메뉴 건너뛰기




Volumn 175, Issue 2, 2009, Pages 772-785

Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; CYCLOOXYGENASE 2; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E4 RECEPTOR AGONIST; UNCLASSIFIED DRUG;

EID: 68449103187     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2009.081099     Document Type: Article
Times cited : (84)

References (66)
  • 1
    • 0031734171 scopus 로고    scopus 로고
    • The cell and molecular biology of fracture healing
    • Einhorn T: The cell and molecular biology of fracture healing. Clin Orthop 1998, 355S:S7-S21
    • (1998) Clin Orthop , vol.355 S
    • Einhorn, T.1
  • 2
    • 33646201771 scopus 로고    scopus 로고
    • The science of fracture healing
    • Einhorn TA: The science of fracture healing. J Orthop Trauma 2005, 19:S4-6
    • (2005) J Orthop Trauma , vol.19
    • Einhorn, T.A.1
  • 3
    • 0037376627 scopus 로고    scopus 로고
    • Fracture healing as a post-natal developmental process: Molecular, spatial, and temporal aspects of its regulation
    • Gerstenfeld LC, Cullinane DM, Barnes GL, Graves DT, Einhorn TA: Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 2003, 88:873-884
    • (2003) J Cell Biochem , vol.88 , pp. 873-884
    • Gerstenfeld, L.C.1    Cullinane, D.M.2    Barnes, G.L.3    Graves, D.T.4    Einhorn, T.A.5
  • 4
    • 0030049390 scopus 로고    scopus 로고
    • Prostaglandin synthase 2
    • Herschman HR: Prostaglandin synthase 2. Biochem Biophys Acta 1996, 1229:125-140
    • (1996) Biochem Biophys Acta , vol.1229 , pp. 125-140
    • Herschman, H.R.1
  • 5
    • 0033791318 scopus 로고    scopus 로고
    • Cyclooxygenases: Structural, cellular, and molecular biology
    • Smith WL, DeWitt DL, Garavito RM: Cyclooxygenases: structural, cellular, and molecular biology. Ann Rev Biochem 2000, 69:145-182
    • (2000) Ann Rev Biochem , vol.69 , pp. 145-182
    • Smith, W.L.1    DeWitt, D.L.2    Garavito, R.M.3
  • 6
    • 0027536371 scopus 로고
    • Prostaglandins: Mechanisms of action and regulation of production in bone
    • Raisz LG, Pilbeam CC, Fall PM: Prostaglandins: mechanisms of action and regulation of production in bone. Osteoporos Int 1993, 3 Suppl 1:136-140
    • (1993) Osteoporos Int , vol.3 , Issue.SUPPL. 1 , pp. 136-140
    • Raisz, L.G.1    Pilbeam, C.C.2    Fall, P.M.3
  • 8
    • 34249729416 scopus 로고    scopus 로고
    • Prostaglandin E receptors
    • Sugimoto Y, Narumiya S: Prostaglandin E receptors. J Biol Chem 2007, 282:11613-11617
    • (2007) J Biol Chem , vol.282 , pp. 11613-11617
    • Sugimoto, Y.1    Narumiya, S.2
  • 10
    • 0034455647 scopus 로고    scopus 로고
    • The role of prostaglandin E receptor subtypes (EP1. EP2, EP3, and EP4) in bone resorption: An analysis using specific agonists for the respective EPs
    • Suzawa T, Miyaura C, Inada M, Maruyama T, Sugimoto Y, Ushikubi F, Ichikawa A, Narumiya S, Suda T: The role of prostaglandin E receptor subtypes (EP1. EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs Endocrinology 2000, 141:1554-1559
    • (2000) Endocrinology , vol.141 , pp. 1554-1559
    • Suzawa, T.1    Miyaura, C.2    Inada, M.3    Maruyama, T.4    Sugimoto, Y.5    Ushikubi, F.6    Ichikawa, A.7    Narumiya, S.8    Suda, T.9
  • 11
    • 0033073969 scopus 로고    scopus 로고
    • The anabolic effect of PGE2 in rat bone marrow cultures is mediated via the EP4 receptor subtype
    • Weinreb M, Grosskopf A, Shir N: The anabolic effect of PGE2 in rat bone marrow cultures is mediated via the EP4 receptor subtype. Am J Physiol 1999, 276:E376-E383
    • (1999) Am J Physiol , vol.276
    • Weinreb, M.1    Grosskopf, A.2    Shir, N.3
  • 18
    • 0036259278 scopus 로고    scopus 로고
    • Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
    • Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ: Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest 2002, 109:1405-1415
    • (2002) J Clin Invest , vol.109 , pp. 1405-1415
    • Zhang, X.1    Schwarz, E.M.2    Young, D.A.3    Puzas, J.E.4    Rosier, R.N.5    O'Keefe, R.J.6
  • 19
    • 0035999429 scopus 로고    scopus 로고
    • Cyclo-oxygenase 2 function is essential for bone fracture healing
    • Simon AM, Manigrasso MB, O'Connor JP: Cyclo-oxygenase 2 function is essential for bone fracture healing. J Bone Miner Res 2002, 17:963-976
    • (2002) J Bone Miner Res , vol.17 , pp. 963-976
    • Simon, A.M.1    Manigrasso, M.B.2    O'Connor, J.P.3
  • 21
    • 0031680203 scopus 로고    scopus 로고
    • Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: Efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects
    • Simon LS, Lanza FL, Lipsky PE, Hubbard RC, Talwalker S, Schwartz BD, Isakson PC, Geis GS: Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects. Arthritis Rheum 1998, 41:1591-1602
    • (1998) Arthritis Rheum , vol.41 , pp. 1591-1602
    • Simon, L.S.1    Lanza, F.L.2    Lipsky, P.E.3    Hubbard, R.C.4    Talwalker, S.5    Schwartz, B.D.6    Isakson, P.C.7    Geis, G.S.8
  • 23
    • 0012429950 scopus 로고    scopus 로고
    • Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs
    • Gerstenfeld LC, Thiede M, Seibert K, Mielke C, Phippard D, Svagr B, Cullinane D, Einhorn TA: Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. J Orthop Res 2003, 21:670-675
    • (2003) J Orthop Res , vol.21 , pp. 670-675
    • Gerstenfeld, L.C.1    Thiede, M.2    Seibert, K.3    Mielke, C.4    Phippard, D.5    Svagr, B.6    Cullinane, D.7    Einhorn, T.A.8
  • 24
    • 33847665704 scopus 로고    scopus 로고
    • Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing
    • Simon AM, O'Connor JP: Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing. J Bone Joint Surg Am 2007, 89:500-511
    • (2007) J Bone Joint Surg Am , vol.89 , pp. 500-511
    • Simon, A.M.1    O'Connor, J.P.2
  • 25
    • 40549106124 scopus 로고    scopus 로고
    • Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat
    • Rundle CH, Strong DD, Chen ST, Linkhart TA, Sheng MH, Wergedal JE, Lau KH, Baylink DJ: Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat. J Gene Med 2008, 10:229-241
    • (2008) J Gene Med , vol.10 , pp. 229-241
    • Rundle, C.H.1    Strong, D.D.2    Chen, S.T.3    Linkhart, T.A.4    Sheng, M.H.5    Wergedal, J.E.6    Lau, K.H.7    Baylink, D.J.8
  • 26
    • 34548246050 scopus 로고    scopus 로고
    • Effects of basic fibroblast growth factor and a prostaglandin E2 receptor subtype 4 agonist on osteoblastogenesis and adipogenesis in aged ovariectomized rats
    • Aguirre JI, Leal ME, Rivera MF, Vanegas SM, Jorgensen M, Wronski TJ: Effects of basic fibroblast growth factor and a prostaglandin E2 receptor subtype 4 agonist on osteoblastogenesis and adipogenesis in aged ovariectomized rats. J Bone Miner Res 2007, 22:877-888
    • (2007) J Bone Miner Res , vol.22 , pp. 877-888
    • Aguirre, J.I.1    Leal, M.E.2    Rivera, M.F.3    Vanegas, S.M.4    Jorgensen, M.5    Wronski, T.J.6
  • 28
    • 0021612066 scopus 로고
    • Production of a standard closed fracture in laboratory animal bone
    • Bonnarens F, Einhorn TA: Production of a standard closed fracture in laboratory animal bone. J Orthop Res 1984, 2:97-101
    • (1984) J Orthop Res , vol.2 , pp. 97-101
    • Bonnarens, F.1    Einhorn, T.A.2
  • 29
    • 3042575000 scopus 로고    scopus 로고
    • Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury
    • Duvall CL, Robert Taylor W, Weiss D, Guldberg RE: Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury. Am J Physiol Heart Circ Physiol 2004, 287:H302-H310
    • (2004) Am J Physiol Heart Circ Physiol , vol.287
    • Duvall, C.L.1    Robert Taylor, W.2    Weiss, D.3    Guldberg, R.E.4
  • 30
    • 33846466474 scopus 로고    scopus 로고
    • Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice
    • Duvall CL, Taylor WR, Weiss D, Wojtowicz AM, Guldberg RE: Impaired angiogenesis, early callus formation, and late stage remodeling in fracture healing of osteopontin-deficient mice. J Bone Miner Res 2007, 22:286-297
    • (2007) J Bone Miner Res , vol.22 , pp. 286-297
    • Duvall, C.L.1    Taylor, W.R.2    Weiss, D.3    Wojtowicz, A.M.4    Guldberg, R.E.5
  • 31
    • 0033047422 scopus 로고    scopus 로고
    • Direct three-dimensional morphometric analysis of human cancellous bone: Microstructural data from spine, femur, iliac crest, and calcaneus
    • Hildebrand T, Laib A, Muller R, Dequeker J, Ruegsegger P: Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J Bone Miner Res 1999, 14:1167-1174
    • (1999) J Bone Miner Res , vol.14 , pp. 1167-1174
    • Hildebrand, T.1    Laib, A.2    Muller, R.3    Dequeker, J.4    Ruegsegger, P.5
  • 32
    • 2942730560 scopus 로고    scopus 로고
    • Quantification of Bone Microarchitecture with the Structure Model Index
    • Hildebrand T, Ruegsegger P: Quantification of Bone Microarchitecture with the Structure Model Index. Comput Methods Biomech Biomed Engin 1997, 1:15-23
    • (1997) Comput Methods Biomech Biomed Engin , vol.1 , pp. 15-23
    • Hildebrand, T.1    Ruegsegger, P.2
  • 35
    • 2342655817 scopus 로고    scopus 로고
    • Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation
    • Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ: Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: tGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation. Bone 2004, 34:809-817
    • (2004) Bone , vol.34 , pp. 809-817
    • Zhang, X.1    Ziran, N.2    Goater, J.J.3    Schwarz, E.M.4    Puzas, J.E.5    Rosier, R.N.6    Zuscik, M.7    Drissi, H.8    O'Keefe, R.J.9
  • 36
    • 0031570725 scopus 로고    scopus 로고
    • Zymography: A single-step staining method for quantitation of proteolytic activity on substrate gels
    • Leber TM, Balkwill FR: Zymography: a single-step staining method for quantitation of proteolytic activity on substrate gels. Anal Biochem 1997, 249:24-28
    • (1997) Anal Biochem , vol.249 , pp. 24-28
    • Leber, T.M.1    Balkwill, F.R.2
  • 37
    • 70350523833 scopus 로고    scopus 로고
    • Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ-prostaglandin E2 dependent proliferation of growth plate chondrocytes
    • Brochhausen C, Neuland P, Kirkpatrick CJ, Nusing RM, Klaus G: Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ-prostaglandin E2 dependent proliferation of growth plate chondrocytes. Arthritis Res Ther 2006, 8:R78
    • (2006) Arthritis Res Ther , vol.8
    • Brochhausen, C.1    Neuland, P.2    Kirkpatrick, C.J.3    Nusing, R.M.4    Klaus, G.5
  • 38
    • 0025739077 scopus 로고
    • Long-term anabolic effects of prostaglandin-E2 on tibial diaphyseal bone in male rats
    • Jee WS, Ke HZ, Li XJ: Long-term anabolic effects of prostaglandin-E2 on tibial diaphyseal bone in male rats. Bone Miner 1991, 15:33-55
    • (1991) Bone Miner , vol.15 , pp. 33-55
    • Jee, W.S.1    Ke, H.Z.2    Li, X.J.3
  • 39
    • 0023686528 scopus 로고
    • Bone formation induced in an infant by systemic prostaglandin-E2 administration
    • Jorgensen HR, Svanholm H, Host A: Bone formation induced in an infant by systemic prostaglandin-E2 administration. Acta Orthop Scand 1988, 59:464-466
    • (1988) Acta Orthop Scand , vol.59 , pp. 464-466
    • Jorgensen, H.R.1    Svanholm, H.2    Host, A.3
  • 40
    • 0034746416 scopus 로고    scopus 로고
    • Systemic prostaglandin E2 increases cancellous bone formation and mass in aging rats and stimulates their bone marrow osteogenic capacity in vivo and in vitro
    • Keila S, Kelner A, Weinreb M: Systemic prostaglandin E2 increases cancellous bone formation and mass in aging rats and stimulates their bone marrow osteogenic capacity in vivo and in vitro. J Endocrinol 2001, 168:131-139
    • (2001) J Endocrinol , vol.168 , pp. 131-139
    • Keila, S.1    Kelner, A.2    Weinreb, M.3
  • 42
    • 85047680922 scopus 로고    scopus 로고
    • The effect of prostaglandin E2 on costochondral chondrocyte differentiation is mediated by cyclic adenosine 3′,5′-monophosphate and protein kinase C
    • Schwartz Z, Gilley RM, Sylvia VL, Dean DD, Boyan BD: The effect of prostaglandin E2 on costochondral chondrocyte differentiation is mediated by cyclic adenosine 3′,5′-monophosphate and protein kinase C. Endocrinology 1998, 139:1825-1834
    • (1998) Endocrinology , vol.139 , pp. 1825-1834
    • Schwartz, Z.1    Gilley, R.M.2    Sylvia, V.L.3    Dean, D.D.4    Boyan, B.D.5
  • 43
    • 0033304843 scopus 로고    scopus 로고
    • Arachidonic acid directly mediates the rapid effects of 24,25-dihydroxyvitamin D3 via protein kinase C and indirectly through prostaglandin production in resting zone chondrocytes
    • Schwartz Z, Sylvia VL, Curry D, Luna MH, Dean DD, Boyan BD: Arachidonic acid directly mediates the rapid effects of 24,25-dihydroxyvitamin D3 via protein kinase C and indirectly through prostaglandin production in resting zone chondrocytes. Endocrinology 1999, 140:2991-3002
    • (1999) Endocrinology , vol.140 , pp. 2991-3002
    • Schwartz, Z.1    Sylvia, V.L.2    Curry, D.3    Luna, M.H.4    Dean, D.D.5    Boyan, B.D.6
  • 44
    • 0037067182 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways
    • Rosado E, Schwartz Z, Sylvia VL, Dean DD, Boyan BD: Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways. Biochim Biophys Acta 2002, 1590:1-15
    • (2002) Biochim Biophys Acta , vol.1590 , pp. 1-15
    • Rosado, E.1    Schwartz, Z.2    Sylvia, V.L.3    Dean, D.D.4    Boyan, B.D.5
  • 45
    • 0034678738 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 regulation of resting zone chondrocytes is mediated by two separate but interacting pathways
    • Sylvia VL, Schwartz Z, Dean DD, Boyan BD: Transforming growth factor-beta1 regulation of resting zone chondrocytes is mediated by two separate but interacting pathways. Biochim Biophys Acta 2000, 1496:311-324
    • (2000) Biochim Biophys Acta , vol.1496 , pp. 311-324
    • Sylvia, V.L.1    Schwartz, Z.2    Dean, D.D.3    Boyan, B.D.4
  • 46
    • 0035919729 scopus 로고    scopus 로고
    • Agonist-induced internalization and mitogen-activated protein kinase activation of the human prostaglandin EP4 receptor
    • Desai S, Ashby B: Agonist-induced internalization and mitogen-activated protein kinase activation of the human prostaglandin EP4 receptor. FEBS Lett 2001, 501:156-160
    • (2001) FEBS Lett , vol.501 , pp. 156-160
    • Desai, S.1    Ashby, B.2
  • 47
    • 0033664001 scopus 로고    scopus 로고
    • Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: Role of the carboxyl terminus in EP4 receptor sequestration
    • Desai S, April H, Nwaneshiudu C, Ashby B: Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration. Mol Pharmacol 2000, 58:1279-1286
    • (2000) Mol Pharmacol , vol.58 , pp. 1279-1286
    • Desai, S.1    April, H.2    Nwaneshiudu, C.3    Ashby, B.4
  • 48
    • 22344439814 scopus 로고    scopus 로고
    • Differential regulation of phosphorylation of the cAMP response element-binding protein after activation of EP2 and EP4 prostanoid receptors by prostaglandin E2
    • Fujino H, Salvi S, Regan JW: Differential regulation of phosphorylation of the cAMP response element-binding protein after activation of EP2 and EP4 prostanoid receptors by prostaglandin E2. Mol Pharmacol 2005, 68:251-259
    • (2005) Mol Pharmacol , vol.68 , pp. 251-259
    • Fujino, H.1    Salvi, S.2    Regan, J.W.3
  • 49
    • 30044434401 scopus 로고    scopus 로고
    • EP(4) prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein
    • Fujino H, Regan JW: EP(4) prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein. Mol Pharmacol 2006, 69:5-10
    • (2006) Mol Pharmacol , vol.69 , pp. 5-10
    • Fujino, H.1    Regan, J.W.2
  • 51
    • 0034769736 scopus 로고    scopus 로고
    • Review: Molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis
    • Fosslien E: Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis. Ann Clin Lab Sci 2001, 31:325-348
    • (2001) Ann Clin Lab Sci , vol.31 , pp. 325-348
    • Fosslien, E.1
  • 52
    • 0032750920 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing
    • Jones MK, Wang H, Peskar BM, Levin E, Itani RM, Sarfeh IJ, Tarnawski AS: Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med 1999, 5:1418-1423
    • (1999) Nat Med , vol.5 , pp. 1418-1423
    • Jones, M.K.1    Wang, H.2    Peskar, B.M.3    Levin, E.4    Itani, R.M.5    Sarfeh, I.J.6    Tarnawski, A.S.7
  • 53
    • 0034791297 scopus 로고    scopus 로고
    • NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis
    • Dormond O, Foletti A, Paroz C, Ruegg C: NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis. Nat Med 2001, 7:1041-1047
    • (2001) Nat Med , vol.7 , pp. 1041-1047
    • Dormond, O.1    Foletti, A.2    Paroz, C.3    Ruegg, C.4
  • 56
    • 33747377104 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase (COX)-2 affects endothelial progenitor cell proliferation
    • Colleselli D, Bijuklic K, Mosheimer BA, Kahler CM: Inhibition of cyclooxygenase (COX)-2 affects endothelial progenitor cell proliferation. Exp Cell Res 2006, 312:2933-2941
    • (2006) Exp Cell Res , vol.312 , pp. 2933-2941
    • Colleselli, D.1    Bijuklic, K.2    Mosheimer, B.A.3    Kahler, C.M.4
  • 60
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
    • Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N: VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 1999, 5:623-628
    • (1999) Nat Med , vol.5 , pp. 623-628
    • Gerber, H.P.1    Vu, T.H.2    Ryan, A.M.3    Kowalski, J.4    Werb, Z.5    Ferrara, N.6
  • 63
    • 0027998147 scopus 로고
    • Gelatinase activity during wound healing
    • Agren MS: Gelatinase activity during wound healing. Br J Dermatol 1994, 131:634-640
    • (1994) Br J Dermatol , vol.131 , pp. 634-640
    • Agren, M.S.1
  • 64
    • 55249118574 scopus 로고    scopus 로고
    • Three matrix metalloproteinases are required in vivo for macrophage migration during embryonic development
    • Tomlinson ML, Garcia-Morales C, Abu-Elmagd M, Wheeler GN: Three matrix metalloproteinases are required in vivo for macrophage migration during embryonic development. Mech Dev 2008, 125:1059-1070
    • (2008) Mech Dev , vol.125 , pp. 1059-1070
    • Tomlinson, M.L.1    Garcia-Morales, C.2    Abu-Elmagd, M.3    Wheeler, G.N.4
  • 66
    • 33751006970 scopus 로고    scopus 로고
    • Matrix metalloproteinase 9 (MMP-9) is upregulated during scarless wound healing in athymic nude mice
    • Manuel JA, Gawronska-Kozak B: Matrix metalloproteinase 9 (MMP-9) is upregulated during scarless wound healing in athymic nude mice. Matrix Biol 2006, 25:505-514
    • (2006) Matrix Biol , vol.25 , pp. 505-514
    • Manuel, J.A.1    Gawronska-Kozak, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.