"Vasocrine" signalling from perivascular fat: A mechanism linking insulin resistance to vascular disease

Lancet

Volumn 365, Issue 9473, 2005, Pages 1817-1820

  Yudkin, John S ^a   Eringa, Etto ^b   Stehouwer, Coen D A ^c  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ARTERIOLE; ATHEROGENESIS; ATHEROSCLEROSIS; BODY FAT; CREMASTER MUSCLE; HUMAN; INSULIN RESISTANCE; LIPID STORAGE; MUSCLE BLOOD FLOW; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; VASCULAR DISEASE; VASOCONSTRICTION; VASODILATATION;

EID: 19744362790     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)66585-3     Document Type: Note

References (22)

1. JS Yudkin, CDA Stehouwer, JJ Emeis, SW Coppack C-reactive protein in healthy subjects: association with obesity, insulin resistance, and endothelial dysfunction Arterioscler Thromb Vasc Biol 19 1999 972 978
2. AD Baron, HO Steinberg, H Chaker, R Leaming, A Johnson, G Brechtel Insulin-mediated skeletal muscle vasodilation contributes to both insulin sensitivity and responsiveness in lean humans J Clin Invest 96 1995 786 792
3. PJ Randle Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years Diabetes Metab Rev 14 1998 263 283
4. RK Davda, KT Stepniakowski, G Lu, ME Ullian, TL Goodfriend Oleic acid inhibits endothelial nitric oxide synthase by a protein kinase C-independent mechanism Hypertension 26 1995 764 770
5. ED Abel, O Peroni, JK Kim Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver Nature 409 2001 729 733
6. A Seppala-Lindroos, S Vehkavaara, A-M Hakkinen Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men J Clin Endocrinol Metab 87 2002 3023 3028
7. DE Kelley, LJ Mandarino Fuel selection in human skeletal muscle in insulin resistance: a reexamination Diabetes 49 2000 677 683
8. L Zhang, MA Vincent, SM Richards Insulin sensitivity of muscle capillary recruitment in vivo Diabetes 53 2004 447 453
9. M Coggins, J Lindner, S Rattigan Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment Diabetes 50 2001 2682 2690
10. EH Serné, RG IJzerman, RO Gans Direct evidence for insulin-induced capillary recruitment in skin of healthy subjects during physiological hyperinsulinemia Diabetes 51 2002 1515 1522
11. AS Greene, PJ Tonellato, J Lui, JH Lombard, AW Cowley Microvascular rarefaction and tissue vascular resistance in hypertension Am J Physiol 256 1989 H126 H131
12. S Rattigan, MG Clark, EJ Barrett Hemodynamic actions of insulin in rat skeletal muscle. Evidence for capillary recruitment Diabetes 46 1997 1381 1388
13. EC Eringa, CDA Stehouwer, GP van Nieuw Amerongen, L Ouwehand, N Westerhof, P Sipkema Vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by ERK1/2 activation in endothelium Am J Physiol Heart Circ Physiol 287 2004 H2043 H2048
14. F Mohamed, JC Monge, A Gordon, P Cernacek, D Blais, DJ Stewart Lack of role for nitric oxide (NO) in the selective destabilisation of endothelial NO synthase mRNA by tumor necrosis factor-alpha Arterioscler Thromb Vasc Biol 15 1995 52 57
15. L Zhang, CM Wheatley, SM Richards, EJ Barrett, MG Clark, S Rattigan TNF-alpha acutely inhibits vascular effects of physiological but not high insulin or contraction Am J Physiol Endocrinol Metab 285 2003 E654 E660
16. AN Schechter, MT Gladwin Hemoglobin and the paracrine and endocrine functions of nitric oxide N Engl J Med 348 2003 1483 1485
17. RF Furchgott, JV Zawadaki The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Nature 288 1980 373 376
18. MG Wallis, CM Wheatley, S Rattigan, EJ Barrett, AD Clark, MG Clark Insulin-mediated hemodynamic changes are impaired in muscle of Zucker obese rats Diabetes 51 2002 3492 3498
19. JMB Newman, JT Steen, MG Clark Vessels supplying septa and tendons as functional shunts in perfused rat hindlimb Microvasc Res 54 1997 49 57
20. T Mazurek, LF Zhang, A Zalewski Human epicardial adipose tissue is a source of inflammatory mediators Circulation 108 2003 2460 2466
21. G Iacobellis, MC Ribaudo, F Assael Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk J Clin Endocrinol Metab 88 2003 5163 5168
22. P Arner Regional differences in protein production by human adipose tissue Biochem Soc Trans 29 2001 72 75