Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment

Bone

Volumn 62, Issue , 2014, Pages 79-89

  Yukata, Kiminori ^c   Xie, Chao ^a   Li, Tian Fang ^a   Takahata, Masahiko ^a   Hoak, Donna ^a   Kondabolu, Sirish ^a   Zhang, Xinping ^a   Awad, Hani A ^a   Schwarz, Edward M ^a   Beck, Christopher A ^b   Jonason, Jennifer H ^a   O'Keefe, Regis J ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c TOKUSHIMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Fracture healing; Mesenchymal stem cell; Parathyroid hormone; Periosteum; Wnt catenin signaling

Indexed keywords

BETA CATENIN; CYCLIN D1; DICKKOPF 1 PROTEIN; MESSENGER RNA; OSTEOCALCIN; PARATHYROID HORMONE[1-34]; SCLEROSTIN; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX9; ANABOLIC AGENT; PARATHYROID HORMONE;

ADULT; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOMECHANICS; BIOSYNTHESIS; BONE MARROW CELL; BONE RADIOGRAPHY; BONE REGENERATION; BONE REMODELING; CALLUS; CARTILAGE CELL; CELL COUNT; CELL DIFFERENTIATION; CELL EXPANSION; CELL MATURATION; CELL POPULATION; CELL PROLIFERATION; CELL STIMULATION; COL10A1 GENE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; FRACTURE HEALING; GENE; GENE EXPRESSION; HISTOPATHOLOGY; HORMONAL THERAPY; MECHANICAL TORSION; MICRO-COMPUTED TOMOGRAPHY; MOLECULAR DYNAMICS; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCALCIN GENE; OSTERIX GENE; OUTCOME ASSESSMENT; PERIOSTEUM; RUNX2 GENE; SYSTEMIC THERAPY; TIBIA FRACTURE; TISSUE DIFFERENTIATION; TREATMENT RESPONSE; WNT SIGNALING PATHWAY; ANIMAL; BONE DEVELOPMENT; C57BL MOUSE; CARTILAGE; CELL AGING; CYTOLOGY; DRUG EFFECTS; HUMAN; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; STEM CELL; TIBIAL FRACTURES;

AGING; ANABOLIC AGENTS; ANIMALS; BIOMECHANICAL PHENOMENA; BONE REGENERATION; BONY CALLUS; CARTILAGE; CELL AGING; CELL PROLIFERATION; FEMALE; FRACTURE HEALING; HUMANS; MICE, INBRED C57BL; OSTEOGENESIS; PARATHYROID HORMONE; PERIOSTEUM; STEM CELLS; TIBIAL FRACTURES; WNT SIGNALING PATHWAY;

EID: 84896851309     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2014.02.002     Document Type: Article

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