Long-term cadmium exposure and the association with bone mineral density and fractures in a population-based study among women

Journal of Bone and Mineral Research

Volumn 26, Issue 3, 2011, Pages 486-495

  Engström, Annette ^a   Michaëlsson, Karl ^b   Suwazono, Yasushi ^c   Wolk, Alicja ^a   Vahter, Marie ^a   Åkesson, Agneta ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

bone mineral density; cadmium; DXA; fractures; osteoporosis

Indexed keywords

CADMIUM;

ADULT; AGED; ARTICLE; BONE DENSITY; BONE INJURY; COHORT ANALYSIS; DISEASE SEVERITY; DUAL ENERGY X RAY ABSORPTIOMETRY; ENVIRONMENTAL EXPOSURE; FEMALE; FEMUR NECK; FOOD; FOREARM FRACTURE; FRACTURE; FRAGILITY FRACTURE; HIP; HUMAN; LONG TERM EXPOSURE; LUMBAR SPINE; MAJOR CLINICAL STUDY; OSTEOPOROSIS; POPULATION RESEARCH; SMOKING;

AGED; BONE DENSITY; CADMIUM; CONFIDENCE INTERVALS; CREATININE; ENVIRONMENTAL EXPOSURE; FEMALE; FRACTURES, BONE; HUMANS; LINEAR MODELS; MAGNESIUM; MIDDLE AGED; ODDS RATIO; OSTEOPOROSIS; RISK FACTORS; SWEDEN; TIME FACTORS;

EID: 79951846688     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.224     Document Type: Article

References (33)

1. Amzal B, Julin B, Vahter M, Wolk A, Johanson G, Åkesson A,. Population toxicokinetic modeling of cadmium for health risk assessment. Environ Health Perspect. 2009; 117: 1293-1301.
2. Järup L, Åkesson A,. Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol. 2009; 238: 201-208.
3. Alfvén T, Elinder CG, Carlsson MD, et al. Low-level cadmi (Pubitemid 30484528)
4. Staessen JA, Roels HA, Emelianov D, et al. Environmental exposure to cadmium, forearm bone density, and risk of fractures: prospective population study. Public Health and Environmental Exposure to Cadmium (PheeCad) Study Group. Lancet. 1999; 353: 1140-1144. (Pubitemid 29155207)
5. Wang H, Zhu G, Shi Y, et al. Influence of environmental cadmium exposure on forearm bone density. J Bone Miner Res. 2003; 18: 553-560. (Pubitemid 36241073)
6. Åkesson A, Bjellerup P, Lundh T, et al. Cadmium-induced effects on bone in a population-based study of women. Environ Health Perspect. 2006; 114: 830-834. (Pubitemid 43871729)
7. Gallagher CM, Kovach JS, Meliker JR,. Urinary cadmium and osteoporosis in U.S. Women >or= 50 years of age: NHANES 1988-1994 and 1999-2004. Environ Health Perspect. 2008; 116: 1338-1343.
8. Horiguchi H, Oguma E, Sasaki S, et al. Environmental exposure to cadmium at a level insufficient to induce renal tubular dysfunction does not affect bone density among female Japanese farmers. Environ Res. 2005; 97: 83-92. (Pubitemid 39336394)
9. Rignell-Hydbom A, Skerfving S, Lundh T, et al. Exposure to cadmium and persistent organochlorine pollutants and its association with bone mineral density and markers of bone metabolism on postmenopausal women. Environ Res. 2009; 109: 991-996.
10. Trzcinka-Ochocka M, Jakubowski M, Szymczak W, Janasik B, Brodzka R,. The effects of low environmental cadmium exposure on bone density. Environ Res. 2010; 110: 286-293.
11. Wallin E, Rylander L, Jönsson BA, Lundh T, Isaksson A, Hagmar L,. Exposure to CB-153 and p,p'-DDE and bone mineral density and bone metabolism markers in middle-aged and elderly men and women. Osteoporos Int. 2005; 16: 2085-2094. (Pubitemid 41790931)
12. Alfvén T, Elinder CG, Hellström L, Lagarde F, Järup L,. Cadmium exposure and distal forearm fractures. J Bone Miner Res. 2004; 19: 900-905. (Pubitemid 41103446)
13. Wolk A, Larsson SC, Johansson JE, Ekman P,. Long-term fatty fish consumption and renal cell carcinoma incidence in women. JAMA. 2006; 296: 1371-1376. (Pubitemid 44427423)
14. Elinder CG, Kjellström T, Linnman L, Pershagen G,. Urinary excretion of cadmium and zinc among persons from Sweden. Environ Res. 1978; 15: 473-484. (Pubitemid 8377181)
15. The National Board of Health and Welfare. Classification of Diseases and Related Health Problems 1997-version 2010. 1997; 1-941 (in Swedish). Available at
16. Leidig-Bruckner G, Ziegler R,. Diabetes mellitus a risk for osteoporosis? Exp Clin Endocrinol Diabetes. 2001; 109 (Suppl 2): S493-514. (Pubitemid 32577598)
17. Michaëlsson K, Holmberg L, Mallmin H, et al. Diet and hip fracture risk: a case-control study. Study Group of the Multiple Risk Survey on Swedish Women for Eating Assessment. Int J Epidemiol. 1995; 24: 771-782.
18. Orlowski C, Piotrowski JK, Subdys JK, Gross A,. Urinary cadmium as indicator of renal cadmium in humans: an autopsy study. Hum Exp Toxicol. 1998; 17: 302-306. (Pubitemid 28342337)
19. Kippler M, Lönnerdal B, Goessler W, Ekström EC, Arifeen SE, Vahter M,. Cadmium interacts with the transport of essential micronutrients in the mammary gland-a study in rural Bangladeshi women. Toxicology. 2009; 257: 64-69.
20. Orsini N, Bellocco R, Bottai M, et al. Validity of self-reported total physical activity questionnaire among older women. Eur J Epidemiol. 2008; 23: 661-667.
21. Center JR, Nguyen TV, Pocock NA, Eisman JA,. Volumetric bone density at the femoral neck as a common measure of hip fracture risk for men and women. J Clin Endocrinol Metab. 2004; 89: 2776-2782. (Pubitemid 38766365)
22. WHO. Assessment of fracture risk and its application to screening to postmenopausal osteoporosis: technical report series 843. 1994; World Health Organization, Geneva.
23. Gedeborg R, Engquist H, Berglund L, Michaëlsson K,. Identification of incident injuries in hospital discharge registers. Epidemiology. 2008; 19: 860-867.
24. Gelman A,. Scaling regression inputs by dividing by two standard deviations. Stat Med. 2008; 27: 2865-2873. (Pubitemid 351982681)
25. Heinzl H, Kaider A,. Gaining more flexibility in Cox proportional hazards regression models with cubic spline functions. Comput Methods Programs Biomed. 1997; 54: 201-208. (Pubitemid 27496007)
26. Buchet JP, Lauwerys R, Roels H, et al. Renal effects of cadmium body burden of the general population. Lancet. 1990; 336: 699-702. (Pubitemid 20309126)
27. Kanis JA, McCloskey EV, Johansson H, Oden A, Melton LJ 3rd, Khaltaev N,. A reference standard for the description of osteoporosis. Bone. 2008; 42: 467-475.
28. Bhattacharyya MH,. Cadmium osteotoxicity in experimental animals: mechanisms and relationship to human exposures. Toxicol Appl Pharmacol. 2009; 238: 258-265.
29. Nawrot T, Geusens P, Nulens T, Nemery B,. Occupational cadmium exposure and calcium excretion, bone density and osteoporosis in men. J Bone Miner Res. 2010; 25: 1441-1445.
30. Schutte R, Nawrot TS, Richart T, et al. Bone resorption and environmental exposure to cadmium in women: a population study. Environ Health Perspect. 2008; 116: 777-783. (Pubitemid 351943934)
31. Brzõska MM, Moniuszko-Jakoniuk J,. Low-level lifetime exposure to cadmium decreases skeletal mineralization and enhances bone loss in aged rats. Bone. 2004; 35: 1180-1191. (Pubitemid 39487365)
32. Brzõska MM, Majewska K, Moniuszko-Jakoniuk J,. Mineral status and mechanical properties of lumbar spine of female rats chronically exposed to various levels of cadmium. Bone. 2004; 34: 517-526. (Pubitemid 38314916)
33. Engström A, Skerving S, Lidfeldt J, et al. Cadmium-induced bone effect is not mediated via low serum 1,25-dihydroxy vitamin D. Environ Res. 2009; 109: 188-192.