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Volumn 7, Issue 2, 2015, Pages 139-157

Adipokines and their receptors: Potential new targets in cardiovascular diseases

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPOCYTOKINE RECEPTOR; ADIPONECTIN RECEPTOR; APELIN RECEPTOR; LEPTIN RECEPTOR; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PROTEIN S 100; RESISTIN;

EID: 84923131513     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.14.147     Document Type: Review
Times cited : (8)

References (166)
  • 4
    • 65549109680 scopus 로고    scopus 로고
    • Obesity and cardiovascular disease: Risk factor, paradox, and impact of weight loss
    • Lavie CJ, Milani RV, Ventura HO. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J. Am. Coll. Cardiol. 53(21), 1925-1932 (2009).
    • (2009) J. Am. Coll. Cardiol. , vol.53 , Issue.21 , pp. 1925-1932
    • Lavie, C.J.1    Milani, R.V.2    Ventura, H.O.3
  • 5
    • 84903610293 scopus 로고    scopus 로고
    • Heart failure and obesity in adults: Pathophysiology, clinical manifestations and management
    • Alpert MA, Agrawal H, Aggarwal K, Kumar SA, Kumar A. Heart failure and obesity in adults: pathophysiology, clinical manifestations and management. Curr. Heart Fail. Rep,11(2), 156-165 (2014).
    • (2014) Curr. Heart Fail. Rep , vol.11 , Issue.2 , pp. 156-165
    • Alpert, M.A.1    Agrawal, H.2    Aggarwal, K.3    Kumar, S.A.4    Kumar, A.5
  • 6
    • 84884795205 scopus 로고    scopus 로고
    • APpEaLINg therapeutic target for obesity cardiomyopathy J
    • Wende AR, Young ME. APpEaLINg therapeutic target for obesity cardiomyopathy J. Mol. Cell Cardiol. 63, 165-168 (2013).
    • (2013) Mol. Cell Cardiol. , vol.63 , pp. 165-168
    • Wende, A.R.1    Young, M.E.2
  • 7
    • 79959779173 scopus 로고    scopus 로고
    • Myocardial, perivascular, and epicardial fat
    • Iozzo P. Myocardial, perivascular, and epicardial fat. Diabetes Care 34(Suppl. 2), S371-S379 (2011).
    • (2011) Diabetes Care , vol.34 , pp. S371-S379
    • Iozzo, P.1
  • 8
    • 19744362790 scopus 로고    scopus 로고
    • Vasocrine signalling from perivascular fat: A mechanism linking insulin resistance to vascular disease
    • Yudkin JS, Eringa E, Stehouwer CD. "Vasocrine" signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease. Lancet 365(9473), 1817-1820 (2005).
    • (2005) Lancet , vol.365 , Issue.9473 , pp. 1817-1820
    • Yudkin, J.S.1    Eringa, E.2    Stehouwer, C.D.3
  • 9
    • 48349146146 scopus 로고    scopus 로고
    • The double role of epicardial adipose tissue as pro-and anti-inflammatory organ
    • Iacobellis G, Barbaro G. The double role of epicardial adipose tissue as pro-and anti-inflammatory organ. Horm. Metab. Res. 40(7), 442-445 (2008).
    • (2008) Horm. Metab. Res. , vol.40 , Issue.7 , pp. 442-445
    • Iacobellis, G.1    Barbaro, G.2
  • 10
    • 70450172525 scopus 로고    scopus 로고
    • Echocardiographic epicardial fat: A review of research and clinical applications
    • quiz 1417-1318
    • Iacobellis G, Willens HJ. Echocardiographic epicardial fat: a review of research and clinical applications. J. Am. Soc. Echocardiogr. 22(12), 1311-1319; quiz 1417-1318 (2009).
    • (2009) J. Am. Soc. Echocardiogr. , vol.22 , Issue.12 , pp. 1311-1319
    • Iacobellis, G.1    Willens, H.J.2
  • 13
    • 0027717002 scopus 로고
    • A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11
    • O'dowd BF, Heiber M, Chan A et al. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene 136(1-2), 355-360 (1993).
    • (1993) Gene , vol.136 , Issue.1-2 , pp. 355-360
    • O'Dowd, B.F.1    Heiber, M.2    Chan, A.3
  • 14
    • 0032552988 scopus 로고    scopus 로고
    • Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor
    • Tatemoto K, Hosoya M, Habata Y et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem. Biophys. Res. Commun. 251(2), 471-476 (1998).
    • (1998) Biochem. Biophys. Res. Commun. , vol.251 , Issue.2 , pp. 471-476
    • Tatemoto, K.1    Hosoya, M.2    Habata, Y.3
  • 15
    • 0032826034 scopus 로고    scopus 로고
    • Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum
    • Habata Y, Fujii R, Hosoya M et al. Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum. Biochim. Biophys. Acta 1452(1), 25-35 (1999).
    • (1999) Biochim. Biophys. Acta , vol.1452 , Issue.1 , pp. 25-35
    • Habata, Y.1    Fujii, R.2    Hosoya, M.3
  • 16
    • 84872117088 scopus 로고    scopus 로고
    • Serum apelin-12 level is elevated in schoolchildren with atopic asthma
    • Machura E, Ziora K, Ziora D et al. Serum apelin-12 level is elevated in schoolchildren with atopic asthma. Respir. Med. 107(2), 196-201 (2013).
    • (2013) Respir. Med. , vol.107 , Issue.2 , pp. 196-201
    • MacHura, E.1    Ziora, K.2    Ziora, D.3
  • 17
    • 84865146998 scopus 로고    scopus 로고
    • APJ acts as a dual receptor in cardiac hypertrophy
    • Scimia MC, Hurtado C, Ray S et al. APJ acts as a dual receptor in cardiac hypertrophy. Nature 488(7411), 394-398 (2012).
    • (2012) Nature , vol.488 , Issue.7411 , pp. 394-398
    • Scimia, M.C.1    Hurtado, C.2    Ray, S.3
  • 18
    • 55849094397 scopus 로고    scopus 로고
    • Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
    • Chun HJ, Ali ZA, Kojima Y et al. Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J. Clin. Invest. 118(10), 3343-3354 (2008).
    • (2008) J. Clin. Invest. , vol.118 , Issue.10 , pp. 3343-3354
    • Chun, H.J.1    Ali, Z.A.2    Kojima, Y.3
  • 19
    • 0034647520 scopus 로고    scopus 로고
    • Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin
    • Hosoya M, Kawamata Y, Fukusumi S et al. Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin. J. Biol. Chem. 275(28), 21061-21067 (2000).
    • (2000) J. Biol. Chem. , vol.275 , Issue.28 , pp. 21061-21067
    • Hosoya, M.1    Kawamata, Y.2    Fukusumi, S.3
  • 20
    • 0035938189 scopus 로고    scopus 로고
    • Molecular properties of apelin: Tissue distribution and receptor binding
    • Kawamata Y, Habata Y, Fukusumi S et al. Molecular properties of apelin: tissue distribution and receptor binding. Biochim. Biophys. Acta 1538(2-3), 162-171 (2001).
    • (2001) Biochim. Biophys. Acta , vol.1538 , Issue.2-3 , pp. 162-171
    • Kawamata, Y.1    Habata, Y.2    Fukusumi, S.3
  • 21
    • 12344312427 scopus 로고    scopus 로고
    • Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells
    • Kleinz MJ, Skepper JN, Davenport AP. Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells. Regul. Pept. 126(3), 233-240 (2005).
    • (2005) Regul. Pept. , vol.126 , Issue.3 , pp. 233-240
    • Kleinz, M.J.1    Skepper, J.N.2    Davenport, A.P.3
  • 22
    • 0037341188 scopus 로고    scopus 로고
    • Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin
    • Medhurst AD, Jennings CA, Robbins MJ et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J. Neuro Chem. 84(5), 1162-1172 (2003).
    • (2003) J. Neuro Chem. , vol.84 , Issue.5 , pp. 1162-1172
    • Medhurst, A.D.1    Jennings, C.A.2    Robbins, M.J.3
  • 23
    • 0034697792 scopus 로고    scopus 로고
    • Distribution of mRNA encoding B78/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues
    • O'carroll AM, Selby TL, Palkovits M, Lolait SJ. Distribution of mRNA encoding B78/apj, the rat homologue of the human APJ receptor, and its endogenous ligand apelin in brain and peripheral tissues. Biochim. Biophys. Acta 1492(1), 72-80 (2000).
    • (2000) Biochim. Biophys. Acta , vol.1492 , Issue.1 , pp. 72-80
    • O'Carroll, A.M.1    Selby, T.L.2    Palkovits, M.3    Lolait, S.J.4
  • 24
    • 20144380036 scopus 로고    scopus 로고
    • Apelin, a newly identified adipokine up-regulated by insulin and obesity
    • Boucher J, Masri B, Daviaud D et al. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 146(4), 1764-1771 (2005).
    • (2005) Endocrinology , vol.146 , Issue.4 , pp. 1764-1771
    • Boucher, J.1    Masri, B.2    Daviaud, D.3
  • 25
    • 84881178678 scopus 로고    scopus 로고
    • Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction
    • Ceylan-Isik AF, Kandadi MR, Xu X et al. Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction. J. Mol. Cell Cardiol. 63, 4-13 (2013).
    • (2013) J. Mol. Cell Cardiol. , vol.63 , pp. 4-13
    • Ceylan-Isik, A.F.1    Kandadi, M.R.2    Xu, X.3
  • 26
    • 84899944315 scopus 로고    scopus 로고
    • Associations between serum apelin-12 levels and obesity-related markers in Chinese children
    • Ba HJ, Chen HS, Su Z et al. Associations between serum apelin-12 levels and obesity-related markers in Chinese children. PLoS One 9(1), e86577 (2014).
    • (2014) PLoS One , vol.9 , Issue.1 , pp. e86577
    • Ba, H.J.1    Chen, H.S.2    Su, Z.3
  • 27
    • 28844479589 scopus 로고    scopus 로고
    • Apelin: A novel neurohumoral modulator of the cardiovascular system. Pathophysiologic importance and potential use as a therapeutic target
    • Falcao-PiRes. I, Leite-Moreira AF. Apelin: a novel neurohumoral modulator of the cardiovascular system. Pathophysiologic importance and potential use as a therapeutic target. Rev. Port. Cardiol. 24(10), 1263-1276 (2005).
    • (2005) Rev. Port. Cardiol. , vol.24 , Issue.10 , pp. 1263-1276
    • Falcao-Pires, I.1    Leite-Moreira, A.F.2
  • 28
    • 84896738066 scopus 로고    scopus 로고
    • The relationship between apelin and cardiac parameters in patients on peritoneal dialysis: Is there a new cardiac marker
    • Karadag S, Ozturk S, Gursu M et al. The relationship between apelin and cardiac parameters in patients on peritoneal dialysis: is there a new cardiac marker BMC Nephrol 15(1), 18 (2014).
    • (2014) BMC Nephrol , vol.15 , Issue.1 , pp. 18
    • Karadag, S.1    Ozturk, S.2    Gursu, M.3
  • 30
    • 0042165829 scopus 로고    scopus 로고
    • Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure
    • Foldes G, Horkay F, Szokodi I et al. Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure. Biochem. Biophys. Res. Commun. 308(3), 480-485 (2003).
    • (2003) Biochem. Biophys. Res. Commun. , vol.308 , Issue.3 , pp. 480-485
    • Foldes, G.1    Horkay, F.2    Szokodi, I.3
  • 31
    • 44849144176 scopus 로고    scopus 로고
    • The apelinergic system: The role played in human physiology and pathology and potential therapeutic applications
    • Ladeiras-Lopes R, Ferreira-Martins J, Leite-Moreira AF. The apelinergic system: the role played in human physiology and pathology and potential therapeutic applications. Arq. Bras. Cardiol. 90(5), 343-349 (2008).
    • (2008) Arq. Bras. Cardiol. , vol.90 , Issue.5 , pp. 343-349
    • Ladeiras-Lopes, R.1    Ferreira-Martins, J.2    Leite-Moreira, A.F.3
  • 32
    • 2942711581 scopus 로고    scopus 로고
    • Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressurein vivo
    • Ishida J, Hashimoto T, Hashimoto Y et al. Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressurein vivo. J. Biol. Chem. 279(25), 26274-26279 (2004).
    • (2004) J. Biol. Chem. , vol.279 , Issue.25 , pp. 26274-26279
    • Ishida, J.1    Hashimoto, T.2    Hashimoto, Y.3
  • 33
    • 0035084443 scopus 로고    scopus 로고
    • [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man
    • Katugampola SD, Maguire JJ, Matthewson SR, Davenport AP. [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br. J. Pharmacol. 132(6), 1255-1260 (2001).
    • (2001) Br. J. Pharmacol. , vol.132 , Issue.6 , pp. 1255-1260
    • Katugampola, S.D.1    Maguire, J.J.2    Matthewson, S.R.3    Davenport, A.P.4
  • 35
    • 33746402829 scopus 로고    scopus 로고
    • Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats
    • Zhang J, Ren CX, Qi YF et al. Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats. Life Sci. 79(12), 1153-1159 (2006).
    • (2006) Life Sci. , vol.79 , Issue.12 , pp. 1153-1159
    • Zhang, J.1    Ren, C.X.2    Qi, Y.F.3
  • 36
    • 84879237561 scopus 로고    scopus 로고
    • Sustained cardiovascular actions of APJ agonism during renin-angiotensin system activation and in patients with heart failure
    • Barnes GD, Alam S, Carter G et al. Sustained cardiovascular actions of APJ agonism during renin-angiotensin system activation and in patients with heart failure. Circ. Heart Fail. 6(3), 482-491 (2013).
    • (2013) Circ. Heart Fail. , vol.6 , Issue.3 , pp. 482-491
    • Barnes, G.D.1    Alam, S.2    Carter, G.3
  • 37
    • 18544378161 scopus 로고    scopus 로고
    • Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase
    • Vickers C, Hales P, Kaushik V et al. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J. Biol. Chem. 277(17), 14838-14843 (2002).
    • (2002) J. Biol. Chem. , vol.277 , Issue.17 , pp. 14838-14843
    • Vickers, C.1    Hales, P.2    Kaushik, V.3
  • 38
    • 84890090677 scopus 로고    scopus 로고
    • Apelin is a positive regulator of ACE2 in failing hearts
    • Sato T, Suzuki T, Watanabe H et al. Apelin is a positive regulator of ACE2 in failing hearts. J. Clin. Invest. 123(12), 5203-5211 (2013).
    • (2013) J. Clin. Invest. , vol.123 , Issue.12 , pp. 5203-5211
    • Sato, T.1    Suzuki, T.2    Watanabe, H.3
  • 39
    • 84862284803 scopus 로고    scopus 로고
    • Targeting the ACE2 and apelin pathways are novel therapies for heart failure: Opportunities and challenges
    • Kazemi-Bajestani SM, Patel VB, Wang W, Oudit GY. Targeting the ACE2 and apelin pathways are novel therapies for heart failure: opportunities and challenges. Cardiol. Res. Pract. 2012, 823193 (2012).
    • (2012) Cardiol. Res. Pract. , vol.2012 , pp. 823193
    • Kazemi-Bajestani, S.M.1    Patel, V.B.2    Wang, W.3    Oudit, G.Y.4
  • 40
    • 0035015269 scopus 로고    scopus 로고
    • Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain
    • Reaux A, De Mota N, Skultetyova I et al. Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain. J. Neuro Chem. 77(4), 1085-1096 (2001).
    • (2001) J. Neuro Chem. , vol.77 , Issue.4 , pp. 1085-1096
    • Reaux, A.1    De Mota, N.2    Skultetyova, I.3
  • 41
    • 0037032005 scopus 로고    scopus 로고
    • Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility
    • Szokodi I, Tavi P, Foldes G et al. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ. Res. 91(5), 434-440 (2002).
    • (2002) Circ. Res. , vol.91 , Issue.5 , pp. 434-440
    • Szokodi, I.1    Tavi, P.2    Foldes, G.3
  • 42
    • 19944373052 scopus 로고    scopus 로고
    • The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo
    • Ashley EA, Powers J, Chen M et al. The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Cardiovasc. Res. 65(1), 73-82 (2005).
    • (2005) Cardiovasc. Res. , vol.65 , Issue.1 , pp. 73-82
    • Ashley, E.A.1    Powers, J.2    Chen, M.3
  • 43
    • 33751160364 scopus 로고    scopus 로고
    • Apelin increases contractility in failing cardiac muscle
    • Dai T, Ramirez-Correa G, Gao WD. Apelin increases contractility in failing cardiac muscle. Eur. J. Pharmacol. 553(1-3), 222-228 (2006).
    • (2006) Eur. J. Pharmacol. , vol.553 , Issue.1-3 , pp. 222-228
    • Dai, T.1    Ramirez-Correa, G.2    Gao, W.D.3
  • 44
    • 29244481551 scopus 로고    scopus 로고
    • Apelin protects myocardial injury induced by isoproterenol in rats
    • Jia YX, Pan CS, Zhang J et al. Apelin protects myocardial injury induced by isoproterenol in rats. Regul. Pept. 133(1-3), 147-154 (2006).
    • (2006) Regul. Pept. , vol.133 , Issue.1-3 , pp. 147-154
    • Jia, Y.X.1    Pan, C.S.2    Zhang, J.3
  • 46
    • 0141615870 scopus 로고    scopus 로고
    • Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction
    • Chen MM, Ashley EA, Deng DX et al. Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation 108(12), 1432-1439 (2003).
    • (2003) Circulation , vol.108 , Issue.12 , pp. 1432-1439
    • Chen, M.M.1    Ashley, E.A.2    Deng, D.X.3
  • 47
    • 33744816839 scopus 로고    scopus 로고
    • Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure
    • Chong KS, Gardner RS, Morton JJ, Ashley EA, Mcdonagh TA. Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure. Eur. J. Heart Fail. 8(4), 355-360 (2006).
    • (2006) Eur. J. Heart Fail. , vol.8 , Issue.4 , pp. 355-360
    • Chong, K.S.1    Gardner, R.S.2    Morton, J.J.3    Ashley, E.A.4    McDonagh, T.A.5
  • 48
    • 29244471763 scopus 로고    scopus 로고
    • Apelin: A new plasma marker of cardiopulmonary disease
    • Goetze JP, Rehfeld JF, Carlsen J et al. Apelin: a new plasma marker of cardiopulmonary disease. Regul. Pept. 133(1-3), 134-138 (2006).
    • (2006) Regul. Pept. , vol.133 , Issue.1-3 , pp. 134-138
    • Goetze, J.P.1    Rehfeld, J.F.2    Carlsen, J.3
  • 49
    • 33947205566 scopus 로고    scopus 로고
    • Utility of plasma apelin and other indices of cardiac dysfunction in the clinical assessment of patients with dilated cardiomyopathy
    • Miettinen KH, Magga J, Vuolteenaho O et al. Utility of plasma apelin and other indices of cardiac dysfunction in the clinical assessment of patients with dilated cardiomyopathy. Regul. Pept. 140(3), 178-184 (2007).
    • (2007) Regul. Pept. , vol.140 , Issue.3 , pp. 178-184
    • Miettinen, K.H.1    Magga, J.2    Vuolteenaho, O.3
  • 51
    • 77149158112 scopus 로고    scopus 로고
    • Correlation between plasma levels of apelin and myocardial hypertrophy in rats and humans: Possible target for treatment Expert Opin
    • Falcao-Pires. I, Goncalves N, Gavina C et al. Correlation between plasma levels of apelin and myocardial hypertrophy in rats and humans: possible target for treatment Expert Opin. Ther. Targets 14(3), 231-241 (2010).
    • (2010) Ther. Targets , vol.14 , Issue.3 , pp. 231-241
    • Falcao-Pires, I.1    Goncalves, N.2    Gavina, C.3
  • 52
    • 34249800363 scopus 로고    scopus 로고
    • Hypoxia inducible factor regulates the cardiac expression and secretion of apelin
    • Ronkainen VP, Ronkainen JJ, Hanninen SL et al. Hypoxia inducible factor regulates the cardiac expression and secretion of apelin. FASEB J. 21(8), 1821-1830 (2007).
    • (2007) FASEB J. , vol.21 , Issue.8 , pp. 1821-1830
    • Ronkainen, V.P.1    Ronkainen, J.J.2    Hanninen, S.L.3
  • 53
    • 84866426382 scopus 로고    scopus 로고
    • Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1
    • Pchejetski D, Foussal C, Alfarano C et al. Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1. Eur. Heart J. 33(18), 2360-2369 (2012).
    • (2012) Eur. Heart J. , vol.33 , Issue.18 , pp. 2360-2369
    • Pchejetski, D.1    Foussal, C.2    Alfarano, C.3
  • 54
    • 35348857484 scopus 로고    scopus 로고
    • Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemia-reperfusion injury
    • Simpkin JC, Yellon DM, Davidson SM, Lim SY, Wynne AM, Smith CC. Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemia-reperfusion injury. Basic Res. Cardiol. 102(6), 518-528 (2007).
    • (2007) Basic Res. Cardiol. , vol.102 , Issue.6 , pp. 518-528
    • Simpkin, J.C.1    Yellon, D.M.2    Davidson, S.M.3    Lim, S.Y.4    Wynne, A.M.5    Smith, C.C.6
  • 55
    • 80053279944 scopus 로고    scopus 로고
    • Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ERdependent apoptotic pathways in a time-dependent fashion
    • Tao J, Zhu W, Li Y et al. Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ERdependent apoptotic pathways in a time-dependent fashion. Am. J. Physiol. Heart Circ. Physiol. 301(4), H1471-H1486 (2011).
    • (2011) Am. J. Physiol. Heart Circ. Physiol. , vol.301 , Issue.4 , pp. H1471-H1486
    • Tao, J.1    Zhu, W.2    Li, Y.3
  • 56
    • 67349152630 scopus 로고    scopus 로고
    • Apelin protects heart against ischemia/reperfusion injury in rat
    • Zeng XJ, Zhang LK, Wang HX, Lu LQ, Ma LQ, Tang CS. Apelin protects heart against ischemia/reperfusion injury in rat. Peptides 30(6), 1144-1152 (2009).
    • (2009) Peptides , vol.30 , Issue.6 , pp. 1144-1152
    • Zeng, X.J.1    Zhang, L.K.2    Wang, H.X.3    Lu, L.Q.4    Ma, L.Q.5    Tang, C.S.6
  • 57
    • 0033515761 scopus 로고    scopus 로고
    • Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
    • Arita Y, Kihara S, Ouchi N et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257(1), 79-83 (1999).
    • (1999) Biochem. Biophys. Res. Commun. , vol.257 , Issue.1 , pp. 79-83
    • Arita, Y.1    Kihara, S.2    Ouchi, N.3
  • 58
    • 84874430535 scopus 로고    scopus 로고
    • Role of adipokines in cardiovascular disease
    • Mattu HS, Randeva HS. Role of adipokines in cardiovascular disease. J. Endocrinol. 216(1), T17-36 (2013).
    • (2013) J. Endocrinol. , vol.216 , Issue.1 , pp. T17-36
    • Mattu, H.S.1    Randeva, H.S.2
  • 59
    • 0035852760 scopus 로고    scopus 로고
    • Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    • Fruebis J, Tsao TS, Javorschi S et al. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl Acad. Sci. USA 98(4), 2005-2010 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , Issue.4 , pp. 2005-2010
    • Fruebis, J.1    Tsao, T.S.2    Javorschi, S.3
  • 60
    • 0037119375 scopus 로고    scopus 로고
    • Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30)
    • Tsao TS, Murrey HE, Hug C, Lee DH, Lodish HF. Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). J. Biol. Chem. 277(33), 29359-29362 (2002).
    • (2002) J. Biol. Chem. , vol.277 , Issue.33 , pp. 29359-29362
    • Tsao, T.S.1    Murrey, H.E.2    Hug, C.3    Lee, D.H.4    Lodish, H.F.5
  • 61
    • 0347379841 scopus 로고    scopus 로고
    • Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways
    • Tsao TS, Tomas E, Murrey HE et al. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J. Biol. Chem. 278(50), 50810-50817 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.50 , pp. 50810-50817
    • Tsao, T.S.1    Tomas, E.2    Murrey, H.E.3
  • 62
    • 0037984387 scopus 로고    scopus 로고
    • Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity
    • Pajvani UB, Du X, Combs TP et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J. Biol. Chem. 278(11), 9073-9085 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.11 , pp. 9073-9085
    • Pajvani, U.B.1    Du, X.2    Combs, T.P.3
  • 63
    • 0037462684 scopus 로고    scopus 로고
    • Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis
    • Yamauchi T, Kamon J, Waki H et al. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J. Biol. Chem. 278(4), 2461-2468 (2003).
    • (2003) J. Biol. Chem. , vol.278 , Issue.4 , pp. 2461-2468
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3
  • 64
    • 3142761477 scopus 로고    scopus 로고
    • T-cadherin is a receptor for hexameric and high-molecularweight forms of Acrp30/adiponectin
    • Hug C, Wang J, Ahmad NS, Bogan JS, Tsao TS, Lodish HF. T-cadherin is a receptor for hexameric and high-molecularweight forms of Acrp30/adiponectin. Proc. Natl Acad. Sci. USA 101(28), 10308-10313 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.28 , pp. 10308-10313
    • Hug, C.1    Wang, J.2    Ahmad, N.S.3    Bogan, J.S.4    Tsao, T.S.5    Lodish, H.F.6
  • 65
    • 34250169052 scopus 로고    scopus 로고
    • Adiponectin and its receptors are expressed in adult ventricular cardiomyocytes and upregulated by activation of peroxisome proliferator-activated receptor gamma
    • Ding G, Qin Q, He N et al. Adiponectin and its receptors are expressed in adult ventricular cardiomyocytes and upregulated by activation of peroxisome proliferator-activated receptor gamma. J. Mol. Cell Cardiol. 43(1), 73-84 (2007).
    • (2007) J. Mol. Cell Cardiol. , vol.43 , Issue.1 , pp. 73-84
    • Ding, G.1    Qin, Q.2    He, N.3
  • 66
    • 33744925901 scopus 로고    scopus 로고
    • Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart
    • Fujioka D, Kawabata K, Saito Y et al. Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart. Am. J. Physiol. Heart Circ. Physiol. 290(6), H2409-H2416 (2006).
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.290 , Issue.6 , pp. H2409-H2416
    • Fujioka, D.1    Kawabata, K.2    Saito, Y.3
  • 67
    • 24944532986 scopus 로고    scopus 로고
    • Adiponectin is synthesized and secreted by human and murine cardiomyocytes
    • Pineiro R, Iglesias MJ, Gallego R et al. Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Lett 579(23), 5163-5169 (2005).
    • (2005) FEBS Lett , vol.579 , Issue.23 , pp. 5163-5169
    • Pineiro, R.1    Iglesias, M.J.2    Gallego, R.3
  • 68
    • 84886413782 scopus 로고    scopus 로고
    • Adipocytokines in relation to cardiovascular disease
    • Van De Voorde J, Pauwels B, Boydens C, Decaluwe K. Adipocytokines in relation to cardiovascular disease. Metabolism 62(11), 1513-1521 (2013).
    • (2013) Metabolism , vol.62 , Issue.11 , pp. 1513-1521
    • Van De Voorde, J.1    Pauwels, B.2    Boydens, C.3    Decaluwe, K.4
  • 69
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T, Kamon J, Waki H et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7(8), 941-946 (2001).
    • (2001) Nat. Med. , vol.7 , Issue.8 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3
  • 70
    • 34249298701 scopus 로고    scopus 로고
    • Hypoadiponectinemia as a predictor for the development of hypertension: A 5-year prospective study
    • Chow WS, Cheung BM, Tso AW et al. Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study. Hypertension 49(6), 1455-1461 (2007).
    • (2007) Hypertension , vol.49 , Issue.6 , pp. 1455-1461
    • Chow, W.S.1    Cheung, B.M.2    Tso, A.W.3
  • 71
    • 19944369735 scopus 로고    scopus 로고
    • Adiponectin-mediated modulation of hypertrophic signals in the heart
    • Shibata R, Ouchi N, Ito M et al. Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat. Med. 10(12), 1384-1389 (2004).
    • (2004) Nat. Med. , vol.10 , Issue.12 , pp. 1384-1389
    • Shibata, R.1    Ouchi, N.2    Ito, M.3
  • 72
    • 0038293399 scopus 로고    scopus 로고
    • Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: Evidence for independent roles of age and sex
    • Cnop M, Havel PJ, Utzschneider KM et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 46(4), 459-469 (2003).
    • (2003) Diabetologia , vol.46 , Issue.4 , pp. 459-469
    • Cnop, M.1    Havel, P.J.2    Utzschneider, K.M.3
  • 74
    • 31044441605 scopus 로고    scopus 로고
    • Adiponectin serum concentrations in men with coronary artery disease: The LUdwigshafen RIsk and Cardiovascular Health (LURIC) study
    • Pilz S, Maerz W, Weihrauch G et al. Adiponectin serum concentrations in men with coronary artery disease: the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study. Clin. Chim. Acta 364(1-2), 251-255 (2006).
    • (2006) Clin. Chim. Acta , vol.364 , Issue.1-2 , pp. 251-255
    • Pilz, S.1    Maerz, W.2    Weihrauch, G.3
  • 75
    • 2442583540 scopus 로고    scopus 로고
    • Adiponectin and atherosclerotic disease
    • Shimada K, Miyazaki T, Daida H. Adiponectin and atherosclerotic disease. Clin. Chim. Acta 344(1-2), 1-12 (2004).
    • (2004) Clin. Chim. Acta , vol.344 , Issue.1-2 , pp. 1-12
    • Shimada, K.1    Miyazaki, T.2    Daida, H.3
  • 76
    • 0033613545 scopus 로고    scopus 로고
    • Novel modulator for endothelial adhesion molecules: Adipocyte-derived plasma protein adiponectin
    • Ouchi N, Kihara S, Arita Y et al. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation 100(25), 2473-2476 (1999).
    • (1999) Circulation , vol.100 , Issue.25 , pp. 2473-2476
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3
  • 77
    • 0035957040 scopus 로고    scopus 로고
    • Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages
    • Ouchi N, Kihara S, Arita Y et al. Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 103(8), 1057-1063 (2001).
    • (2001) Circulation , vol.103 , Issue.8 , pp. 1057-1063
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3
  • 78
    • 34249900491 scopus 로고    scopus 로고
    • Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo
    • Ouedraogo R, Gong Y, Berzins B et al. Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J. Clin. Invest. 117(6), 1718-1726 (2007).
    • (2007) J. Clin. Invest. , vol.117 , Issue.6 , pp. 1718-1726
    • Ouedraogo, R.1    Gong, Y.2    Berzins, B.3
  • 79
    • 0042466384 scopus 로고    scopus 로고
    • Regulation of adiponectin by adipose tissue-derived cytokines: In vivo and in vitro investigations in humans
    • Bruun JM, Lihn AS, Verdich C et al. Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am. J. Physiol. Endocrinol. Metab. 285(3), E527-E533 (2003).
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.285 , Issue.3 , pp. E527-E533
    • Bruun, J.M.1    Lihn, A.S.2    Verdich, C.3
  • 80
    • 0037129861 scopus 로고    scopus 로고
    • Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell
    • Arita Y, Kihara S, Ouchi N et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 105(24), 2893-2898 (2002).
    • (2002) Circulation , vol.105 , Issue.24 , pp. 2893-2898
    • Arita, Y.1    Kihara, S.2    Ouchi, N.3
  • 81
  • 82
    • 84900326177 scopus 로고    scopus 로고
    • Adiponectin/T-cadherin and apelin/APJ expression in human arteries and periadventitial fat: Implication of local adipokine signaling in atherosclerosis Cardiovasc
    • Kostopoulos CG, Spiroglou SG, Varakis JN, Apostolakis E, Papadaki HH. Adiponectin/T-cadherin and apelin/APJ expression in human arteries and periadventitial fat: implication of local adipokine signaling in atherosclerosis Cardiovasc. Pathol. 23(3), 131-138 (2014).
    • (2014) Pathol. , vol.23 , Issue.3 , pp. 131-138
    • Kostopoulos, C.G.1    Spiroglou, S.G.2    Varakis, J.N.3    Apostolakis, E.4    Papadaki, H.H.5
  • 83
    • 34249670301 scopus 로고    scopus 로고
    • Adiponectin protects against the development of systolic dysfunction following myocardial infarction
    • Shibata R, Izumiya Y, Sato K et al. Adiponectin protects against the development of systolic dysfunction following myocardial infarction. J. Mol. Cell Cardiol. 42(6), 1065-1074 (2007).
    • (2007) J. Mol. Cell Cardiol. , vol.42 , Issue.6 , pp. 1065-1074
    • Shibata, R.1    Izumiya, Y.2    Sato, K.3
  • 84
    • 4544341108 scopus 로고    scopus 로고
    • Associations among plasma adiponectin, hypertension, left ventricular diastolic function and left ventricular mass index
    • Hong SJ, Park CG, Seo HS, Oh DJ, Ro YM. Associations among plasma adiponectin, hypertension, left ventricular diastolic function and left ventricular mass index. Blood Press. 13(4), 236-242 (2004).
    • (2004) Blood Press. , vol.13 , Issue.4 , pp. 236-242
    • Hong, S.J.1    Park, C.G.2    Seo, H.S.3    Oh, D.J.4    Ro, Y.M.5
  • 85
    • 33344473170 scopus 로고    scopus 로고
    • Impaired expression of cardiac adiponectin in leptin-deficient mice with viral myocarditis
    • Takahashi T, Yu F, Saegusa S et al. Impaired expression of cardiac adiponectin in leptin-deficient mice with viral myocarditis. Int. Heart J. 47(1), 107-123 (2006).
    • (2006) Int. Heart J. , vol.47 , Issue.1 , pp. 107-123
    • Takahashi, T.1    Yu, F.2    Saegusa, S.3
  • 86
    • 48049089164 scopus 로고    scopus 로고
    • Extension of coronary artery disease is associated with increased IL-6 and decreased adiponectin gene expression in epicardial adipose tissue
    • Eiras S, Teijeira-Fernandez E, Shamagian LG, Fernandez AL, Vazquez-Boquete A, Gonzalez-Juanatey JR. Extension of coronary artery disease is associated with increased IL-6 and decreased adiponectin gene expression in epicardial adipose tissue. Cytokine 43(2), 174-180 (2008).
    • (2008) Cytokine , vol.43 , Issue.2 , pp. 174-180
    • Eiras, S.1    Teijeira-Fernandez, E.2    Shamagian, L.G.3    Fernandez, A.L.4    Vazquez-Boquete, A.5    Gonzalez-Juanatey, J.R.6
  • 88
    • 33744979305 scopus 로고    scopus 로고
    • Adiponectin replenishment ameliorates obesity-related hypertension
    • Ohashi K, Kihara S, Ouchi N et al. Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension 47(6), 1108-1116 (2006).
    • (2006) Hypertension , vol.47 , Issue.6 , pp. 1108-1116
    • Ohashi, K.1    Kihara, S.2    Ouchi, N.3
  • 89
    • 34147163464 scopus 로고    scopus 로고
    • Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress
    • Tao L, Gao E, Jiao X et al. Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress. Circulation 115(11), 1408-1416 (2007).
    • (2007) Circulation , vol.115 , Issue.11 , pp. 1408-1416
    • Tao, L.1    Gao, E.2    Jiao, X.3
  • 90
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 372(6505), 425-432 (1994).
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 91
    • 0034453068 scopus 로고    scopus 로고
    • Glucose metabolism raTher. Than insulin is a main determinant of leptin secretion in humans
    • Wellhoener P, Fruehwald-Schultes B, Kern W et al. Glucose metabolism raTher. than insulin is a main determinant of leptin secretion in humans. J. Clin. Endocrinol. Metab. 85(3), 1267-1271 (2000).
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , Issue.3 , pp. 1267-1271
    • Wellhoener, P.1    Fruehwald-Schultes, B.2    Kern, W.3
  • 92
    • 0029157428 scopus 로고
    • Transient increase in obese gene expression after food intake or insulin administration
    • Saladin R, De Vos P, Guerre-Millo M et al. Transient increase in obese gene expression after food intake or insulin administration. Nature 377(6549), 527-529 (1995).
    • (1995) Nature , vol.377 , Issue.6549 , pp. 527-529
    • Saladin, R.1    De Vos, P.2    Guerre-Millo, M.3
  • 94
    • 0031769566 scopus 로고    scopus 로고
    • Plasma leptin levels are increased in survivors of acute sepsis: Associated loss of diurnal rhythm, in cortisol and leptin secretion
    • Bornstein SR, Licinio J, Tauchnitz R et al. Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm, in cortisol and leptin secretion. J. Clin. Endocrinol. Metab. 83(1), 280-283 (1998).
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , Issue.1 , pp. 280-283
    • Bornstein, S.R.1    Licinio, J.2    Tauchnitz, R.3
  • 95
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • Tartaglia LA, Dembski M, Weng X et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 83(7), 1263-1271 (1995).
    • (1995) Cell , vol.83 , Issue.7 , pp. 1263-1271
    • Tartaglia, L.A.1    Dembski, M.2    Weng, X.3
  • 96
    • 33748970803 scopus 로고    scopus 로고
    • Leptin and atherosclerosis
    • Beltowski J. Leptin and atherosclerosis. Atherosclerosis 189(1), 47-60 (2006).
    • (2006) Atherosclerosis , vol.189 , Issue.1 , pp. 47-60
    • Beltowski, J.1
  • 97
    • 0037148928 scopus 로고    scopus 로고
    • Leptin-replacement therapy for lipodystrophy
    • Oral EA, Simha V, Ruiz E et al. Leptin-replacement therapy for lipodystrophy. N. Engl. J. Med. 346(8), 570-578 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , Issue.8 , pp. 570-578
    • Oral, E.A.1    Simha, V.2    Ruiz, E.3
  • 98
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive-leptin concentrations in normal-weight and obese humans
    • Considine RV, Sinha MK, Heiman ML et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334(5), 292-295 (1996).
    • (1996) N. Engl. J. Med. , vol.334 , Issue.5 , pp. 292-295
    • Considine, R.V.1    Sinha, M.K.2    Heiman, M.L.3
  • 99
    • 84856975510 scopus 로고    scopus 로고
    • Challenges and opportunities of defining clinical leptin resistance
    • Myers MG Jr, Heymsfield SB, Haft C et al. Challenges and opportunities of defining clinical leptin resistance. Cell Metab. 15(2), 150-156 (2012).
    • (2012) Cell Metab. , vol.15 , Issue.2 , pp. 150-156
    • Myers, M.G.1    Heymsfield, S.B.2    Haft, C.3
  • 100
    • 0033931981 scopus 로고    scopus 로고
    • Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
    • El-Haschimi K, Pierroz DD, Hileman SM, Bjorbaek C, Flier JS. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J. Clin. Invest. 105(12), 1827-1832 (2000).
    • (2000) J. Clin. Invest. , vol.105 , Issue.12 , pp. 1827-1832
    • El-Haschimi, K.1    Pierroz, D.D.2    Hileman, S.M.3    Bjorbaek, C.4    Flier, J.S.5
  • 101
    • 34447643051 scopus 로고    scopus 로고
    • Leptin as a cardiac hypertrophic factor: A potential target for therapeutics
    • Karmazyn M, Purdham DM, Rajapurohitam V, Zeidan A. Leptin as a cardiac hypertrophic factor: a potential target for therapeutics. Trends Cardiovasc. Med. 17(6), 206-211 (2007).
    • (2007) Trends Cardiovasc. Med. , vol.17 , Issue.6 , pp. 206-211
    • Karmazyn, M.1    Purdham, D.M.2    Rajapurohitam, V.3    Zeidan, A.4
  • 102
    • 34249983235 scopus 로고    scopus 로고
    • The emerging role of adipokines as mediators of inflammation and immune responses
    • Lago F, Dieguez C, Gomez-Reino J, Gualillo O. The emerging role of adipokines as mediators of inflammation and immune responses. Cytokine Growth Factor Rev. 18(3-4), 313-325 (2007).
    • (2007) Cytokine Growth Factor Rev. , vol.18 , Issue.3-4 , pp. 313-325
    • Lago, F.1    Dieguez, C.2    Gomez-Reino, J.3    Gualillo, O.4
  • 103
    • 0037023656 scopus 로고    scopus 로고
    • Leptin induces endothelin-1 in endothelial cells in vitro
    • Quehenberger P, Exner M, Sunder-Plassmann R et al. Leptin induces endothelin-1 in endothelial cells in vitro. Circ. Res. 90(6), 711-718 (2002).
    • (2002) Circ. Res. , vol.90 , Issue.6 , pp. 711-718
    • Quehenberger, P.1    Exner, M.2    Sunder-Plassmann, R.3
  • 104
    • 27744518880 scopus 로고    scopus 로고
    • Leptin induces vascular smooth muscle cell hypertrophy through angiotensin IIand endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy
    • Zeidan A, Purdham DM, Rajapurohitam V, Javadov S, Chakrabarti S, Karmazyn M. Leptin induces vascular smooth muscle cell hypertrophy through angiotensin IIand endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy. J. Pharmacol. Exp. Ther. 315(3), 1075-1084 (2005).
    • (2005) J. Pharmacol. Exp. Ther. , vol.315 , Issue.3 , pp. 1075-1084
    • Zeidan, A.1    Purdham, D.M.2    Rajapurohitam, V.3    Javadov, S.4    Chakrabarti, S.5    Karmazyn, M.6
  • 105
    • 0032741972 scopus 로고    scopus 로고
    • Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice
    • Howard JK, Lord GM, Matarese G et al. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J. Clin. Invest. 104(8), 1051-1059 (1999).
    • (1999) J. Clin. Invest. , vol.104 , Issue.8 , pp. 1051-1059
    • Howard, J.K.1    Lord, G.M.2    Matarese, G.3
  • 107
    • 84899703983 scopus 로고    scopus 로고
    • Advances in understanding the interrelations between leptin resistance and obesity
    • Pan H, Guo J, Su Z. Advances in understanding the interrelations between leptin resistance and obesity. Physiol. Behav. 30, 157-169 (2014).
    • (2014) Physiol. Behav. , vol.30 , pp. 157-169
    • Pan, H.1    Guo, J.2    Su, Z.3
  • 109
    • 0031606279 scopus 로고    scopus 로고
    • Chronic leptin infusion increases arterial pressure
    • Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension 31(1 Pt 2), 409-414 (1998).
    • (1998) Hypertension , vol.31 , Issue.1 , pp. 409-414
    • Shek, E.W.1    Brands, M.W.2    Hall, J.E.3
  • 110
    • 0033304576 scopus 로고    scopus 로고
    • Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects
    • Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J. Clin. Endocrinol. Metab. 84(10), 3686-3695 (1999).
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , Issue.10 , pp. 3686-3695
    • Ozata, M.1    Ozdemir, I.C.2    Licinio, J.3
  • 111
    • 33746733607 scopus 로고    scopus 로고
    • The inhibitory effect of leptin on angiotensin II-induced vasoconstriction is blunted in spontaneously hypertensive rats
    • Rodriguez A, Fruhbeck G, Gomez-Ambrosi J et al. The inhibitory effect of leptin on angiotensin II-induced vasoconstriction is blunted in spontaneously hypertensive rats. J. Hypertens. 24(8), 1589-1597 (2006).
    • (2006) J. Hypertens. , vol.24 , Issue.8 , pp. 1589-1597
    • Rodriguez, A.1    Fruhbeck, G.2    Gomez-Ambrosi, J.3
  • 112
    • 14644423890 scopus 로고    scopus 로고
    • NO/redox disequilibrium in the failing heart and cardiovascular system
    • Hare JM, Stamler JS. NO/redox disequilibrium in the failing heart and cardiovascular system. J. Clin. Invest. 115(3), 509-517 (2005).
    • (2005) J. Clin. Invest. , vol.115 , Issue.3 , pp. 509-517
    • Hare, J.M.1    Stamler, J.S.2
  • 113
    • 31944447118 scopus 로고    scopus 로고
    • Leptin regulates cardiomyocyte contractile function through endothelin-1 receptor-NADPH oxidase pathway
    • Dong F, Zhang X, Ren J. Leptin regulates cardiomyocyte contractile function through endothelin-1 receptor-NADPH oxidase pathway. Hypertension 47(2), 222-229 (2006).
    • (2006) Hypertension , vol.47 , Issue.2 , pp. 222-229
    • Dong, F.1    Zhang, X.2    Ren, J.3
  • 114
    • 55249127504 scopus 로고    scopus 로고
    • High-fat diet-induced obesity leads to resistance to leptininduced cardiomyocyte contractile response
    • Ren J, Zhu BH, Relling DP, Esberg LB, Ceylan-Isik AF. High-fat diet-induced obesity leads to resistance to leptininduced cardiomyocyte contractile response. Obesity (Silver Spring) 16(11), 2417-2423 (2008).
    • (2008) Obesity (Silver Spring) , vol.16 , Issue.11 , pp. 2417-2423
    • Ren, J.1    Zhu, B.H.2    Relling, D.P.3    Esberg, L.B.4    Ceylan-Isik, A.F.5
  • 115
    • 33846877618 scopus 로고    scopus 로고
    • Electrophysiological characterization of left ventricular myocytes from obese Sprague-Dawley rat
    • Ricci E, Smallwood S, Chouabe C et al. Electrophysiological characterization of left ventricular myocytes from obese Sprague-Dawley rat. Obesity (Silver Spring) 14(5), 778-786 (2006).
    • (2006) Obesity (Silver Spring) , vol.14 , Issue.5 , pp. 778-786
    • Ricci, E.1    Smallwood, S.2    Chouabe, C.3
  • 116
    • 31344444358 scopus 로고    scopus 로고
    • Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes
    • Madani S, De Girolamo S, Munoz DM, Li RK, Sweeney G. Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes. Cardiovasc. Res. 69(3), 716-725 (2006).
    • (2006) Cardiovasc. Res. , vol.69 , Issue.3 , pp. 716-725
    • Madani, S.1    De Girolamo, S.2    Munoz, D.M.3    Li, R.K.4    Sweeney, G.5
  • 117
    • 0035905758 scopus 로고    scopus 로고
    • The hormone resistin links obesity to diabetes
    • Steppan CM, Bailey ST, Bhat S et al. The hormone resistin links obesity to diabetes. Nature 409(6818), 307-312 (2001).
    • (2001) Nature , vol.409 , Issue.6818 , pp. 307-312
    • Steppan, C.M.1    Bailey, S.T.2    Bhat, S.3
  • 118
    • 63849103057 scopus 로고    scopus 로고
    • Role of resistin in insulin sensitivity in rodents and humans
    • Barnes KM, Miner JL. Role of resistin in insulin sensitivity in rodents and humans. Curr. Protein Pept. Sci. 10(1), 96-107 (2009).
    • (2009) Curr. Protein Pept. Sci. , vol.10 , Issue.1 , pp. 96-107
    • Barnes, K.M.1    Miner, J.L.2
  • 119
    • 33745782087 scopus 로고    scopus 로고
    • High plasma resistin level is associated with enhanced highly sensitive C-reactive protein and leukocytes
    • Kunnari A, Ukkola O, Paivansalo M, Kesaniemi YA. High plasma resistin level is associated with enhanced highly sensitive C-reactive protein and leukocytes. J. Clin. Endocrinol. Metab. 91(7), 2755-2760 (2006).
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , Issue.7 , pp. 2755-2760
    • Kunnari, A.1    Ukkola, O.2    Paivansalo, M.3    Kesaniemi, Y.A.4
  • 120
    • 17844392652 scopus 로고    scopus 로고
    • Resistin, an adipokine with potent proinflammatory properties
    • Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A. Resistin, an adipokine with potent proinflammatory properties. J. Immunol. 174(9), 5789-5795 (2005).
    • (2005) J. Immunol. , vol.174 , Issue.9 , pp. 5789-5795
    • Bokarewa, M.1    Nagaev, I.2    Dahlberg, L.3    Smith, U.4    Tarkowski, A.5
  • 121
    • 23044439100 scopus 로고    scopus 로고
    • Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway
    • Silswal N, Singh AK, Aruna B, Mukhopadhyay S, Ghosh S, Ehtesham NZ. Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway. Biochem. Biophys. Res. Commun. 334(4), 1092-1101 (2005).
    • (2005) Biochem. Biophys. Res. Commun. , vol.334 , Issue.4 , pp. 1092-1101
    • Silswal, N.1    Singh, A.K.2    Aruna, B.3    Mukhopadhyay, S.4    Ghosh, S.5    Ehtesham, N.Z.6
  • 122
    • 9344252820 scopus 로고    scopus 로고
    • Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways
    • Calabro P, Samudio I, Willerson JT, Yeh ET. Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways. Circulation 110(21), 3335-3340 (2004).
    • (2004) Circulation , vol.110 , Issue.21 , pp. 3335-3340
    • Calabro, P.1    Samudio, I.2    Willerson, J.T.3    Yeh, E.T.4
  • 123
    • 33645048165 scopus 로고    scopus 로고
    • Adipokine resistin promotes in vitro angiogenesis of human endothelial cells
    • Mu H, Ohashi R, Yan S et al. Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc. Res. 70(1), 146-157 (2006).
    • (2006) Cardiovasc. Res. , vol.70 , Issue.1 , pp. 146-157
    • Mu, H.1    Ohashi, R.2    Yan, S.3
  • 124
    • 34948856487 scopus 로고    scopus 로고
    • Resistin induces lipolysis and re-esterification of triacylglycerol stores, and increases cholesteryl ester deposition, in human macrophages
    • Rae C, Robertson SA, Taylor JM, Graham A. Resistin induces lipolysis and re-esterification of triacylglycerol stores, and increases cholesteryl ester deposition, in human macrophages. FEBS Lett. 581(25), 4877-4883 (2007).
    • (2007) FEBS Lett. , vol.581 , Issue.25 , pp. 4877-4883
    • Rae, C.1    Robertson, S.A.2    Taylor, J.M.3    Graham, A.4
  • 125
    • 77954418344 scopus 로고    scopus 로고
    • Tissue factor is induced by resistin in human coronary artery endothelial cells by the NF-kB-dependent pathway
    • Calabro P, Cirillo P, Limongelli G et al. Tissue factor is induced by resistin in human coronary artery endothelial cells by the NF-kB-dependent pathway. J. Vasc. Res. 48(1), 59-66 (2011).
    • (2011) J. Vasc. Res. , vol.48 , Issue.1 , pp. 59-66
    • Calabro, P.1    Cirillo, P.2    Limongelli, G.3
  • 126
    • 77953788470 scopus 로고    scopus 로고
    • Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells
    • Chen C, Jiang J, Lu JM et al. Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 299(1), H193-H201 (2010).
    • (2010) Am. J. Physiol. Heart Circ. Physiol. , vol.299 , Issue.1 , pp. H193-H201
    • Chen, C.1    Jiang, J.2    Lu, J.M.3
  • 127
    • 57249115900 scopus 로고    scopus 로고
    • Induction of angiogenesis by murine resistin: Putative role of PI3-kinase and NOdependent pathways
    • Robertson SA, Rae CJ, Graham A. Induction of angiogenesis by murine resistin: putative role of PI3-kinase and NOdependent pathways. Regul. Pept. 152(1-3), 41-47 (2009).
    • (2009) Regul. Pept. , vol.152 , Issue.1-3 , pp. 41-47
    • Robertson, S.A.1    Rae, C.J.2    Graham, A.3
  • 128
    • 79959493241 scopus 로고    scopus 로고
    • Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats
    • Chemaly ER, Hadri L, Zhang S et al. Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats. J. Mol. Cell Cardiol. 51(2), 144-155 (2011).
    • (2011) J. Mol. Cell Cardiol. , vol.51 , Issue.2 , pp. 144-155
    • Chemaly, E.R.1    Hadri, L.2    Zhang, S.3
  • 129
    • 34249104938 scopus 로고    scopus 로고
    • Resistin, acute coronary syndrome and prognosis results from the AtheroGene study
    • Lubos E, Messow CM, Schnabel R et al. Resistin, acute coronary syndrome and prognosis results from the AtheroGene study. Atherosclerosis 193(1), 121-128 (2007).
    • (2007) Atherosclerosis , vol.193 , Issue.1 , pp. 121-128
    • Lubos, E.1    Messow, C.M.2    Schnabel, R.3
  • 130
    • 19944433652 scopus 로고    scopus 로고
    • Visfatin: A protein secreted by visceral fat that mimics the effects of insulin
    • Fukuhara A, Matsuda M, Nishizawa M et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 307(5708), 426-430 (2005).
    • (2005) Science , vol.307 , Issue.5708 , pp. 426-430
    • Fukuhara, A.1    Matsuda, M.2    Nishizawa, M.3
  • 131
    • 0027958452 scopus 로고
    • Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor
    • Samal B, Sun Y, Stearns G, Xie C, Suggs S, McNiece I. Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol. Cell Biol. 14(2), 1431-1437 (1994).
    • (1994) Mol. Cell Biol. , vol.14 , Issue.2 , pp. 1431-1437
    • Samal, B.1    Sun, Y.2    Stearns, G.3    Xie, C.4    Suggs, S.5    McNiece, I.6
  • 132
    • 0036856578 scopus 로고    scopus 로고
    • Pre-B-cell colonyenhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis
    • Rongvaux A, Shea RJ, Mulks MH et al. Pre-B-cell colonyenhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. Eur. J. Immunol. 32(11), 3225-3234 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , Issue.11 , pp. 3225-3234
    • Rongvaux, A.1    Shea, R.J.2    Mulks, M.H.3
  • 133
    • 33749433515 scopus 로고    scopus 로고
    • The adipokine visfatin is markedly elevated in obese children
    • Haider DG, Holzer G, Schaller G et al. The adipokine visfatin is markedly elevated in obese children. J. Pediatr. Gastroenterol. Nutr. 43(4), 548-549 (2006).
    • (2006) J. Pediatr. Gastroenterol. Nutr. , vol.43 , Issue.4 , pp. 548-549
    • Haider, D.G.1    Holzer, G.2    Schaller, G.3
  • 134
    • 33646052892 scopus 로고    scopus 로고
    • Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding
    • Haider DG, Schindler K, Schaller G, Prager G, Wolzt M, Ludvik B. Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding. J. Clin. Endocrinol. Metab. 91(4), 1578-1581 (2006).
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , Issue.4 , pp. 1578-1581
    • Haider, D.G.1    Schindler, K.2    Schaller, G.3    Prager, G.4    Wolzt, M.5    Ludvik, B.6
  • 135
    • 55949117816 scopus 로고    scopus 로고
    • Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: A crosssectional study
    • Retnakaran R, Youn BS, Liu Y et al. Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a crosssectional study. Clin. Endocrinol. (Oxford) 69(6), 885-893 (2008).
    • (2008) Clin. Endocrinol. (Oxford) , vol.69 , Issue.6 , pp. 885-893
    • Retnakaran, R.1    Youn, B.S.2    Liu, Y.3
  • 136
    • 62249179991 scopus 로고    scopus 로고
    • Drug discovery possibilities from visfatin cardioprotection Curr
    • Hausenloy DJ. Drug discovery possibilities from visfatin cardioprotection Curr. Opin. Pharmacol. 9(2), 202-207 (2009).
    • (2009) Opin. Pharmacol. , vol.9 , Issue.2 , pp. 202-207
    • Hausenloy, D.J.1
  • 137
    • 33745243693 scopus 로고    scopus 로고
    • Decreased plasma visfatin concentrations in women with gestational diabetes mellitus
    • Chan TF, Chen YL, Lee CH et al. Decreased plasma visfatin concentrations in women with gestational diabetes mellitus. J. Soc. Gynecol. Investig. 13(5), 364-367 (2006).
    • (2006) J. Soc. Gynecol. Investig. , vol.13 , Issue.5 , pp. 364-367
    • Chan, T.F.1    Chen, Y.L.2    Lee, C.H.3
  • 138
    • 33747745349 scopus 로고    scopus 로고
    • Reduced plasma visfatin/pre-B cell colony-enhancing factor in obesity is not related to insulin resistance in humans
    • Pagano C, Pilon C, Olivieri M et al. Reduced plasma visfatin/pre-B cell colony-enhancing factor in obesity is not related to insulin resistance in humans. J. Clin. Endocrinol. Metab. 91(8), 3165-3170 (2006).
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , Issue.8 , pp. 3165-3170
    • Pagano, C.1    Pilon, C.2    Olivieri, M.3
  • 139
    • 52049098545 scopus 로고    scopus 로고
    • Visfatin: Structure, function and relation to diabetes mellitus and other dysfunctions
    • Adeghate E. Visfatin: structure, function and relation to diabetes mellitus and other dysfunctions. Curr. Med. Chem. 15(18), 1851-1862 (2008).
    • (2008) Curr. Med. Chem. , vol.15 , Issue.18 , pp. 1851-1862
    • Adeghate, E.1
  • 140
    • 33947150636 scopus 로고    scopus 로고
    • Insulin-like effects of visfatin on human osteoblasts
    • Xie H, Tang SY, Luo XH et al. Insulin-like effects of visfatin on human osteoblasts. Calcif. Tissue Int. 80(3), 201-210 (2007).
    • (2007) Calcif. Tissue Int. , vol.80 , Issue.3 , pp. 201-210
    • Xie, H.1    Tang, S.Y.2    Luo, X.H.3
  • 141
    • 33847279330 scopus 로고    scopus 로고
    • Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: Possible role in inflammation and plaque destabilization
    • Dahl TB, Yndestad A, Skjelland M et al. Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization. Circulation 115(8), 972-980 (2007).
    • (2007) Circulation , vol.115 , Issue.8 , pp. 972-980
    • Dahl, T.B.1    Yndestad, A.2    Skjelland, M.3
  • 142
    • 33947247655 scopus 로고    scopus 로고
    • Association between plasma visfatin and vascular endothelial function in patients with type 2 diabetes mellitus
    • Takebayashi K, Suetsugu M, Wakabayashi S, Aso Y, Inukai T. Association between plasma visfatin and vascular endothelial function in patients with type 2 diabetes mellitus. Metabolism 56(4), 451-458 (2007).
    • (2007) Metabolism , vol.56 , Issue.4 , pp. 451-458
    • Takebayashi, K.1    Suetsugu, M.2    Wakabayashi, S.3    Aso, Y.4    Inukai, T.5
  • 143
    • 67349083892 scopus 로고    scopus 로고
    • Pre-B cell colony enhancing factor (PBEF)/visfatin induces secretion of MCP-1 in human endothelial cells: Role in visfatin-induced angiogenesis
    • Adya R, Tan BK, Chen J, Randeva HS. Pre-B cell colony enhancing factor (PBEF)/visfatin induces secretion of MCP-1 in human endothelial cells: role in visfatin-induced angiogenesis. Atherosclerosis 205(1), 113-119 (2009).
    • (2009) Atherosclerosis , vol.205 , Issue.1 , pp. 113-119
    • Adya, R.1    Tan, B.K.2    Chen, J.3    Randeva, H.S.4
  • 144
    • 34147118466 scopus 로고    scopus 로고
    • Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2
    • Kim SR, Bae SK, Choi KS et al. Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2. Biochem. Biophys. Res. Commun. 357(1), 150-156 (2007).
    • (2007) Biochem. Biophys. Res. Commun. , vol.357 , Issue.1 , pp. 150-156
    • Kim, S.R.1    Bae, S.K.2    Choi, K.S.3
  • 145
    • 79955656950 scopus 로고    scopus 로고
    • Visfatin exerts angiogenic effects on human umbilical vein endothelial cells through the mTOR signaling pathway
    • Park JW, Kim WH, Shin SH et al. Visfatin exerts angiogenic effects on human umbilical vein endothelial cells through the mTOR signaling pathway. Biochim. Biophys. Acta 1813(5), 763-771 (2011).
    • (2011) Biochim. Biophys. Acta , vol.1813 , Issue.5 , pp. 763-771
    • Park, J.W.1    Kim, W.H.2    Shin, S.H.3
  • 146
    • 84873293264 scopus 로고    scopus 로고
    • Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling
    • Pillai VB, Sundaresan NR, Kim G et al. Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling. Am. J. Physiol. Heart Circ. Physiol. 304(3), H415-H426 (2013).
    • (2013) Am. J. Physiol. Heart Circ. Physiol. , vol.304 , Issue.3 , pp. H415-H426
    • Pillai, V.B.1    Sundaresan, N.R.2    Kim, G.3
  • 147
    • 77953502568 scopus 로고    scopus 로고
    • Effects of visfatin on proliferation and collagen synthesis in rat cardiac fibroblasts
    • Yu XY, Qiao SB, Guan HS, Liu SW, Meng XM. Effects of visfatin on proliferation and collagen synthesis in rat cardiac fibroblasts. Horm. Metab. Res. 42(7), 507-513 (2010).
    • (2010) Horm. Metab. Res. , vol.42 , Issue.7 , pp. 507-513
    • Yu, X.Y.1    Qiao, S.B.2    Guan, H.S.3    Liu, S.W.4    Meng, X.M.5
  • 149
    • 0043253165 scopus 로고    scopus 로고
    • The mammalian fatty acid-binding protein multigene family: Molecular and genetic insights into function
    • Hertzel AV, Bernlohr DA. The mammalian fatty acid-binding protein multigene family: molecular and genetic insights into function. Trends Endocrinol. Metab. 11(5), 175-180 (2000).
    • (2000) Trends Endocrinol. Metab. , vol.11 , Issue.5 , pp. 175-180
    • Hertzel, A.V.1    Bernlohr, D.A.2
  • 150
    • 84918771088 scopus 로고    scopus 로고
    • Differential association of S100A9, an inflammatory marker, and p53, a cell cycle marker, expression with epicardial adipocyte size in patients with cardiovascular disease
    • Agra RM, Fernandez-Trasancos A, Sierra J, Gonzalez-Juanatey JR, Eiras S. Differential association of S100A9, an inflammatory marker, and p53, a cell cycle marker, expression with epicardial adipocyte size in patients with cardiovascular disease. Inflammation 37(5), 1504-1512 (2014).
    • (2014) Inflammation , vol.37 , Issue.5 , pp. 1504-1512
    • Agra, R.M.1    Fernandez-Trasancos, A.2    Sierra, J.3    Gonzalez-Juanatey, J.R.4    Eiras, S.5
  • 151
    • 0029847504 scopus 로고    scopus 로고
    • Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
    • Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 274(5291), 1377-1379 (1996).
    • (1996) Science , vol.274 , Issue.5291 , pp. 1377-1379
    • Hotamisligil, G.S.1    Johnson, R.S.2    Distel, R.J.3    Ellis, R.4    Papaioannou, V.E.5    Spiegelman, B.M.6
  • 153
    • 34250904186 scopus 로고    scopus 로고
    • Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2
    • Furuhashi M, Tuncman G, Gorgun CZ et al. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 447(7147), 959-965 (2007).
    • (2007) Nature , vol.447 , Issue.7147 , pp. 959-965
    • Furuhashi, M.1    Tuncman, G.2    Gorgun, C.Z.3
  • 154
    • 33646493482 scopus 로고    scopus 로고
    • A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease
    • Tuncman G, Erbay E, Hom X et al. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc. Natl Acad. Sci. USA 103(18), 6970-6975 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.18 , pp. 6970-6975
    • Tuncman, G.1    Erbay, E.2    Hom, X.3
  • 155
    • 70349260934 scopus 로고    scopus 로고
    • Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction: A new link between obesity and heart disease
    • Lamounier-Zepter V, Look C, Alvarez J et al. Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction: a new link between obesity and heart disease. Circ. Res. 105(4), 326-334 (2009).
    • (2009) Circ. Res. , vol.105 , Issue.4 , pp. 326-334
    • Lamounier-Zepter, V.1    Look, C.2    Alvarez, J.3
  • 157
    • 13444302216 scopus 로고    scopus 로고
    • S100B expression modulates left ventricular remodeling after myocardial infarction in mice
    • Tsoporis JN, Marks A, Haddad A, Dawood F, Liu PP, Parker TG. S100B expression modulates left ventricular remodeling after myocardial infarction in mice. Circulation 111(5), 598-606 (2005).
    • (2005) Circulation , vol.111 , Issue.5 , pp. 598-606
    • Tsoporis, J.N.1    Marks, A.2    Haddad, A.3    Dawood, F.4    Liu, P.P.5    Parker, T.G.6
  • 158
    • 77951668568 scopus 로고    scopus 로고
    • S100A1: A regulator of striated muscle sarcoplasmic reticulum Ca2+ handling, sarcomeric, and mitochondrial function
    • Volkers M, Rohde D, Goodman C, Most P. S100A1: a regulator of striated muscle sarcoplasmic reticulum Ca2+ handling, sarcomeric, and mitochondrial function. J. BioMed. Biotechnol. 2010, 178614 (2010).
    • (2010) J. BioMed. Biotechnol. , vol.2010 , pp. 178614
    • Volkers, M.1    Rohde, D.2    Goodman, C.3    Most, P.4
  • 159
    • 84879561616 scopus 로고    scopus 로고
    • Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1
    • Yamaguchi N, Chakraborty A, Huang TQ et al. Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1. Am. J. Physiol. Heart Circ. Physiol. 305(1), H86-H94 (2013).
    • (2013) Am. J. Physiol. Heart Circ. Physiol. , vol.305 , Issue.1 , pp. H86-H94
    • Yamaguchi, N.1    Chakraborty, A.2    Huang, T.Q.3
  • 160
    • 33748754119 scopus 로고    scopus 로고
    • Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction
    • Most P, Seifert H, Gao E et al. Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction. Circulation 114(12), 1258-1268 (2006).
    • (2006) Circulation , vol.114 , Issue.12 , pp. 1258-1268
    • Most, P.1    Seifert, H.2    Gao, E.3
  • 163
    • 84901304987 scopus 로고    scopus 로고
    • Differential effects of S100 proteins A2 and A6 on cardiac Ca cycling and contractile performance
    • Wang W, Asp ML, Guerrero-Serna G, Metzger JM. Differential effects of S100 proteins A2 and A6 on cardiac Ca cycling and contractile performance. J. Mol. Cell Cardiol. 72C, 117-125 (2014).
    • (2014) J. Mol. Cell Cardiol. , vol.72 C , pp. 117-125
    • Wang, W.1    Asp, M.L.2    Guerrero-Serna, G.3    Metzger, J.M.4
  • 164
    • 84873469030 scopus 로고    scopus 로고
    • Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts
    • Tamaki Y, Iwanaga Y, Niizuma S et al. Metastasis-associated protein, S100A4 mediates cardiac fibrosis potentially through the modulation of p53 in cardiac fibroblasts. J. Mol. Cell Cardiol. 57, 72-81 (2013).
    • (2013) J. Mol. Cell Cardiol. , vol.57 , pp. 72-81
    • Tamaki, Y.1    Iwanaga, Y.2    Niizuma, S.3
  • 165
    • 84902186793 scopus 로고    scopus 로고
    • S100a8/a9 released by CD11b+Gr1+ neutrophils activates cardiac fibroblasts to initiate angiotensin II-induced cardiac inflammation and injury
    • Wu Y, Li Y, Zhang C et al. S100a8/a9 released by CD11b+Gr1+ neutrophils activates cardiac fibroblasts to initiate angiotensin II-induced cardiac inflammation and injury. Hypertension, 63(6), 1241-1250 (2014).
    • (2014) Hypertension , vol.63 , Issue.6 , pp. 1241-1250
    • Wu, Y.1    Li, Y.2    Zhang, C.3
  • 166
    • 33745096005 scopus 로고    scopus 로고
    • Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products
    • Ehlermann P, Eggers K, Bierhaus A et al. Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products. Cardiovasc. Diabetol. 5, 6 (2006).
    • (2006) Cardiovasc. Diabetol. , vol.5 , pp. 6
    • Ehlermann, P.1    Eggers, K.2    Bierhaus, A.3


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