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Volumn 121, Issue 1, 2013, Pages 97-104

Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling

Author keywords

Bone mineral density; Lead; Mesenchymal stem cells; Rat; Wnt signaling

Indexed keywords

BETA CATENIN; FAT DROPLET; LEAD; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; SCLEROSTIN; TRANSCRIPTION FACTOR RUNX2;

EID: 84872060161     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1205374     Document Type: Article
Times cited : (79)

References (40)
  • 1
    • 17044419650 scopus 로고    scopus 로고
    • Effects of acute and chronic oval exposure of lead on blood pressure and bone mineral density in rats
    • Bagchi D, Preuss HG. 2005. Effects of acute and chronic oval exposure of lead on blood pressure and bone mineral density in rats. J Inorg Biochem 99(5):1155-1164.
    • (2005) J Inorg Biochem , vol.99 , Issue.5 , pp. 1155-1164
    • Bagchi, D.1    Preuss, H.G.2
  • 2
    • 0026641584 scopus 로고
    • Osteon morphometry in females with femoral neck fractures
    • Barth RW, Williams JL, Kaplan FS. 1992. Osteon morphometry in females with femoral neck fractures. Clin Orthop Relat Res 283:178-186.
    • (1992) Clin Orthop Relat Res , vol.283 , pp. 178-186
    • Barth, R.W.1    Williams, J.L.2    Kaplan, F.S.3
  • 3
    • 34548206799 scopus 로고    scopus 로고
    • The association between blood lead levels and osteoporosis among adults-results from the Third National Health and Nutrition Examination Survey (NHANES III)
    • Campbell JR, Auinger P. 2007. The association between blood lead levels and osteoporosis among adults-results from the Third National Health and Nutrition Examination Survey (NHANES III). Environ Health Perspect 115:1018-1022.
    • (2007) Environ Health Perspect , vol.115 , pp. 1018-1022
    • Campbell, J.R.1    Auinger, P.2
  • 4
    • 20844463259 scopus 로고    scopus 로고
    • Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency
    • Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, et al. 2005. Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency. Environ Health Perspect 113:749-755.
    • (2005) Environ Health Perspect , vol.113 , pp. 749-755
    • Carmouche, J.J.1    Puzas, J.E.2    Zhang, X.3    Tiyapatanaputi, P.4    Cory-Slechta, D.A.5    Gelein, R.6
  • 5
    • 84873303733 scopus 로고
    • Preventing Lead Poisoning In Young Children
    • Centers for Disease Control and Prevention, Available, [accessed 27 November 2012]
    • Centers for Disease Control and Prevention. 1991. Preventing Lead Poisoning in Young Children. Atlanta, GA:Centers for Disease Control and Prevention. Available: http://www.cdc.gov/nceh/lead/publications/prevleadpoisoning.pdf [accessed 27 November 2012].
    • (1991) Atlanta, GA:Centers For Disease Control and Prevention
  • 6
    • 77953483918 scopus 로고    scopus 로고
    • A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/β-catenin signaling
    • Chen JR, Lazarenko OP, Shankar K, Blackburn ML, Badger TM, Ronis MJ. 2010. A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/β-catenin signaling. J Bone Miner Res 25(5):1117-1127.
    • (2010) J Bone Miner Res , vol.25 , Issue.5 , pp. 1117-1127
    • Chen, J.R.1    Lazarenko, O.P.2    Shankar, K.3    Blackburn, M.L.4    Badger, T.M.5    Ronis, M.J.6
  • 7
    • 1642290381 scopus 로고    scopus 로고
    • PPARγ1 synthesis and adipogenesis in C3H10T1/2 cells depends on S-phase progression, but does not require mitotic clonal expansion
    • Cho YC, Jefcoate CR. 2004. PPARγ1 synthesis and adipogenesis in C3H10T1/2 cells depends on S-phase progression, but does not require mitotic clonal expansion. J Cell Biochem 91(2):336-353.
    • (2004) J Cell Biochem , vol.91 , Issue.2 , pp. 336-353
    • Cho, Y.C.1    Jefcoate, C.R.2
  • 8
    • 77956928374 scopus 로고    scopus 로고
    • Enhanced learning deficits in female rats following lifetime Pb exposure combined with prenatal stress
    • Cory-Slechta DA, Stern S, Weston D, Allen JL, Lui S. 2010. Enhanced learning deficits in female rats following lifetime Pb exposure combined with prenatal stress. Toxicol Sci 117(2):427-438.
    • (2010) Toxicol Sci , vol.117 , Issue.2 , pp. 427-438
    • Cory-Slechta, D.A.1    Stern, S.2    Weston, D.3    Allen, J.L.4    Lui, S.5
  • 10
    • 0031037251 scopus 로고    scopus 로고
    • Effect of lead on bone development and bone mass: A morphometric, densitometric, and histomorphometric study in growing rats
    • Escribano A, Revilla M, Hernandez ER, Seco C, Gonzalez-Riola J, et al. 1997. Effect of lead on bone development and bone mass: a morphometric, densitometric, and histomorphometric study in growing rats. Calcif Tissue Int 60(2):200-203.
    • (1997) Calcif Tissue Int , vol.60 , Issue.2 , pp. 200-203
    • Escribano, A.1    Revilla, M.2    Hernandez, E.R.3    Seco, C.4    Gonzalez-Riola, J.5
  • 11
    • 67650431302 scopus 로고    scopus 로고
    • Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
    • Fulciniti M, Tassone P, Hideshima T, Vallet S, Nanjappa P, Ettenberg SA, et al. 2009. Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood 114(2):371-379.
    • (2009) Blood , vol.114 , Issue.2 , pp. 371-379
    • Fulciniti, M.1    Tassone, P.2    Hideshima, T.3    Vallet, S.4    Nanjappa, P.5    Ettenberg, S.A.6
  • 13
    • 0027159075 scopus 로고
    • Lead toxicity: Current concerns
    • Goyer RA. 1993. Lead toxicity: current concerns. Environ Health Perspect 100:177-187.
    • (1993) Environ Health Perspect , vol.100 , pp. 177-187
    • Goyer, R.A.1
  • 15
    • 53149122891 scopus 로고    scopus 로고
    • Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins
    • Guo R, Yamashita M, Zhang Q, Zhou Q, Chen D, Reynolds DG, et al. 2008. Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins. J Biol Chem 283(34):23084-23092.
    • (2008) J Biol Chem , vol.283 , Issue.34 , pp. 23084-23092
    • Guo, R.1    Yamashita, M.2    Zhang, Q.3    Zhou, Q.4    Chen, D.5    Reynolds, D.G.6
  • 18
    • 50249087989 scopus 로고    scopus 로고
    • Relationship of blood lead levels to incident nonspine fractures and falls in older women: The study of osteoporotic fractures
    • Khalil N, Cauley JA, Wilson JW, Talbott EO, Morrow L, Hochber MC, et al. 2008. Relationship of blood lead levels to incident nonspine fractures and falls in older women: the study of osteoporotic fractures. J Bone Miner Res 23(9):1217-1225.
    • (2008) J Bone Miner Res , vol.23 , Issue.9 , pp. 1217-1225
    • Khalil, N.1    Cauley, J.A.2    Wilson, J.W.3    Talbott, E.O.4    Morrow, L.5    Hochber, M.C.6
  • 19
    • 0027230969 scopus 로고
    • Regulation of osteoblastic gene expression by lead
    • Klein RF, Wiren KM. 1993. Regulation of osteoblastic gene expression by lead. Endocrinology 132:2531-2537.
    • (1993) Endocrinology , vol.132 , pp. 2531-2537
    • Klein, R.F.1    Wiren, K.M.2
  • 20
    • 34250201079 scopus 로고    scopus 로고
    • Chibby promotes adipocyte differentiation through inhibition of β-catenin signaling
    • Li FQ, Singh AM, Mofunanya A, Love D, Terada N, Moon RT, et al. 2007. Chibby promotes adipocyte differentiation through inhibition of β-catenin signaling. Mol Cell Biol 27(12):4347-4354.
    • (2007) Mol Cell Biol , vol.27 , Issue.12 , pp. 4347-4354
    • Li, F.Q.1    Singh, A.M.2    Mofunanya, A.3    Love, D.4    Terada, N.5    Moon, R.T.6
  • 21
    • 44449099165 scopus 로고    scopus 로고
    • Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
    • Li X, Ominsky MS, Niu QT, Sun N, Daugherty B, D'Agostin D, et al. 2008. Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res 23(6):860-869.
    • (2008) J Bone Miner Res , vol.23 , Issue.6 , pp. 860-869
    • Li, X.1    Ominsky, M.S.2    Niu, Q.T.3    Sun, N.4    Daugherty, B.5    D'Agostin, D.6
  • 22
    • 65549152230 scopus 로고    scopus 로고
    • Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
    • Li X, Ominsky MS, Warmington KS, Morony S, Gong J, Cao J, et al. 2009. Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res 24(4):578-588.
    • (2009) J Bone Miner Res , vol.24 , Issue.4 , pp. 578-588
    • Li, X.1    Ominsky, M.S.2    Warmington, K.S.3    Morony, S.4    Gong, J.5    Cao, J.6
  • 23
    • 21244480924 scopus 로고    scopus 로고
    • Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    • Li X, Zhang Y, Kang H, Liu W, Liu P, Zhang J, et al. 2005. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem 280(20):19883-19887.
    • (2005) J Biol Chem , vol.280 , Issue.20 , pp. 19883-19887
    • Li, X.1    Zhang, Y.2    Kang, H.3    Liu, W.4    Liu, P.5    Zhang, J.6
  • 24
    • 0019973356 scopus 로고
    • National estimates of blood lead levels: United States, 1976-1980: Association with selected demographic and socioeconomic factors
    • Mahaffey KR, Annest JL, Roberts J, Murphy RS. 1982. National estimates of blood lead levels: United States, 1976-1980: association with selected demographic and socioeconomic factors. N Engl J Med 307:573-579.
    • (1982) N Engl J Med , vol.307 , pp. 573-579
    • Mahaffey, K.R.1    Annest, J.L.2    Roberts, J.3    Murphy, R.S.4
  • 25
    • 80455137144 scopus 로고    scopus 로고
    • Raman spectroscopy detects deterioration in biomechanical properties of bone in a glucocorticoid-treated mouse model of rheumatoid arthritis
    • Maher JR, Takahata M, Awad HA, Berger AJ. 2011. Raman spectroscopy detects deterioration in biomechanical properties of bone in a glucocorticoid-treated mouse model of rheumatoid arthritis. J Biomed Opt 16(8):087012.
    • (2011) J Biomed Opt , vol.16 , Issue.8 , pp. 087012
    • Maher, J.R.1    Takahata, M.2    Awad, H.A.3    Berger, A.J.4
  • 27
    • 7244245638 scopus 로고    scopus 로고
    • Bone density-related predictors of blood lead level among peri- and postmenopausal women in the United States: The Third National Health and Nutrition Examination Survey, 1988-1994
    • Nash D, Magder LS, Sherwin R, Rubin FJ, Silbergeld EK. 2004. Bone density-related predictors of blood lead level among peri- and postmenopausal women in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994. Am J Epidemiol 160(9):901-911.
    • (2004) Am J Epidemiol , vol.160 , Issue.9 , pp. 901-911
    • Nash, D.1    Magder, L.S.2    Sherwin, R.3    Rubin, F.J.4    Silbergeld, E.K.5
  • 28
    • 2342613539 scopus 로고    scopus 로고
    • Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications
    • Nuttall ME, Gimble JM. 2004. Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol 4(3):290-294.
    • (2004) Curr Opin Pharmacol , vol.4 , Issue.3 , pp. 290-294
    • Nuttall, M.E.1    Gimble, J.M.2
  • 29
    • 78650958526 scopus 로고    scopus 로고
    • Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
    • Padhi D, Jang G, Stouch B, Fang L, Posvar E. 2011. Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody. J Bone Miner Res 26(1):19-26.
    • (2011) J Bone Miner Res , vol.26 , Issue.1 , pp. 19-26
    • Padhi, D.1    Jang, G.2    Stouch, B.3    Fang, L.4    Posvar, E.5
  • 30
    • 0027592017 scopus 로고
    • A rapid Zeeman graphite furnace atomic absorption spectrometric method for the determination of lead in blood
    • Parsons PJ. 1993. A rapid Zeeman graphite furnace atomic absorption spectrometric method for the determination of lead in blood. Spectrochim Acta 48B:925-939.
    • (1993) Spectrochim Acta , vol.48 B , pp. 925-939
    • Parsons, P.J.1
  • 31
    • 84872053458 scopus 로고    scopus 로고
    • Lead toxicity in the skeleton and its role in osteoporosis
    • Holick MF, Dawson-Hughes B, eds. Totowa, NJ:Humana Press
    • Puzas JE, Campbell JR, O'Keefe RJ, Rosier RN. 2004. Lead toxicity in the skeleton and its role in osteoporosis. In: Nutrition and Bone Heath (Holick MF, Dawson-Hughes B, eds). Totowa, NJ:Humana Press, 363-376.
    • (2004) Nutrition and Bone Heath , pp. 363-376
    • Puzas, J.E.1    Campbell, J.R.2    O'Keefe, R.J.3    Rosier, R.N.4
  • 32
    • 33846026749 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling is a normal physiological response to mechanical loading in bone
    • Robinson JA, Chatterjee-Kishore M, Yaworsky PJ, Cullen DM, Zhao W, Li C, et al. 2006. Wnt/β-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem 281(42):31720-31728.
    • (2006) J Biol Chem , vol.281 , Issue.42 , pp. 31720-31728
    • Robinson, J.A.1    Chatterjee-Kishore, M.2    Yaworsky, P.J.3    Cullen, D.M.4    Zhao, W.5    Li, C.6
  • 34
    • 38449097094 scopus 로고    scopus 로고
    • Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor
    • Ryan EP, Holz JD, Mulcahey M, Sheu TJ, Gasiewicz, TA, Puzas JE. 2007. Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor. J Bone Miner Res 22(10):1571-1580.
    • (2007) J Bone Miner Res , vol.22 , Issue.10 , pp. 1571-1580
    • Ryan, E.P.1    Holz, J.D.2    Mulcahey, M.3    Sheu, T.J.4    Gasiewicz, T.A.5    Puzas, J.E.6
  • 35
    • 0026705308 scopus 로고
    • Lead inhibits secretion of osteonectin/SPARC without significantly altering collagen or Hsp47 production in osteoblast-like ROS 17/2.8
    • Sauk JJ, Smith T, Silbergeld EK, Fowler BA, Somerman MJ. 1992. Lead inhibits secretion of osteonectin/SPARC without significantly altering collagen or Hsp47 production in osteoblast-like ROS 17/2.8. Toxicol Appl Pharmacol 116(2):240-247.
    • (1992) Toxicol Appl Pharmacol , vol.116 , Issue.2 , pp. 240-247
    • Sauk, J.J.1    Smith, T.2    Silbergeld, E.K.3    Fowler, B.A.4    Somerman, M.J.5
  • 36
    • 61449361112 scopus 로고    scopus 로고
    • Targeting the Wnt signaling pathway to augment bone formation
    • Shahnazari M, Yao W, Corr M, Lane NE. 2008. Targeting the Wnt signaling pathway to augment bone formation. Curr Osteoporos Rep 6(4):142-148.
    • (2008) Curr Osteoporos Rep , vol.6 , Issue.4 , pp. 142-148
    • Shahnazari, M.1    Yao, W.2    Corr, M.3    Lane, N.E.4
  • 37
    • 49549089736 scopus 로고    scopus 로고
    • Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women
    • Syed FA, Oursler MJ, Hefferanm TE, Peterson JM, Riggs BL, Khosla S. 2008. Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women. Osteoporos Int 19(9):1323-1330.
    • (2008) Osteoporos Int , vol.19 , Issue.9 , pp. 1323-1330
    • Syed, F.A.1    Oursler, M.J.2    Hefferanm, T.E.3    Peterson, J.M.4    Riggs, B.L.5    Khosla, S.6
  • 39
    • 0036724870 scopus 로고    scopus 로고
    • Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis
    • Verma S, Rajaratnam JH, Denton J, Hoyland JA, Byers RJ. 2002. Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol 55(9):693-698.
    • (2002) J Clin Pathol , vol.55 , Issue.9 , pp. 693-698
    • Verma, S.1    Rajaratnam, J.H.2    Denton, J.3    Hoyland, J.A.4    Byers, R.J.5
  • 40
    • 0036313522 scopus 로고    scopus 로고
    • Correlation of bone mineral density with strength and microstructural parameters of cortical bone in vitro
    • Wachter NJ, Krischak GD, Mentzel M, Sarkar MR, Ebinger T, Kinzl L, et al. 2002. Correlation of bone mineral density with strength and microstructural parameters of cortical bone in vitro. Bone 31(1):90-95.
    • (2002) Bone , vol.31 , Issue.1 , pp. 90-95
    • Wachter, N.J.1    Krischak, G.D.2    Mentzel, M.3    Sarkar, M.R.4    Ebinger, T.5    Kinzl, L.6


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