Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A4

Biochemical Pharmacology

Volumn 85, Issue 12, 2013, Pages 1795-1802

  Hanson, Julien ^a,b   Ferreirós, Nerea ^c   Pirotte, Bernard ^b   Geisslinger, Gerd ^c   Offermanns, Stefan ^a,c  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

ALX; Formyl peptide receptor; FPR2; Lipoxin; Resolution of inflammation

Indexed keywords

BETA ARRESTIN; CALCIUM; CYCLIC AMP; FORMYL PEPTIDE RECEPTOR 2; FORMYLPEPTIDE RECEPTOR; LIPOXIN A; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; LIPOXINS; MICE; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, LIPOXIN;

EID: 84878890699     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.04.019     Document Type: Article

References (48)

1. C.N. Serhan, M. Hamberg, and B. Samuelsson Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes Proc Natl Acad Sci USA 81 1984 5335 5339 (Pubitemid 14048742)
2. C.N. Serhan, M. Hamberg, and B. Samuelsson Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes Biochem Biophys Res Commun 118 1984 943 949 (Pubitemid 14194804)
3. C.N. Serhan Lipoxin biosynthesis and its impact in inflammatory and vascular events Biochim Biophys Acta 1212 1994 1 25 (Pubitemid 24123884)
4. N. Chiang, C.N. Serhan, S.E. Dahlen, J.M. Drazen, D.W. Hay, and G.E. Rovati The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo Pharmacol Rev 58 2006 463 487 (Pubitemid 44394909)
5. S. Nigam, S. Fiore, F.W. Luscinskas, and Serhan C.N. Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion J Cell Physiol 143 1990 512 523
6. C. Godson, S. Mitchell, K. Harvey, N.A. Petasis, N. Hogg, and H.R. Brady Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages J Immunol 164 2000 1663 1667 (Pubitemid 30108713)
7. U. Ramstedt, C.N. Serhan, K.C. Nicolaou, S.E. Webber, H. Wigzell, and B. Samuelsson Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: studies on stereospecificity of inhibition and mode of action J Immunol 138 1987 266 270 (Pubitemid 17218429)
8. Y. Le, P.M. Murphy, and J.M. Wang Formyl-peptide receptors revisited Trends Immunol 23 2002 541 548 (Pubitemid 35223553)
9. B. McMahon, S. Mitchell, H.R. Brady, and C. Godson Lipoxins: revelations on resolution Trends Pharmacol Sci 22 2001 391 395 (Pubitemid 32718624)
10. C.N. Serhan, N. Chiang, and T.E. Van Dyke Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators Nat Rev Immunol 8 2008 349 361 (Pubitemid 351595216)
11. S. Fiore, S.W. Ryeom, P.F. Weller, and C.N. Serhan Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils J Biol Chem 267 1992 16168 16176
12. S. Fiore, M. Romano, E.M. Reardon, and C.N. Serhan Induction of functional lipoxin A4 receptors in HL-60 cells Blood 81 1993 3395 3403 (Pubitemid 23172926)
13. S. Fiore, J.F. Maddox, H.D. Perez, and C.N. Serhan Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor J Exp Med 180 1994 253 260 (Pubitemid 24181074)
14. R.D. Ye, F. Boulay, J.M. Wang, C. Dahlgren, C. Gerard, and M. Parmentier International Union of Basic and Clinical Pharmacology LXXIII. Nomenclature for the formyl peptide receptor (FPR) family Pharmacol Rev 61 2009 119 161
15. N. Chiang, I.M. Fierro, K. Gronert, and C.N. Serhan Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation J Exp Med 191 2000 1197 1208
16. M.J. Rabiet, E. Huet, and F. Boulay Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR Eur J Immunol 35 2005 2486 2495 (Pubitemid 41179770)
17. T. Christophe, A. Karlsson, C. Dugave, M.J. Rabiet, F. Boulay, and C. Dahlgren The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2 J Biol Chem 276 2001 21585 21593
18. H.L. Tiffany, J.L. Gao, E. Roffe, J.M. Sechler, and P.M. Murphy Characterization of Fpr-rs8, an atypical member of the mouse formyl peptide receptor gene family J Innate Immun 3 2011 519 529
19. J.L. Gao, H. Chen, J.D. Filie, C.A. Kozak, and P.M. Murphy Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse Genomics 51 1998 270 276 (Pubitemid 28395033)
20. Z.G. Wang, and R.D. Ye Characterization of two new members of the formyl peptide receptor gene family from 129S6 mice Gene 299 2002 57 63 (Pubitemid 35379827)
21. T. Takano, S. Fiore, J.F. Maddox, H.R. Brady, N.A. Petasis, and C.N. Serhan Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors J Exp Med 185 1997 1693 1704 (Pubitemid 27203265)
22. M.W. Vaughn, R.J. Proske, and D.L. Haviland Identification, cloning, and functional characterization of a murine lipoxin A4 receptor homologue gene J Immunol 169 2002 3363 3369 (Pubitemid 35013186)
23. H.L. Tiffany, M.C. Lavigne, Y.H. Cui, J.M. Wang, T.L. Leto, and J.L. Gao Amyloid-β induces chemotaxis and oxidant stress by acting at formylpeptide receptor 2, a G protein-coupled receptor expressed in phagocytes and brain J Biol Chem 276 2001 23645 23652
24. T.S. Liang, J.M. Wang, P.M. Murphy, and J.L. Gao Serum amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophils Biochem Biophys Res Commun 270 2000 331 335 (Pubitemid 30446837)
25. H.Q. He, D. Liao, Z.G. Wang, Z.L. Wang, H.C. Zhou, and M.W. Wang Functional characterization of three mouse formyl Peptide receptors Mol Pharmacol 83 2013 389 398
26. T. Christophe, A. Karlsson, M.J. Rabiet, F. Boulay, and C. Dahlgren Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4 Scand J Immunol 56 2002 470 476 (Pubitemid 35373683)
27. H. Forsman, and C. Dahlgren Lipoxin A(4) metabolites/analogues from two commercial sources have no effects on TNF-alpha-mediated priming or activation through the neutrophil formyl peptide receptors Scand J Immunol 70 2009 396 402
28. H. Forsman, K. Onnheim, E. Andreasson, and C. Dahlgren What formyl peptide receptors, if any, are triggered by compound 43 and lipoxin A4 Scand J Immunol 74 2011 227 234
29. S.K. Shenoy, and R.J. Lefkowitz Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes J Biol Chem 280 2005 15315 15324 (Pubitemid 40562888)
30. 2+ reporters at the single-cell level Proc Natl Acad Sci USA 97 2000 7260 7265 (Pubitemid 30431451)
31. F. Fan, B.F. Binkowski, B.L. Butler, P.F. Stecha, M.K. Lewis, and K.V. Wood Novel genetically encoded biosensors using firefly luciferase ACS Chem Biol 3 2008 346 351
32. S. Offermanns, and M.I. Simon G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C J Biol Chem 270 1995 15175 15180
33. M.J. Marinissen, and J.S. Gutkind G-protein-coupled receptors and signaling networks: emerging paradigms Trends Pharmacol Sci 22 2001 368 376 (Pubitemid 32592476)
34. R.J. Lefkowitz, and S.K. Shenoy Transduction of receptor signals by beta-arrestins Science 308 2005 512 517
35. T.H. Lee, P. Lympany, A.E. Crea, and B.W. Spur Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: structure-function relationships Biochem Biophys Res Commun 180 1991 1416 1421
36. C. Schumacher, and V. von Tscharner Practical instructions for radioactively labeled ligand receptor binding studies Anal Biochem 222 1994 262 269 (Pubitemid 24319555)
37. J.A. Koenig Radioligand binding in intact cells Methods Mol Biol 106 1999 89 98
38. G.E. Rovati Rational experimental design and data analysis for ligand binding studies: tricks, tips and pitfalls Pharmacol Res 28 1993 277 299 (Pubitemid 24027030)
39. S. Fiore, and C.N. Serhan Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction Biochemistry 34 1995 16678 16686
40. Y.S. Bae, J.C. Park, R. He, R.D. Ye, J.Y. Kwak, and P.G. Suh Differential signaling of formyl peptide receptor-like 1 by Trp-Lys-Tyr-Met-Val-Met-CONH2 or lipoxin A4 in human neutrophils Mol Pharmacol 64 2003 721 730 (Pubitemid 37048577)
41. S. Krishnamoorthy, A. Recchiuti, N. Chiang, S. Yacoubian, C.H. Lee, and R. Yang Resolvin D1 binds human phagocytes with evidence for proresolving receptors Proc Natl Acad Sci USA 107 2010 1660 1665
42. P. Maderna, D.C. Cottell, T. Toivonen, N. Dufton, J. Dalli, and M. Perretti FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis FASEB J 24 2010 4240 4249
43. A.L. Stenfeldt, J. Karlsson, C. Wenneras, J. Bylund, H. Fu, and C. Dahlgren Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor Inflammation 30 2007 224 229 (Pubitemid 350284401)
44. H. Fu, L. Bjorkman, P. Janmey, A. Karlsson, J. Karlsson, and C. Movitz The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding peptide BMC Cell Biol 5 2004 50
45. J.L. Sharman, C.P. Mpamhanga, M. Spedding, P. Germain, B. Staels, and C. Dacquet IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data Nucleic Acids Res 39 2011 D534 D538
46. S.P. Alexander, A. Mathie, and J.A. Peters Guide to receptors and channels (GRAC), 5th edition Br J Pharmacol 164 Suppl. 1 2011 S1 S324
47. S.N. Cooray, L. Chan, T.R. Webb, L. Metherell, and A.J. Clark Accessory proteins are vital for the functional expression of certain G protein-coupled receptors Mol Cell Endocrinol 300 2009 17 24
48. M. Durstin, J.L. Gao, H.L. Tiffany, D. McDermott, and P.M. Murphy Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes Biochem Biophys Res Commun 201 1994 174 179 (Pubitemid 24213710)