메뉴 건너뛰기




Volumn 46, Issue 6, 2010, Pages 1604-1612

Healing of non-displaced fractures produced by fatigue loading of the mouse ulna

Author keywords

Fatigue loading; FGF signaling; Fracture healing; Hypoxia; Mouse ulna; Woven bone

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE SIALOPROTEIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 16; FIBROBLAST GROWTH FACTOR 18; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 3; FIBROBLAST GROWTH FACTOR 9; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NERVE CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR OSTERIX;

EID: 77953028993     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2010.02.030     Document Type: Article
Times cited : (41)

References (40)
  • 1
    • 39149143035 scopus 로고    scopus 로고
    • Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis
    • Ai-Aql Z.S., Alagl A.S., Graves D.T., Gerstenfeld L.C., Einhorn T.A. Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J Dent Res 2008, 87:107-118.
    • (2008) J Dent Res , vol.87 , pp. 107-118
    • Ai-Aql, Z.S.1    Alagl, A.S.2    Graves, D.T.3    Gerstenfeld, L.C.4    Einhorn, T.A.5
  • 2
    • 0037376627 scopus 로고    scopus 로고
    • Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation
    • Gerstenfeld L.C., Cullinane D.M., Barnes G.L., Graves D.T., Einhorn T.A. Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 2003, 88:873-884.
    • (2003) J Cell Biochem , vol.88 , pp. 873-884
    • Gerstenfeld, L.C.1    Cullinane, D.M.2    Barnes, G.L.3    Graves, D.T.4    Einhorn, T.A.5
  • 3
    • 0037119434 scopus 로고    scopus 로고
    • Transcriptional profiling of bone regeneration. Insight into the molecular complexity of wound repair
    • Hadjiargyrou M., Lombardo F., Zhao S., Ahrens W., Joo J., Ahn H., et al. Transcriptional profiling of bone regeneration. Insight into the molecular complexity of wound repair. J Biol Chem 2002, 277:30177-30182.
    • (2002) J Biol Chem , vol.277 , pp. 30177-30182
    • Hadjiargyrou, M.1    Lombardo, F.2    Zhao, S.3    Ahrens, W.4    Joo, J.5    Ahn, H.6
  • 4
    • 1642333512 scopus 로고    scopus 로고
    • Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair
    • Komatsu D.E., Hadjiargyrou M. Activation of the transcription factor HIF-1 and its target genes, VEGF, HO-1, iNOS, during fracture repair. Bone 2004, 34:680-688.
    • (2004) Bone , vol.34 , pp. 680-688
    • Komatsu, D.E.1    Hadjiargyrou, M.2
  • 5
    • 0029008655 scopus 로고
    • Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing
    • Bostrom M.P., Lane J.M., Berberian W.S., Missri A.A., Tomin E., Weiland A., et al. Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing. J Orthop Res 1995, 13:357-367.
    • (1995) J Orthop Res , vol.13 , pp. 357-367
    • Bostrom, M.P.1    Lane, J.M.2    Berberian, W.S.3    Missri, A.A.4    Tomin, E.5    Weiland, A.6
  • 6
    • 0036181393 scopus 로고    scopus 로고
    • Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing
    • Cho T.J., Gerstenfeld L.C., Einhorn T.A. Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J Bone Miner Res 2002, 17:513-520.
    • (2002) J Bone Miner Res , vol.17 , pp. 513-520
    • Cho, T.J.1    Gerstenfeld, L.C.2    Einhorn, T.A.3
  • 8
    • 0034999587 scopus 로고    scopus 로고
    • Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing
    • Kon T., Cho T.J., Aizawa T., Yamazaki M., Nooh N., Graves D., et al. Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing. J Bone Miner Res 2001, 16:1004-1014.
    • (2001) J Bone Miner Res , vol.16 , pp. 1004-1014
    • Kon, T.1    Cho, T.J.2    Aizawa, T.3    Yamazaki, M.4    Nooh, N.5    Graves, D.6
  • 9
    • 0032712814 scopus 로고    scopus 로고
    • Cartilage-derived retinoic acid-sensitive protein and type II collagen expression during fracture healing are potential targets for Sox9 regulation
    • Sakano S., Zhu Y., Sandell L.J. Cartilage-derived retinoic acid-sensitive protein and type II collagen expression during fracture healing are potential targets for Sox9 regulation. J Bone Miner Res 1999, 14:1891-1901.
    • (1999) J Bone Miner Res , vol.14 , pp. 1891-1901
    • Sakano, S.1    Zhu, Y.2    Sandell, L.J.3
  • 10
    • 0034858649 scopus 로고    scopus 로고
    • Spatial and temporal gene expression in chondrogenesis during fracture healing and the effects of basic fibroblast growth factor
    • Nakajima F., Ogasawara A., Goto K., Moriya H., Ninomiya Y., Einhorn T.A., et al. Spatial and temporal gene expression in chondrogenesis during fracture healing and the effects of basic fibroblast growth factor. J Orthop Res 2001, 19:935-944.
    • (2001) J Orthop Res , vol.19 , pp. 935-944
    • Nakajima, F.1    Ogasawara, A.2    Goto, K.3    Moriya, H.4    Ninomiya, Y.5    Einhorn, T.A.6
  • 11
    • 0034751369 scopus 로고    scopus 로고
    • Spatial and temporal gene expression for fibroblast growth factor type I receptor (FGFR1) during fracture healing in the rat
    • Nakajima A., Nakajima F., Shimizu S., Ogasawara A., Wanaka A., Moriya H., et al. Spatial and temporal gene expression for fibroblast growth factor type I receptor (FGFR1) during fracture healing in the rat. Bone 2001, 29:458-466.
    • (2001) Bone , vol.29 , pp. 458-466
    • Nakajima, A.1    Nakajima, F.2    Shimizu, S.3    Ogasawara, A.4    Wanaka, A.5    Moriya, H.6
  • 12
    • 0141450484 scopus 로고    scopus 로고
    • Expression of fibroblast growth factor receptor-3 (FGFR3), signal transducer and activator of transcription-1, and cyclin-dependent kinase inhibitor p21 during endochondral ossification: differential role of FGFR3 in skeletal development and fracture repair
    • Nakajima A., Shimizu S., Moriya H., Yamazaki M. Expression of fibroblast growth factor receptor-3 (FGFR3), signal transducer and activator of transcription-1, and cyclin-dependent kinase inhibitor p21 during endochondral ossification: differential role of FGFR3 in skeletal development and fracture repair. Endocrinology 2003, 144:4659-4668.
    • (2003) Endocrinology , vol.144 , pp. 4659-4668
    • Nakajima, A.1    Shimizu, S.2    Moriya, H.3    Yamazaki, M.4
  • 14
    • 61649087194 scopus 로고    scopus 로고
    • Fibroblast growth factor expression during skeletal fracture healing in mice
    • Schmid G.J., Kobayashi C., Sandell L.J., Ornitz D.M. Fibroblast growth factor expression during skeletal fracture healing in mice. Dev Dyn 2009, 238:766-774.
    • (2009) Dev Dyn , vol.238 , pp. 766-774
    • Schmid, G.J.1    Kobayashi, C.2    Sandell, L.J.3    Ornitz, D.M.4
  • 15
    • 41949092558 scopus 로고    scopus 로고
    • Fibroblast growth factor regulation of neovascularization
    • Murakami M., Simons M. Fibroblast growth factor regulation of neovascularization. Curr Opin Hematol 2008, 15:215-220.
    • (2008) Curr Opin Hematol , vol.15 , pp. 215-220
    • Murakami, M.1    Simons, M.2
  • 16
    • 33846214070 scopus 로고    scopus 로고
    • FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate
    • Liu Z., Lavine K.J., Hung I.H., Ornitz D.M. FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. Dev Biol 2007, 302:80-91.
    • (2007) Dev Biol , vol.302 , pp. 80-91
    • Liu, Z.1    Lavine, K.J.2    Hung, I.H.3    Ornitz, D.M.4
  • 17
    • 34347248067 scopus 로고    scopus 로고
    • FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod
    • Hung I.H., Yu K., Lavine K.J., Ornitz D.M. FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod. Dev Biol 2007, 307:300-313.
    • (2007) Dev Biol , vol.307 , pp. 300-313
    • Hung, I.H.1    Yu, K.2    Lavine, K.J.3    Ornitz, D.M.4
  • 18
    • 0021612066 scopus 로고
    • Production of a standard closed fracture in laboratory animal bone
    • Bonnarens F., Einhorn T.A. Production of a standard closed fracture in laboratory animal bone. J Orthop Res 1984, 2:97-101.
    • (1984) J Orthop Res , vol.2 , pp. 97-101
    • Bonnarens, F.1    Einhorn, T.A.2
  • 19
    • 0027558772 scopus 로고
    • A standardized experimental fracture in the mouse tibia
    • Hiltunen A., Vuorio E., Aro H.T. A standardized experimental fracture in the mouse tibia. J Orthop Res 1993, 11:305-312.
    • (1993) J Orthop Res , vol.11 , pp. 305-312
    • Hiltunen, A.1    Vuorio, E.2    Aro, H.T.3
  • 21
    • 47849096220 scopus 로고    scopus 로고
    • Genetic variation in the patterns of skeletal progenitor cell differentiation and progression during endochondral bone formation affects the rate of fracture healing
    • Jepsen K.J., Price C., Silkman L.J., Nicholls F.H., Nasser P., Hu B., et al. Genetic variation in the patterns of skeletal progenitor cell differentiation and progression during endochondral bone formation affects the rate of fracture healing. J Bone Miner Res 2008, 23:1204-1216.
    • (2008) J Bone Miner Res , vol.23 , pp. 1204-1216
    • Jepsen, K.J.1    Price, C.2    Silkman, L.J.3    Nicholls, F.H.4    Nasser, P.5    Hu, B.6
  • 22
    • 69449084918 scopus 로고    scopus 로고
    • Fixation compliance in a mouse osteotomy model induces two different processes of bone healing but does not lead to delayed union
    • Grongroft I., Heil P., Matthys R., Lezuo P., Tami A., Perren S., et al. Fixation compliance in a mouse osteotomy model induces two different processes of bone healing but does not lead to delayed union. J Biomech 2009, 42:2089-2096.
    • (2009) J Biomech , vol.42 , pp. 2089-2096
    • Grongroft, I.1    Heil, P.2    Matthys, R.3    Lezuo, P.4    Tami, A.5    Perren, S.6
  • 23
    • 0141679313 scopus 로고    scopus 로고
    • Degradation of bone structural properties by accumulation and coalescence of microcracks
    • Danova N.A., Colopy S.A., Radtke C.L., Kalscheur V.L., Markel M.D., Vanderby R., et al. Degradation of bone structural properties by accumulation and coalescence of microcracks. Bone 2003, 33:197-205.
    • (2003) Bone , vol.33 , pp. 197-205
    • Danova, N.A.1    Colopy, S.A.2    Radtke, C.L.3    Kalscheur, V.L.4    Markel, M.D.5    Vanderby, R.6
  • 26
    • 33845777529 scopus 로고    scopus 로고
    • Use of the rat forelimb compression model to create discrete levels of bone damage in vivo
    • Uthgenannt B.A., Silva M.J. Use of the rat forelimb compression model to create discrete levels of bone damage in vivo. J Biomech 2007, 40:317-324.
    • (2007) J Biomech , vol.40 , pp. 317-324
    • Uthgenannt, B.A.1    Silva, M.J.2
  • 27
    • 5344272497 scopus 로고    scopus 로고
    • Response of the osteocyte syncytium adjacent to and distant from linear microcracks during adaptation to cyclic fatigue loading
    • Colopy S.A., Benz-Dean J., Barrett J.G., Sample S.J., Lu Y., Danova N.A., et al. Response of the osteocyte syncytium adjacent to and distant from linear microcracks during adaptation to cyclic fatigue loading. Bone 2004, 35:881-891.
    • (2004) Bone , vol.35 , pp. 881-891
    • Colopy, S.A.1    Benz-Dean, J.2    Barrett, J.G.3    Sample, S.J.4    Lu, Y.5    Danova, N.A.6
  • 28
    • 0036311868 scopus 로고    scopus 로고
    • In vivo fatigue loading of the rat ulna induces both bone formation and resorption and leads to time-related changes in bone mechanical properties and density
    • Hsieh Y.F., Silva M.J. In vivo fatigue loading of the rat ulna induces both bone formation and resorption and leads to time-related changes in bone mechanical properties and density. J Orthop Res 2002, 20:764-771.
    • (2002) J Orthop Res , vol.20 , pp. 764-771
    • Hsieh, Y.F.1    Silva, M.J.2
  • 29
    • 38449109142 scopus 로고    scopus 로고
    • Skeletal self-repair: stress fracture healing by rapid formation and densification of woven bone
    • Uthgenannt B.A., Kramer M.H., Hwu J.A., Wopenka B., Silva M.J. Skeletal self-repair: stress fracture healing by rapid formation and densification of woven bone. J Bone Miner Res 2007, 22:1548-1556.
    • (2007) J Bone Miner Res , vol.22 , pp. 1548-1556
    • Uthgenannt, B.A.1    Kramer, M.H.2    Hwu, J.A.3    Wopenka, B.4    Silva, M.J.5
  • 31
    • 58249105081 scopus 로고    scopus 로고
    • Stress fracture healing: fatigue loading of the rat ulna induces upregulation in expression of osteogenic and angiogenic genes that mimic the intramembranous portion of fracture repair
    • Wohl G.R., Towler D.A., Silva M.J. Stress fracture healing: fatigue loading of the rat ulna induces upregulation in expression of osteogenic and angiogenic genes that mimic the intramembranous portion of fracture repair. Bone 2009, 44:320-330.
    • (2009) Bone , vol.44 , pp. 320-330
    • Wohl, G.R.1    Towler, D.A.2    Silva, M.J.3
  • 32
    • 0041762493 scopus 로고    scopus 로고
    • Bone development and age-related bone loss in male C57BL/6J mice
    • Ferguson V.L., Ayersa R.A., Bateman T.A., Simske S.J. Bone development and age-related bone loss in male C57BL/6J mice. Bone 2003, 33:387-398.
    • (2003) Bone , vol.33 , pp. 387-398
    • Ferguson, V.L.1    Ayersa, R.A.2    Bateman, T.A.3    Simske, S.J.4
  • 33
    • 0036756329 scopus 로고    scopus 로고
    • Validation of a technique for studying functional adaptation of the mouse ulna in response to mechanical loading
    • Lee K.C., Maxwell A., Lanyon L.E. Validation of a technique for studying functional adaptation of the mouse ulna in response to mechanical loading. Bone 2002, 31:407-412.
    • (2002) Bone , vol.31 , pp. 407-412
    • Lee, K.C.1    Maxwell, A.2    Lanyon, L.E.3
  • 34
    • 0036862205 scopus 로고    scopus 로고
    • Mechanotransduction in bone: genetic effects on mechanosensitivity in mice
    • Robling A.G., Turner C.H. Mechanotransduction in bone: genetic effects on mechanosensitivity in mice. Bone 2002, 31:562-569.
    • (2002) Bone , vol.31 , pp. 562-569
    • Robling, A.G.1    Turner, C.H.2
  • 36
    • 34249913494 scopus 로고    scopus 로고
    • The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development
    • Wang Y., Wan C., Deng L., Liu X., Cao X., Gilbert S.R., et al. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest 2007, 117:1616-1626.
    • (2007) J Clin Invest , vol.117 , pp. 1616-1626
    • Wang, Y.1    Wan, C.2    Deng, L.3    Liu, X.4    Cao, X.5    Gilbert, S.R.6
  • 37
    • 33751506452 scopus 로고    scopus 로고
    • BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing
    • Tsuji K., Bandyopadhyay A., Harfe B.D., Cox K., Kakar S., Gerstenfeld L., et al. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet 2006, 38:1424-1429.
    • (2006) Nat Genet , vol.38 , pp. 1424-1429
    • Tsuji, K.1    Bandyopadhyay, A.2    Harfe, B.D.3    Cox, K.4    Kakar, S.5    Gerstenfeld, L.6
  • 38
    • 38649128127 scopus 로고    scopus 로고
    • Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration
    • Wan C., Gilbert S.R., Wang Y., Cao X., Shen X., Ramaswamy G., et al. Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration. Proc Natl Acad Sci U S A 2008, 105:686-691.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 686-691
    • Wan, C.1    Gilbert, S.R.2    Wang, Y.3    Cao, X.4    Shen, X.5    Ramaswamy, G.6
  • 39
    • 50249185592 scopus 로고    scopus 로고
    • Functional adaptation to loading of a single bone is neuronally regulated and involves multiple bones
    • Sample S.J., Behan M., Smith L., Oldenhoff W.E., Markel M., Kalscheur V.L., et al. Functional adaptation to loading of a single bone is neuronally regulated and involves multiple bones. J Bone Miner Res 2008, 23:1372-1381.
    • (2008) J Bone Miner Res , vol.23 , pp. 1372-1381
    • Sample, S.J.1    Behan, M.2    Smith, L.3    Oldenhoff, W.E.4    Markel, M.5    Kalscheur, V.L.6
  • 40
    • 74249114163 scopus 로고    scopus 로고
    • Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones
    • Sugiyama T., Price J.S., Lanyon L.E. Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones. Bone 2009, 46:314-321.
    • (2009) Bone , vol.46 , pp. 314-321
    • Sugiyama, T.1    Price, J.S.2    Lanyon, L.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.