Effect of nicotine and tobacco administration method on the mechanical properties of healing bone following closed fracture

Journal of Orthopaedic Research

Volumn 28, Issue 9, 2010, Pages 1235-1239

  Hastrup, Sidsel Gaarn ^a,b   Chen, Xinqian ^b   Bechtold, Joan E ^b,c   Kyle, Richard F ^b   Rahbek, Ole ^a   Keyler, Daniel E ^c   Skoett, Martin ^a   Soeballe, Kjeld ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b Excelen Center for Bone and Joint Research and Education   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Delivery method; Fracture healing strength; Nicotine; Rats; Tobacco

Indexed keywords

COTININE; NICOTINE; SODIUM CHLORIDE; NICOTINIC AGENT; PLANT EXTRACT; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENERGY ABSORPTION; FEMUR FRACTURE; FRACTURE HEALING; INTRAMEDULLARY NAIL; MALE; MECHANICAL TORSION; NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; RAT; RIGIDITY; SMOKING; TOBACCO; ANIMAL; DISEASE MODEL; DRUG DELIVERY SYSTEM; FRACTURE; INFUSION PUMP; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; RADIOGRAPHY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; FRACTURE HEALING; FRACTURES, CLOSED; INFUSION PUMPS; MALE; NICOTINE; NICOTINIC AGONISTS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; TOBACCO; TORSION, MECHANICAL; WATER;

EID: 77955871103     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21106     Document Type: Article

References (12)

1. Skott M, Andreassen TT, Ulrich-Vinther M, et al. 2006. Tobacco extract but not nicotine impairs the mechanical strength of fracture healing in rats. J Orthop Res 24:1472-1479. (Pubitemid 44083263)
2. Friess DM, Chen X, Bourgeault C, et al. 2007. Nicotine does not inhibit fracture repair in rats. Trans Orthop Res 32:223.
3. Abulencia AE, Friedlaender GE, Troiano NW, et al. 1999. The influence of nicotine on fracture repair in rats. Trans Orthop Res 24:342.
4. Akhter MP, Iwaniec UT, Haynatzki GR, et al. 2003. Effects of nicotine on bone mass and strength in aged female rats. J Orthop Res 21:14-19. (Pubitemid 36163322)
5. Cobb TK, Gabrielsen TA, Campbell DC, et al. 1994. Cigarette smoking and nonunion after ankle arthrodesis. Foot Ankle Int 15:64-67.
6. Silcox DH III, Daftari T, Boden SD, et al. 1995. The effect of nicotine on spinal fusion. Spine 20:1549-1553.
7. Wing KJ, Fisher CG, O'Connell JX, et al. 2000. Stopping nicotine exposure before surgery. The effect on spinal fusion in a rabbit model. Spine 25:30-34.
8. Yuhara S, Kasagi S, Inoue A, et al. 1999. Effects of nicotine on cultured cells suggest that it can influence the formation and resorption of bone. Eur J Pharmacol 383:387-393.
9. Demady DR, Lowe ER, Everett AC, et al. 2003. Metabolism-based inactivation of neuronal nitric-oxide synthase by components of cigarette and cigarette smoke. Drug Metab Dispos 31:932-937.
10. Bonnarens F, Einhorn TA. 1984. Production of a standard closed fracture in laboratory animal bone. J Orthop Res 2:97-101. (Pubitemid 14034681)
11. Jacob P III, Wilson M, Benowitz NL. 1981. Improved gas chromatographic method for the determination of nicotine and cotinine in biologic fluids. J Chromatogr 222:61-70. (Pubitemid 11141159)
12. Murphy SE, Link CA, Jensen J, et al. 2004. A comparison of urinary biomarkers of tobacco and carcinogen exposure in smokers. Cancer Epidemiol Biomarkers Prev 13:1617-1623. (Pubitemid 39331883)