Cardioprotective potential of annexin-A1 mimetics in myocardial infarction

Pharmacology and Therapeutics

Volumn 148, Issue , 2015, Pages 47-65

  Qin, Chengxue ^a,d   Yang, Yuan H ^b   May, Lauren ^c   Gao, Xiaoming ^a   Stewart, Alastair G ^d   Tu, Yan ^d   Woodman, Owen L ^e   Ritchie, Rebecca H ^a,c,d  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH MEDICAL CENTRE   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e RMIT UNIVERSITY   (Australia)

Author keywords

Ac2 26; Cardiomyopathy; Cardioprotection; Formyl peptide receptors; Inflammation; Ischemia reperfusion

Indexed keywords

AC 2 26; CARDIOVASCULAR AGENT; CGEN 855A; FORMYLPEPTIDE RECEPTOR; FORMYLPEPTIDE RECEPTOR 2; FORMYLPEPTIDE RECEPTOR AGONIST; FORMYLPEPTIDE RECEPTOR ANTAGONIST; GLUCOCORTICOID; INTERCELLULAR ADHESION MOLECULE 1; LIPOCORTIN 1; PADGEM PROTEIN; PEPTIDOMIMETIC AGENT; UNCLASSIFIED DRUG; CARDIOTONIC AGENT;

ADAPTIVE IMMUNITY; ANTICOAGULANT THERAPY; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CELLULAR SECRETION; DESENSITIZATION; HEART CONTRACTION; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; INFLAMMATION; INNATE IMMUNITY; LEUKOCYTE; LEUKOCYTE ACTIVATION; MONOCYTE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REPERFUSION INJURY; SECOND MESSENGER; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TISSUE DISTRIBUTION; ANIMAL; METABOLISM; MYOCARDIAL INFARCTION;

ANIMALS; ANNEXIN A1; CARDIOTONIC AGENTS; HUMANS; MYOCARDIAL INFARCTION; RECEPTORS, FORMYL PEPTIDE;

EID: 84923294440     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2014.11.012     Document Type: Review

References (284)

1. S.M. Albelda, C.W. Smith, and P.A. Ward Adhesion molecules and inflammatory injury FASEB J 8 8 1994 504 512
2. A.L. Alessandri, L.P. Sousa, C.D. Lucas, A.G. Rossi, V. Pinho, and M.M. Teixeira Resolution of inflammation: mechanisms and opportunity for drug development Pharmacol Therapeut 139 2 2013 189 212
3. M.P. Ambrose, and G.W. Hunninghake Corticosteroids increase lipocortin I in alveolar epithelial cells Am J Respir Cell Mol Biol 3 4 1990 349 353
4. J.L. Anderson, C.D. Adams, E.M. Antman, C.R. Bridges, R.M. Califf, and D.E. Casey Jr. 2011 ACCF/AHA focused update incorporated into the ACC/AHA 2007 Guidelines for the management of patients with unstable angina/Non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Circulation 123 18 2011 e426 e579
5. F. Arslan, D.P. de Kleijn, and G. Pasterkamp Innate immune signaling in cardiac ischemia Nat Rev Cardiol 8 5 2011 292 300
6. S. Arur, U.E. Uche, K. Rezaul, M. Fong, V. Scranton, and A.E. Cowan Annexin I is an endogenous ligand that mediates apoptotic cell engulfment Dev Cell 4 4 2003 587 598
7. A.S. Baas, and B.C. Berk Differential activation of mitogen-activated protein kinases by H2O2 and O2- in vascular smooth muscle cells Circ Res 77 1 1995 29 36
8. B.A. Babbin, M.G. Laukoetter, P. Nava, S. Koch, W.Y. Lee, and C.T. Capaldo Annexin A1 regulates intestinal mucosal injury, inflammation, and repair J Immunol 181 7 2008 5035 5044
9. E.B. Babiychuk, K. Monastyrskaya, and A. Draeger Fluorescent annexin A1 reveals dynamics of ceramide platforms in living cells Traffic 9 10 2008 1757 1775
10. Y.S. Bae, J.Y. Song, Y. Kim, R. He, R.D. Ye, and J.Y. Kwak Differential activation of formyl peptide receptor signaling by peptide ligands Mol Pharmacol 64 4 2003 841 847
11. Y.S. Bae, H.Y. Lee, E.J. Jo, J.I. Kim, H.K. Kang, and R.D. Ye Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling J Immunol 173 1 2004 607 614
12. C. Bandeira-Melo, A.G. Bonavita, B.L. Diaz, P.M.R. e Silva, V.F. Carvalho, and P.J. Jose A novel effect for annexin 1-derived peptide ac2-26: reduction of allergic inflammation in the rat J Pharmacol Exp Ther 313 3 2005 1416 1422
13. E. Beaulieu, and E.F. Morand Role of GILZ in immune regulation, glucocorticoid actions and rheumatoid arthritis Nat Rev Rheumatol 7 6 2011 340 348
14. I.M.E. Beck, W.V. Berghe, L. Vermeulen, K.R. Yamamoto, G. Haegeman, and K. De Bosscher Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases Endocr Rev 30 7 2009 830 882
15. S. Bena, V. Brancaleone, J.M. Wang, M. Perretti, and R.J. Flower Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling J Biol Chem 287 29 2012 24690 24697
16. M. Benoit, B. Desnues, and J.L. Mege Macrophage polarization in bacterial infections J Immunol 181 6 2008 3733 3739
17. M.E. Bianchi DAMPs, PAMPs and alarmins: all we need to know about danger J Leukoc Biol 81 1 2007 1 5
18. G.J. Blackwell, R. Carnuccio, M. Di Rosa, R.J. Flower, L. Parente, and P. Persico Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids Nature 287 5778 1980 147 149
19. K.E. Blume, S. Soeroes, H. Keppeler, S. Stevanovic, D. Kretschmer, and M. Rautenberg Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic "find-me" signal J Immunol 188 1 2012 135 145
20. K.E. Blume, S. Soeroes, M. Waibel, H. Keppeler, S. Wesselborg, and M. Herrmann Cell surface externalization of Annexin A1 as a failsafe mechanism preventing inflammatory responses during secondary necrosis J Immunol 183 12 2009 8138 8147
21. V. Brancaleone, J. Dalli, S. Bena, R.J. Flower, G. Cirino, and M. Perretti Evidence for an anti-inflammatory loop centered on polymorphonuclear leukocyte formyl peptide receptor 2/lipoxin A4 receptor and operative in the inflamed microvasculature J Immunol 186 8 2011 4905 4914
22. P.J. Buchanan, P. McNally, B.J. Harvey, and V. Urbach Lipoxin A(4)-mediated KATP potassium channel activation results in cystic fibrosis airway epithelial repair Am J Physiol Lung Cell Mol Physiol 305 2 2013 L193 L201
23. R.W. Burli, H. Xu, X.M. Zou, K. Muller, J. Golden, and M. Frohn Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents Bioorg Med Chem Lett 16 14 2006 3713 3718
24. E. Camors, V. Monceau, and D. Charlemagne Annexins and Ca2+ handling in the heart Cardiovasc Res 65 4 2005 793 802
25. D.L. Carden, and D.N. Granger Pathophysiology of ischaemia-reperfusion injury J Pathol 190 3 2000 255 266
26. D. Caron, H. Maaroufi, S. Michaud, R.M. Tanguay, and R.L. Faure Annexin A1 is regulated by domains cross-talk through post-translational phosphorylation and SUMOYlation Cell Signal 25 10 2013 1962 1969
27. L.P. Chapman, M.J. Epton, J.C. Buckingham, J.F. Morris, and H.C. Christian Evidence for a role of the adenosine 5′-triphosphate-binding cassette transporter A1 in the externalization of annexin I from pituitary folliculo-stellate cells Endocrinology 144 3 2003 1062 1073
28. P. Chatelain, J.G. Latour, D. Tran, M. de Lorgeril, G. Dupras, and M. Bourassa Neutrophil accumulation in experimental myocardial infarcts: relation with extent of injury and effect of reperfusion Circulation 75 5 1987 1083 1090
29. K. Chen, Y. Le, Y. Liu, W. Gong, G. Ying, and J. Huang A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses J Immunol 184 7 2010 3331 3335
30. K. Chen, M. Liu, Y. Liu, T. Yoshimura, W. Shen, and Y. Le Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis J Clin Invest 123 4 2013 1694 1704
31. N. Chiang, C.N. Serhan, S.E. Dahlen, J.M. Drazen, D.W. Hay, and G.E. Rovati The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo Pharmacol Rev 58 3 2006 463 487
32. P. Christia, and N.G. Frangogiannis Targeting inflammatory pathways in myocardial infarction Eur J Clin Invest 43 9 2013 986 995
33. P. Christmas, J. Callaway, J. Fallon, J. Jones, and H.T. Haigler Selective secretion of annexin 1, a protein without a signal sequence, by the human prostate gland J Biol Chem 266 4 1991 2499 2507
34. T. Christophe, A. Karlsson, C. Dugave, M.J. Rabiet, F. Boulay, and C. Dahlgren The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2 J Biol Chem 276 24 2001 21585 21593
35. A. Cilibrizzi, M.T. Quinn, L.N. Kirpotina, I.A. Schepetkin, J. Holderness, and R.D. Ye 6-Methyl-2,4-Disubstituted Pyridazin-3(2H)-ones: A Novel Class of Small-Molecule Agonists for Formyl Peptide Receptors J Med Chem 52 16 2009 5044 5057
36. G. Cirino, C. Cicala, L. Sorrentino, G. Ciliberto, G. Arpaia, and M. Perretti Anti-inflammatory actions of an N-terminal peptide from human lipocortin 1 Br J Pharmacol 108 3 1993 573 574
37. A. Civelek, M. Roth, P. Lemke, W.P. Klovekorn, and E.P. Bauer Leukocyte-depleted secondary blood cardioplegia attenuates reperfusion injury after myocardial ischemia J Thorac Cardiovasc Surg 51 5 2003 249 254
38. A.R. Clark Anti-inflammatory functions of glucocorticoid-induced genes Mol Cell Endocrinol 275 1-2 2007 79 97
39. A.R. Clark, and M.G. Belvisi Maps and legends: the quest for dissociated ligands of the glucocorticoid receptor Pharmacol Ther 134 1 2012 54 67
40. E. Cristante, S. McArthur, C. Mauro, E. Maggioli, I.A. Romero, and M. Wylezinska-Arridge Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications Proc Natl Acad Sci U S A 110 3 2013 832 841
41. F. D'Acquisto, N. Paschalidis, A.L. Sampaio, A. Merghani, R.J. Flower, and M. Perretti Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells Eur J Immunol 37 11 2007 3131 3142
42. F. D'Acquisto, G. Piras, and L. Rattazzi Pro-inflammatory and pathogenic properties of Annexin-A1: the whole is greater than the sum of its parts Biochem Pharmacol 85 9 2013 1213 1218
43. C.W. D'Acunto, H. Gbelcova, M. Festa, and T. Ruml The complex understanding of Annexin A1 phosphorylation Cell Signal 26 1 2014 173 178
44. J. Dalli, A.P. Consalvo, V. Ray, C. Di Filippo, M. D'Amico, and N. Mehta Proresolving and tissue-protective actions of annexin A1-based cleavage-resistant peptides are mediated by formyl peptide receptor 2/lipoxin A4 receptor J Immunol 190 12 2013 6478 6487
45. J. Dalli, T. Montero-Melendez, S. McArthur, and M. Perretti Annexin A1 N-terminal derived Peptide ac2-26 exerts chemokinetic effects on human neutrophils Front Pharmacol 3 2012 28
46. J. Dalli, L.V. Norling, D. Renshaw, D. Cooper, K.Y. Leung, and M. Perretti Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles Blood 112 6 2008 2512 2519
47. A.S. Damazo, A.L. Sampaio, C.M. Nakata, R.J. Flower, M. Perretti, and S.M. Oliani Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis BMC Immunol 12 2011 59
48. A.S. Damazo, S. Yona, F. D'Acquisto, R.J. Flower, S.M. Oliani, and M. Perretti Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation Am J Pathol 166 6 2005 1607 1617
49. A.S. Damazo, S. Yona, R.J. Flower, M. Perretti, and S.M. Oliani Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis J Immunol 176 7 2006 4410 4418
50. M. D'Amico, C. Di Filippo, M. La, E. Solito, P.G. McLean, and R.J. Flower Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment FASEB J 14 13 2000 1867 1869
51. R. Debret, H. El Btaouri, L. Duca, I. Rahman, S. Radke, and B. Haye Annexin AI processing is associated with caspase-dependent apoptosis in BZR cells FEBS Lett 546 2-3 2003 195 202
52. O. Dewald, P. Zymek, K. Winkelmann, A. Koerting, G. Ren, and T. Abou-Khamis CCL2/Monocyte chemoattractant protein-1 regulates inflammatory responses critical to healing myocardial infarcts Circ Res 96 8 2005 881 889
53. R. Dreier, K.W. Schmid, V. Gerke, and K. Riehemann Differential expression of annexins I, II and IV in human tissues: an immunohistochemical study Histochem Cell Biol 110 2 1998 137 148
54. N. Dufton, R. Hannon, V. Brancaleone, J. Dalli, H.B. Patel, and M. Gray Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation J Immunol 184 5 2010 2611 2619
55. N. Dufton, and M. Perretti Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists Pharmacol Ther 127 2 2010 175 188
56. C. Duilio, G. Ambrosio, P. Kuppusamy, A. DiPaula, L.C. Becker, and J.L. Zweier Neutrophils are primary source of O2 radicals during reperfusion after prolonged myocardial ischemia Am J Physiol Heart Circ Physiol 280 6 2001 H2649 H2657
57. K. Ebnet, and D. Vestweber Molecular mechanisms that control leukocyte extravasation: the selectins and the chemokines Histochem Cell Biol 112 1 1999 1 23
58. Y. Enc, P. Karaca, U. Ayoglu, G. Camur, E. Kurc, and S. Cicek The acute cardioprotective effect of glucocorticoid in myocardial ischemia-reperfusion injury occurring during cardiopulmonary bypass Heart Vessels 21 3 2006 152 156
59. R.L. Engler, M.D. Dahlgren, D.D. Morris, M.A. Peterson, and G.W. Schmid-Schonbein Role of leukocytes in response to acute myocardial ischemia and reflow in dogs Am J Physiol 251 2 Pt 2 1986 H314 H323
60. M.L. Entman, K. Youker, T. Shoji, G. Kukielka, S.B. Shappell, and A.A. Taylor Neutrophil induced oxidative injury of cardiac myocytes. A compartmented system requiring CD11b/CD18-ICAM-1 adherence J Clin Invest 90 4 1992 1335 1345
61. J.D. Ernst, E. Hoye, R.A. Blackwood, and D. Jaye Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules J Clin Invest 85 4 1990 1065 1071
62. S. Ernst, N. Zobiack, K. Boecker, V. Gerke, and U. Rescher Agonist-induced trafficking of the low-affinity formyl peptide receptor FPRL1 Cell Mol Life Sci 61 13 2004 1684 1692
63. O. Ertracht, A. Malka, S. Atar, and O. Binah The mitochondria as a target for cardioprotection in acute myocardial ischemia Pharmacol Ther 142 1 2014 33 40
64. F.N. Facio, A.A. Sena, L.P. Araujo, G.E. Mendes, I. Castro, and M.A.M. Luz Annexin 1 mimetic peptide protects against renal ischemia/reperfusion injury in rats J Mol Med 89 1 2011 51 63
65. X. Fan, S. Krahling, D. Smith, P. Williamson, and R.A. Schlegel Macrophage surface expression of annexins I and II in the phagocytosis of apoptotic lymphocytes Mol Biol Cell 15 6 2004 2863 2872
66. S.M. Farooq, and A.W. Stadnyk Neutrophil infiltration of the colon is independent of the FPR1 yet FPR1 deficient mice show differential susceptibilities to acute versus chronic induced colitis Dig Dis Sci 57 7 2012 1802 1812
67. R.A. Fava, J. McKanna, and S. Cohen Lipocortin I (p35) is abundant in a restricted number of differentiated cell types in adult organs J Cell Physiol 141 2 1989 284 293
68. D.P. Faxon Development of systems of care for ST-elevation myocardial infarction patients: current state of ST-elevation myocardial infarction care Circulation 116 2 2007 e29 e32
69. D.P. Faxon, R.J. Gibbons, N.A. Chronos, P.A. Gurbel, F. Sheehan, and H.-M. Investigators The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study J Am Coll Cardiol 40 7 2002 1199 1204
70. S. Fiore, J.F. Maddox, H.D. Perez, and C.N. Serhan Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor J Exp Med 180 1 1994 253 260
71. R.J. Flower, and G.J. Blackwell Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation Nature 278 5703 1979 456 459
72. R.J. Flower, and N.J. Rothwell Lipocortin-1 - Cellular mechanisms and clinical relevance Trends Pharmacol Sci 15 3 1994 71 76
73. H. Forsman, J. Bylund, T.I. Oprea, A. Karlsson, F. Boulay, and M.J. Rabiet The leukocyte chemotactic receptor FPR2, but not the closely related FPR1, is sensitive to cell-penetrating pepducins with amino acid sequences descending from the third intracellular receptor loop Biochimica et biophysica acta 1833 8 2013 1914 1923
74. N.G. Frangogiannis, M.L. Lindsey, L.H. Michael, K.A. Youker, R.B. Bressler, and L.H. Mendoza Resident cardiac mast cells degranulate and release preformed TNF-alpha, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion Circulation 98 7 1998 699 710
75. N.G. Frangogiannis, C.W. Smith, and M.L. Entman The inflammatory response in myocardial infarction Cardiovasc Res 53 1 2002 31 47
76. R.J. Freer, A.R. Day, J.A. Radding, E. Schiffmann, S. Aswanikumar, and H.J. Showell Further studies on the structural requirements for synthetic peptide chemoattractants Biochemistry 19 11 1980 2404 2410
77. S. Fukushima, S.R. Coppen, A. Varela-Carver, K. Yamahara, P. Sarathchandra, and R.T. Smolenski A novel strategy for myocardial protection by combined antibody therapy inhibiting both P-selectin and intercellular adhesion molecule-1 via retrograde intracoronary route Circulation 114 1 Suppl. 2006 I251 I256
78. J.L. Gao, and P.M. Murphy Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains J Biol Chem 268 34 1993 25395 25401
79. J.L. Gao, E.J. Lee, and P.M. Murphy Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor J Exp Med 189 4 1999 657 662
80. X.M. Gao, D.A. White, A.M. Dart, and X.J. Du Post-infarct cardiac rupture: recent insights on pathogenesis and therapeutic interventions Pharmacol Ther 134 2 2012 156 179
81. T.S. Gastardelo, A.S. Damazo, J. Dalli, R.J. Flower, M. Perretti, and S.M. Oliani Functional and ultrastructural analysis of annexin A1 and its receptor in extravasating neutrophils during acute inflammation Am J Pathol 174 1 2009 177 183
82. F.N.E. Gavins Are formyl peptide receptors novel targets for therapeutic intervention in ischaemia-reperfusion injury? Trends Pharmacol Sci 31 6 2010 266 276
83. F.N. Gavins, J. Dalli, R.J. Flower, D.N. Granger, and M. Perretti Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation FASEB J 21 8 2007 1751 1758
84. F.N.E. Gavins, A.M. Kamal, M. D'Amico, S.M. Oliani, and M. Perretti Formyl-peptide receptor is not involved in the protection afforded by annexin 1 in murine acute myocardial infarct FASEB J 19 1 2005 100 102
85. F.N.E. Gavins, G. Leoni, and S.J. Getting Annexin 1 and melanocortin peptide therapy for protection against ischaemic-reperfusion damage in the heart ScientificWorldJournal 6 2006 1008 1023
86. F.N.E. Gavins, S. Yona, A.M. Kamal, R.J. Flower, and M. Perretti Leukocyte antiadhesive actions of annexin 1: ALYR- and FPR-related anti-inflammatory mechanisms Blood 101 10 2003 4140 4147
87. V. Gerke, C.E. Creutz, and S.E. Moss Annexins: linking Ca2+ signalling to membrane dynamics Nat Rev Mol Cell Biol 6 6 2005 449 461
88. V. Gerke, and S.E. Moss Annexins: from structure to function Physiol Rev 82 2 2002 331 371
89. S.J. Getting, R.J. Flower, and M. Perretti Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1 Br J Pharmacol 120 6 1997 1075 1082
90. A.P. Girol, K.K. Mimura, C.C. Drewes, S.M. Bolonheis, E. Solito, and S.H. Farsky Anti-inflammatory mechanisms of the annexin A1 protein and its mimetic peptide Ac2-26 in models of ocular inflammation in vivo and in vitro J Immunol 190 11 2013 5689 5701
91. M.P. Giovannoni, I.A. Schepetkin, A. Cilibrizzi, L. Crocetti, A.I. Khlebnikov, and C. Dahlgren Further studies on 2-arylacetamide pyridazin-3(2H)-ones: design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists Eur J Med Chem 64 2013 512 528
92. Global-Data MI therapeutics-pipeline assessment & market forecasts to 2018 GDHC306-PRT 2011
93. S. Gordon Alternative activation of macrophages Nat Rev Immunol 3 1 2003 23 35
94. J.M. Gordon, G.J. Dusting, O.L. Woodman, and R.H. Ritchie Cardioprotective action of CRF peptide urocortin against simulated ischemia in adult rat cardiomyocytes Am J Physiol Heart Circ Physiol 284 1 2003 H330 H336
95. N.J. Goulding, J.L. Godolphin, M.B. Sampson, P.J. Maddison, and R.J. Flower Hydrocortisone induces lipocortin 1 production by peripheral blood mononuclear cells in vivo in man Biochem Soc Trans 18 2 1990 306 307
96. J.M. Gripentrog, and H.M. Miettinen Formyl peptide receptor-mediated ERK1/2 activation occurs through G(i) and is not dependent on beta-arrestin1/2 Cell Signal 20 2 2008 424 431
97. M. Grzybowski, R.D. Welch, L. Parsons, C.E. Ndumele, E. Chen, and R. Zalenski The association between white blood cell count and acute myocardial infarction in-hospital mortality: findings from the National Registry of Myocardial Infarction Acad Emerg Med 11 10 2004 1049 1060
98. M. Gwechenberger, L.H. Mendoza, K.A. Youker, N.G. Frangogiannis, C.W. Smith, and L.H. Michael Cardiac myocytes produce interleukin-6 in culture and in viable border zone of reperfused infarctions Circulation 99 4 1999 546 551
99. P.J. Haas, C.J. de Haas, W. Kleibeuker, M.J. Poppelier, K.P. van Kessel, and J.A. Kruijtzer N-terminal residues of the chemotaxis inhibitory protein of Staphylococcus aureus are essential for blocking formylated peptide receptor but not C5a receptor J Immunol 173 9 2004 5704 5711
100. H.T. Haigler, and P. Christmas Annexin 1 is secreted by the human prostate Biochem Soc Trans 18 6 1990 1104 1106
101. R. Hannon, J.D. Croxtall, S.J. Getting, F. Roviezzo, S. Yona, and M.J. Paul-Clark Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse FASEB J 17 2 2003 253 255
102. J. Hanson, N. Ferreiros, B. Pirotte, G. Geisslinger, and S. Offermanns Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A(4) Biochem Pharmacol 85 12 2013 1795 1802
103. A. Hashimoto, Y. Murakami, H. Kitasato, I. Hayashi, and H. Endo Glucocorticoids co-interact with lipoxin A4 via lipoxin A4 receptor (ALX) up-regulation Biomed Pharmacother 61 1 2007 81 85
104. N. Hatori, R.L. Roberts, H. Tadokoro, L. Ryden, K. Satomura, and M.C. Fishbein Differences in infarct size with lidocaine as compared with bretylium tosylate in acute myocardial ischemia and reperfusion in pigs J Cardiovasc Pharmacol 18 4 1991 581 588
105. Y. Hayashi, Y. Sawa, M. Nishimura, H. Ichikawa, K. Kagisaki, and S. Ohtake Clinical evaluation of leukocyte-depleted blood cardioplegia for pediatric open heart operation Ann Thorac Surg 69 6 2000 1914 1919
106. R.P.G. Hayhoe, A.M. Kamal, E. Solito, R.J. Flower, D. Cooper, and M. Perretti Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement Blood 107 5 2006 2123 2130
107. R. Hayward, B. Campbell, Y.K. Shin, R. Scalia, and A.M. Lefer Recombinant soluble P-selectin glycoprotein ligand-1 protects against myocardial ischemic reperfusion injury in cats Cardiovasc Res 41 1 1999 65 76
108. R. He, H. Sang, and R.D. Ye Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R Blood 101 4 2003 1572 1581
109. I. Hecht, J. Rong, A.L.F. Sampaio, C. Hermesh, C. Rutledge, and R. Shemesh A novel peptide agonist of formyl-peptide receptor-like 1 (ALX) displays anti-inflammatory and cardioprotective effects J Pharmacol Exp Ther 328 2 2009 426 434
110. H.P. Hobbach, and P. Schuster Pharmacodynamic and clinical trials of glycoprotein IIb/IIIa inhibitors and potential relationship of results to dosing Z Kardiol 92 3 2003 213 218
111. L.D. Horwitz, J.S. Wallner, D.E. Decker, and S.E. Buxser Efficacy of lipid soluble, membrane-protective agents against hydrogen peroxide cytotoxicity in cardiac myocytes Free Radic Biol Med 21 6 1996 743 753
112. J.Y. Hu, Y. Le, W. Gong, N.M. Dunlop, J.L. Gao, and P.M. Murphy Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1 J Leukoc Biol 70 1 2001 155 161
113. E.L. Hughes, P.O. Cover, J.C. Buckingham, and F.N.E. Gavins Role and interactions of annexin A1 and oestrogens in the manifestation of sexual dimorphisms in cerebral and systemic inflammation Br J Pharmacol 169 3 2013 539 553
114. F. Hullin, P. Raynal, J.M. Ragab-Thomas, J. Fauvel, and H. Chap Effect of dexamethasone on prostaglandin synthesis and on lipocortin status in human endothelial cells. Inhibition of prostaglandin I2 synthesis occurring without alteration of arachidonic acid liberation and of lipocortin synthesis J Biol Chem 264 6 1989 3506 3513
115. T.L. Hwang, C.H. Hung, C.Y. Hsu, Y.T. Huang, Y.C. Tsai, and P.W. Hsieh Design and synthesis of tryptophan containing dipeptide derivatives as formyl peptide receptor 1 antagonist Org Biomol Chem 11 22 2013 3742 3755
116. B. Ibanez, V. Fuster, J. Jimenez-Borreguero, and J.J. Badimon Lethal myocardial reperfusion injury: a necessary evil? Int J Cardiol 151 1 2011 3 11
117. U. Ikeda Inflammation and coronary artery disease Curr Vasc Pharmacol 1 1 2003 65 70
118. M. Ishido Overexpression of Bcl-2 inhibits nuclear localization of annexin I during tumor necrosis factor-alpha-mediated apoptosis in porcine renal LLC-PK1 cells Regul Pept 124 1-3 2005 45 51
119. C.L. Ivey, F.M. Williams, P.D. Collins, P.J. Jose, and T.J. Williams Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8 J Clin Invest 95 6 1995 2720 2728
120. F. Jansen, X. Yang, F.F. Hoyer, K. Paul, N. Heiermann, and M.U. Becher Endothelial microparticle uptake in target cells is annexin I/phosphatidylserine receptor dependent and prevents apoptosis Arterioscler Thromb Vasc Biol 32 8 2012 1925 1935
121. R.B. Jennings, J. Charles Steenbergen, and K.A. Rerimer Myocardial ischaemia and reperfusion Monogr Pathol 37 1995 47 80
122. Y. Jia, E.F. Morand, W. Song, Q. Cheng, A. Stewart, and Y.H. Yang Regulation of lung fibroblast activation by annexin A1 J Cell Physiol 228 2 2013 476 484
123. C. John, P. Cover, E. Solito, J. Morris, H. Christian, and R. Flower Annexin 1-dependent actions of glucocorticoids in the anterior pituitary gland: roles of the N-terminal domain and protein kinase C Endocrinology 143 8 2002 3060 3070
124. S.R. Jolly, W.J. Kane, B.G. Hook, G.D. Abrams, S.L. Kunkel, and B.R. Lucchesi Reduction of myocardial infarct size by neutrophil depletion: effect of duration of occlusion Am Heart J 112 4 1986 682 690
125. K. Jung, P. Kim, F. Leuschner, R. Gorbatov, J.K. Kim, and T. Ueno Endoscopic time-lapse imaging of immune cells in infarcted mouse hearts Circ Res 112 6 2013 891 899
126. N. Kamaly, G. Fredman, M. Subramanian, S. Gadde, A. Pesic, and L. Cheung Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles Proc Natl Acad Sci U S A 110 16 2013 6506 6511
127. T. Kenakin Functional selectivity and biased receptor signaling J Pharmacol Exp Ther 336 2 2011 296 302
128. T. Khau, S.Y. Langenbach, M. Schuliga, T. Harris, C.N. Johnstone, and R.L. Anderson Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2 FASEB J 25 2 2011 483 496
129. H. Kin, N.P. Wang, M.E. Halkos, F. Kerendi, R.A. Guyton, and Z.Q. Zhao Neutrophil depletion reduces myocardial apoptosis and attenuates NFkappaB activation/TNFalpha release after ischemia and reperfusion J Surg Res 135 1 2006 170 178
130. C. Klein, J.I. Paul, K. Sauve, M.M. Schmidt, L. Arcangeli, and J. Ransom Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast Nat Biotechnol 16 13 1998 1334 1337
131. E. Kolaczkowska, M. Chadzinska, A. Scislowska-Czarnecka, B. Plytycz, G. Opdenakker, and B. Arnold Gelatinase B/matrix metalloproteinase-9 contributes to cellular infiltration in a murine model of zymosan peritonitis Immunobiology 211 3 2006 137 148
132. R. Kolesnick The therapeutic potential of modulating the ceramide/sphingomyelin pathway J Clin Invest 110 1 2002 3 8
133. R.T. Kovacic, R. Tizard, R.L. Cate, A.Z. Frey, and B.P. Wallner Correlation of gene and protein structure of rat and human lipocortin I Biochemistry 30 37 1991 9015 9021
134. G. Krikun, C.J. Lockwood, X.X. Wu, X.D. Zhou, S. Guller, and C. Calandri The expression of the placental anticoagulant protein, annexin V, by villous trophoblasts: immunolocalization and in vitro regulation Placenta 15 6 1994 601 612
135. G.L. Kukielka, H.K. Hawkins, L. Michael, A.M. Manning, K. Youker, and C. Lane Regulation of intercellular adhesion molecule-1 (ICAM-1) in ischemic and reperfused canine myocardium J Clin Invest 92 3 1993 1504 1516
136. G.L. Kukielka, C.W. Smith, G.J. LaRosa, A.M. Manning, L.H. Mendoza, and T.J. Daly Interleukin-8 gene induction in the myocardium after ischemia and reperfusion in vivo J Clin Invest 95 1 1995 89 103
137. A.G. Kumar, C.M. Ballantyne, L.H. Michael, G.L. Kukielka, K.A. Youker, and M.L. Lindsey Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium Circulation 95 3 1997 693 700
138. I. Kurose, R. Wolf, M.B. Grisham, and D.N. Granger Modulation of ischemia/reperfusion-induced microvascular dysfunction by nitric oxide Circ Res 74 3 1994 376 382
139. F.G. Kushner, M. Hand, S.C. Smith Jr., S.B. King III, J.L. Anderson, and E.M. Antman 2009 Focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 Guideline and 2007 focused update) and ACC/AHA/SCAI Guidelines on percutaneous coronary intervention (updating the 2005 Guideline and 2007 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Circulation 120 22 2009 2271 2306
140. J.H. Kwon, J.H. Lee, K.S. Kim, Y.W. Chung, and I.Y. Kim Regulation of cytosolic phospholipase A2 phosphorylation by proteolytic cleavage of annexin A1 in activated mast cells J Immunol 188 11 2012 5665 5673
141. M. La, M. D'Amico, S. Bandiera, C. Di Filippo, S.M. Oliani, and F.N.E. Gavins Annexin 1 peptides protect against experimental myocardial ischemia-reperfusion: analysis of their mechanism of action FASEB J 15 12 2001 2247 2256
142. M. La, A. Tailor, M. D'Amico, R.J. Flower, and M. Perretti Analysis of the protection afforded by annexin 1 in ischaemia-reperfusion injury: focus on neutrophil recruitment Eur J Pharmacol 429 1-3 2001 263 278
143. Y. Le, W. Gong, B. Li, N.M. Dunlop, W. Shen, and S.B. Su Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and formyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation J Immunol 163 12 1999 6777 6784
144. J.A. Le Good, W.H. Ziegler, D.B. Parekh, D.R. Alessi, P. Cohen, and P.J. Parker Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1 Science 281 5385 1998 2042 2045
145. M.J. Lenardo, and D. Baltimore NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control Cell 58 2 1989 227 229
146. G. Leoni, A. Alam, P.A. Neumann, J.D. Lambeth, G. Cheng, and J. McCoy Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair J Clin Invest 123 1 2013 443 454
147. Y. Li, L. Cai, H. Wang, P. Wu, W. Gu, and Y. Chen Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2 Oncogene 30 36 2011 3887 3899
148. M. Lindsey, K. Wedin, M.D. Brown, C. Keller, A.J. Evans, and J. Smolen Matrix-dependent mechanism of neutrophil-mediated release and activation of matrix metalloproteinase 9 in myocardial ischemia/reperfusion Circulation 103 17 2001 2181 2187
149. M.L. Lindsey, and R. Zamilpa Temporal and spatial expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases following myocardial infarction Cardiovasc Ther 30 1 2012 31 41
150. M.R. Litt, R.W. Jeremy, H.F. Weisman, J.A. Winkelstein, and L.C. Becker Neutrophil depletion limited to reperfusion reduces myocardial infarct size after 90 minutes of ischemia. Evidence for neutrophil-mediated reperfusion injury Circulation 80 6 1989 1816 1827
151. Y. Liu, X.M. Gao, L. Fang, N.L. Jennings, Y. Su, and Q, X. Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction Arterioscler Thromb Vasc Biol 31 4 2011 834 841
152. X. Liu, B. Ma, A.B. Malik, H. Tang, T. Yang, and B. Sun Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases Nat Immunol 13 5 2012 457 464
153. N.K. Liu, Y.P. Zhang, S. Han, J. Pei, L.Y. Xu, and P.H. Lu Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury J Neuropathol Exp Neurol 66 10 2007 932 943
154. A.G. Loberg, J. Stallard, J. Dunning, and J. Dark Can leucocyte depletion reduce reperfusion injury following cardiopulmonary bypass? Interact Cardiovasc Thorac Surg 12 2 2011 232 237
155. R. Luthra, R.R. Singh, M.G. Luthra, Y.X. Li, C. Hannah, and A.M. Romans MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers Oncogene 27 52 2008 6667 6678
156. J. Ma, T. Chen, J. Mandelin, A. Ceponis, N.E. Miller, and M. Hukkanen Regulation of macrophage activation Cell Mol Life Sci 60 11 2003 2334 2346
157. X.L. Ma, P.S. Tsao, and A.M. Lefer Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion J Clin Invest 88 4 1991 1237 1243
158. X.L. Ma, A.S. Weyrich, D.J. Lefer, and A.M. Lefer Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium Circ Res 72 2 1993 403 412
159. W.S. Maaty, C.I. Lord, J.M. Gripentrog, M. Riesselman, G. Keren-Aviram, and T. Liu Identification of C-terminal phosphorylation sites of N-formyl peptide receptor-1 (FPR1) in human blood neutrophils J Biol Chem 288 38 2013 27042 27058
160. P. Maderna, D.C. Cottell, T. Toivonen, N. Dufton, J. Dalli, and M. Perretti FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis FASEB J 24 11 2010 4240 4249
161. P. Maderna, S. Yona, M. Perretti, and C. Godson Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26) J Immunol 174 6 2005 3727 3733
162. Y. Maekawa, T. Anzai, T. Yoshikawa, Y. Asakura, T. Takahashi, and S. Ishikawa Prognostic significance of peripheral monocytosis after reperfused acute myocardial infarction:a possible role for left ventricular remodeling J Am Coll Cardiol 39 2 2002 241 246
163. G.R. Martin, M. Perretti, R.J. Flower, and J.L. Wallace Annexin-1 modulates repair of gastric mucosal injury Am J Physiol Gastrointest Liver Physiol 294 3 2008 G764 G769
164. F.A. Masoudi, R.O. Bonow, R.G. Brindis, C.P. Cannon, J. Debuhr, and S. Fitzgerald ACC/AHA 2008 statement on performance measurement and reperfusion therapy: a report of the ACC/AHA Task Force on Performance Measures (Work Group to address the challenges of performance measurement and reperfusion therapy) Circulation 118 24 2008 2649 2661
165. S.R.J. Maxwell, and G.Y.H. Lip Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options Int J Cardiol 58 2 1997 95 117
166. J.A. McKanna Lipocortin 1 in apoptosis: mammary regression Anat Rec 242 1 1995 1 10
167. B. McMahon, C. Stenson, F. McPhillips, A. Fanning, H.R. Brady, and C. Godson Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors J Biol Chem 275 36 2000 27566 27575
168. C.C. Michel, and F.E. Curry Microvascular permeability Physiol Rev 79 3 1999 703 761
169. I. Migeotte, D. Communi, and M. Parmentier Formyl peptide receptors: A promiscuous subfamily of G protein-coupled receptors controlling immune responses Cytokine Growth Factor Rev 17 6 2006 501 519
170. A.L. Moens, M.J. Claeys, J.P. Timmermans, and C.J. Vrints Myocardial ischemia/reperfusion-injury, a clinical view on a complex pathophysiological process Int J Cardiol 100 2 2005 179 190
171. T. Montero-Melendez, J. Dalli, and M. Perretti Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors Cell Death Differ 20 4 2013 567 575
172. E.F. Morand, P. Hutchinson, A. Hargreaves, N.J. Goulding, N.W. Boyce, and S.R. Holdsworth Detection of intracellular lipocortin 1 in human leukocyte subsets Clin Immunol Immunopathol 76 2 1995 195 202
173. J.F. Morris, H.C. Christian, L.P. Chapman, M.J. Epton, J.C. Buckingham, and H. Ozawa Steroid effects on secretion from subsets of lactotrophs: role of folliculo-stellate cells and annexin 1 Arch Physiol Biochem 110 1-2 2002 54 61
174. A. Muesch, E. Hartmann, K. Rohde, A. Rubartelli, R. Sitia, and T.A. Rapoport A novel pathway for secretory proteins? Trends Biochem Sci 15 3 1990 86 88
175. E. Murphy, and C. Steenbergen Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury Physiol Rev 88 2 2008 581 609
176. M. Nahrendorf, F.K. Swirski, E. Aikawa, L. Stangenberg, T. Wurdinger, and J.L. Figueiredo The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions J Exp Med 204 12 2007 3037 3047
177. M. Nanamori, X.Y. Cheng, J.H. Mei, H.R. Sang, Y.X. Xuan, and C.H. Zhou A novel nonpeptide ligand for formyl peptide receptor-like 1 Mol Pharmacol 66 5 2004 1213 1222
178. R. Newton Anti-inflammatory glucocorticoids: changing concepts Eur J Pharmacol 724 2014 231 236
179. F.S. Ng, K.Y. Wong, S.P. Guan, F.B. Mustafa, T.S. Kajiji, and P. Bist Annexin-1-deficient mice exhibit spontaneous airway hyperresponsiveness and exacerbated allergen-specific antibody responses in a mouse model of asthma Clin Exp Allergy 41 12 2011 1793 1803
180. S.J. Nicholls, and Y. Kataoka Update in therapeutic approaches to plaque stabilization Curr Atheroscler Rep 16 3 2014 392-392
181. J.I. Odegaard, and A. Chawla Alternative macrophage activation and metabolism Annu Rev Pathol 6 2011 275 297
182. S. Omer, D. Meredith, J.F. Morris, and H.C. Christian Evidence for the role of adenosine 5′-triphosphate-binding cassette (ABC)-A1 in the externalization of annexin 1 from pituitary folliculostellate cells and ABCA1-transfected cell models Endocrinology 147 7 2006 3219 3227
183. K. Ono, A. Matsumori, Y. Furukawa, H. Igata, T. Shioi, and K. Matsushima Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 Lab Invest 79 2 1999 195 203
184. G.M. Palatianos, G. Balentine, E.G. Papadakis, C.D. Triantafillou, M.I. Vassili, and A. Lidoriki Neutrophil depletion reduces myocardial reperfusion morbidity Ann Thorac Surg 77 3 2004 956 961
185. J.L. Park, and B.R. Lucchesi Mechanisms of myocardial reperfusion injury Ann Thorac Surg 68 5 1999 1905 1912
186. N. Paschalidis, A.J. Iqbal, F. Maione, E.G. Wood, M. Perretti, and R.J. Flower Modulation of experimental autoimmune encephalomyelitis by endogenous annexin A1 J Neuroinflammation 6 2009 33
187. H.B. Patel, K.N. Kornerup, A.L. Sampaio, F. D'Acquisto, M.P. Seed, and A.P. Girol The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis Ann Rheum Dis 71 2012 1872 1980
188. J.N. Peart, and J.P. Headrick Clinical cardioprotection and the value of conditioning responses Am J Physiol Heart Circ Physiol 296 6 2009 H1705 H1720
189. M. Perretti The annexin 1 receptor(s): is the plot unravelling? Trends Pharmacol Sci 24 11 2003 574 579
190. M. Perretti To resolve or not to resolve: Annexin A1 pushes resolution on track J Leukoc Biol 92 2 2012 245 247
191. M. Perretti, A. Ahluwalia, J.G. Harris, N.J. Goulding, and R.J. Flower Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody J Immunol 151 8 1993 4306 4314
192. M. Perretti, N. Chiang, M. La, I.M. Fierro, S. Marullo, and S.J. Getting Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor Nat Med 8 11 2002 1296 1302
193. M. Perretti, J.D. Croxtall, S.K. Wheller, N.J. Goulding, R. Hannon, and R.J. Flower Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration Nat Med 2 11 1996 1259 1262
194. M. Perretti, and F. D'Acquisto Annexin A1 and glucocorticoids as effectors of the resolution of inflammation Nat Rev Immunol 9 1 2009 62 70
195. M. Perretti, and J. Dalli Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics Br J Pharmacol 158 4 2009 936 946
196. M. Perretti, and R.J. Flower Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1 J Immunol 150 3 1993 992 999
197. M. Perretti, S.J. Getting, E. Solito, P.M. Murphy, and J.L. Gao Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics Am J Pathol 158 6 2001 1969 1973
198. H.M. Peshavariya, C.J. Taylor, C. Goh, G.S. Liu, F. Jiang, and E.C. Chan Annexin peptide Ac2-26 suppresses TNFalpha-induced inflammatory responses via inhibition of Rac1-dependent NADPH oxidase in human endothelial cells PLoS One 8 4 2013 e60790
199. B.M. Peskar, K. Ehrlich, R. Schuligoi, and B.A. Peskar Role of lipoxygenases and the lipoxin A(4)/annexin 1 receptor in ischemia-reperfusion-induced gastric mucosal damage in rats Pharmacology 84 5 2009 294 299
200. R.N. Pinckard, M.S. Olson, P.C. Giclas, R. Terry, J.T. Boyer, and R.A. O'Rourke Consumption of classical complement components by heart subcellular membranes in vitro and in patients after acute myocardial infarction J Clin Invest 56 3 1975 740 750
201. C. Pinilla, B.S. Edwards, J.R. Appel, T. Yates-Gibbins, M.A. Giulianotti, and J.L. Medina-Franco Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries Mol Pharmacol 84 3 2013 314 324
202. A. Planaguma, T. Domenech, I. Jover, I. Ramos, S. Sentellas, and R. Malhotra Lack of activity of 15-epi-lipoxin A(4) on FPR2/ALX and CysLT1 receptors in interleukin-8-driven human neutrophil function Clin Exp Immunol 173 2 2013 298 309
203. D. Pupjalis, J. Goetsch, D.J. Kottas, V. Gerke, and U. Rescher Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling EMBO Mol Med 3 2 2011 102 114
204. C. Qin, K.D. Buxton, S. Pepe, A.H. Cao, K. Venardos, and J.E. Love Reperfusion-induced myocardial dysfunction is prevented by endogenous annexin-A1 and its N-terminal-derived peptide Ac-ANX-A1(2-26) Br J Pharmacol 168 1 2013 238 252
205. C. Qin, S. Yap, and O.L. Woodman Antioxidants in the prevention of myocardial ischemia/reperfusion injury Expert Rev Clin Pharmacol 2 2009 673 695
206. M.J. Rabiet, E. Huet, and F. Boulay Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR Eur J Immunol 35 8 2005 2486 2495
207. M.J. Rabiet, L. Macari, C. Dahlgren, and F. Boulay N-formyl peptide receptor 3 (FPR3) departs from the homologous FPR2/ALX receptor with regard to the major processes governing chemoattractant receptor regulation, expression at the cell surface, and phosphorylation J Biol Chem 286 30 2011 26718 26731
208. N.C. Raju, J.W. Eikelboom, and J. Hirsh Platelet ADP-receptor antagonists for cardiovascular disease: past, present and future Nat Clin Pract Cardiovasc Med 5 12 2008 766 780
209. T. Reffelmann, and R.A. Kloner The "no-reflow" phenomenon: basic science and clinical correlates Heart 87 2 2002 162 168
210. A.M. Reilly, X. Sun, D.A. Williams, and G.J. Dusting Dexamethasone inhibits endotoxin-induced changes in calcium and contractility in rat isolated papillary muscle Cell Calcium 26 1-2 1999 1 8
211. K.M. Reinhart, C.M. White, and W.L. Baker Prasugrel: a critical comparison with clopidogrel Pharmacotherapy 29 12 2009 1441 1451
212. G. Ren, O. Dewald, and N.G. Frangogiannis Inflammatory mechanisms in myocardial infarction Curr Drug Targets Inflamm Allergy 2 3 2003 242 256
213. U. Rescher, and V. Gerke Annexins - unique membrane binding proteins with diverse functions J Cell Sci 117 Pt 13 2004 2631 2639
214. M. Resnati, I. Pallavicini, J.M. Wang, J. Oppenheim, C.N. Serhan, and M. Romano The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R Proc Natl Acad Sci U S A 99 3 2002 1359 1364
215. R.H. Ritchie, J.M. Gordon, O.L. Woodman, A.H. Cao, and G.J. Dusting Annexin-1 peptide Anx-1(2-26) protects adult rat cardiac myocytes from cellular injury induced by simulated ischaemia Br J Pharmacol 145 4 2005 495 502
216. R.H. Ritchie, X.L. Sun, J.L. Bilszta, L.M. Gulluyan, and G.J. Dusting Cardioprotective actions of an N-terminal fragment of annexin-1 in rat myocardium in vitro Eur J Pharmacol 461 2-3 2003 171 179
217. R.H. Ritchie, X.L. Sun, and G.J. Dusting Lipocortin-1 preserves myocardial responsiveness to beta-adrenergic stimulation in rat papillary muscle Clin Exp Pharmacol Physiol 26 7 1999 522 524
218. A. Roberts Anticoagulation therapy: Otamixaban fails in NSTE-ACS Nat Rev Cardiol 10 11 2013 615
219. R. Roberts, V. DeMello, and B.E. Sobel Deleterious effects of methylprednisolone in patients with myocardial infarction Circulation 53 3 Suppl. 1976 I204 I206
220. J. Romisch, E. Schuler, B. Bastian, T. Burger, F.G. Dunkel, and A. Schwinn Annexins I to VI: quantitative determination in different human cell types and in plasma after myocardial infarction Blood Coagul Fibrinolysis 3 1 1992 11 17
221. J.L. Romson, B.G. Hook, S.L. Kunkel, G.D. Abrams, M.A. Schork, and B.R. Lucchesi Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog Circulation 67 5 1983 1016 1023
222. A. Rosengarth, J. Rosgen, H.J. Hinz, and V. Gerke Folding energetics of ligand binding proteins II. Cooperative binding of Ca2+ to annexin I J Mol Biol 306 4 2001 825 835
223. T. Sakamoto, W.T. Repasky, K. Uchida, A. Hirata, and F. Hirata Modulation of cell death pathways to apoptosis and necrosis of H2O2-treated rat thymocytes by lipocortin I Biochem Biophys Res Commun 220 3 1996 643 647
224. P. Sawmynaden, and M. Perretti Glucocorticoid upregulation of the annexin-A1 receptor in leukocytes Biochem Biophys Res Commun 349 4 2006 1351 1355
225. M. Scannell, M.B. Flanagan, A. Destefani, K.J. Wynne, G. Cagney, and C. Godson Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages J Immunol 178 7 2007 4595 4605
226. M. Scannell, and P. Maderna Lipoxins and annexin-1: resolution of inflammation and regulation of phagocytosis of apoptotic cells ScientificWorldJournal 6 2006 1555 1573
227. M. Seddon, Y.H. Looi, and A.M. Shah Oxidative stress and redox signalling in cardiac hypertrophy and heart failure Heart 93 8 2007 903 907
228. R. Selvatici, S. Falzarano, A. Mollica, and S. Spisani Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils Eur J Pharmacol 534 1-3 2006 1 11
229. H. Shimomura, H. Ogawa, H. Arai, Y. Moriyama, K. Takazoe, and N. Hirai Serial changes in plasma levels of soluble P-selectin in patients with acute myocardial infarction Am J Cardiol 81 4 1998 397 400
230. F. Simiele, A. Recchiuti, D. Mattoscio, A. De Luca, E. Cianci, and S. Franchi Transcriptional regulation of the human FPR2/ALX gene: evidence of a heritable genetic variant that impairs promoter activity FASEB J 26 3 2012 1323 1333
231. S.F. Smith, T.D. Tetley, A. Guz, and R.J. Flower Detection of lipocortin 1 in human lung lavage fluid: lipocortin degradation as a possible proteolytic mechanism in the control of inflammatory mediators and inflammation Environ Health Perspect 85 1990 135 144
232. E. Solito, C. de Coupade, L. Parente, R.J. Flower, and F. Russo-Marie IL-6 stimulates annexin 1 expression and translocation and suggests a new biological role as class II acute phase protein Cytokine 10 7 1998 514 521
233. L.P. Sousa, A.L. Alessandri, V. Pinho, and M.M. Teixeira Pharmacological strategies to resolve acute inflammation Curr Opin Pharmacol 13 4 2013 625 631
234. D.G. Souza, C.T. Fagundes, F.A. Amaral, D. Cisalpino, L.P. Sousa, and A.T. Vieira The required role of endogenously produced lipoxin A(4) and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in mice J Immunol 179 12 2007 8533 8543
235. S.A. Spinler, and C. Rees Review of prasugrel for the secondary prevention of atherothrombosis J Manag Care Pharm 15 5 2009 383 395
236. L. Spurr, S. Nadkarni, M. Pederzoli-Ribeil, N.J. Goulding, M. Perretti, and F. D'Acquisto Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets Int Immunopharmacol 11 1 2011 55 66
237. S.B. Su, W. Gong, J.L. Gao, W. Shen, P.M. Murphy, and J.J. Oppenheim A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells J Exp Med 189 2 1999 395 402
238. Y. Tabe, L. Jin, R. Contractor, D. Gold, P. Ruvolo, and S. Radke Novel role of HDAC inhibitors in AML1/ETO AML cells: activation of apoptosis and phagocytosis through induction of annexin A1 Cell Death Differ 14 8 2007 1443 1456
239. J.C. Tardif, J.F. Tanguay, S.S. Wright, V. Duchatelle, T. Petroni, and J.C. Gregoire Effects of the P-selectin antagonist inclacumab on myocardial damage after percutaneous coronary intervention for non-ST-segment elevation myocardial infarction: results of the SELECT-ACS trial J Am Coll Cardiol 61 20 2013 2048 2055
240. K. Thygesen, J.S. Alpert, A.S. Jaffe, M.L. Simoons, B.R. Chaitman, and H.D. White Third universal definition of myocardial infarction Circulation 126 16 2012 2020 2035
241. L. Timmers, G. Pasterkamp, V.C. de Hoog, F. Arslan, Y. Appelman, and D.P. de Kleijn The innate immune response in reperfused myocardium Cardiovasc Res 94 2 2012 276 283
242. D. Tousoulis, C. Antoniades, N. Koumallos, and C. Stefanadis Pro-inflammatory cytokines in acute coronary syndromes: from bench to bedside Cytokine Growth Factor Rev 17 4 2006 225 233
243. P.S. Tsao, and A.M. Lefer Time course and mechanism of endothelial dysfunction in isolated ischemic- and hypoxic-perfused rat hearts Am J Physiol 259 6 Pt 2 1990 H1660 H1666
244. F.H. Tsao, K.C. Meyer, X. Chen, N.S. Rosenthal, and J. Hu Degradation of annexin I in bronchoalveolar lavage fluid from patients with cystic fibrosis Am J Respir Cell Mol Biol 18 1 1998 120 128
245. H. Tsujioka, T. Imanishi, H. Ikejima, A. Kuroi, S. Takarada, and T. Tanimoto Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction J Am Coll Cardiol 54 2 2009 130 138
246. J.P. Vago, C.R.C. Nogueira, L.P. Tavares, F.M. Soriani, F. Lopes, and R.C. Russo Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis J Leukoc Biol 92 2 2012 249 258
247. A.M. van der Laan, M. Nahrendorf, and J.J. Piek Healing and adverse remodelling after acute myocardial infarction: role of the cellular immune response Heart 98 18 2012 1384 1390
248. A.W. van't Hof, and M. Valgimigli Defining the role of platelet glycoprotein receptor inhibitors in STEMI: focus on tirofiban Drugs 69 1 2009 85 100
249. S. Vandervelde, M.J. van Amerongen, R.A. Tio, A.H. Petersen, M.J. van Luyn, and M.C. Harmsen Increased inflammatory response and neovascularization in reperfused vs. non-reperfused murine myocardial infarction Cardiovasc Pathol 15 2 2006 83 90
250. S. Vandevyver, L. Dejager, J. Tuckermann, and C. Libert New insights into the anti-inflammatory mechanisms of glucocorticoids: an emerging role for glucocorticoid-receptor-mediated transactivation Endocrinology 154 3 2013 993 1007
251. N. Vergnolle, P. Pages, R. Guimbaud, S. Chaussade, L. Bueno, and J. Escourrou Annexin 1 is secreted in situ during ulcerative colitis in humans Inflamm Bowel Dis 10 5 2004 584 592
252. S. Verma, P.W.M. Fedak, R.D. Weisel, J. Butany, V. Rao, and A. Maitland Fundamentals of reperfusion injury for the clinical cardiologist Circulation 105 20 2002 2332 2336
253. J. Vinten-Johansen Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury Cardiovasc Res 61 3 2004 481 497
254. L. Vong, F. D'Acquisto, M. Pederzoli-Ribeil, L. Lavagno, R.J. Flower, and V. Witko-Sarsat Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3 J Biol Chem 282 41 2007 29998 30004
255. A. Walther, K. Riehemann, and V. Gerke A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR Mol Cell 5 5 2000 831 840
256. O. Warren, C. Alexiou, R. Massey, D. Leff, S. Purkayastha, and J. Kinross The effects of various leukocyte filtration strategies in cardiac surgery Eur J Cardiothorac Surg 31 4 2007 665 676
257. S. Wein, M. Fauroux, J. Laffitte, P. de Nadai, C. Guaini, and F. Pons Mediation of annexin 1 secretion by a probenecid-sensitive ABC-transporter in rat inflamed mucosa Biochem Pharmacol 67 6 2004 1195 1202
258. K. Wenzel-Seifert, and R. Seifert Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E J Immunol 150 10 1993 4591 4599
259. H. Weyd, L. Abeler-Dorner, B. Linke, A. Mahr, V. Jahndel, and S. Pfrang Annexin A1 on the surface of early apoptotic cells suppresses CD8+ T cell immunity PLoS One 8 4 2013 e62449
260. A.S. Weyrich, M. Buerke, K.H. Albertine, and A.M. Lefer Time course of coronary vascular endothelial adhesion molecule expression during reperfusion of the ischemic feline myocardium J Leukoc Biol 57 1 1995 45 55
261. H.D. White Oral antiplatelet therapy for atherothrombotic disease: current evidence and new directions Am Heart J 161 3 2011 450 461
262. D.A. White, Y. Su, P. Kanellakis, H. Kiriazis, E.F. Morand, and R. Bucala Differential roles of cardiac and leukocyte derived macrophage migration inhibitory factor in inflammatory responses and cardiac remodelling post myocardial infarction J Mol Cell Cardiol 69 2014 32 42
263. S.D. Wiviott, D. Trenk, A.L. Frelinger, M. O'Donoghue, F.J. Neumann, and A.D. Michelson Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 trial Circulation 116 25 2007 2923 2932
264. World Health Organization http://www.who.int/mediacentre/factsheets/fs317/en/ (accessed on 24 August 2013, 1:00 PM).
265. S.H. Wu, X.H. Wu, C. Lu, L. Dong, and Z.Q. Chen Lipoxin A4 inhibits proliferation of human lung fibroblasts induced by connective tissue growth factor Am J Respir Cell Mol Biol 34 1 2006 65 72
266. Y.H. Yang, D. Aeberli, A. Dacumos, J.R. Xue, and E.F. Morand Annexin-1 regulates macrophage IL-6 and TNF via glucocorticoid-induced leucine zipper J Immunol 183 2 2009 1435 1445
267. Y. Yang, P. Hutchinson, and E.F. Morand Inhibitory effect of annexin I on synovial inflammation in rat adjuvant arthritis Arthritis Rheum 42 7 1999 1538 1544
268. Y. Yang, M. Leech, P. Hutchinson, S.R. Holdsworth, and E.F. Morand Antiinflammatory effect of lipocortin 1 in experimental arthritis Inflammation 21 6 1997 583 596
269. Y.H. Yang, E.F. Morand, S.J. Getting, M. Paul-Clark, D.L. Liu, and S. Yona Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis Arthritis Rheum 50 3 2004 976 984
270. Y.H. Yang, E. Morand, and M. Leech Annexin A1: potential for glucocorticoid sparing in RA Nat Rev Rheumatol 9 10 2013 595 603
271. Y.H. Yang, W. Song, J.A. Deane, W. Kao, J.D. Ooi, and D. Ngo Deficiency of Annexin A1 in CD4+ T cells exacerbates T cell-dependent inflammation J Immunol 190 3 2013 997 1007
272. Y.H. Yang, M.L. Toh, C.D. Clyne, M. Leech, D. Aeberli, and J. Xue Annexin 1 negatively regulates IL-6 expression via effects on p38 MAPK and MAPK phosphatase-1 J Immunol 177 11 2006 8148 8153
273. K. Yasojima, C. Schwab, E.G. McGeer, and P.L. McGeer Human heart generates complement proteins that are upregulated and activated after myocardial infarction Circ Res 83 8 1998 860 869
274. S. Yazid, L.V. Norling, and R.J. Flower Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system Prostaglandins Other Lipid Mediat 98 3-4 2012 94 100
275. S. Yazid, E. Solito, H. Christian, S. McArthur, N. Goulding, and R. Flower Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1 Biochem Pharmacol 77 12 2009 1814 1826
276. R.D. Ye, F. Boulay, J.M. Wang, C. Dahlgren, C. Gerard, and M. Parmentier International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family Pharmacol Rev 61 2 2009 119 161
277. U. Zeymer, A. Margenet, M. Haude, C. Bode, J.M. Lablanche, and H. Heuer Randomized comparison of eptifibatide versus abciximab in primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction: results of the EVA-AMI Trial J Am Coll Cardiol 56 6 2010 463 469
278. Z. Zhang, L. Huang, W. Zhao, and B. Rigas Annexin 1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation: anticancer effects in vitro and in vivo Cancer Res 70 6 2010 2379 2388
279. Q. Zhang, M. Raoof, Y. Chen, Y. Sumi, T. Sursal, and W. Junger Circulating mitochondrial DAMPs cause inflammatory responses to injury Nature 464 7285 2010 104 107
280. Z.Q. Zhao, D.J. Lefer, H. Sato, K.K. Hart, P.R. Jefforda, and J. Vinten-Johansen Monoclonal antibody to ICAM-1 preserves postischemic blood flow and reduces infarct size after ischemia-reperfusion in rabbit J Leukoc Biol 62 3 1997 292 300
281. Z.Q. Zhao, M. Nakamura, N.P. Wang, J.N. Wilcox, S. Shearer, and R.S. Ronson Reperfusion induces myocardial apoptotic cell death Cardiovasc Res 45 3 2000 651 660
282. Q. Zhao, L. Shao, X. Hu, G. Wu, J. Du, and J. Xia Lipoxin A4 preconditioning and postconditioning protect myocardial ischemia/reperfusion injury in rats Mediators Inflamm 2013 2013 231351
283. C.H. Zhou, S. Zhang, M. Nanamori, Y.Y. Zhang, Q. Liu, and N. Li Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1 Mol Pharmacol 72 4 2007 976 983
284. L. Zhu, and P. He Platelet-activating factor increases endothelial [Ca2+]i and NO production in individually perfused intact microvessels Am J Physiol Heart Circ Physiol 288 6 2005 H2869 H2877