Annexin-1-deficient mice exhibit spontaneous airway hyperresponsiveness and exacerbated allergen-specific antibody responses in a mouse model of asthma

Clinical and Experimental Allergy

Volumn 41, Issue 12, 2011, Pages 1793-1803

  Ng, F S P ^a   Wong, K Y ^a   Guan, S P ^a,b   Mustafa, F B ^a   Kajiji, T S ^c   Bist, P ^a   Biswas, S K ^c   Wong, W S F ^a,b   Lim, L H K ^a,d  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c AGENCY FOR SCIENCE   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Airway hyperresponsiveness; Allergen specific antibody production; Asthma

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; LIPOCORTIN 1; METHACHOLINE; OVALBUMIN;

AIRWAY RESISTANCE; ANIMAL CELL; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ARTICLE; ASTHMA; CONTROLLED STUDY; FEMALE; LUNG COMPLIANCE; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT DISEASE; WILD TYPE;

ALLERGENS; ANIMALS; ANNEXIN A1; ANNEXINS; ANTIBODY SPECIFICITY; ASTHMA; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; EOSINOPHILS; FEMALE; IMMUNITY, HUMORAL; IMMUNOGLOBULIN E; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; OVALBUMIN;

EID: 82155161944     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2011.03855.x     Document Type: Article

References (38)

1. Errasfa M, Russo-Marie F. A purified lipocortin shares the anti-inflammatory effect of glucocorticosteroids in vivo in mice. Br J Pharmacol 1989; 97:1051-8.
2. Barnes PJ. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci 1998; 94:557-72.
3. Yang YH, Hutchinson P, Leech M, Morand EF. Exacerbation of adjuvant arthritis by adrenalectomy is associated with reduced leukocyte lipocortin 1. J Rheumatol 1997; 24:1758-64.
4. Loxley HD, Cowell AM, Flower RJ, Buckingham JC. Effects of lipocortin 1 and dexamethasone on the secretion of corticotrophin-releasing factors in the rat: in vitro and in vivo studies. J Neuroendocrinol 1993; 5:51-61.
5. Van Hal PT, Overbeek SE, Hoogsteden HC et al. Eicosanoids and lipocortin-1 in BAL fluid in asthma: effects of smoking and inhaled glucocorticoids. J Appl Physiol 1996; 81:548-55.
6. De Caterina R, Sicari R, Giannessi D et al. Macrophage-specific eicosanoid synthesis inhibition and lipocortin-1 induction by glucocorticoids. J Appl Physiol 1993; 75:2368-75.
7. Smith SF, Tetley TD, Guz A, Flower RJ. Detection of lipocortin 1 in human lung lavage fluid: lipocortin degradation as a possible proteolytic mechanism in the control of inflammatory mediators and inflammation. Environ Health Perspect 1990; 85:135-44.
8. Vishwanatha JK, Davis RG, Rubinstein I, Floreani A. Annexin I degradation in bronchoalveolar lavage fluids from healthy smokers: a possible mechanism of inflammation. Clin Cancer Res 1998; 4:2559-64.
9. Lim LH, Pervaiz S. Annexin 1: the new face of an old molecule. FASEB J 2007; 21:968-75.
10. Lim LH, Solito E, Russo-Marie F, Flower RJ, Perretti M. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci USA 1998; 95:14535-9.
11. Perretti M, Croxtall JD, Wheller SK, Goulding NJ, Hannon R, Flower RJ. Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration. Nat Med 1996; 2:1259-62.
12. Hannon R, Croxtall JD, Getting SJ et al. Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB J 2003; 17:253-5.
13. Chatterjee BE, Yona S, Rosignoli Get al. Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J Leukoc Biol 2005; 78:639-46.
14. D'Acquisto F, Merghani A, Lecona E et al. Annexin-1 modulates T-cell activation and differentiation. Blood 2007; 109:1095-102.
15. Getting SJ, Flower RJ, Perretti M. Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1. Br J Pharmacol 1997; 120:1075-82.
16. Bandeira-Melo C, Bonavita AG, Diaz BL et al. A novel effect for annexin 1-derived peptide ac2-26: reduction of allergic inflammation in the rat. J Pharmacol Exp Ther 2005; 313:1416-22.
17. D'Acquisto F, Paschalidis N, Sampaio AL, Merghani A, Flower RJ, Perretti M. Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells. Eur J Immunol 2007; 37:3131-42.
18. Hamelmann E, Schwarze J, Takeda K et al. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 1997; 156:766-75.
19. Tan Y, Lim LH. Trans-Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation. Br J Pharmacol 2008; 155:995-1004.
20. Mitzner W, Tankersley C. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med 1998; 158:340-1.
21. Bao Z, Guan S, Cheng C et al. A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kappaB pathway. Am J Respir Crit Care Med 2009; 179:657-65.
22. Bizzarro V, Fontanella B, Franceschelli S et al. Role of annexin A1 in mouse myoblast cell differentiation. J Cell Physiol 2010; 224:757-65.
23. McArthur S, Yazid S, Christian H et al. Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization. FASEB J 2009; 23:4000-10.
24. Patel DM, Ahmad SF, Weiss DG, Gerke V, Kuznetsov SA. Annexin A1 is a new functional linker between actin filaments and phagosomes during phagocytosis. J Cell Sci 2011; 124:578-88.
25. Finotto S, Neurath MF, Glickman JN et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002; 295:336-8.
26. Kamal AM, Smith SF, De Silva Wijayasinghe M, Solito E, Corrigan CJ. An annexin 1 (ANXA1)-derived peptide inhibits prototype antigen-driven human T cell Th1 and Th2 responses in vitro. Clin Exp Allergy 2001; 31:1116-25.
27. Dittrich AM, Erbacher A, Specht S et al. Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine asthma model. J Immunol 2008; 180:1792-9.
28. Kadkhoda K, Wang S, Fan Y et al. ICOS ligand expression is essential for allergic airway hyperresponsiveness. Int Immunol 2011; 23:239-49.
29. Morand EF, Hutchinson P, Hargreaves A, Goulding NJ, Boyce NW, Holdsworth SR. Detection of intracellular lipocortin 1 in human leukocyte subsets. Clin Immunol Immunopathol 1995; 76:195-202.
30. Falini B, Tiacci E, Liso A et al. Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1). Lancet 2004; 363:1869-70.
31. Teixeira MM, Das AM, Miotla JM, Perretti M, Hellewell PG. The role of lipocortin-1 in the inhibitory action of dexamethasone on eosinophil trafficking in cutaneous inflammatory reactions in the mouse. Br J Pharmacol 1998; 123:538-44.
32. Das AM, Flower RJ, Hellewell PG, Teixeira MM, Perretti M. A novel murine model of allergic inflammation to study the effect of dexamethasone on eosinophil recruitment. Br J Pharmacol 1997; 121:97-104.
33. Rescher U, Danielczyk A, Markoff A, Gerke V. Functional activation of the formyl peptide receptor by a new endogenous ligand in human lung A549 cells. J Immunol 2002; 169:1500-4.
34. Levy BD, De Sanctis GT, Devchand PR et al. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Nat Med 2002; 8:1018-23.
35. Perretti M, D'Acquisto F. Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat Rev Immunol 2009; 9:62-70.
36. Gavins FN, Sawmynaden P, Chatterjee BE, Perretti M. A twist in anti-inflammation: annexin 1 acts via the lipoxin A4 receptor. Prostaglandins Leukot Essent Fatty Acids 2005; 73:211-19.
37. Huggins A, Paschalidis N, Flower RJ, Perretti M, D'Acquisto F. Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation. FASEB J 2009; 23:985-96.
38. Bist P, Leow SC, Phua QH et al. Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-kappaB: implication in breast cancer metastasis. Oncogene 2011; 30:3174-85.