Adipokines as novel cardiovascular disease markers. Pathological and clinical considerations;Adipocitocinas como nuevos marcadores de la enfermedad cardiovascular. Perspectivas fisiopatológicas y clínicas

Revista Espanola de Cardiologia

Volumn 62, Issue SUPPL. 2, 2009, Pages 9-16

  González Juanatey, José R ^a   Paz, Francisca Lago ^a   Eiras, Sonia ^a   Teijeira Fernández, Elvis ^a  

^a Instituto de Salud Carlos III   (Spain)

Author keywords

Adipokines; Cardiomyocytes; Epicardial fat

Indexed keywords

ADIPOCYTOKINE; CYTOKINE; GHRELIN; ROSIGLITAZONE;

ADIPOSE TISSUE; CARDIOVASCULAR RISK; CELL METABOLISM; CELL STRUCTURE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE SEVERITY; HEART MUSCLE CELL; HUMAN; HYPERTENSION; INTRAABDOMINAL FAT; REVIEW; SUBCUTANEOUS FAT;

EID: 70349156479     PISSN: 03008932     EISSN: 15792242     Source Type: Journal    
DOI: 10.1016/S0300-8932(09)72117-7     Document Type: Article

References (53)

1. D. Mozaffarian, P.W. Wilson, and W.B. Kannel Beyond established and novel risk factors: lifestyle risk factors for cardiovascular disease Circulation 117 2008 3031 3038
2. M.J. Medrano, R. Pastor-Barriuso, R. Boix, J.L. Del Barrio, J. Damián, and R. Álvarez Riesgo coronario atribuible a los factores de riesgo cardiovascular en población española Rev Esp Cardiol 60 2007 1250 1256 (Pubitemid 350294324)
3. J.P. Despres, and I. Lemieux Abdominal obesity and metabolic syndrome Nature 444 2006 881 887 (Pubitemid 46024995)
4. M.E. Trujillo, and P.E. Scherer Adipose tissue-derived factors: impact on health and disease Endocr Rev 27 2006 762 778 (Pubitemid 44936059)
5. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman Positional cloning of the mouse obese gene and its human homologue Nature 372 1994 425 432 (Pubitemid 24365442)
6. P.E. Scherer, S. Williams, M. Fogliano, G. Baldini, and H.F. Lodish A novel serum protein similar to C1q, produced exclusively in adipocytes J Biol Chem 270 1995 26746 26749
7. A. Fukuhara, M. Matsuda, M. Nishizawa, K. Segawa, M. Tanaka, and K. Kishimoto Visfatin: a protein secreted by visceral fat that mimics the effects of insulin Science 307 2005 426 430 (Pubitemid 40139988)
8. D.K. Lee, S.R. George, and B.F. O'Dowd Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity Trends Pharmacol Sci 27 2006 190 194
9. G.B. Di Gregorio, A. Yao-Borengasser, N. Rasouli, V. Varma, T. Lu, and L.M. Miles Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone Diabetes 54 2005 2305 2313 (Pubitemid 41134256)
10. M.C. Alessi, F. Peiretti, P. Morange, M. Henry, G. Nalbone, and I. Juhan-Vague Production of plasminogen activator inhibitor 1 by human adipose tissue: possible link between visceral fat accumulation and vascular disease Diabetes 46 1997 860 867 (Pubitemid 27188265)
11. F. Lago, C. Dieguez, J. Gomez-Reino, and O. Gualillo The emerging role of adipokines as mediators of inflammation and immune responses Cytokine Growth Factor Rev 18 2007 313 325 (Pubitemid 46891288)
12. P.A. Kern, S. Ranganathan, C. Li, L. Wood, and G. Ranganathan Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance Am J Physiol Endocrinol Metab 280 2001 E745 E751 (Pubitemid 32466842)
13. T. Skurk, C. Alberti-Huber, C. Herder, and H. Hauner Relationship between adipocyte size and adipokine expression and secretion J Clin Endocrinol Metab 92 2007 1023 1033 (Pubitemid 46465679)
14. G.A. Bewick, A. Kent, D. Campbell, M. Patterson, M.A. Ghatei, and S.R. Bloom, et al. Mice with hyperghrelinemia are hyperphagic, glucose intolerant and have reduced leptin sensitivity Diabetes 58 2009 840 846
15. J. Isgaard, A. Barlind, and I. Johansson Cardiovascular effects of ghrelin and growth hormone secretagogues Cardiovasc Hematol Disord Drug Targets 8 2008 133 137
16. Y. Yano, K. Toshinai, T. Inokuchi, K. Kangawa, K. Shimada, and K. Kario, et al. Plasma des-acyl ghrelin, but not plasma HMW adiponectin, is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensive patients Atherosclerosis 2008 Epub ahead of print
17. D.O. Schwenke, T. Tokudome, I. Kishimoto, T. Horio, M. Shirai, and P.A. Cragg, et al. Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality Endocrinology 149 2008 5172 5176
18. X. Xu, B.S. Jhun, C.H. Ha, and Z.G. Jin Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation Endocrinology 149 2008 4183 4192
19. X.B. Xu, J.J. Pang, J.M. Cao, C. Ni, R.K. Xu, and X.Z. Peng GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure Am J Physiol Heart Circ Physiol 289 2005 H1643 H1651 (Pubitemid 41369008)
20. N. Nagaya, M. Kojima, and K. Kangawa Ghrelin, a novel growth hormone-releasing peptide, in the treatment of cardiopulmonary-associated cachexia Intern Med 45 2006 127 134 (Pubitemid 43349437)
21. P. Pusztai, B. Sarman, E. Ruzicska, J. Toke, K. Racz, and A. Somogyi, et al. Ghrelin: a new peptide regulating the neurohormonal system, energy homeostasis and glucose metabolism Diabetes Metab Res Rev 24 2008 343 352
22. M.J. Iglesias, R. Pineiro, M. Blanco, R. Gallego, C. Dieguez, and O. Gualillo Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes Cardiovasc Res 62 2004 481 488 (Pubitemid 38648962)
23. Y. Arita, S. Kihara, N. Ouchi, M. Takahashi, K. Maeda, and J. Miyagawa Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity Biochem Biophys Res Commun 257 1999 79 83 (Pubitemid 29299050)
24. T. Kadowaki, and T. Yamauchi Adiponectin and adiponectin receptors Endocr Rev 26 2005 439 451 (Pubitemid 40686653)
25. M.J. Yoon, G.Y. Lee, J.J. Chung, Y.H. Ahn, S.H. Hong, and J.B. Kim Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha Diabetes 55 2006 2562 2570
26. M. Bluher, J.W. Bullen Jr, J.H. Lee, S. Kralisch, M. Fasshauer, and N. Kloting Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training J Clin Endocrinol Metab 91 2006 2310 2316 (Pubitemid 43855022)
27. W.S. Chow, B.M. Cheung, A.W. Tso, A. Xu, N.M. Wat, and C.H. Fong Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study Hypertension 49 2007 1455 1461 (Pubitemid 46809394)
28. Y. Iwashima, T. Katsuya, K. Ishikawa, N. Ouchi, M. Ohishi, and K. Sugimoto Hypoadiponectinemia is an independent risk factor for hypertension Hypertension 43 2004 1318 1323 (Pubitemid 38691756)
29. L. Fontana, J.C. Eagon, M.E. Trujillo, P.E. Scherer, and S. Klein Visceral fat adipokine secretion is associated with systemic inflammation in obese humans Diabetes 56 2007 1010 1013 (Pubitemid 46525079)
30. D.C. Chan, P.H. Barrett, E.M. Ooi, J. Ji, D.T. Chan, and G.F. Watts Very-low density lipoprotein metabolism and plasma adiponectin as predictors of high-density lipoprotein apolipoprotein A-I kinetics in obese and non-obese men J Clin Endocrinol Metab 94 2008 989 997
31. R. Ouedraogo, Y. Gong, B. Berzins, X. Wu, K. Mahadev, and K. Hough Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo J Clin Invest 117 2007 1718 1726 (Pubitemid 46871356)
32. T. Pischon, C.J. Girman, G.S. Hotamisligil, N. Rifai, F.B. Hu, and E.B. Rimm Plasma adiponectin levels and risk of myocardial infarction in men JAMA 291 2004 1730 1737 (Pubitemid 38489895)
33. R. Wolk, P. Berger, R.J. Lennon, E.S. Brilakis, D.E. Davison, and V.K. Somers Association between plasma adiponectin levels and unstable coronary syndromes Eur Heart J 28 2007 292 298 (Pubitemid 46254633)
34. M.B. Schulze, I. Shai, E.B. Rimm, T. Li, N. Rifai, and F.B. Hu Adiponectin and future coronary heart disease events among men with type 2 diabetes Diabetes 54 2005 534 539
35. S. Kojima, T. Funahashi, T. Sakamoto, S. Miyamoto, H. Soejima, and J. Hokamaki The variation of plasma concentrations of a novel, adipocyte derived protein, adiponectin, in patients with acute myocardial infarction Heart 89 2003 667 (Pubitemid 36606220)
36. F. Otsuka, S. Sugiyama, S. Kojima, H. Maruyoshi, T. Funahashi, and K. Matsui Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease J Am Coll Cardiol 48 2006 1155 1162 (Pubitemid 44345143)
37. E. Cavusoglu, C. Ruwende, V. Chopra, S. Yanamadala, C. Eng, and L.T. Clark Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain Eur Heart J 27 2006 2300 2309 (Pubitemid 44453573)
38. R. Schnabel, C.M. Messow, E. Lubos, C. Espinola-Klein, H.J. Rupprecht, and C. Bickel, et al. Association of adiponectin with adverse outcome in coronary artery disease patients: results from the AtheroGene study Eur Heart J 29 2008 649 657
39. R. Shibata, K. Sato, D.R. Pimentel, Y. Takemura, S. Kihara, and K. Ohashi Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms Nat Med 11 2005 1096 1103 (Pubitemid 41486832)
40. R. Shibata, Y. Izumiya, K. Sato, K. Papanicolaou, S. Kihara, and W.S. Colucci Adiponectin protects against the development of systolic dysfunction following myocardial infarction J Mol Cell Cardiol 42 2007 1065 1074 (Pubitemid 46829193)
41. R. Pineiro, M.J. Iglesias, R. Gallego, K. Raghay, S. Eiras, and J. Rubio Adiponectin is synthesized and secreted by human and murine cardiomyocytes FEBS Lett 579 2005 5163 5169 (Pubitemid 41318086)
42. G. Ding, Q. Qin, N. He, S.C. Francis-David, J. Hou, and J. Liu Adiponectin and its receptors are expressed in adult ventricular cardiomyocytes and upregulated by activation of peroxisome proliferator-activated receptor gamma J Mol Cell Cardiol 43 2007 73 84 (Pubitemid 46898422)
43. H. Sell, D. Dietze-Schroeder, K. Eckardt, and J. Eckel Cytokine secretion by human adipocytes is differentially regulated by adiponectin, AICAR, and troglitazone Biochem Biophys Res Commun 343 2006 700 706
44. I. Mertens, D. Ballaux, T. Funahashi, Y. Matsuzawa, M. Van der Planken, and A. Verrijken, et al. Inverse relationship between plasminogen activator inhibitor-I activity and adiponectin in overweight and obese women. Interrelationship with visceral adipose tissue, insulin resistance, HDL-chol and inflammation Thromb Haemost 94 2005 1190 1195
45. I.B. Bauche, S. Ait El Mkadem, R. Rezsohazy, T. Funahashi, N. Maeda, and L.M. Miranda Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice Biochem Biophys Res Commun 345 2006 1414 1424 (Pubitemid 43817889)
46. G. Iacobellis, D. Corradi, and A.M. Sharma Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart Nat Clin Pract Cardiovasc Med 2 2005 536 543 (Pubitemid 41670345)
47. D. Corradi, R. Maestri, S. Callegari, P. Pastori, M. Goldoni, and T.V. Luong The ventricular epicardial fat is related to the myocardial mass in normal, ischemic and hypertrophic hearts Cardiovasc Pathol 13 2004 313 316 (Pubitemid 39531917)
48. G. Iacobellis, M.C. Ribaudo, A. Zappaterreno, C.V. Iannucci, and F. Leonetti Relation between epicardial adipose tissue and left ventricular mass Am J Cardiol 94 2004 1084 1087 (Pubitemid 39336453)
49. G. Iacobellis, M.C. Ribaudo, F. Assael, E. Vecci, C. Tiberti, and A. Zappaterreno Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk J Clin Endocrinol Metab 88 2003 5163 5168 (Pubitemid 37452712)
50. T. Mazurek, L. Zhang, A. Zalewski, J.D. Mannion, J.T. Diehl, and H. Arafat Human epicardial adipose tissue is a source of inflammatory mediators Circulation 108 2003 2460 2466 (Pubitemid 37444406)
51. S. Eiras, E. Teijeira-Fernandez, L.G. Shamagian, A.L. Fernandez, A. Vazquez-Boquete, and J.R. Gonzalez-Juanatey Extension of coronary artery disease is associated with increased IL-6 and decreased adiponectin gene expression in epicardial adipose tissue Cytokine 43 2008 174 180
52. E. Teijeira-Fernandez, S. Eiras, L. Grigorian-Shamagian, A. Fernandez, B. Adrio, and J.R. Gonzalez-Juanatey Epicardial adipose tissue expression of adiponectin is lower in patients with hypertension J Hum Hypertens 22 2008 856 863
53. M.J. Iglesias, S. Eiras, R. Piñeiro, D. López-Otero, R. Gallego, and A.L. Fernández Influencia del sexo en la expresión de adiponectina y leptina en el tejido adiposo epicárdico y subcutáneo. Estudio en pacientes sometidos a cirugía cardiaca Rev Esp Cardiol 59 2006 1252 1260 (Pubitemid 46188824)