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The mechanistic basis of infarct healing
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Maekawa Y, Anzai T, Yoshikawa T, et al. Prognostic significance of peripheral monocytosis after reperfused acute myocardial infarction: a possible role for left ventricular remodeling. J Am Coll Cardiol 2002; 39:241-6. Clinical study demonstrating an important association between the peak monocyte count and adverse LV remodelling following reperfused acute MI. (Pubitemid 34084628)
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Pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to primary percutaneous coronary intervention in acute myocardial infarction: The COMplement inhibition in Myocardial infarction treated with Angioplasty (COMMA) trial
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Randomised clinical trial showing no beneficial effect of adjuvant treatment with the C5 complement inhibitor pexelizumab on infarct size in patients undergoing primary percutaneous coronary intervention
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Granger CB, Mahaffey KW, Weaver WD, et al. Pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to primary percutaneous coronary intervention in acute myocardial infarction: the COMplement inhibition in Myocardial infarction treated with Angioplasty (COMMA) trial. Circulation 2003;108:1184-90. Randomised clinical trial showing no beneficial effect of adjuvant treatment with the C5 complement inhibitor pexelizumab on infarct size in patients undergoing primary percutaneous coronary intervention.
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The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: The results of the HALT-MI study
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Randomised clinical trial demonstrating no reduction of infarct size after treatment with an antibody to the CD11/ CD18 integrin receptor, Hu23F2G, in patients undergoing primary percutaneous coronary intervention
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Faxon DP, Gibbons RJ, Chronos NA, et al. The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study. J Am Coll Cardiol 2002;40:1199-204. Randomised clinical trial demonstrating no reduction of infarct size after treatment with an antibody to the CD11/ CD18 integrin receptor, Hu23F2G, in patients undergoing primary percutaneous coronary intervention.
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Faxon, D.P.1
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Nahrendorf M, Swirski FK, Aikawa E, et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 2007;204:3037-47. First experimental study showing that monocyte subsets are sequentially mobilised following acute MI in mice and that these subsets have different functions. (Pubitemid 350179569)
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Clinical study demonstrating for the first time an association between the peak level of classical monocytes in blood and myocardial salvage in patients with acute MI, treated with primary percutaneous coronary intervention
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Tsujioka H, Imanishi T, Ikejima H, et al. Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction. J Am Coll Cardiol 2009; 54:130-8. Clinical study demonstrating for the first time an association between the peak level of classical monocytes in blood and myocardial salvage in patients with acute MI, treated with primary percutaneous coronary intervention.
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Clinical study showing that a high concentration of classical monocytes in blood is associated with impaired functional outcome following primary percutaneous coronary intervention
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van der Laan AM, Hirsch A, Robbers LF, et al. A proinflammatory monocyte response is associated with myocardial injury and impaired functional outcome in patients with ST-segment elevation myocardial infarction monocytes and myocardial infarction. Am Heart J 2012;163 :57-65.e2. Clinical study showing that a high concentration of classical monocytes in blood is associated with impaired functional outcome following primary percutaneous coronary intervention.
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Van Der Laan, A.M.1
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Wojakowski W, Tendera M, Michalowska A, et al. Mobilization of CD34/CXCR4+, CD34/CD117+, c-met+ stem cells, and mononuclear cells expressing early cardiac, muscle, and endothelial markers into peripheral blood in patients with acute myocardial infarction. Circulation 2004;110 :3213-20. (Pubitemid 39525068)
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Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001;410:701-5. This experimental study is one of the first to show that bone marrow cell therapy ameliorates outcome after acute MI in mice. (Pubitemid 32290358)
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New England Journal of Medicine
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Schachinger, V.1
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Zimmet H, Porapakkham P, Porapakkham P, et al. Short- and longterm outcomes of intracoronary and endogenously mobilized bone marrow stem cells in the treatment of ST-segment elevation myocardial infarction: a meta-analysis of randomized control trials. Eur J Heart Fail 2012;14:91-105.
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PET/MRI of inflammation in myocardial infarction
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One of the first studies unequivocally demonstrating the presence of macrophages in the remote zone after acute MI
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Lee WW, Marinelli B, van der Laan AM, et al. PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol 2012; 59:153-63. One of the first studies unequivocally demonstrating the presence of macrophages in the remote zone after acute MI.
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Lee, W.W.1
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