Nicotinic modulation of gene expression in osteoblast cells, MG-63

Bone

Volumn 48, Issue 4, 2011, Pages 903-909

  Rothem, David E ^a   Rothem, Lilah ^b   Dahan, Aviva ^b   Eliakim, Rami ^a,c   Soudry, Michael ^a,c  

^a Rambam Health Care Campus ^*  (Israel)

^b Rambam Health Care Campus   (Israel)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Gene expression; Microarray; NAChR; NAChR antagonists; Nicotine; Osteoblast

Indexed keywords

NICOTINE; NICOTINIC RECEPTOR;

APOPTOSIS; ARTICLE; BONE METABOLISM; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; OSTEOBLAST; UPREGULATION;

BASE SEQUENCE; CELL LINE; DNA PRIMERS; GENE EXPRESSION PROFILING; HUMANS; NICOTINE; NICOTINIC ANTAGONISTS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOBLASTS;

EID: 79952701242     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2010.12.007     Document Type: Article

References (45)

1. Tsiridis E., Upadhyay N., Giannoudis P. Molecular aspects of fracture healing: which are the important molecules?. Injury 2007, 38:11-25.
2. Daniell H.W. Osteoporosis of the slender smoker: vertebral compression fractures and loss of metacarpal cortex in relation to postmenopausal cigarette smoking and lack of obesity. Arch. Int. Med. 1976, 136:298-304.
3. Dolev E. Cigarette smoking and osteoporosis. Harefuah 1997, 132:511-513.
4. Grisso J.A., Kelsey J.L., O'Brien L.A., Miles C.G., Sidney S., Maislin G., LaPann K., Moritz D., Peters B. Risk factors for hip fractures in men. Am. J. Epidemiol. 1997, 145:786-793.
5. Krall E.A., Dawson H.B. Smoking and bone loss among postmenopausal women. J. Bone Miner. Res. 1991, 6:331-338.
6. Krall E.A., Dawson H.B. Smoking increases bone loss and decreases intestinal calcium absorption. J. Bone Miner. Res. 1999, 14:215-220.
7. Mussolino M.E., Looker A.C., Madans J.H., Langlois J.A., Orwoll E.S. Risk factors for hip fracture in white men: the NHANES I Epidemiologic Follow-up Study. J. Bone Miner. Res. 1998, 13:918-924.
8. Mazess R.B., Barden H.S. Bone density in premenopausal women: effects of age dietary intake, physical activity, smoking and birth control pills. Am. J. Clin. Nutr. 1991, 153:132-142.
9. Brown C.W., Orme T.J., Richardson H.D. The rate of pseudarthrosis (surgical nonunion) in patients who are smokers and patients who are nonsmokers: a comparison study. Spine 1985, 11:942-949.
10. Ishikawa S.N., Murphy G.A., Richardson E.G. The effect of cigarette smoking on hindfoot fusions. Foot Ankle Int. 2002, 23:996-998.
11. Kyro A., Usenius J.P., Aarnio M., Kunnamo I., Avikainen V. Are smokers a risk group for delayed healing of the tibial shaft fracture?. Ann. Chir. Et. Gynecol. 1993, 82:254-262.
12. Millar N.S., Harkness P.C. Assembly and trafficking of nicotinic acetylcholine receptors. Mol. Membr. Biol. 2008, 25:279-292.
13. Buisson P., Picard F., Bertrand D. Neuronal nicotinic acetylcholine receptors: from biophysical properties to human diseases. Neuronal nicotinic acetylcholine receptors 2000, 272-299. Springer, Berlin. F. Clementi, C. Gotti, D. Fornasari (Eds.).
14. Walker L.M., Preston M.R., Magnay J.L., Thomas P.B.M., El Haj A.J. Nicotinic regulation of c-fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ culture. Bone 2001, 28:603-608.
15. Romano S.J., Corriveau R.A., Schwarz R.I., Berg D.K. Expression of the nicotinic receptor alpha 7 gene in tendon and periosteum during early development. J. Neurochem. 1997, 68:640-648.
16. En-Nosse M., Hartmann S., Trinkaus K., Alt V., Stigler B., Heiss C., Kilian O., Schnettler R., Lips K.S. Expression of non-neuronal cholinergic system in osteoblast-like cells and its involvement in osteogenesis. Cell Tissue Res. 2009, 338:203-215.
17. Raikin S.M., Landsman J.C., Alexander V.A., Froimson M.I., Plaxton N.A. Effect of nicotine on the rate and strength of long bone fracture healing. Clin. Orthop. 1998, 353:231-237.
18. Syversen U., Nordsletten L., Falch J.A., Madsen J.E., Nilsen O.G., Waldum H.L. Effect of lifelong nicotine inhalation on bone mass and mechanical properties in female rat femurs. Calcif. Tissue Int. 1999, 65:246-249.
19. Kim K.S., Yoon S.T., Park J.S., Li J., Park M.S., Hutton Inhibition W.C. of proteoglycan and type II collagen synthesis of disc nucleus cells by nicotine. J. Neurosurg. 2003, 99:291-297.
20. Fang M.A., Frost P.J., Iida-Klein A., Hahn T.J. Effects of nicotine on cellular function in UMR 106 osteoblast-like cells. Bone 1991, 12:283-286.
21. Katono T., Kawato T., Tanabe N., Suzuki N., Yamanaka K., Oka H., Motohashi M. Maeno, Nicotine treatment induces expression of matrix metalloproteinases in human osteoblastic Saos-2 cells. Acta Biochim. Biophys. Sin. 2006, 38:874-882.
22. Rothem D.E., Rothem L., Soudry M., Dahan A., Eliakim R. Nicotine modulates bone metabolism-associated gene expression in osteoblast cells. J. Bone Miner. Metab. 2009, 27:555-561.
23. Dunckley T., Lukas R.J. Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line. J. Biol. Chem. 2003, 278:15633-15640.
24. Lukas R.J., Norman S.A., Lucero L. Characterization of nicotinic acetylcholine receptors expressed by cells of the SH-SY5Y human neuroblastoma clonal line. Mol. Cell. Neurosci. 1993, 4:1-12.
25. Papke R.L., Sanberg P.R., Shytle R.D. Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes. J. Pharmacol. Exp. Ther. 2001, 297:646-656.
26. Ramji D.P., Foka P. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem. J. 2002, 365:561-575.
27. Kon T., Cho T.J., Aizawa T., Yamazaki M., Nooh N., Graves D., Gerstenfeld L.C., Einhorn T.A. Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing. J. Bone Miner. Res. 2001, 16:1004-1014.
28. Iyer V.V., Kadakia T.B., McCabe L.R., Schwartz R.C. CCAAT/enhancer-binding protein-beta has a role in osteoblast proliferation and differentiation. Exp. Cell Res. 2004, 295:128-137.
29. Sato T., Abe T., Nakamoto N., Tomaru Y., Koshikiya N., Nojima J., Kokabu S., Sakata Y., Kobayashi A., Yoda T. Nicotine induces cell proliferation in association with cyclin D1 up-regulation and inhibits cell differentiation in association with p53 regulation in a murine pre-osteoblastic cell line. Biochem. Biophys. Res. Commun. 2008, 377:126-130.
30. Segrelles C., Moral M., Lorz C., Santos M., Lu J., Cascallana J.L., Lara M.F., Carbajal S., Martínez-Cruz A.B., García-Escudero R., Beltran L., Segovia J.C., Bravo A., DiGiovanni J., Paramio J.M. Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling. Mol. Biol. Cell 2008, 19:137-149.
31. Wong W.W., Puthalakath H. Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway. IUBMB Life 2008, 60:390-397.
32. Nishikawa T., Tsuno N.H., Tsuchiya T., Yoneyama S., Yamada J., Shuno Y., Okaji Y., Tanaka J., Kitayama J., Takahashi K., Nagawa H. Sulforaphane stimulates activation of proapoptotic protein bax leading to apoptosis of endothelial progenitor cells. Ann. Surg. Oncol. 2009, 16:534-543.
33. Rundle C.H., Wang X., Sheng M.H., Wergedal J.E., Lau K.H., Mohan S. Bax deficiency in mice increases cartilage production during fracture repair through a mechanism involving increased chondrocyte proliferation without changes in apoptosis. Bone 2008, 43:880-888.
34. Lofthouse R.A., Davis J.R., Frondoza C.G., Jinnah R.H., Hungerford D.S., Hare J.M. Identification of caveolae and detection of caveolin in normal human osteoblasts. J. Bone Joint Surg. Br. 2001, 83:124-129.
35. Cantiani L., Manara M.C., Zucchini C., De Sanctis P., Zuntini M., Valvassori L., Serra M., Olivero M., Di Renzo M.F., Colombo M.P., Picci P., Scotlandi K. Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling. Cancer Res. 2007, 67:7675-7685.
36. Wu D., Terrian D.M. Regulation of caveolin-1 expression and secretion by a protein kinase C (PKC) epsilon signaling pathway in human prostate cancer cells. J. Biol. Chem. 2002, 277:40449-40455.
37. Thompson T.C., Timme T.L., Li L., Goltsov A. Caveolin-1, a metastasis-related gene that promotes cell survival in prostate cancer. Apoptosis 1999, 4:233-237.
38. Dass C.R., Khachigian L.M., Choong P.F. c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model. Mol. Cancer Res. 2008, 6:1289-1292.
39. Zenz R., Eferl R., Scheinecker C., Redlich K., Smolen J., Schonthaler H.B., Kenner L., Tschachler E., Wagner E.F. Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease. Arthritis Res. Ther. 2008, 10:201-210.
40. Nelson J.B., Nguyen S.H., Wu-Wong J.R., Opgenorth T.J., Dixon D.B., Chung L.W., Inoue N. New bone formation in an osteoblastic tumor model is increased by endothelin-1 overexpression and decreased by endothelin A receptor blockade. Urology 1999, 53:1063-1069.
41. Rosol T.J. Pathogenesis of bone metastases: role of tumor-related proteins. J. Bone Miner. Res. 2000, 15:844-850.
42. Kitten A.M., Andrews C.J.J. Endothelin-1 expression in long-term cultures of fetal rat calvarial osteoblasts: regulation by BMP-7. Cell Physiol. 2001, 187:218-225.
43. Carducci M.A., Jimeno A. Targeting bone metastasis in prostate cancer with endothelin receptor antagonists. Clin. Cancer Res. 2006, 12:6296-6300.
44. Van Sant C., Wang G., Anderson M.G., Trask O.J., Lesniewski R., Semizarov D. Endothelin signaling in osteoblasts: global genome view and implication of the calcineurin/NFAT pathway. Mol. Cancer Ther. 2007, 6:253-261.
45. Arias H.R., Richards V.E., Ng D., Ghafoori M.E., Le V., Mousa S.A. Role of non-neuronal nicotinic acetylcholine receptors in angiogenesis. Int. J. Biochem. Cell Biol. 2009, 41:1441-1451.