulation in the fracture callus of older rats with delayed healing. J Orthop Res. 2007; 25 (4): 488-94.
    • (2007) J Orthop Res. , vol.25 , Issue.4 , pp. 488-494
    • Meyer, M.H.1    Meyer, Jr.R.A.2
  • 116
    • 32944462633 scopus 로고    scopus 로고
    • Risk factors, treatment, and outcomes associated with nonunion of the midshaft humerus fracture
    • Green E, Lubahn JD, Evans J., Risk factors, treatment, and outcomes associated with nonunion of the midshaft humerus fracture. J Surg Orthop Adv. 2005; 14 (2): 64-72.
    • (2005) J Surg Orthop Adv. , vol.14 , Issue.2 , pp. 64-72
    • Green, E.1    Lubahn, J.D.2    Evans, J.3
  • 118
    • 84883867456 scopus 로고    scopus 로고
    • Wnt3a reestablishes osteogenic capacity to bone grafts from aged animals
    • Leucht P, Jiang J, Cheng D, et al., Wnt3a reestablishes osteogenic capacity to bone grafts from aged animals. J Bone Joint Surg Am. 2013; 95 (14): 1278-88.
    • (2013) J Bone Joint Surg Am. , vol.95 , Issue.14 , pp. 1278-1288
    • Leucht, P.1    Jiang, J.2    Cheng, D.3
  • 119
    • 75749090492 scopus 로고    scopus 로고
    • Systemic signals regulate ageing and rejuvenation of blood stem cell niches
    • Mayack SR, Shadrach JL, Kim FS, Wagers AJ., Systemic signals regulate ageing and rejuvenation of blood stem cell niches. Nature. 2010; 463 (7280): 495-500.
    • (2010) Nature. , vol.463 , Issue.7280 , pp. 495-500
    • Mayack, S.R.1    Shadrach, J.L.2    Kim, F.S.3    Wagers, A.J.4
  • 120
    • 84867208183 scopus 로고    scopus 로고
    • Age-associated inflammation inhibits epidermal stem cell function
    • Doles J, Storer M, Cozzuto L, Roma G, Keyes WM., Age-associated inflammation inhibits epidermal stem cell function. Genes Dev. 2012; 26 (19): 2144-53.
    • (2012) Genes Dev. , vol.26 , Issue.19 , pp. 2144-2153
    • Doles, J.1    Storer, M.2    Cozzuto, L.3    Roma, G.4    Keyes, W.M.5
  • 121
    • 77953402288 scopus 로고    scopus 로고
    • Restoration of regenerative osteoblastogenesis in aged mice: Modulation of TNF
    • Wahl EC, Aronson J, Liu L, et al., Restoration of regenerative osteoblastogenesis in aged mice: modulation of TNF. J Bone Miner Res. 2010; 25 (1): 114-23.
    • (2010) J Bone Miner Res. , vol.25 , Issue.1 , pp. 114-123
    • Wahl, E.C.1    Aronson, J.2    Liu, L.3
  • 122
    • 77954717770 scopus 로고    scopus 로고
    • Rejuvenation of the inflammatory system stimulates fracture repair in aged mice
    • Xing Z, Lu C, Hu D, Miclau T 3rd, Marcucio RS., Rejuvenation of the inflammatory system stimulates fracture repair in aged mice. J Orthop Res. 2010; 28 (8): 1000-6.
    • (2010) J Orthop Res. , vol.28 , Issue.8 , pp. 1000-1006
    • Xing, Z.1    Lu, C.2    Hu, D.3    Miclau, T.4    Marcucio, R.S.5
  • 123
    • 84857831360 scopus 로고    scopus 로고
    • Nicotine replacement for smoking cessation during pregnancy
    • Oncken C., Nicotine replacement for smoking cessation during pregnancy. N Engl J Med. 2012; 366 (9): 846-7.
    • (2012) N Engl J Med. , vol.366 , Issue.9 , pp. 846-847
    • Oncken, C.1
  • 124
    • 84893848184 scopus 로고    scopus 로고
    • Nicotine content of electronic cigarettes, its release in vapour and its consistency across batches: Regulatory implications
    • Mar;
    • Goniewicz ML, Hajek P, McRobbie H., Nicotine content of electronic cigarettes, its release in vapour and its consistency across batches: regulatory implications. Addiction. 2014 Mar; 109 (3): 500-7.
    • (2014) Addiction. , vol.109 , Issue.3 , pp. 500-507
    • Goniewicz, M.L.1    Hajek, P.2    McRobbie, H.3
  • 125
    • 33845532070 scopus 로고    scopus 로고
    • Nicotine intake and dose response when smoking reduced-nicotine content cigarettes
    • Benowitz NL, Jacob P 3rd, Herrera B., Nicotine intake and dose response when smoking reduced-nicotine content cigarettes. Clin Pharmacol Ther. 2006; 80 (6): 703-14.
    • (2006) Clin Pharmacol Ther. , vol.80 , Issue.6 , pp. 703-714
    • Benowitz, N.L.1    Jacob, P.2    Herrera, B.3
  • 126
    • 68949146637 scopus 로고    scopus 로고
    • Nicotine modulates bone metabolism-associated gene expression in osteoblast cells
    • Rothem DE, Rothem L, Soudry M, Dahan A, Eliakim R., Nicotine modulates bone metabolism-associated gene expression in osteoblast cells. J Bone Miner Metab. 2009; 27 (5): 555-61.
    • (2009) J Bone Miner Metab. , vol.27 , Issue.5 , pp. 555-561
    • Rothem, D.E.1    Rothem, L.2    Soudry, M.3    Dahan, A.4    Eliakim, R.5
  • 127
    • 84879182798 scopus 로고    scopus 로고
    • Dose-dependent effects of nicotine on proliferation and differentiation of human bone marrow stromal cells and the antagonistic action of Vitamin C
    • Shen Y, Liu HX, Ying XZ, et al., Dose-dependent effects of nicotine on proliferation and differentiation of human bone marrow stromal cells and the antagonistic action of vitamin C. J Cell Biochem. 2013; 114 (8): 1720-8.
    • (2013) J Cell Biochem. , vol.114 , Issue.8 , pp. 1720-1728
    • Shen, Y.1    Liu, H.X.2    Ying, X.Z.3
  • 128
    • 79952701242 scopus 로고    scopus 로고
    • Nicotinic modulation of gene expression in osteoblast cells
    • Rothem DE, Rothem L, Dahan A, Eliakim R, Soudry M., Nicotinic modulation of gene expression in osteoblast cells. MG-63. Bone. 2011; 48 (4): 903-9.
    • (2011) MG-63. Bone. , vol.48 , Issue.4 , pp. 903-909
    • Rothem, D.E.1    Rothem, L.2    Dahan, A.3    Eliakim, R.4    Soudry, M.5
  • 129
    • 54449088019 scopus 로고    scopus 로고
    • Nicotine induces cell proliferation in association with cyclin D1 up-regulation and inhibits cell differentiation in association with p53 regulation in a murine pre-osteoblastic cell line
    • Sato T, Abe T, Nakamoto N, et al., Nicotine induces cell proliferation in association with cyclin D1 up-regulation and inhibits cell differentiation in association with p53 regulation in a murine pre-osteoblastic cell line. Biochem Biophys Res Commun. 2008; 377 (1): 126-30.
    • (2008) Biochem Biophys Res Commun. , vol.377 , Issue.1 , pp. 126-130
    • Sato, T.1    Abe, T.2    Nakamoto, N.3
  • 130
    • 77958192876 scopus 로고    scopus 로고
    • Suppressive effects of nicotine on the cytodifferentiation of murine periodontal ligament cells
    • Yanagita M, Kojima Y, Kawahara T, et al., Suppressive effects of nicotine on the cytodifferentiation of murine periodontal ligament cells. Oral Dis. 2010; 16 (8): 812-7.
    • (2010) Oral Dis. , vol.16 , Issue.8 , pp. 812-817
    • Yanagita, M.1    Kojima, Y.2    Kawahara, T.3
  • 131
    • 79958783108 scopus 로고    scopus 로고
    • Influence of low-dose nicotine on bone healing
    • Ma L, Sham MH, Zheng LW, Cheung LK., Influence of low-dose nicotine on bone healing. J Trauma. 2011; 70 (6): E117-21.
    • (2011) J Trauma. , vol.70 , Issue.6 , pp. E117-E121
    • Ma, L.1    Sham, M.H.2    Zheng, L.W.3    Cheung, L.K.4
  • 132
    • 77953529300 scopus 로고    scopus 로고
    • Uncoupled angiogenesis and osteogenesis in nicotine-compromised bone healing
    • Ma L, Zheng LW, Sham MH, Cheung LK., Uncoupled angiogenesis and osteogenesis in nicotine-compromised bone healing. J Bone Miner Res. 2010; 25 (6): 1305-13.
    • (2010) J Bone Miner Res. , vol.25 , Issue.6 , pp. 1305-1313
    • Ma, L.1    Zheng, L.W.2    Sham, M.H.3    Cheung, L.K.4
  • 133
    • 84870242116 scopus 로고    scopus 로고
    • The effect of transdermal nicotine on fracture healing in a rabbit model
    • Donigan JA, Fredericks DC, Nepola JV, Smucker JD., The effect of transdermal nicotine on fracture healing in a rabbit model. J Orthop Trauma. 2012; 26 (12): 724-7.
    • (2012) J Orthop Trauma. , vol.26 , Issue.12 , pp. 724-727
    • Donigan, J.A.1    Fredericks, D.C.2    Nepola, J.V.3    Smucker, J.D.4
  • 134
    • 66149124107 scopus 로고    scopus 로고
    • The multiple faces of nicotine and its implications in tissue and wound repair
    • Martin JW, Mousa SS, Shaker O, Mousa SA., The multiple faces of nicotine and its implications in tissue and wound repair. Exp Dermatol. 2009; 18 (6): 497-505.
    • (2009) Exp Dermatol. , vol.18 , Issue.6 , pp. 497-505
    • Martin, J.W.1    Mousa, S.S.2    Shaker, O.3    Mousa, S.A.4
  • 135
    • 77955871103 scopus 로고    scopus 로고
    • Effect of nicotine and tobacco administration method on the mechanical properties of healing bone following closed fracture
    • Hastrup SG, Chen X, Bechtold JE, et al., Effect of nicotine and tobacco administration method on the mechanical properties of healing bone following closed fracture. J Orthop Res. 2010; 28 (9): 1235-9.
    • (2010) J Orthop Res. , vol.28 , Issue.9 , pp. 1235-1239
    • Hastrup, S.G.1    Chen, X.2    Bechtold, J.E.3
  • 136
    • 33845896577 scopus 로고    scopus 로고
    • Smoking delays chondrogenesis in a mouse model of closed tibial fracture healing
    • El-Zawawy HB, Gill CS, Wright RW, Sandell LJ., Smoking delays chondrogenesis in a mouse model of closed tibial fracture healing. J Orthop Res. 2006; 24 (12): 2150-8.
    • (2006) J Orthop Res. , vol.24 , Issue.12 , pp. 2150-2158
    • El-Zawawy, H.B.1    Gill, C.S.2    Wright, R.W.3    Sandell, L.J.4
  • 137
    • 84155192347 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a)pyrene
    • Kung MH, Yukata K, O'Keefe RJ, Zuscik MJ., Aryl hydrocarbon receptor-mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a)pyrene. J Cell Physiol. 2012; 227 (3): 1062-70.
    • (2012) J Cell Physiol. , vol.227 , Issue.3 , pp. 1062-1070
    • Kung, M.H.1    Yukata, K.2    O'Keefe, R.J.3    Zuscik, M.J.4
  • 138
    • 67649306791 scopus 로고    scopus 로고
    • Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT)
    • Partch CL, Card PB, Amezcua CA, Gardner KH., Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT). J Biol Chem. 2009; 284 (22): 15184-92.
    • (2009) J Biol Chem. , vol.284 , Issue.22 , pp. 15184-15192
    • Partch, C.L.1    Card, P.B.2    Amezcua, C.A.3    Gardner, K.H.4
  • 140
    • 84871928938 scopus 로고    scopus 로고
    • Telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke
    • Huang J, Okuka M, Lu W, et al., Telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke. Reprod Toxicol. 2013; 35: 89-95.
    • (2013) Reprod Toxicol. , vol.35 , pp. 89-95
    • Huang, J.1    Okuka, M.2    Lu, W.3
  • 141
    • 77952672824 scopus 로고    scopus 로고
    • Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro
    • Huang J, Okuka M, McLean M, Keefe DL, Liu L., Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro. Free Radic Biol Med. 2010; 48 (12): 1663-76.
    • (2010) Free Radic Biol Med. , vol.48 , Issue.12 , pp. 1663-1676
    • Huang, J.1    Okuka, M.2    McLean, M.3    Keefe, D.L.4    Liu, L.5
  • 142
    • 77953492668 scopus 로고    scopus 로고
    • Occupational cadmium exposure and calcium excretion, bone density, and osteoporosis in men
    • Nawrot T, Geusens P, Nulens TS, Nemery B., Occupational cadmium exposure and calcium excretion, bone density, and osteoporosis in men. J Bone Miner Res. 2010; 25 (6): 1441-5.
    • (2010) J Bone Miner Res. , vol.25 , Issue.6 , pp. 1441-1445
    • Nawrot, T.1    Geusens, P.2    Nulens, T.S.3    Nemery, B.4
  • 143
    • 82555168916 scopus 로고    scopus 로고
    • Diet and nutrients are contributing factors that influence blood cadmium levels
    • Madeddu R, Solinas G, Forte G, et al., Diet and nutrients are contributing factors that influence blood cadmium levels. Nutr Res. 2011; 31 (9): 691-7.
    • (2011) Nutr Res. , vol.31 , Issue.9 , pp. 691-697
    • Madeddu, R.1    Solinas, G.2    Forte, G.3
  • 144
    • 79951846688 scopus 로고    scopus 로고
    • Long-term cadmium exposure and the association with bone mineral density and fractures in a population-based study among women
    • Engstrom A, Michaelsson K, Suwazono Y, Wolk A, Vahter M, Akesson A., Long-term cadmium exposure and the association with bone mineral density and fractures in a population-based study among women. J Bone Miner Res. 2011; 26 (3): 486-95.
    • (2011) J Bone Miner Res. , vol.26 , Issue.3 , pp. 486-495
    • Engstrom, A.1    Michaelsson, K.2    Suwazono, Y.3    Wolk, A.4    Vahter, M.5    Akesson, A.6
  • 145
    • 0024456999 scopus 로고
    • Fetal and infant lead exposure: Effects on growth in stature
    • Shukla R, Bornschein RL, Dietrich KN, et al., Fetal and infant lead exposure: effects on growth in stature. Pediatrics. 1989; 84 (4): 604-12.
    • (1989) Pediatrics. , vol.84 , Issue.4 , pp. 604-612
    • Shukla, R.1    Bornschein, R.L.2    Dietrich, K.N.3
  • 146
    • 7244245638 scopus 로고    scopus 로고
    • Bone density-related predictors of blood lead level among peri- and postmenopausal women in the United States: The Third National Health and Nutrition Examination Survey, 1988-1994
    • Nash D, Magder LS, Sherwin R, Rubin RJ, Silbergeld EK., Bone density-related predictors of blood lead level among peri- and postmenopausal women in the United States: The Third National Health and Nutrition Examination Survey, 1988-1994. Am J Epidemiol. 2004; 160 (9): 901-11.
    • (2004) Am J Epidemiol. , vol.160 , Issue.9 , pp. 901-911
    • Nash, D.1    Magder, L.S.2    Sherwin, R.3    Rubin, R.J.4    Silbergeld, E.K.5
  • 147
    • 84872060161 scopus 로고    scopus 로고
    • Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling
    • Beier EE, Maher JR, Sheu TJ, et al., Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling. Environ Health Perspect. 2013; 121 (1): 97-104.
    • (2013) Environ Health Perspect. , vol.121 , Issue.1 , pp. 97-104
    • Beier, E.E.1    Maher, J.R.2    Sheu, T.J.3
  • 148
    • 20844463259 scopus 로고    scopus 로고
    • Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency
    • Carmouche JJ, Puzas JE, Zhang X, et al., Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency. Environ Health Perspect. 2005; 113 (6): 749-55.
    • (2005) Environ Health Perspect. , vol.113 , Issue.6 , pp. 749-755
    • Carmouche, J.J.1    Puzas, J.E.2    Zhang, X.3
  • 149
    • 84867259197 scopus 로고    scopus 로고
    • Sclerostin levels associated with inhibition of the Wnt/beta-catenin signaling and reduced bone turnover in type 2 diabetes mellitus
    • Gaudio A, Privitera F, Battaglia K, et al., Sclerostin levels associated with inhibition of the Wnt/beta-catenin signaling and reduced bone turnover in type 2 diabetes mellitus. J Clin Endocrinol Metab. 2012; 97 (10): 3744-50.
    • (2012) J Clin Endocrinol Metab. , vol.97 , Issue.10 , pp. 3744-3750
    • Gaudio, A.1    Privitera, F.2    Battaglia, K.3
  • 150
    • 84866162213 scopus 로고    scopus 로고
    • Circulating osteogenic precursor cells in type 2 diabetes mellitus
    • Manavalan JS, Cremers S, Dempster DW, et al., Circulating osteogenic precursor cells in type 2 diabetes mellitus. J Clin Endocrinol Metab. 2012; 97 (9): 3240-50.
    • (2012) J Clin Endocrinol Metab. , vol.97 , Issue.9 , pp. 3240-3250
    • Manavalan, J.S.1    Cremers, S.2    Dempster, D.W.3
  • 151
    • 84860714853 scopus 로고    scopus 로고
    • Circulating sclerostin levels and bone turnover in type 1 and type 2 diabetes
    • Gennari L, Merlotti D, Valenti R, et al., Circulating sclerostin levels and bone turnover in type 1 and type 2 diabetes. J Clin Endocrinol Metab. 2012; 97 (5): 1737-44.
    • (2012) J Clin Endocrinol Metab. , vol.97 , Issue.5 , pp. 1737-1744
    • Gennari, L.1    Merlotti, D.2    Valenti, R.3
  • 152
    • 77954693022 scopus 로고    scopus 로고
    • TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1
    • Kayal RA, Siqueira M, Alblowi J, et al., TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1. J Bone Miner Res. 2010; 25 (7): 1604-15.
    • (2010) J Bone Miner Res. , vol.25 , Issue.7 , pp. 1604-1615
    • Kayal, R.A.1    Siqueira, M.2    Alblowi, J.3
  • 153
    • 84872409354 scopus 로고    scopus 로고
    • Chemokine expression is upregulated in chondrocytes in diabetic fracture healing
    • Alblowi J, Tian C, Siqueira MF, et al., Chemokine expression is upregulated in chondrocytes in diabetic fracture healing. Bone. 2013; 53 (1): 294-300.
    • (2013) Bone , vol.53 , Issue.1 , pp. 294-300
    • Alblowi, J.1    Tian, C.2    Siqueira, M.F.3
  • 154
    • 73549115418 scopus 로고    scopus 로고
    • High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing
    • Alblowi J, Kayal RA, Siqueira M, et al., High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing. Am J Pathol. 2009; 175 (4): 1574-85.
    • (2009) Am J Pathol. , vol.175 , Issue.4 , pp. 1574-1585
    • Alblowi, J.1    Kayal, R.A.2    Siqueira, M.3
  • 155
    • 53349162244 scopus 로고    scopus 로고
    • Molecular basis for affected cartilage formation and bone union in fracture healing of the streptozotocin-induced diabetic rat
    • Ogasawara A, Nakajima A, Nakajima F, Goto K, Yamazaki M., Molecular basis for affected cartilage formation and bone union in fracture healing of the streptozotocin-induced diabetic rat. Bone. 2008; 43 (5): 832-9.
    • (2008) Bone , vol.43 , Issue.5 , pp. 832-839
    • Ogasawara, A.1    Nakajima, A.2    Nakajima, F.3    Goto, K.4    Yamazaki, M.5
  • 156
    • 84870331618 scopus 로고    scopus 로고
    • Vitamin D3 and insulin combined treatment promotes titanium implant osseointegration in diabetes mellitus rats
    • Wu YY, Yu T, Yang XY, et al., Vitamin D3 and insulin combined treatment promotes titanium implant osseointegration in diabetes mellitus rats. Bone. 2013; 52 (1): 1-8.
    • (2013) Bone , vol.52 , Issue.1 , pp. 1-8
    • Wu, Y.Y.1    Yu, T.2    Yang, X.Y.3
  • 158
    • 84898634971 scopus 로고    scopus 로고
    • Leptin receptor deficient diabetic (db/db) mice are compromised in postnatal bone regeneration
    • Apr;
    • Rlszer T, Jõzsa T, Kiss-Tõth ED, De Clerck N, Balogh L., Leptin receptor deficient diabetic (db/db) mice are compromised in postnatal bone regeneration. Cell Tissue Res. 2014 Apr; 356 (1): 195-206.
    • (2014) Cell Tissue Res. , vol.356 , Issue.1 , pp. 195-206
    • Rlszer, T.1    Jõzsa, T.2    Kiss-Tõth, E.D.3    De Clerck, N.4    Balogh, L.5
  • 159
    • 84873964702 scopus 로고    scopus 로고
    • Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus
    • Hamann C, Rauner M, Hohna Y, et al., Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus. J Bone Miner Res. 2013; 28 (3): 627-38.
    • (2013) J Bone Miner Res. , vol.28 , Issue.3 , pp. 627-638
    • Hamann, C.1    Rauner, M.2    Hohna, Y.3
  • 160
    • 84875231921 scopus 로고    scopus 로고
    • Local insulin therapy affects fracture healing in a rat model
    • Park AG, Paglia DN, Al-Zube L, et al., Local insulin therapy affects fracture healing in a rat model. J Orthop Res. 2013; 31 (5): 776-82.
    • (2013) J Orthop Res. , vol.31 , Issue.5 , pp. 776-782
    • Park, A.G.1    Paglia, D.N.2    Al-Zube, L.3
  • 161
    • 24944574404 scopus 로고    scopus 로고
    • The effects of local insulin delivery on diabetic fracture healing
    • Gandhi A, Beam HA, O'Connor JP, Parsons JR, Lin SS., The effects of local insulin delivery on diabetic fracture healing. Bone. 2005; 37 (4): 482-90.
    • (2005) Bone , vol.37 , Issue.4 , pp. 482-490
    • Gandhi, A.1    Beam, H.A.2    O'Connor, J.P.3    Parsons, J.R.4    Lin, S.S.5
  • 163
    • 84875264883 scopus 로고    scopus 로고
    • Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation
    • Liu W, Long Q, Chen K, et al., Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation. Biochem Biophys Res Commun. 2013; 431 (4): 767-71.
    • (2013) Biochem Biophys Res Commun. , vol.431 , Issue.4 , pp. 767-771
    • Liu, W.1    Long, Q.2    Chen, K.3
  • 164
    • 80755129126 scopus 로고    scopus 로고
    • The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation
    • Hom JR, Quintanilla RA, Hoffman DL, et al., The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Dev Cell. 2011; 21 (3): 469-78.
    • (2011) Dev Cell. , vol.21 , Issue.3 , pp. 469-478
    • Hom, J.R.1    Quintanilla, R.A.2    Hoffman, D.L.3
  • 165
    • 84875953755 scopus 로고    scopus 로고
    • Stem cell metabolism in tissue development and aging
    • Shyh-Chang N, Daley GQ, Cantley LC., Stem cell metabolism in tissue development and aging. Development. 2013; 140 (12): 2535-47.
    • (2013) Development. , vol.140 , Issue.12 , pp. 2535-2547
    • Shyh-Chang, N.1    Daley, G.Q.2    Cantley, L.C.3
  • 166
    • 79952209101 scopus 로고    scopus 로고
    • Mitochondrial rejuvenation after induced pluripotency
    • Suhr ST, Chang EA, Tjong J, et al., Mitochondrial rejuvenation after induced pluripotency. PLoS One. 2010; 5 (11): e14095.
    • (2010) PLoS One. , vol.5 , Issue.11 , pp. e14095
    • Suhr, S.T.1    Chang, E.A.2    Tjong, J.3
  • 167
    • 80055092772 scopus 로고    scopus 로고
    • Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism
    • Stoll EA, Cheung W, Mikheev AM, et al., Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism. J Biol Chem. 2011; 286 (44): 38592-601.
    • (2011) J Biol Chem. , vol.286 , Issue.44 , pp. 38592-38601
    • Stoll, E.A.1    Cheung, W.2    Mikheev, A.M.3
  • 168
    • 84860614281 scopus 로고    scopus 로고
    • Short-term calorie restriction enhances skeletal muscle stem cell function
    • Cerletti M, Jang YC, Finley LW, Haigis MC, Wagers AJ., Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell. 2012; 10 (5): 515-9.
    • (2012) Cell Stem Cell. , vol.10 , Issue.5 , pp. 515-519
    • Cerletti, M.1    Jang, Y.C.2    Finley, L.W.3    Haigis, M.C.4    Wagers, A.J.5
  • 169
    • 84875066481 scopus 로고    scopus 로고
    • Notch regulates blastema proliferation and prevents differentiation during adult zebrafish fin regeneration
    • Munch J, Gonzalez-Rajal A, de la Pompa JL., Notch regulates blastema proliferation and prevents differentiation during adult zebrafish fin regeneration. Development. 2013; 140 (7): 1402-11.
    • (2013) Development. , vol.140 , Issue.7 , pp. 1402-1411
    • Munch, J.1    Gonzalez-Rajal, A.2    De La Pompa, J.L.3
  • 170
    • 84860511975 scopus 로고    scopus 로고
    • Notch signaling and cardiac repair
    • Gude N, Sussman M., Notch signaling and cardiac repair. J Mol Cell Cardiol. 2012; 52 (6): 1226-32.
    • (2012) J Mol Cell Cardiol. , vol.52 , Issue.6 , pp. 1226-1232
    • Gude, N.1    Sussman, M.2
  • 171
    • 20244378183 scopus 로고    scopus 로고
    • Activation of Notch signaling pathway precedes heart regeneration in zebrafish
    • (Suppl 1)
    • Raya A, Koth CM, Buscher D, et al., Activation of Notch signaling pathway precedes heart regeneration in zebrafish. Proc Natl Acad Sci U S A. 2003; 100 (Suppl 1): 11889-95.
    • (2003) Proc Natl Acad Sci U S A. , vol.100 , pp. 11889-11895
    • Raya, A.1    Koth, C.M.2    Buscher, D.3
  • 172
    • 84859758887 scopus 로고    scopus 로고
    • Neurogenic subventricular zone stem/progenitor cells are Notch1-dependent in their active but not quiescent state
    • Basak O, Giachino C, Fiorini E, Macdonald HR, Taylor V., Neurogenic subventricular zone stem/progenitor cells are Notch1-dependent in their active but not quiescent state. J Neurosci. 2012; 32 (16): 5654-66.
    • (2012) J Neurosci. , vol.32 , Issue.16 , pp. 5654-5666
    • Basak, O.1    Giachino, C.2    Fiorini, E.3    MacDonald, H.R.4    Taylor, V.5
  • 173
    • 77951229591 scopus 로고    scopus 로고
    • RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development
    • Dong Y, Jesse AM, Kohn A, et al., RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development. 2010; 137 (9): 1461-71.
    • (2010) Development. , vol.137 , Issue.9 , pp. 1461-1471
    • Dong, Y.1    Jesse, A.M.2    Kohn, A.3
  • 174
    • 40449084522 scopus 로고    scopus 로고
    • Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
    • Hilton MJ, Tu X, Wu X, et al., Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med. 2008; 14 (3): 306-14.
    • (2008) Nat Med. , vol.14 , Issue.3 , pp. 306-314
    • Hilton, M.J.1    Tu, X.2    Wu, X.3
  • 175
    • 84880506919 scopus 로고    scopus 로고
    • Wnt activation in nail epithelium couples nail growth to digit regeneration
    • Takeo M, Chou WC, Sun Q, et al., Wnt activation in nail epithelium couples nail growth to digit regeneration. Nature. 2013; 499 (7457): 228-32.
    • (2013) Nature. , vol.499 , Issue.7457 , pp. 228-232
    • Takeo, M.1    Chou, W.C.2    Sun, Q.3
  • 176
    • 79956287890 scopus 로고    scopus 로고
    • The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells
    • Guo L, Zhao RC, Wu Y., The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells. Exp Hematol. 2011; 39 (6): 608-16.
    • (2011) Exp Hematol. , vol.39 , Issue.6 , pp. 608-616
    • Guo, L.1    Zhao, R.C.2    Wu, Y.3
  • 177
    • 84897009273 scopus 로고    scopus 로고
    • Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts
    • Fakhry M, Hamade E, Badran B, Buchet R, Magne D., Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts. World J Stem Cells. 2013; 5 (4): 136-48.
    • (2013) World J Stem Cells. , vol.5 , Issue.4 , pp. 136-148
    • Fakhry, M.1    Hamade, E.2    Badran, B.3    Buchet, R.4    Magne, D.5
  • 178
    • 77953067173 scopus 로고    scopus 로고
    • MicroRNA-140 plays dual roles in both cartilage development and homeostasis
    • Miyaki S, Sato T, Inoue A, et al., MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev. 2010; 24 (11): 1173-85.
    • (2010) Genes Dev. , vol.24 , Issue.11 , pp. 1173-1185
    • Miyaki, S.1    Sato, T.2    Inoue, A.3
  • 179
    • 41149123358 scopus 로고    scopus 로고
    • Dicer-dependent pathways regulate chondrocyte proliferation and differentiation
    • Kobayashi T, Lu J, Cobb BS, et al., Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A. 2008; 105 (6): 1949-54.
    • (2008) Proc Natl Acad Sci U S A. , vol.105 , Issue.6 , pp. 1949-1954
    • Kobayashi, T.1    Lu, J.2    Cobb, B.S.3
  • 180
    • 23344439006 scopus 로고    scopus 로고
    • The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb
    • Harfe BD, McManus MT, Mansfield JH, Hornstein E, Tabin CJ., The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A. 2005; 102 (31): 10898-903.
    • (2005) Proc Natl Acad Sci U S A. , vol.102 , Issue.31 , pp. 10898-10903
    • Harfe, B.D.1    McManus, M.T.2    Mansfield, J.H.3    Hornstein, E.4    Tabin, C.J.5
  • 181
    • 84864115273 scopus 로고    scopus 로고
    • MIR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1
    • Kim KM, Park SJ, Jung SH, et al., miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1. J Bone Miner Res. 2012; 27 (8): 1669-79.
    • (2012) J Bone Miner Res. , vol.27 , Issue.8 , pp. 1669-1679
    • Kim, K.M.1    Park, S.J.2    Jung, S.H.3
  • 182
    • 82755177370 scopus 로고    scopus 로고
    • Alcohol induced epigenetic perturbations during the inflammatory stage of fracture healing
    • Sampson HW, Chaput CD, Brannen J, et al., Alcohol induced epigenetic perturbations during the inflammatory stage of fracture healing. Exp Biol Med (Maywood). 2011; 236 (12): 1389-401.
    • (2011) Exp Biol Med (Maywood). , vol.236 , Issue.12 , pp. 1389-1401
    • Sampson, H.W.1    Chaput, C.D.2    Brannen, J.3
  • 183
    • 84892611163 scopus 로고    scopus 로고
    • Inhibition of MIR-92a enhances fracture healing via promoting angiogenesis in a model of stabilized fracture in young mice
    • Murata K, Ito H, Yoshitomi H, et al., Inhibition of miR-92a enhances fracture healing via promoting angiogenesis in a model of stabilized fracture in young mice. J Bone Miner Res. 2014; 29 (2): 316-26.
    • (2014) J Bone Miner Res. , vol.29 , Issue.2 , pp. 316-326
    • Murata, K.1    Ito, H.2    Yoshitomi, H.3
  • 184
    • 84901226648 scopus 로고    scopus 로고
    • Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures
    • Seeliger C, Karpinski K, Haug AT, et al., Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures. J Bone Miner Res. 2014; 29 (8): 1718-28.
    • (2014) J Bone Miner Res. , vol.29 , Issue.8 , pp. 1718-1728
    • Seeliger, C.1    Karpinski, K.2    Haug, A.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.